Antihypercholesterolemic effect of Bacopa monniera linn. on high cholesterol diet induced hypercholesterolemia in rats

Asian Pacific Journal of Tropical Medicine

Volumn 5, Issue 12, 2012, Pages 949-955

  Kamesh, Venkatakrishnan ^a   Sumathi, Thangarajan ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Antioxidant status; Bacopa monniera; Cardiac markers enzymes; Histopathology; Hypercholesterolemia; Lipid profile

Indexed keywords

ASPARTATE AMINOTRANSFERASE; BACOPA MONNIERI EXTRACT; CATALASE; CHOLESTEROL; CREATINE KINASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; HIGH DENSITY LIPOPROTEIN; LACTATE DEHYDROGENASE; LOW DENSITY LIPOPROTEIN; PHOSPHOLIPID; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERCHOLESTEROMIC ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; HYPERCHOLESTEROLEMIA; LIPID PEROXIDATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TREATMENT DURATION;

ANALYSIS OF VARIANCE; ANIMALS; ANTICHOLESTEREMIC AGENTS; ANTIOXIDANTS; AORTA; BACOPA; CATALASE; CHOLESTEROL; CHOLESTEROL, DIETARY; DIET, HIGH-FAT; ETHANOL; GLUTATHIONE; HYPERCHOLESTEROLEMIA; LIPID PEROXIDATION; LIPOPROTEINS; LIVER; MALE; PHOSPHOLIPIDS; PLANT EXTRACTS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; TRIGLYCERIDES;

EID: 84872416583     PISSN: 19957645     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1995-7645(12)60180-1     Document Type: Article

References (52)

