Renoprevention: A new concept for reengineering nephrology care-An economic impact and patient outcome analysis of two hypothetical patient management paradigms in the CCU

Renal Failure

Volumn 35, Issue 1, 2013, Pages 23-28

  Onuigbo, MacAulay A C ^a,b  

^a Mayo Clinic Health System   (United States)

^b Mayo Health System Practice Based Research Network MHS PBRN   (United States)

Author keywords

Acute kidney injury; Economic analysis; End stage renal disease; Renoprevention; Syndrome of rapid onset end stage renal disease

Indexed keywords

CREATININE; HYDRALAZINE; LISINOPRIL;

ACUTE KIDNEY FAILURE; ADVERSE OUTCOME; AGED; ARTICLE; CASE REPORT; CLINICAL PRACTICE; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY DISEASE; CORONARY CARE UNIT; COST CONTROL; CREATININE BLOOD LEVEL; DESCRIPTIVE RESEARCH; DRUG SAFETY; HEART CATHETERIZATION; HOSPITAL COST; HOSPITAL DISCHARGE; HUMAN; HYPERVOLEMIA; HYPOTENSION; KIDNEY FAILURE; KIDNEY FUNCTION; MALE; PATIENT CARE; PREVENTIVE MEDICINE; PRIORITY JOURNAL; RENOPREVENTION; TREATMENT OUTCOME;

ACUTE KIDNEY INJURY; AGED; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CORONARY ARTERY DISEASE; CORONARY CARE UNITS; CREATININE; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; GLOMERULAR FILTRATION RATE; HOSPITAL CHARGES; HUMANS; INCIDENCE; LISINOPRIL; MALE; NEPHROLOGY; PROGNOSIS; RENAL INSUFFICIENCY, CHRONIC; RESEARCH DESIGN; RISK FACTORS; WISCONSIN;

EID: 84872481961     PISSN: 0886022X     EISSN: 15256049     Source Type: Journal    
DOI: 10.3109/0886022X.2012.741644     Document Type: Article

References (63)

