Central skeletal sarcoidosis: A case report with sustained remission only on methotrexate, and a literature review on the imaging approach, treatment, and assessment of disease activity

Modern Rheumatology

Volumn 23, Issue 1, 2013, Pages 175-181

  Sakellariou, Grigorios T ^a   Anastasilakis, Athanasios D ^a   Karanikolas, Dimitrios ^a   Vounotrypidis, Periklis ^a   Berberidis, Charalampos ^a  

^a 424 General Army Hospital   (Greece)

Author keywords

Bone; Methotrexate; MRI; Sarcoidosis; Scan

Indexed keywords

ANALGESIC AGENT; DIPEPTIDYL CARBOXYPEPTIDASE; FOLIC ACID; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISONE; RISEDRONIC ACID; TECHNETIUM 99M;

ADULT; BONE SCINTISCANNING; CASE REPORT; CLINICAL ASSESSMENT; DISEASE ACTIVITY; DRUG WITHDRAWAL; FOLLOW UP; HUMAN; INFLAMMATION; LABORATORY TEST; LOW BACK PAIN; LUMBAR SPINE; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; REMISSION; REVIEW; SARCOIDOSIS; VERTEBRA;

BONE DISEASES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LUMBAR VERTEBRAE; MAGNETIC RESONANCE IMAGING; MALE; METHOTREXATE; MIDDLE AGED; PEPTIDYL-DIPEPTIDASE A; RADIONUCLIDE IMAGING; REMISSION INDUCTION; SARCOIDOSIS; TREATMENT OUTCOME;

EID: 84872496003     PISSN: 14397595     EISSN: 14397609     Source Type: Journal    
DOI: 10.1007/s10165-012-0631-z     Document Type: Review

References (28)

