Psychological and neural mechanisms of trait mindfulness in reducing depression vulnerability

Social Cognitive and Affective Neuroscience

Volumn 8, Issue 1, 2013, Pages 56-64

  Paul, Natalie A ^a   Stanton, Steven J ^b   Greeson, Jeffrey M ^a   Smoski, Moria J ^a   Wang, Lihong ^a,c  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY   (United States)

^c TSINGHUA UNIVERSITY   (China)

Author keywords

fMRI; Insula; Mindfulness; Negative bias; Non reactivity; Rumination

Indexed keywords

ARTICLE; AWARENESS; BRAIN; COPING BEHAVIOR; DEPRESSION; DISEASE PREDISPOSITION; HUMAN; MALE; MEDITATION; MENTAL STRESS; NUCLEAR MAGNETIC RESONANCE IMAGING; PERSONALITY TEST; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; REFERENCE VALUE; RISK FACTOR; SELF CONCEPT; TEMPERAMENT;

AWARENESS; BRAIN; DEPRESSION; DISEASE SUSCEPTIBILITY; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MEDITATION; PERSONALITY TESTS; REFERENCE VALUES; RESILIENCE, PSYCHOLOGICAL; RISK FACTORS; SELF CONCEPT; STRESS, PSYCHOLOGICAL; TEMPERAMENT;

MLCS; MLOWN;

EID: 84872412027     PISSN: 17495016     EISSN: 17495024     Source Type: Journal    
DOI: 10.1093/scan/nss070     Document Type: Article

References (87)

