Identification of metabolites of arbidol by ultra-high performance liquid chromatography tandem mass spectrometry

Yaoxue Xuebao

Volumn 47, Issue 11, 2012, Pages 1521-1526

  Liu, Xiao ^a,b   Li, Huan ^a   Bi, Kai Shun ^b   Chen, Xiao Hui ^b   Cai, Hao ^a   Cai, Bao Chang ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Arbidol; Isotope; Metabolite; UPLC MS MS

Indexed keywords

ARBIDOL; DRUG METABOLITE; ISOTOPE;

ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; BLOOD ANALYSIS; CHEMICAL ANALYSIS; DEMETHYLATION; DRUG GLUCURONIDATION; DRUG METABOLISM; FECES ANALYSIS; NONHUMAN; OXIDATION; RAT; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS;

ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FECES; FEMALE; INDOLES; MALE; RATS; RATS, WISTAR; TANDEM MASS SPECTROMETRY;

EID: 84872503068     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Semenenko TA, Selkova EP, Gotvianskaia TP, et al. Mechanisms of arbidole's immunomodulating action [J]. Epidemiol Immunobiol, 2005, 6: 24-28.
2. Beliaev AL, Burtseva EI, Slepushkin AN, et al. Arbidol-a new drug for prevention of influenza and acute viral respiratory infections in children [J]. Vestn Ross Akad Med Nauk, 1996, 8: 34-37.
3. Hong LP, Chen YF. Prevention and treatment of influenza in children, acute viral respiratory infections of chemical drugs-arbidol [J]. Shanghai Med Pharm J, 2007, 28: 409-411.
4. Zelena E, Dunn WB, Broadhurst D, et al. Development of a robust and repeatable UPLC-MS method for the long-term metabolomic study of human serum [J]. Anal Chem, 2009, 81: 1357-1364.
5. Wang LN, Song M, Hang TJ, et al. Metabolites of 1-(1-(6-methoxyl-2- naphthyl)ethyl)-2-(4-nitrobenzyl)-6, 7-dimethoxyl1, 2, 3, 4- tetrahydroisoquinoline hydrobromide in rat by LC-MS/MS method [J]. Acta Pharm Sin, 2007, 42: 1176-1182.
6. Xu LL, He YQ, Guo X, et al. Identification of metabolites of nobiletin in rats using ultra-performance liquid chromatography coupled with triple quadrupole mass spectrometry [J]. Acta Pharm Sin, 2011, 46: 1483-1487.
7. Zhang WS, Li AL. Medicinal Chemistry [M]. Beijing: Higher Education Press, 1999: 49.
8. Wang YY, Chen XY, Li Q, et al. Metabolite identification of arbidol in human urine by the study of CID fragmentation pathways using HPLC coupled with ion trap mass spectrometry [J]. J Mass Spectrom, 2008, 43: 1099-1109.
9. Li SK, Bai DL. Application of chiral sulfoxides in asymmetric synthesis [J]. Prog Chem, 2001, 13: 351-359.