The N-acetylcysteine-insensitive acetic acid-induced yeast programmed cell death occurs without macroautophagy

Current Pharmaceutical Biotechnology

Volumn 13, Issue 15, 2012, Pages 2705-2711

  Antonacci, Lucia ^a   Guaragnella, Nicoletta ^a   Ždralević, Maša ^a   Passarella, Salvatore ^b   Marra, Ersilia ^a   Giannattasio, Sergio ^a  

^a CNR   (Italy)

^b UNIVERSITY OF MOLISE   (Italy)

Author keywords

Cytochrome c; Macroautophagy; N acetylcysteine; Programmed cell death; Saccharomyces cerevisiae; YCA1

Indexed keywords

ACETIC ACID; ACETYLCYSTEINE; CYTOCHROME C; FUNGAL ENZYME; METACASPASE YCA1; NITROGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL VIABILITY; COLONY FORMING UNIT; CONTROLLED STUDY; ENZYME ACTIVITY; FUNGAL STRAIN; IMMUNOBLOTTING; MACROAUTOPHAGY; NICK END LABELING; NONHUMAN; PH; SACCHAROMYCES CEREVISIAE; YEAST;

ACETIC ACID; ACETYLCYSTEINE; ALKALINE PHOSPHATASE; ANTIOXIDANTS; CASPASES; CYTOCHROMES C; IN SITU NICK-END LABELING; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 84872560734     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920112804724819     Document Type: Article

References (45)