1. Anicha, C.L., Ode, S., Moeller, S.K., Robinson, M.D. (2012). Toward a cognitive view of trait mindfulness: distinct cognitive skills predict its observing and nonreactivity facets. Journal of Personality, 80(2), 255-85.
2. Aron, A.R., Poldrack, R.A. (2005). The cognitive neuroscience of response inhibition: relevance for genetic research in attention-deficit/hyperactivity disorder. Biological Psychiatry, 57(11), 1285-92.
3. Baer, R.A., Smith, G.T., Hopkins, J., Krietemeyer, J., Toney, L. (2006). Using self-report assessment methods to explore facets of mindfulness. Assessment, 13(1), 27-45.
4. Baron Short, E., Kose, S., Mu, Q., et al. (2010). Regional brain activation during meditation shows time and practice effects: an exploratory FMRI study. Evidence-Based Complementary and Alternative Medicine, 7(1), 121-7.
5. Beck, A.T. (1987). Cognitive models of depression. Journal of Cognitive Psychotherapy, 1, 5-37.
6. Beck, A.T., Steer, R.A., Brown, G.K. (1996). Manual for the Beck Depression inventory-II. San Antonio, TX: Psychological Corporation.
7. Bishop, S.R., Lau, M., Shapiro, S., et al. (2004). Mindfulness: a proposed operational definition. Clinical Psychology: Science and Practice, 11(3), 230-41.
8. Bohlmeijer, E., Prenger, R., Taal, E., Cuijpers, P. (2010). The effects of mindfulness-based stress reduction therapy on mental health of adults with a chronic medical disease: a meta-analysis. Journal of Psychosomatic Research, 68(6), 539-44, [doi: DOI: 10.1016/ j.jpsychores.2009.10.005].
9. Bolger, N., Schilling, E.A. (1991). Personality and the problems of everyday life: the role of neuroticism in exposure and reactivity to daily stressors. Journal of Personality, 59(3), 355-86.
10. Bondolfi, G., Jermann, F., der Linden, M.V., et al. (2010). Depression relapse prophylaxis with Mindfulness-Based Cognitive Therapy: replication and extension in the Swiss health care system. Journal of Affective Disorders, 122(3), 224-31.
11. Bränström, R., Duncan, L.G., Moskowitz, J.T. (2011). The association between dispositional mindfulness, psychological well-being, and perceived health in a Swedish population-based sample. British Journal of Health Psychology, 16(2), 300-16.
12. Brefczynski-Lewis, J.A., Lutz, A., Schaefer, H.S., Levinson, D.B., Davidson, R.J. (2007). Neural correlates of attentional expertise in long-term meditation practitioners. Proceedings of the National Academy of Sciences of the United States of America, 104(27), 11483-8.
13. Brown, K.W., Goodman, R.J., Inzlicht, M. (2012). Dispositional mindfulness and the attenuation of neural responses to emotional stimuli. Social, Cognitive, and Affective Neuroscience. doi: 10.1093/scan/nss004.
14. Brown, K.W., Ryan, R.M. (2003). The benefits of being present: mindfulness and its role in psychological well-being. Journal of Personality and Social Psychology, 84(4), 822-48.
15. Carpenter, L.L., Tyrka, A.R., McDougle, C.J., et al. (2004). Cerebrospinal fluid corticotropin-releasing factor and perceived early-life stress in depressed patients and healthy control subjects. Neuropsychopharmacology, 29(4), 777-84.
16. Chadwick, P., Hember, M., Symes, J., Peters, E., Kuipers, E., Dagnan, D. (2008). Responding mindfully to unpleasant thoughts and images: reliability and validity of the Southampton mindfulness questionnaire (SMQ). The British Journal of Clinical Psychology, 47(Pt 4), 451-5.
17. Cohen, S., Kamarck, T., Mermelstein, R. (1983). A global measure of perceived stress. Journal of Health and Social Behavior, 24(4), 385-96.
18. Craig, A.D. (2003). Interoception: the sense of the physiological condition of the body. Current Opinion in Neurobiology, 13(4), 500-5.
19. Craigie, M.A., Rees, C.S., Marsh, A., Nathan, P. (2008). Mindfulness-based cognitive therapy for generalized anxiety disorder: a preliminary evaluation. Behavioural and Cognitive Psychotherapy, 36(5), 553-68.
20. Critchley, H.D., Wiens, S., Rotshtein, P., Ohman, A., Dolan, R.J. (2004). Neural systems supporting interoceptive awareness. [10.1038/nn1176]. Nature Neuroscience, 7(2), 189-95.
21. Damasio, A.R., Grabowski, T.J., Bechara, A., et al. (2000). Subcortical and cortical brain activity during the feeling of self-generated emotions. Nature Neuroscience, 3(10), 1049-56.
22. Deyo, M., Wilson, K.A., Ong, J., Koopman, C. (2009). Mindfulness and rumination: does mindfulness training lead to reductions in the ruminative thinking associated with depression? Explore (New York, N.Y.), 5(5), 265-71.
23. Dobkin, P.L., Zhao, Q. (2011). Increased mindfulness_the active component of the mindfulness-based stress reduction program? Complementary Therapies in Clinical Practice, 17(1), 22-7.
24. Dolcos, F., Kragel, P., Wang, L., McCarthy, G. (2006). Role of the inferior frontal cortex in coping with distracting emotions. Neuroreport, 17(15), 1591-4.