1. Neville E, Carstairs LS, James DG. Sarcoidosis of bone. Q J Med. 1977;46:215-27.
2. Shorr AF, Murphy FT, Gilliland WR, Hnatiuk W. Osseous disease in patients with pulmonary sarcoidosis and musculoskeletal symptoms. Respir Med. 2000;94:228-32.
3. Ortapamuk H, Naldoken S. Multisystemic sarcoidosis with uncommon osseous involvement demonstrated by Ga-67 citrate and Tc-99m MDP. Clin Nucl Med. 2004;29:60-2.
4. Nishiyama Y, Yamamoto Y, Fukunaga K, Takinami H, Iwado Y, Satoh K, et al. Comparative evaluation of 18F-FDG PET and 67 Ga scintigraphy in patients with sarcoidosis. J Nucl Med. 2006;47:1571-6.
5. Kobayashi A, Shinozaki T, Shinjyo Y, Kato K, Oriuchi N, Watanabe H, et al. FDG PET in the clinical evaluation of sarcoidosis with bone lesions. Ann Nucl Med. 2000;14:311-3.
6. Ludwig V, Fordice S, Lamar R, Martin WH, Delbeke D. Unsuspected skeletal sarcoidosis mimicking metastatic disease on FDG positron emission tomography and bone scintigraphy. Clin Nucl Med. 2003;28:176-9.
7. Fisher AJ, Gilula LA, Kyriakos M, Holzaepfel CD. MR imaging changes of lumbar vertebral sarcoidosis. AJR Am J Roentgenol. 1999;173:354-6.
8. Lisle D, Mitchell K, Crouch M, Windsor M. Sarcoidosis of the thoracic and lumbar spine: imaging findings with an emphasis on magnetic resonance imaging. Australas Radiol. 2004;48:404-7.
9. Poyanli A, Poyanli O, Sencer S, Akan K, Sayrak H, Acunas B. Vertebral sarcoidosis: imaging findings. Eur Radiol. 2000;10:92-4.
10. Rua-Figueroa I, Gantes MA, Erausquin C, Mhaidli H, Montesdeoca A. Vertebral sarcodosis: clinical and imagings findings. Semin Arthritis Rheum. 2002;31:346-52.
11. Johns CJ, Michele TM. The clinical management of sarcoidosis: a 50-year experience at the Johns Hopkins Hospital. Medicine (Baltimore). 1999;78:65-111.
12. Shorr AF, Murphy FT, Kelly WF, Kaplan KJ, Gilliland WR, Shapeero LG. Osseous sarcoidosis: clinical, radiographic, and therapeutic observations. J Clin Rheumatol. 1998;4:186-92.
13. Mana J, Gomez-Vaquero C, Dorca J, Pujol R. Vertebral and rib sarcoidosis: long-term clinical remission with methotrexate. Clin Rheumatol. 1999;18:492-4.
14. Garg S, Garg K, Altaf M, Magaldi JA. Refractory vertebral sarcoidosis responding to infliximab. J Clin Rheumatol. 2008;14:238-40.
15. Hasni SA, Kunz D, Finzel K, Gruber BL. Osseous sarcoidosis treated with tumor necrosis factor-inhibitors. Spine. 2010;35:E904-7.
16. Clarencon F, Silbermann-Hoffman O, Lebreton C, Fernandez P, Kerrou K, Marchand-Adam S, et al. Diffuse spine involvement in sarcoidosis with sternal lytic lesions: two case report. Spine. 2007;32:E594-7.
17. Packer CD, Mileti LM. Vertebral sarcoidosis mimicking lytic osseous metastases: development 16 years after apparent resolution of thoracic sarcoidosis. J Clin Rheumatol. 2005;11:105-8.
18. Liu B, Zhang X, Zhang W, Wang JB, Zhang FC. Solitary osseous sarcoidosis: a rare reason for pathologic fracture. Rheumatol Int. doi: 10.1007/s00296-010- 1425-2.
19. Cinti DC, Hawkins HB, Slavin JD Jr. Radioisotope bone scanning in a case of sarcoidosis. Clin Nucl Med. 1985;10:192-4.
20. Binicier O, Sari I, Sen G, Onen F, Akkoc N, Manisali M, et al. Axial sarcoidosis mimicking radiographic sacroiliitis. Rheumatol Int. 2009;29:343-5.
21. Mangino D, Stover DE. Sarcoidosis presenting as metastatic bony disease: a case report and review of the literature on vertebral body sarcoidosis. Respiration. 2004;71:292-4.
22. Talmi D, Smith S, Mulligan ME. Central skeletal sarcoidosis mimicking metastatic disease. Skelet Radiol. 2008;37:757-61.
23. Khiar A, Duet M, Ammari S, Brouland JP, Liote F, Paycha F. Disseminated bone involvement in systemic sarcoidosis mimicking bone metastases. A multimodality imaging approach. Joint Bone Spine. 2011;78:216-7.
24. Valencia MP, Deaver PM, Mammarappallil MC. Sarcoidosis of the thoracic and lumbar vertebrae, mimicking metastasis or multifocal osteomyelitis by MRI: case report. Clin Imaging. 2009;33:478-81.
25. Yanny S, Toms AP, Maciver D, Barker T, Wilson A. Axial osseous sarcoidosis: rare clinical presentation and radiological findings. Clin Radiol. 2010;65:167-71.
26. Waanders F, van Hengel P, Krikke A, Wesseling J, Nieboer P. Sarcoidosis mimicking metastatic disease: a case report and review of the literature. Neth J Med. 2006;64:342-5.
27. Rohatgi PK. Radioisotope scanning in osseous sarcoidosis. AJR Am J Roentgenol. 1980;134:189-91.
28. Fernandez-Ruiz M, Guerra-Vales JM, Castelbon-Fernandez FJ, Llenas-Garcia J, Rodriguez-Peralto JL, Lopez-Lancho R, et al. Sarcoidosis presenting as an osteolytic skull lesion: a case report and review of literature on skull sarcoidosis. Clin Rheumatol. 2007;26:1745-8.