Rapid decline in episodic memory in healthy older adults with high amyloid-β

Journal of Alzheimer's Disease

Volumn 33, Issue 3, 2013, Pages 675-679

  Lim, Yen Ying ^a   Pietrzak, Robert H ^b   Ellis, Kathryn A ^a,c   Jaeger, Judith ^d,e   Harrington, Karra ^a   Ashwood, Tim ^f   Szoeke, Cassandra ^a,c,g   Martins, Ralph N ^h   Bush, Ashley I ^a   Masters, Colin L ^a   Rowe, Christopher C ^a,i   Villemagne, Victor L ^a,i   Ames, David ^a,c   Darby, David ^a,e   Maruff, Paul ^a,e  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL AGEING RESEARCH INSTITUTE   (Australia)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^e CogState Ltd ^*  (Australia)

^f ASTRAZENECA R AND D   (Sweden)

^g CSIRO   (Australia)

^h EDITH COWAN UNIVERSITY   (Australia)

ⁱ AUSTIN HEALTH   (Australia)

Author keywords

Alzheimer's disease; amyloid ; cognitive decline; episodic memory; neuropsychological assessment

Indexed keywords

AMYLOID BETA PROTEIN;

AGED; ARTICLE; COGNITION; CONTROLLED STUDY; EPISODIC MEMORY; FEMALE; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

EID: 84872463568     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-121516     Document Type: Article

References (12)

1. Villemagne VL, Pike KE, Ch'etelat G, Ellis KA, Mulligan RS, Bourgeat P, Ackermann U, Jones G, Szoeke C, Salvado O, Martins R, O'Keefe G, Mathis CA, Klunk WE, Ames D, Masters CL, Rowe CC (2011) Longitudinal assessment ofA and cognition in aging and Alzheimer disease. Ann Neurol 69, 181-192.
2. Stomrud E, Hansson O, Zetterberg H, Blennow K, Minthon L, Londos E (2010) Correlation of longitudinal cerebrospinal fluid biomarkers with cognitive decline in healthy older adults. Arch Neurol 67, 217-223.
3. Gustafson DR, Skoog I, Rosengren L, Zetterberg H, Blennow K (2007) Cerebral spinal fluid -amyloid 1-42 concentration may predict cognitive decline in older women. J Neurol Neurosurg Psychiatry 78, 461-464. (Pubitemid 46662891)
4. Lim YY, Ellis KA, Pietrzak RH, Ames D, Darby D, Harrington K, Martins RN, Masters CL, Rowe C, Savage G, Szoeke C, Villemagne VL, Maruff P, for the AIBL, Research Group (2012) Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults. Neurology, in press.
5. Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR, Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, Yaffe K, Carrillo MC, Thies B, Morrison-Bogorad M, Wagster MV, Phelps CH (2011) Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the national institute on aging and the alzheimer's association workgroup. Alzheimers Dement 7, 280-292.
6. Lim YY, Jaeger J, Harrington K, Ashwood T, Ellis KA, St?offler A, Szoeke C, Lachovitzki R, Martins RN, Savage G, Villemagne V, Bush A, Masters CL, Rowe CC, Ames D, Darby D, Maruff P (2012) The Australian Imaging, Biomarker and Lifestyle - Rate of Change sub-study (AIBL-ROCS): Rationale, design, acceptability and pilot data for the first three months of assessment. J Clin Exp Neuropsychol, in press.
7. Ellis KA, Bush AI, Darby D, De Fazio D, Foster J, Hudson P, Lautenschlager NT, Lenzo N, Martins RN, Maruff P,Masters C, Milner A, Pike K, Rowe C, Savage G, Szoeke C, Taddei K, Villemagne V, Woodward M, Ames D, for the AIBL, Research, Group (2009) The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: Methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease. Int Psychogeriatr 21, 672-687.
8. Kantarci K, Lowe V, Przybelski SA, Weigand SD, Senjem ML, Ivnik RJ, Preboske GM, Roberts R, Geda YE, Boeve BF, Knopman DS, Petersen RC, Jack CR (2012) APOE modifies the association between AB load and cognition in cognitively normal older adults. Neurology 78, 232-240.
9. Cohen J (1992) A power primer. Psychol Bull 112, 155-159.
10. Darby D, Brodtmann A, Pietrzak RH, Fredrickson J, Woodward M, Villemagne V, Fredrickson A, Maruff P, Rowe C (2011) Episodic memory decline predicts cortical amyloid status in community-dwelling older adults. J Alzheimers Dis 27, 627-637.
11. Desikan RS,McEvoy LK, ThompsonWK,Holland D, Brewer JB, Aisen PS, Sperling RA, DaleAM,for the Alzheimer's Disease Neuroimaging Initiative (2012) Amyloid-associated clinical decline occurs only in the presence of elevated p-tau. Arch Neurology 69(6), 709-713.
12. Darby D, Pietrzak RH, Fredrickson J,Woodward M, Moore L, Fredrickson A, Sach J, Maruff P (2012) Intra-individual cognitive decline using a brief computerized cognitive screening test. Alzheimers Dement 8, 95-104.