25. Euge'ne, F., Joormann, J., Cooney, R.E., Atlas, L.Y., Gotlib, I.H. (2010). Neural correlates of inhibitory deficits in depression. Psychiatry Research, 181(1), 30-5.
26. Evans, S., Ferrando, S., Findler, M., Stowell, C., Smart, C., Haglin, D. (2008). Mindfulness-based cognitive therapy for generalized anxiety disorder. Journal of Anxiety Disorders, 22(4), 716-21.
27. Farb, N.A., Segal, Z.V., Mayberg, H., et al. (2007). Attending to the present: mindfulness meditation reveals distinct neural modes of self-reference. Social Cognitive and Affective Neuroscience, 2(4), 313-22.
28. Feder, A., Skipper, J., Blair, J.R., et al. (2011). Tryptophan depletion and emotional processing in healthy volunteers at high risk for depression. Biological Psychiatry, 69(8), 804-7.
29. Feldman, G., Greeson, J., Senville, J. (2010). Differential effects of mindful breathing, progressive muscle relaxation, and loving-kindness meditation on decentering and negative reactions to repetitive thoughts. Behaviour Research and Therapy, 48(10), 1002-11.
30. Frewen, P.A., Evans, E.M., Maraj, N., Dozois, D.J.A., Partridge, K. (2008). Letting go: mindfulness and negative automatic thinking. Cognitive Therapy and Research, 32(6), 758-74.
31. Fritzsche, A., Dahme, B., Gotlib, I.H., et al. (2010). Specificity of cognitive biases in patients with current depression and remitted depression and in patients with asthma. Psychological Medicine, 40(5), 815-26.
32. Goldin, P.R., Gross, J.J. (2010). Effects of mindfulness-based stress reduction (MBSR) on emotion regulation in social anxiety disorder. Emotion, 10(1), 83-91.
33. Gopin, C.B., Burdick, K.E., Derosse, P., Goldberg, T.E., Malhotra, A.K. (2011). Emotional modulation of response inhibition in stable patients with bipolar I disorder: a comparison with healthy and schizophrenia subjects. Bipolar Disorders, 13(2), 164-72.
34. Gotlib, I.H., Krasnoperova, E., Yue, D.N., Joormann, J. (2004). Attentional biases for negative interpersonal stimuli in clinical depression. Journal of Abnormal Psychology, 113(1), 121-35.
35. Grossman, P., Kappos, L., Gensicke, H., et al. (2010). MS quality of life, depression, and fatigue improve after mindfulness training: a randomized trial. Neurology, 75(13), 1141-9.
36. Hanh, T.N. (1976). The Miracle of Mindfulness: An Introduction to the Practice of Meditation. Boston, MA: Beacon Press.
37. Hofmann, S.G., Sawyer, A.T., Witt, A.A., Oh, D. (2010). The effect of mindfulness-based therapy on anxiety and depression: a meta-analytic review. Journal of Consulting and Clinical Psychology, 78(2), 169-83.
38. Holzel, B.K., Carmody, J., Evans, K.C., et al. (2010). Stress reduction correlates with structural changes in the amygdala. Social Cognitive and Affective Neuroscience, 5(1), 11-7.
39. Hölzel, B.K., Carmody, J., Vangel, M., et al. (2011a). Mindfulness practice leads to increases in regional brain gray matter density. Psychiatry Research, 191(1), 36-43.
40. Holzel, B.K., Lazar, S.W., Gard, T., Shuman-Olivier, Z., Vago, D.R., Ott, U. (2011b). How does mindfulness meditation work? Proposing mechanisms of action from a conceptual and neural perspective. Perspectives on Psychological Sciences, 6, 537-59.
41. Hölzel, B.K., Ott, U., Gard, T., et al. (2008). Investigation of mindfulness meditation practitioners with voxel-based morphometry. Social Cognitive and Affective Neuroscience, 3(1), 55-61.
42. Ives-Deliperi, V.L., Solms, M., Meintjes, E.M. (2010). The neural substrates of mindfulness: an fMRI investigation. Social Neuroscience, 6, 231-42.
43. Jain, S., Shapiro, S.L., Swanick, S., et al. (2007). A randomized controlled trial of mindfulness meditation versus relaxation training: effects on distress, positive states of mind, rumination, and distraction. Annals of Behavioral Medicine, 33(1), 11-21.
44. Jansen, L.M., Gispen-de Wied, C.C., Gademan, P.J., De Jonge, R.C., van der Linden, J.A., Kahn, R.S. (1998). Blunted cortisol response to a psychosocial stressor in schizophrenia. Schizophrenia Research, 33(1-2), 87-94.
45. Joormann, J., Gotlib, I.H. (2007). Selective attention to emotional faces following recovery from depression. Journal of Abnormal Psychology, 116(1), 80-5.
46. Joormann, J., Nee, D.E., Berman, M.G., Jonides, J., Gotlib, I.H. (2010). Interference resolution in major depression. Cognitive Affective and Behavioral Neuroscience, 10(1), 21-33.
47. Joormann, J., Siemer, M. (2004). Memory accessibility, mood regulation, and dysphoria: difficulties in repairing sad mood with happy memories? Journal of Abnormal Psychology, 113(2), 179-88.
48. Kendler, K.S., Kuhn, J., Prescott, C.A. (2004). The interrelationship of neuroticism, sex, and stressful life events in the prediction of episodes of major depression. American Journal of Psychiatry, 161(4), 631-6.
49. Keng, S.L., Smoski, M.J., Robins, C.J. (2011). Effects of mindfulness on psychological health: a review of empirical studies. Clinical Psychology Review, 31(6), 1041-56.
