Mechanistic study on the ABC phenomenon of PEG conjugates

Journal of Controlled Release

Volumn 165, Issue 3, 2013, Pages 234-

  Park, Kinam ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN M ANTIBODY; LIPOSOME; MACROGOL; POLYMER;

ACCELERATED BLOOD CLEARANCE; CELL SURFACE; CHEMICAL MODIFICATION; CIRCULATION; DRUG BINDING; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG TRANSPORT; EDITORIAL; ENZYME LINKED IMMUNOSORBENT ASSAY; HYDROPHILICITY; HYDROPHOBICITY; IN VIVO STUDY; LIVER; MACROPHAGE; MICELLE; PLASMA CLEARANCE; PRIORITY JOURNAL;

ANIMALS; GADOLINIUM; LIPOSOMES; MALE; MICELLES; POLYETHYLENE GLYCOLS;

EID: 84872415400     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.01.003     Document Type: Editorial

References (4)

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2. T. Ishida, M. Harada, X.Y. Wang, M. Ichihara, K. Irimura, and H. Kiwada Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes J. Control. Release 105 2005 305 317
3. H. Ma, K. Shiraishi, T. Minowa, K. Kawano, M. Yokoyama, Y. Hattori, and Y. Maitani Accelerated blood clearance was not induced for a gadolinium-containing PEG-poly(l-lysine)-based polymeric micelle in mice Pharm. Res. 27 2 2010 296 302
4. K. Shiraishi, M. Hamano, H. Ma, K. Kawano, Y. Maitani, T. Aoshi, K.J. Ishii, and M. Yokoyama Hydrophobic blocks of PEG-conjugates play a significant role in the accelerated blood clearance (ABC) phenomenon J. Control. Release 165 2013 183 190