1. Ishani A, Xue JL, Himmelfarb J, et al. Acute kidney injury increases risk of ESRD among elderly. J Am Soc Nephrol. 2009;20:223-228.
2. Okusa MD, Chertow GM, Portilla D. Acute Kidney Injury Advisory Group of the American Society of Nephrology. The nexus of acute kidney injury, chronic kidney disease, and World Kidney Day 2009. Clin J Am Soc Nephrol. 2009;4(3):520-522.
3. Onuigbo M.A.. Syndrome of rapid-onset end-stage renal disease (SORO-ESRD): a new unrecognized pattern of CKD progression to ESRD [Abstract]. J Am Soc Nephrol. 2010;21:614A [SAPO2198].
4. Onuigbo M.A.. Syndrome of rapid-onset end-stage renal disease: a new unrecognized pattern of CKD progression to ESRD. Ren Fail. 2010;32(8):954-958.
5. Onuigbo M.A.C, Onuigbo N. Syndrome of rapid onset end-stage renal disease revisited-observations from two chronic kidney disease populations in two continents. US Nephrology. 2010; 5(2):81-85.
6. Onuigbo M.A., Onuigbo N. Chronic Kidney Disease and RAAS Blockade: A New View of Renoprotection. London: Lambert Academic Publishing GmbH 11 & Co. KG; 2011.
7. Onuigbo M, Onuigbo N. The syndrome of rapid onset end-stage renal disease (SOROESRD)-A new M.A.yo Clinic dialysis services experience, January 2010-February 2011. In: Di Iorio B, Heidland A, Onuigbo M, Ronco C, eds. Hemodialysis: How, When and Why. Hauppauge, NY: NOVA Science; 2012. (In Print).
8. Onuigbo M, Onuigbo N. Evidence of the syndrome of rapid onset end stage renal disease (SOROESRD) in the acute kidney injury (AKI) literature-preventable causes of AKI and SOROESRD-A call for re-engineering of nephrology practice paradigms [Abstract]. Perit Dial Int. 2012;32(Suppl. 1):S4.
9. Firth JD. Acute irreversible renal failure [editorial]. Q J Med. 1996;89:397-399. (Pubitemid 26184323)
10. Hsu CY. Linking the population epidemiology of acute renal failure, chronic kidney disease and end-stage renal disease. Curr Opin Nephrol Hypertens. 2007;16(3):221-226.
11. Hsu CY, Ordonez JD, Chertow GM, Fan D, McCulloch CE, Go AS. The risk of acute renal failure in patients with chronic kidney disease. Kidney Int. 2008;74:101-107. (Pubitemid 351841887)
12. Coca SG, Yusuf B, Shlipak MG, Garg AX, Parikh CR. Longterm risk of mortality and other adverse outcomes after acute kidney injury: a systeM.A.tic review and meta-Analysis. Am J Kidney Dis. 2009;53(6):961-973.
13. Khosla N, Soroko SB, Chertow GM, et al. Preexisting chronic kidney disease: a potential for improved outcomes from acute kidney injury. Clin J Am Soc Nephrol. 2009;4:1914-1919.
14. Lo LJ, Go AS, Chertow GM, et al. Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease. Kidney Int. 2009;76:893-899.
15. Thakar CV, Quate-Operacz M, Leonard AC, EckM.A.n MH. Outcomes of hemodialysis patients in a long-term care hospital setting: a single-center study. Am J Kidney Dis. 2010; 55(2):300-306.
16. Waikar SS, WinkelM.A.yer WC. Chronic on acute renal failure: long-term implications of severe acute kidney injury. J AmMed Assoc. 2009;302:1227-1229.
17. Wald R, Quinn RR, Luo J, et al. Chronic dialysis and death among survivors of acute kidney injury requiring dialysis. J Am Med Assoc. 2009;302:1179-1185.
18. Onuigbo M.A., Onuigbo NT. Late onset renal failure from angiotensin blockade (LORFFAB): a prospective thirty-month M.A.yo Health System clinic experience. Med Sci Monit. 2005;11: CR462-CR469. (Pubitemid 41482731)
19. Onuigbo M.A., Onuigbo NT. Use of ultrahigh RAAS blockade: Implications for exacerbation of renal failure. Kidney Int. 2006;69:194-195. (Pubitemid 43117760)
20. Onuigbo M.A., Onuigbo NT. Late-onset renal failure from RAAS blockade. Kidney Int. 2006;70:1378-1379. (Pubitemid 44435207)
21. Onuigbo M, Onuigbo N. Renal failure from RAAS blockade in CKD patients: a prospective 50-month analysis-A call for pragM.A.tic caution to optimize cardiorenal protection with RAAS blockade [Abstract]. Am J Kidney Dis. 2007;49(4):A64.
22. Onuigbo M.A., Onuigbo NT. Late-onset renal failure from angiotensin blockade (LORFFAB) in 100 CKD patients. Int Urol Nephrol. 2008;40:233-239.
23. Onuigbo M.A.. Is renoprotection with RAAS blockade a failed paradigm? Have we learnt any lessons so far? Int J Clin Pract. 2010;64(10):1341-1346. PMID:20716141. DOI:10.1111/j.1742-1241.2010.02448Sep.