1. Galluzzi, L.; Vitale, I.; Abrams, J. M.; Alnemri, E. S.; Baehrecke, E. H.; Blagosklonny, M. V.; Dawson, T.M.; Dawson, V.L.; El-Deiry, W. S.; Fulda, S.; Gottlieb, E.; Green, D. R.; Hengartner, M. O.; Kepp, O.; Knight, R. A.; Kumar, S.; Lipton, S. A.; Lu, X.; Madeo, F.; Malorni, W.; Mehlen, P.; Nuñez, G.; Peter, M. E.; Piacentini, M.; Rubinsztein, D. C.; Shi, Y.; Simon, H. U.; Vandenabeele, P.; White, E.; Yuan, J.; Zhivotovsky, B.; Melino, G.; Kroemer, G.; Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ., 2012, 19(1), 107-120.
2. Bursch, W. The autophagosomal-lysosomal compartment in programmed cell death. Cell Death Differ., 2001, 8(6), 569-581.
3. Yu, L.; Lenardo, M.J.; Baehrecke, E.H. Autophagy and caspases: a new cell death program. Cell Cycle, 2004, 3(9), 1124-1126.
4. Tsujimoto, Y.; Shimizu, S. Another way to die: autophagic programmed cell death. Cell Death Differ., 2005, 12(Suppl. 2), 1528-1534.
5. Fazi, B.; Bursch, W.; Fimia, G.M.; Nardacci, R.; Piacentini, M.; Di Sano, F.; Piredda, L. Fenretinide induces autophagic cell death in caspase-defective breast cancer cells. Autophagy, 2008, 4(4), 435-441.
6. Rami, A. Review: autophagy in neurodegeneration: firefighter and/or incendiarist? Neuropathol. Appl. Neurobiol., 2009, 35(5), 449-461.
7. Wang, C.; Youle, R.J. The role of mitochondria in apoptosis*. Annu. Rev. Genet., 2009, 43, 95-118.
8. Shimizu, S.; Kanaseki, T.; Mizushima, N.; Mizuta, T.; Arakawa-Kobayashi, S.; Thompson, C. B.; Tsujimoto, Y. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat. Cell Biol., 2004, 6(12), 1221-1228.
9. Jiang, J.; Maeda, A.; Ji, J.; Baty, C.J.; Watkins, S.C.; Greenberger, J.S.; Kagan, V.E. Are mitochondrial reactive oxygen species required for autophagy? Biochem. Biophys. Res. Commun., 2011, 412(1), 55-60.
10. Carmona-Gutierrez, D.; Eisenberg, T.; Buttner, S.; Meisinger, C.; Kroemer, G.; Madeo, F. Apoptosis in yeast: triggers, pathways, subroutines. Cell Death Differ., 2010, 17(5), 763-773.
11. Greenwood, M.T.; Ludovico, P. Expressing and functional analysis of mammalian apoptotic regulators in yeast. Cell Death Differ., 2010,17(5), 737-745.
12. Ludovico, P.; Sousa, M.J.; Silva, M.T.; Leao, C.; Corte-Real, M. Saccharomyces cerevisiae commits to a programmed cell death process in response to acetic acid. Microbiology, 2001, 147(Pt. 9), 2409-2415.
13. Guaragnella, N.; Antonacci, L.; Passarella, S.; Marra, E.; Giannattasio, S. Hydrogen peroxide and superoxide anion production during acetic acid-induced yeast programmed cell death. Folia Microbiol., 2007, 52(3), 237-240.
14. Guaragnella, N.; Bobba, A.; Passarella, S.; Marra, E.; Giannattasio, S. Yeast acetic acid-induced programmed cell death can occur without cytochrome c release which requires metacaspase YCA1. FEBS Lett, 2010, 584(1), 224-228.
15. Guaragnella, N.; Passarella, S.; Marra, E.; Giannattasio, S. Knockout of metacaspase and/or cytochrome c results in the activation of a ROS-independent acetic acid-induced programmed cell death pathway in yeast. FEBS Lett, 2010, 584(16), 3655-3660.
16. Guaragnella, N.; Passarella, S.; Marra, E.; Giannattasio, S. Cytochrome c Trp65Ser substitution results in inhibition of acetic acidinduced programmed cell death in Saccharomyces cerevisiae. Mitochondrion, 2011, 11(6), 987-991.
17. Guaragnella, N.; Pereira, C.; Sousa, M.J.; Antonacci, L.; Passarella, S.; Corte-Real, M.; Marra, E.; Giannattasio, S. YCA1 participates in the acetic acid induced yeast programmed cell death also in a manner unrelated to its caspase-like activity. FEBS Lett, 2006, 580(30), 6880-6884.
18. Yang, Z.; Klionsky, D.J. Eaten alive: a history of macroautophagy. Nat. Cell Biol., 2010, 12(9), 814-822.
19. Abeliovich, H.; Klionsky, D.J. Autophagy in yeast: mechanistic insights and physiological function. Microbiol. Mol. Biol. Rev., 2001, 65(3), 463-7.
20. Kissova, I.; Salin, B.; Schaeffer, J.; Bhatia, S.; Manon, S.; Camougrand, N. Selective and non-selective autophagic degradation of mitochondria in yeast. Autophagy, 2007, 3(4), 329-336.
21. Kanki, T.; Klionsky, D.J. The molecular mechanism of mitochondria autophagy in yeast. Mol. Microbiol., 2010, 75(4), 795-800.
22. Deffieu, M.; Bhatia-Kissova, I.; Salin, B.; Galinier, A.; Manon, S.; Camougrand, N. Glutathione participates in the regulation of mitophagy in yeast. J. Biol. Chem., 2009, 284(22), 14828-14837.
