A novel intubation technique for minimally invasive longitudinal studies of rat lungs using hyperpolarized 3He magnetic resonance imaging

Laboratory Animals

Volumn 46, Issue 4, 2012, Pages 311-317

  Fox, M S ^a,b   Welch, I ^a   Hobson, D ^c   Santyr, G E ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF GUELPH   (Canada)

Author keywords

Hyperpolarized noble gases; Intubation; Lungs; Magnetic resonance imaging; Rats

Indexed keywords

HELIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; BREATH HOLDING; CONTROLLED STUDY; ENDOTRACHEAL INTUBATION; ENDOTRACHEAL TUBE; EXTUBATION; FOLEY BALLOON CATHETER; HELIUM NUCLEAR MAGNETIC RESONANCE; HISTOPATHOLOGY; HYPERPOLARIZATION; IMAGE QUALITY; INTRAVENOUS CATHETER; LUNG DEAD SPACE; MALE; MINIMALLY INVASIVE PROCEDURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT; SIGNAL NOISE RATIO; TRACHEA; TRACHEA PRESSURE; TRACHEOTOMY;

ANIMALS; CATHETERS; EQUIPMENT DESIGN; HELIUM; INTUBATION, INTRATRACHEAL; ISOTOPES; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING, INTERVENTIONAL; MALE; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; RESPIRATORY FUNCTION TESTS; TIME FACTORS; TRACHEA; VENTILATORS, MECHANICAL;

ANIMALIA; RATTUS; RODENTIA;

EID: 84872475067     PISSN: 00236772     EISSN: None     Source Type: Journal    
DOI: 10.1258/la.2012.011139     Document Type: Article

References (21)

1. World Health Organization. World Health Statistics 2008 [Online]. Geneva: WHO, 2008
2. Kauczor HU, Hanke A, Van Beek EJ. Assessment of lung ventilation by MR imaging: current status and future perspectives. Eur Radiol 2002;12:1962-70
3. Santyr GE, Lam WW, Parra-Robles JM, Taves TM, Ouriadov AV. Hyperpolarized noble gas magnetic resonance imaging of the animal lung: approaches and applications. J Appl Phys 2009;105:1-13
4. Chen XJ, Hedlund LW, Moller HE, Chawla MS, Maronpot RR, Johnson GA. Detection of emphysema in rat lungs by using magnetic resonance measurements of 3He diffusion. Proc Natl Acad Sci USA 2000;97:11478-81
5. Driehuys B, Hedlund LW. Imaging techniques for small animal models of pulmonary disease: MR microscopy. Toxicol Pathol 2007;35:49-58
6. Mansson S, Wolber J, Driehuys B, Wollmer P, Golman K. Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe. Magn Reson Med 2003;50:1170-9
7. Ward ER, Hedlund LW, Kurylo WC, et al. Proton and hyperpolarized helium magnetic resonance imaging of radiation-induced lung injury in rats. Int J Radiat Oncol Biol Phys 2004;58:1562-9
8. Fox MS, Ouriadov A, Santyr G. Hyperpolarized magnetic resonance imaging of a gastric aspiration model of acute lung injury in the rat lung. Future of Quantitative and Functional Lung Imaging Iowa Proceedings 2008 (Organizing Committee: van Beek E, Gefter W, Hatabu H, Hoffman EA, Kauczor H-U, Rizi R)
9. Reza Akhavan Sharif M, Lam WW, Ouriadov AV, Holdsworth DW, Santyr GE. Comparison of hyperpolarized 3He MRI rat lung volume measurement with micro-computed tomography. NMR Biomed 2010;23:359-67
10. Abdeen N, Cross A, Cron G, et al. Measurement of xenon diffusing capacity in the rat lung by hyperpolarized 129Xe MRI and dynamic spectroscopy in a single breath-hold. Magn Reson Med 2006;56:255-64
11. 129Xe for measurement of absolute ventilated lung volume of rat lungs [Abstract]. ISMRM Proceedings. Stockholm, May 2010
12. Kastl S, Kotschenreuther U, Hille B, Schmidt J, Gepp H, Hohenberger W. Simplification of rat intubation on inclined metal plate. Adv Physiol Educ 2004;28:29-32
13. Emami K, Chia E, Kadlecek S, et al. Regional correlation of emphysematous changes in lung function and structure: a comparison between pulmonary function testing and hyperpolarized MRI metrics. J Appl Physiol 2011;110:225-35
14. Flecknell P. Animal Anaesthesia. 3rd edn. Academic Press. 2009
15. Santyr GE, Lam WW, Ouriadov A. Rapid and efficient mapping of regional ventilation in the rat lung using hyperpolarized 3He with Flip Angle Variation for Offset of RF and Relaxation (FAVOR). Magn Reson Med 2008;59:1304-10
16. Foster-Gareau P, Heyn C, Alejski A, Rutt BK. Imaging single mammalian cells with a 1.5 T clinical MRI scanner. Magn Reson Med 2003;49:968-71
17. Alderson B, Senior JM, Dugdale AH. Tracheal necrosis following tracheal intubation in a dog. J Small Anim Pract 2006;47:754-6
18. Tobias JD, Schwartz L, Rice J, Jatana K, Kang DR. Cuffed endotracheal tubes in infants and children: should we routinely measure the cuff pressure? Int J Pediatr Otorhinolaryngol 2012;76:61-3
19. Lam WW, Holdsworth DW, Du LY, Drangova M, McCormack DG, Santyr GE. Micro-CT imaging of rat lung ventilation using continuous image acquisition during xenon gas contrast enhancement. J Appl Physiol 2007;103:1848-56
20. Chatziioannou AF. Molecular imaging of small animals with dedicated PET tomographs. Eur J Nucl Med Mol Imaging 2002;29:98-114
21. Maruscak AA, Vockeroth DW, Girardi B, et al. Alterations to surfactant precede physiological deterioration during high tidal volume ventilation. Am J Physiol Lung Cell Mol Physiol 2008;294:L974-83