24. Onuigbo M.A., Can ACE. Inhibitors and angiotensin receptor blockers be detrimental in CKD patients? Nephron Clin Pract. 2011;118(4):c407-c419.
25. Onuigbo M.A.C. Reno-prevention vs. reno-protection: A critical re-Appraisal of the evidence-base from the large RAAS blockade trials after ONTARGET-A call for more circumspection. QJM. 2009;102:155-167.
26. Onuigbo M.A., Onuigbo NT. Does renin-Angiotensin aldosterone system blockade exacerbate contrast-induced nephropathy in patients with chronic kidney disease? A prospective 50-month M.A.yo Clinic study. Ren Fail. 2008;30:67-72.
27. Onuigbo M.A., Onuigbo NT. Worsening renal failure in older chronic kidney disease patients with renal artery stenosis concurrently on renin angiotensin aldosterone system blockade: a prospective 50-month M.A.yo-Health-System clinic analysis. QJM. 2008;101:519-527. (Pubitemid 351911994)
28. Onuigbo M.A., Onuigbo NT. Renal failure and concurrent RAAS blockade in older CKD patients with renal artery stenosis: an extended M.A.yo Clinic prospective 63-month experience. Ren Fail. 2008;30:363-371. (Pubitemid 351868682)
29. Onuigbo M.A.. Does concurrent renin-Angiotensin-Aldosterone blockade in (older) chronic kidney disease patients play a role in the acute renal failure epidemic in US hospitalized patients?-three cases of severe acute renal failure encountered in a northwestern Wisconsin Nephrology practice. Hemodial Int. 2009;13 (Suppl. 1):S24-S29.
30. Onuigbo M.A.C. An analytical review of the evidence-base for reno-protection from the large RAAS blockade trials after ONTARGET. Re-visitation of the potential for iatrogenic renal failure with RAAS blockade? A call for caution. Nephron Clin Pract. 2009;113(2):c63-c69.
31. Onuigbo M.A.. The impact of stopping inhibitors of the reninangiotensin system in patients with advanced chronic kidney disease. Nephrol Dial Transplant. 2010;25(4):1344-1345.
32. Louis BM, Hoch BS, Hernandez C, et al. Protection from the nephrotoxicity of contrast dye. Renal Fail. 1996;18(4):639-646. (Pubitemid 26295948)
33. M.A.rkowitz GS, Nasr SH, Klein P, et al. Renal failure due to acute nephrocalcinosis following oral sodium phosphate bowel cleansing. Hum Pathol. 2004;35(6):675-684. (Pubitemid 38881077)
34. Rose M, Karlstadt RG, Walker K. Renal failure following bowel cleansing with a sodium phosphate purgative. Nephrol Dial Transplant. 2005;20(7):1518- 1519. (Pubitemid 41430642)
35. RussM.A.nn S, Lamerato L, M.A.rfatia A, et al. Risk of impaired renal function after colonoscopy: a cohort study in patients receiving either oral sodium phosphate or polyethylene glycol. Am J Gastroenterol. 2007;102(12):2655-2663. (Pubitemid 350179356)
36. Komenda P, Zalunardo N, Burnett S, et al. Conservative outpatient renoprotective protocol in patients with low GFR undergoing contrast angiography: a case series. Clin Exp Nephrol. 2007;11(3):209-213. (Pubitemid 47476789)
37. Khurana A, McLean L, Atkinson S, Foulks CJ. The effect of oral sodium phosphate drug products on renal function in adults undergoing bowel endoscopy. Arch Intern Med. 2008; 168(6):593-597. (Pubitemid 351468394)
38. Arora P, Rajagopalam S, Ranjan R, et al. Preoperative use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers is associated with increased risk for acute kidney injury after cardiovascular surgery. Clin J Am Soc Nephrol. 2008; 3(5):1266-1273.
39. Navarro I, Poveda R, Torras J, Castelao AM, Grinyó JM. Acute renal failure associated to renin angiotensin system (RAS) inhibitors-its burden in a nephrology department. Nephrol Dial Transplant. 2008;23(1):413-414. (Pubitemid 351767396)
40. Eddy AA, Neilson EG. Chronic kidney disease progression. J Am Soc Nephrol. 2006;17:2964-2966. (Pubitemid 44707755)
41. Merino GE, Buselmeier TJ, Kjellstrand CM. Postoperative chronic renal failure: a new syndrome? Ann Surg. 1975;182(1): 37-44.
42. Kjellstrand CM, Ebben J, Davin T. Time of death, recovery of renal function, development of chronic renal failure and need for chronic hemodialysis in patients with acute tubular necrosis. Trans Am Soc Artif Intern Organs. 1981;27:45-50.