1. Braunwald E Shattuck lecture-cardiovascular medicine at the turn of the millennium: triumphs, concerns, and opportunities. New Eng J Med 1997, 337:1360-1369.
2. Kok FJ, van Poppel G, Melse J, Verheul E, Schouten EG, Kruyssen DH, et al. Do antioxidants and polyunsaturated fatty acids have a combined association with coronary atherosclerosis?. Atherosclerosis 1991, 86(1):85-90.
3. Prasad K, Kalra J Experimental atherosclerosis and oxygen free radicals. Angiology 1989, 40(9):835-843.
4. Motta M, Giugno I, Bosco S, Pistone G, Ruello P, Maugeri D, et al. Serum lipoprotein(a) changes in acute myocardial infraction. Panminevra Med 2001, 43:77-80.
5. Maghrani M, Lemhadri A, Zeggwagh NA, El Amraoui A, Haloui M, Jouad H, et al. Effect of retamaraetam on lipid metabolism in normal and recent-onset diabetic rats. J Ethnopharmacol 2004, 90:323-329.
6. Edijala JK, Asagba SO, Eriyamremu GE, Atomatofa U Comparative effects of garden egg fruit, oat and apple on serum lipid profile in rats fed on a high cholesterol diet. Pak J Nutr 2005, 4:245-249.
7. Ross R Atherosclerosis an inflammatory disease. New Engl J Med 1999, 340:115-126.
8. Gutteridge JMC, Halliwell B Antioxidants in nutrition. Health and disease 1996, Oxford University Press, Oxford.
9. Nishant P, Visavadiya AV, Narasimhacharya RL Asparagus root regulates cholesterol metabolism and improves antioxidant status in hypercholesteremic rats. eCAM 2009, 6(2):219-226.
10. Kirtikar K, Basu D Indian medicinal plants 1999, 2:1129-1135. International Book Distributors, Dehradun.
11. Chopra RN, Nayar SL, Chopra IC Glossary of Indian medicinal plants 1956, 32. CSIR, New Delhi.
12. Roodenrys S, Booth D, Bulzoni S, Phipps A, Micallef C, Smoker J Chronic effects of Brahmi (Bacopa monnieri) on human memory. Neuropsychopharmacology 2002, 27:279-281.
13. Tripathi YB, Chaurasia S, Tripathi E, Upadhyay A, Dubey GP Bacopa monniera Linn. As an antioxidant:mechanism of action. Indian J Exp Biol 1996, 34:523-526.
14. Mohanty IR, Maheshwari U, Joseph D, Deshmukh Y Bacopa monniera protects rat heart against ischaemia-reperfusion injury: role of key apoptotic regulatory proteins and enzymes. J Pharm pharmacol 2010, 62(9):1175-1184.
15. Channa S, Dar A, Yaqoob M, Anjum S, Sultani Z, Rahman A Broncho-vasodilatory activity of fractions of pure constituents isolated from Bacopa monniera. J Ethnopharmacol 2003, 86:27-35.
16. Channa S, Dar A, Anjum S, Yaqoob M, Rahman A Anti-inflammatory activity of Bacopa monniera in rodents. J Ethanopharmacol 2006, 104:286-289.
17. Dar A, Channa S Calcium antagonistic activity of Bacopa monniera on vascular and intestinal smooth muscles of rabbit and guinea-pig. J Ethnopharmacol 1999, 66:167-174.
18. Samiulla DS, Prashanth D, Amit A Mast cell stabilizing activity of Bacopa monnieri. Fitoterapia 2001, 72:284-285.
19. Sairam K, Rao CV, Babu MD, Goel RK Prophylactic and curative effects of Bacopa monniera in gastric ulcer models. Phytomed 2001, 8:423-430.
20. Sumathi T, Niranjali Devaraj S Effect of Bacopa monniera, on liver and kidney toxicity in chronic use of opioids. Phytomed 2009, 16:897-903.
21. Indian medicinal plants 1994, International Book Distributors, Dehradun. K. Kirtikar, D. Basu (Eds.).
22. Hou CC, Lin SJ, Cheng JT, Hsu FL Bacopaside III, bacopasaponin G and bacopaside (bacoside) A, B and C from Bacopa monnieri. J Nat Prod 2002, 65:1759-1763.
23. Sudhahar V, Kumar SA, Mythili Y, Varalakshmi P Remedial effect of lupeol and its ester derivative on hypercholesterolemia-induced oxidative and inflammatory stresses. Nutr Res 2007, 27:778-787.
24. Friedewald WT, Levy RI, Fredrickson DS Estimation of concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem 1972, 18:499-502.
25. Ji-Qin Yang, Shijun Li, Frederick E, Domann Garry R, Buettner Larry W Oberley Superoxide generation in v-Ha-ras-transduced human keratinocyte HaCaT cells. Mol Carcinogen 1999, 26:180-188.
26. Rotruck JT, Pope AL, Ganther HE Selenium: biochemical role as a component of glutathione peroxidase. Science 1973, 179:588-590.
27. Stall GEJ, Visser J, Veeger C Purification and properties of glutathione reductase of human erythrocytes. Biochim Biophys Acta 1969, 185:39-48.