23. Kissova, I.B.; Camougrand, N. Glutathione participates in the regulation of mitophagy in yeast. Autophagy, 2009, 5(6), 872-873.
24. Voth, W.P.; Jiang, Y.W.; Stillman, D.J. New 'marker swap' plasmids for converting selectable markers on budding yeast gene disruptions and plasmids. Yeast, 2003, 20(11), 985-993.
25. Boeke, J.D.; LaCroute, F.; Fink, G.R. A positive selection for mutants lacking orotidine-5'-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance. Mol. Gen. Genet., 1984, 197(2), 345-346.
26. Bradford, M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding. Anal. Biochem., 1976, 72, 248-254.
27. Nothwehr, S. F.; Bryant, N. J.; Stevens, T. H. The newly identified yeast GRD genes are required for retention of late-Golgi membrane proteins. Mol. Cell. Biol., 1996, 16(6), 2700-2707.
28. Noda, T.; Matsuura, A.; Wada, Y.; Ohsumi, Y. Novel system for monitoring autophagy in the yeast Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun., 1995, 210(1), 126-132.
29. Qiao, W.; Ellis, C.; Steffen, J.; Wu, C.Y.; Eide, D.J. Zinc status and vacuolar zinc transporters control alkaline phosphatase accumulation and activity in Saccharomyces cerevisiae. Mol. Microbiol., 2009, 72(2), 320-334.
30. Kim, J.; Dalton, V.M.; Eggerton, K.P.; Scott, S.V.; Klionsky, D.J. Apg7p/Cvt2p is required for the cytoplasm-to-vacuole targeting, macroautophagy, and peroxisome degradation pathways. Mol. Biol. Cell, 1999, 10(5), 1337-1351.
31. Tanida, I.; Mizushima, N.; Kiyooka, M.; Ohsumi, M.; Ueno, T.; Ohsumi, Y.; Kominami, E. Apg7p/Cvt2p: A novel proteinactivating enzyme essential for autophagy. Mol. Biol. Cell, 1999, 10(5), 1367-1379.
32. Guaragnella, N.; Antonacci, L.; Passarella, S.; Marra, E.; Giannattasio, S. Achievements and perspectives in yeast acetic acidinduced programmed cell death pathways. Biochem. Soc. Trans., 2011, 39(5), 1538-1543.
33. Giannattasio, S.; Atlante, A.; Antonacci, L.; Guaragnella, N.; Lattanzio, P.; Passarella, S.; Marra, E. Cytochrome c is released from coupled mitochondria of yeast en route to acetic acid-induced programmed cell death and can work as an electron donor and a ROS scavenger. FEBS Lett., 2008, 582(10), 1519-1525.
34. Gozuacik, D.; Kimchi, A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene, 2004, 23(16), 2891-2906.
35. Lee, R.E.; Brunette, S.; Puente, L.G.; Megeney, L.A. Metacaspase Yca1 is required for clearance of insoluble protein aggregates. Proc. Natl. Acad Sci. USA, 2010, 107(30), 13348-13353.
36. Edinger, A.L.; Thompson, C.B. Death by design: apoptosis, necrosis and autophagy. Curr. Opin. Cell Biol., 2004, 16(6), 663-669.
37. Tyagi, N.; Qipshidze, N.; Munjal, C.; Vacek, J.C.; Metreveli, N.; Givvimani, S.; Tyagi, S.C. Tetrahydrocurcumin Ameliorates Homocysteinylated Cytochrome-c Mediated Autophagy in Hyperhomocysteinemia Mice after Cerebral Ischemia. J. Mol. Neurosci., 2012, 47(1), 128-138.
38. Xu, Y.; Kim, S.O.; Li, Y.; Han, J. Autophagy contributes to caspase-independent macrophage cell death. J. Biol. Chem., 2006, 281(28), 19179-19187.
39. Colell, A.; Ricci, J.E.; Tait, S.; Milasta, S.; Maurer, U.; Bouchier-Hayes, L.; Fitzgerald, P.; Guio-Carrion, A.; Waterhouse, N.J.; Li, C.W.; Mari, B.; Barbry, P.; Newmeyer, D.D.; Beere, H. M.; Green, D.R. GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell, 2007, 129(5), 983-997.
40. Lefevre, S.; Sliwa, D.; Auchere, F.; Brossas, C.; Ruckenstuhl, C.; Boggetto, N.; Lesuisse, E.; Madeo, F.; Camadro, J.M.; Santos, R. The yeast metacaspase is implicated in oxidative stress response in frataxin-deficient cells. FEBS Lett., 586(2), 143-148.
41. Okamoto, K.; Kondo-Okamoto, N. Mitochondria and autophagy: Critical interplay between the two homeostats. Biochim. Biophys. Acta, 2011, 1820(5), 595-600.
42. Zafarullah, M.; Li, W.Q.; Sylvester, J.; Ahmad, M. Molecular mechanisms of N-acetylcysteine actions. Cell. Mol. Life Sci., 2003, 60(1), 6-20.
43. Aruoma, O.I.; Halliwell, B.; Hoey, B.M.; Butler, J. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic. Biol. Med., 1989, 6(6), 593-597.
44. Benrahmoune, M.; Therond, P.; Abedinzadeh, Z. The reaction of superoxide radical with N-acetylcysteine. Free Radic. Biol. Med., 2000, 29(8), 775-782.
45. Pereira, C.; Chaves, S.; Alves, S.; Salin, B.; Camougrand, N.; Manon, S.; Sousa, M.J.; Corte-Real, M. Mitochondrial degradation in acetic acid-induced yeast apoptosis: the role of Pep4 and the ADP/ATP carrier. Mol. Microbiol., 2010, 76(6), 1398-1410.