43. Bonomini V, Stefoni S, Vangelista A. Long-term patient and renal prognosis in acute renal failure. Nephron. 1984;36 (3):169-172. (Pubitemid 14178036)
44. Lámeire N, M.A.tthys E, Vanholder R, et al. Causes and prognosis of acute renal failure in elderly patients. Nephrol Dial Transplant. 1987;2(5):316-322. (Pubitemid 18048313)
45. Bhandari S, Turney JH. Survivors of acute renal failure who do not recover renal function. QJM. 1996;89(6):415-421. (Pubitemid 26184326)
46. Robertson S, Newbigging K, Isles CG, BramM.A.h A, Allan A, Norrie J. High incidence of renal failure requiring short-term dialysis: a prospective observational study. QJM. 2002;95 (9):585-590.
47. Al-Homrany M. Epidemiology of acute renal failure in hospitalized patients: experience from southern Saudi Arabia. East Mediterr Health J. 2003;9(5-6):1061-1067. (Pubitemid 40521249)
48. Yehia M, Collins JF, Beca J. Acute renal failure in patients with pre-existing renal dysfunction following coronary artery bypass grafting. Nephrology (Carlton). 2005;10(6):541-543. (Pubitemid 41801831)
49. Bahar I, Akgul A, Ozatik M.A., et al. Acute renal failure following open heart surgery: risk factors and prognosis. Perfusion. 2005; 20(6):317-322. (Pubitemid 41824360)
50. Bagshaw SM, Laupland KB, Doig CJ, et al. Prognosis for longterm survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study. Crit Care. 2005;9:R700-R709. [PMCID: PMC1414056] [PubMed: 16280066].
51. JayakuM.A.r M, Prabahar MR, Fernando EM, M.A.norajan R, VenkatraM.A.n R, BalaraM.A.n V. Epidemiologic trend changes in acute renal failure-A tertiary center experience from South India. Ren Fail. 2006;28(5):405-410. (Pubitemid 44049785)
52. Kaballo BG, Khogali MS, Khalifa EH, Khaiii EA, Ei-Hassan AM, Abu-Aisha H. Patterns of "severe acute renal failure" in a referral center in Sudan: excluding intensive care and M.A.jor surgery patients. Saudi J Kidney Dis Transpl. 2007;18(2):220-225.
53. Ozturk S, Arpaci D, Yazici H, et al. Outcomes of acute renal failure patients requiring intermittent hemodialysis. Ren Fail. 2007;29(8):991-996. (Pubitemid 350232893)
54. Al-Azzam SI, Al-Husein BA, Abu-Dahoud EY, Dawoud TH, Al-MoM.A.ny EM. Etiologies of acute renal failure in a sample of hospitalized Jordanian patients. Ren Fail. 2008; 30(4):373-376. (Pubitemid 351868678)
55. Kelly KJ, Dominguez JH. Rapid progression of diabetic nephropathy is linked to inflamM.A.tion and episodes of acute renal failure. Am J Nephrol. 2010;32(5):469-475.
56. Ahmed AK, KaM.A.th NS, El Kossi M, et al. The impact of stopping inhibitors of the renin-Angiotensin system in patients with advanced chronic kidney disease. Nephrol Dial Transplant. 2010;25(12):3977-3982.
57. Longworth DL. Accountable care organizations, the patientcentered medical home, and health care reform: what does it all mean? Cleve Clin J Med. 2011;78(9):571-582.
58. The Concord Coalition. Escalating health care costs and the federal budget. 2009. Available at: http://www.concordcoalition. org/files/uploaded-for- nodes/docs/Iowa-Handout-final.pdf. Accessed September 12, 2011.
59. The Henry J. Kaiser Family Foundation. Snapshots: Health care spending in the United States and selected OECD countries. 2011. Available at: http://www.kff.org/insurance/snapshot/OECD042111.cfm. Accessed September 12, 2011.
60. Centers for Medicare and Medicaid Services. National health expenditure projections 2010-2020. 2010. Available at: https://www.cms.gov/ NationalHealthExpendData/downloads/proj2010.pdf. Accessed December 20, 2011.
61. Onuigbo M, Onuigbo NT. Reno-prevention: a new concept for re-engineering of nephrology practice: an economic impact and patient outcome analysis of two hypothetical patient scenarios in the CCU [Abstract]. J Am Soc Nephrol. 2011;22:873A [PUB 124].
62. Hammer M, Champy J. Reengineering the Corporation. A M.A.nifesto for Business Revolution. Chapter 2-Reengineering: The Path to Change. New York, NY: HarperCollins; 2001.
63. Yudkin JS, Richter B, Gale EA. Intensified glucose control in type 2 diabetes-whose agenda? Lancet. 2011;377(9773): 1220-1222.