28. Habig WH, Pabst MJ, Jakoby WB Glutathione-S-transferases: the first enzymatic step in mercapturic acid formation. J Biol Chem 1974, 249:7130-7139.
29. Moron MS, Depierre JW, Mannervik B Levels of glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta 1979, 582:67-78.
30. Devasagayam TPA, Tarachand U Decreased lipid peroxidation in rat kidney during gestation. Biochem Biophys Res Commun 1987, 145:134-138.
31. King J The transferase-alanine and aspartate transaminases. Practical clinical enzymology 1965, 121-138. Nostrand Company Limited, London.
32. King J The dehydrogenases or oxidoreductases. Lactate dehydrogenase. Practical clinical enzymology 1965, 83-93. Nostrand Company Limited, London.
33. Okinaka S, Sugita H, Momoi H, Toyokura Y, Watanabe T, Ebashi F, et al. Cysteine-stimulated serum creatine kinase in health and disease. J Lab & Clin Med 1964, 64:299-305.
34. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ Protein measurement with the Folin phenol reagent. J Biol Chem 1951, 193:265-275.
35. Deepa PR, Varalakshmi P Salubrious effect of low molecular weight heparin on atherogenic diet-induced cardiac, hepatic and renal lipid peroxidation and collapse of antioxidant defences. Mol Cell Biochem 2003, 254:111-116.
36. Li H, Wang QJ, Zhu DN, Yang Y, Reinioside C A triterpene saponin of Polygala aureocauda Dunn, exerts hypolipidemic effect on hyperlipidemic mice. Phytother Res 2008, 22(2):159-164.
37. Gerd Assmann, Antonio M, Gotto HDL Cholesterol and protective factors in atherosclerosis. Circulation 2004, 109:8-14.
38. Akila M, Devaraj H Synergistic effect of tincture of crataegus and Mangifera indica L. extract on hyperlipidemic and antioxidant status in atherogenic rats. Vasc Pharmacol 2008, 49:173-177.
39. Warnholtz A, Mollnau H, Oelze M, Wendt M, Maria Wendt, Thomas Munzel Antioxidants and endothelial dysfunction in hyperlipidemia. Current Hypertension report 2001, 3:53-60.
40. Prasad K, Kalra J Oxygen free radicals and hypercholesterolemic atherosclerosis: effect of vitamin E. Am Heart J 1993, 125:958-973.
41. Arivazhagan P, Thilagavathy T, Panneerselvam C Antioxidant lipoate and tissue antioxidants in aged rats. J Nutr Biochem 2000, 11:122-127.
42. Rony KA, John Mathew, Neenu PP, Janardhanan KK Ganoderma lucidum (Fr.) P. Karst occuring in south India attenuates gastric ulceration in rats. Ind J Nat Prod Res 2011, 2(1):19-27.
43. Wang W, Ballatori N Endogenous glutathione conjugates: occurrence and biological functions. Pharmacol Rev 1998, 50:335-356.
44. Leaver MJ, George SG A piscine glutathione S-transferase which efficiently conjugates the end-products of lipid peroxidation. Mar Environ Res 1998, 46:71-74.
45. Pracheta P, Sharma V, Singh L, Paliwal R, Sharma S, Yadav S, et al. Chemopreventive effect of hydroethanolic extract of Euphorbia neriifolia leaves against DENA-induced renal carcinogenesis in mice. Asian Pacific J Cancer Prev 2011, 12:677-683.
46. Adaramoye OA, Nwaneri VO, Anyanwu KC Possible antiatherogenic effect of kolaviron (a Garcinia kola seed extract) in hypercholesterolemic rats. Clin Exp Pharmacol Physiol 2005, 32:40-46.
47. Hsiai T, Berliner JA Oxidative stress as a regulator of murine atherosclerosis. Curr Drug Targets 2007, 8:1222-1229.
48. Kumar SA, Sudhahar V, Varalakshmi P Attenuation of serum lipid abnormalities and cardiac oxidative stress by eicosapentaenoate-lipoate (EPA-LA) derivative in experimental hypercholesterolemia. Clinica Chimica Acta 2005, 355:197-204.
49. Girija K, Lakshman K, Udaya C, Sachi GS, Divya T Anti-diabetic and anti-cholesterolemic activity of methanol extracts of three species of Amaranthus. Asian Pac J Trop Biomed 2011, 1(2):133-138.
50. Johnkennedy N, Adamma E, Nnedimma NC Hypolipidemic effects of aqueous extract of Acalypha capitata leaves in rats fed on high cholesterol diet. Asian Pac J Trop Biomed 2011, 1(Suppl 2):S183-S185.
51. Deepa PR, Varalakshmi P Atheroprotective effect of endogenous heparin-derivative treatment on the aortic distrubances and lipoprotein oxidation in hypercholesterolemic diet fed rats. Clin Chim Acta 2005, 355:119-130.
52. Tang F, Wu X, Wang T, Wang P, Li R, Zhang H, et al. Tanshinone II A attenuates atherosclerotic calcification in rat model by inhibition of oxidative stress. Vascular Pharmacology 2007, 46:427-438.