50. Kim, Y.W., Lee, S.H., Choi, T.K., et al. (2009). Effectiveness of mindfulness-based cognitive therapy as an adjuvant to pharmacotherapy in patients with panic disorder or generalized anxiety disorder. Depression and Anxiety, 26(7), 601-6.
51. Kirschbaum, C., Pirke, K.M., Hellhammer, D.H. (1993). The 'Trier Social Stress Test' a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology, 28(1-2), 76-81.
52. Kumar, S., Feldman, G., Hayes, A. (2008). Changes in mindfulness and emotion regulation in an exposure-based cognitive therapy for depression. Cognitive Therapy and Research, 32(6), 734-44.
53. Kuyken, W., Byford, S., Taylor, R.S., et al. (2008). Mindfulness-based cognitive therapy to prevent relapse in recurrent depression. Journal of Consulting and Clinical Psychology, 76(6), 966-78.
54. Lang, P.J., et al. (1999). International affective picture system (IAPS): Technical manual and affective ratings Gainesville: University of Florida, Center for Research in Psychophysiology.
55. Lazar, S.W., Kerr, C.E., Wasserman, R.H., et al. (2005). Meditation experience is associated with increased cortical thickness. Neuroreport, 16(17), 1893-7.
56. Lyubomirsky, S., Caldwell, N.D., Nolen-Hoeksema, S. (1998). Effects of ruminative and distracting responses to depressed mood on retrieval of autobiographical memories. Journal of Personality and Social Psychology, 75(1), 166-77.
57. Lyubomirsky, S., Nolen-Hoeksema, S. (1995). Effects of self-focused rumination on negative thinking and interpersonal problem solving. Journal of Personality and Social Psychology, 69(1), 176-90.
58. Manna, A., Raffone, A., Perrucci, M.G., et al. (2010). Neural correlates of focused attention and cognitive monitoring in meditation. Brain Research Bulletin, 82(1-2), 46-56.
59. Nolen-Hoeksema, S. (1987). Sex differences in unipolar depression: evidence and theory. Psychologial Bulletin, 101(2), 259-82.
60. Nolen-Hoeksema, S. (1991). Responses to depression and their effects on the duration of depressive episodes. Journal of Abnormal Psychology, 100(4), 569-82.
61. Nolen-Hoeksema, S. (2000). The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. Journal of Abnormal Psychology, 109(3), 504-11, [doi:10.1037/0021-843X.109.3.504].
62. Ossewaarde, L., Hermans, E.J., van Wingen, G.A., et al. (2010). Neural mechanisms underlying changes in stress-sensitivity across the menstrual cycle. Psychoneuroendocrinology, 35(1), 47-55.
63. Pradhan, E.K., Baumgarten, M., Langenberg, P., et al. (2007). Effect of mindfulness-based stress reduction in rheumatoid arthritis patients. Arthritis and Rheumatism, 57(7), 1134-42.
64. Raes, F., Dewulf, D., Van Heeringen, C., Williams, J.M. (2009). Mindfulness and reduced cognitive reactivity to sad mood: evidence from a correlational study and a non-randomized waiting list controlled study. Behaviour Research and Therapy, 47(7), 623-7.
65. Raes, F., Williams, J. (2010). The relationship between mindfulness and uncontrollability of ruminative thinking. Mindfulness, 1(4), 199-203.
66. Ramel, W., Goldin, P.R., Carmona, P.E., McQuaid, J.R. (2004). The effects of mindfulness meditation on cognitive processes and affect in patients with past depression. Cognitive Therapy and Research, 28(4), 433-55.
67. Rosenzweig, S., Greeson, J.M., Reibel, D.K., Green, J.S., Jasser, S.A., Beasley, D. (2010). Mindfulness-based stress reduction for chronic pain conditions: variation in treatment outcomes and role of home meditation practice. Journal of Psychosomatic Research, 68(1), 29-36, [doi: DOI: 10.1016/j.jpsychores.2009.03.010].
68. Schultheiss, O.C., Stanton, S.J. (2009). Assessment of salivary hormones. In: Harmon-Jones, E., Beer, J.S., editors. Methods in Social Neuroscience. New York: Guilford Press, pp. 17-44.
69. Segal, Z.V., Bieling, P., Young, T., et al. (2010). Antidepressant monotherapy vs sequential pharmacotherapy and mindfulness-based cognitive therapy, or placebo, for relapse prophylaxis in recurrent depression. Archives of General Psychiatry, 67(12), 1256-64.
70. Sephton, S.E., Salmon, P., Weissbecker, I., et al. (2007). Mindfulness meditation alleviates depressive symptoms in women with fibromyalgia: results of a randomized clinical trial. Arthritis and Rheumatism, 57(1), 77-85.
71. Shapiro, S.L., Brown, K.W., Thoresen, C., Plante, T.G. (2011). The moderation of mindfulness-based stress reduction effects by trait mindfulness: results from a randomized controlled trial. Journal of Clinical Psychology, 67(3), 267-77.
72. Shapiro, S.L., Oman, D., Thoresen, C.E., Plante, T.G., Flinders, T. (2008). Cultivating mindfulness: effects on well-being. Journal of Clinical Psychology, 64(7), 840-62.
73. Short, E.B., Kose, S., Mu, Q., et al. (2010). Regional brain activation during meditation shows time and practice effects: an exploratory FMRI study. Evidence-Based Complementary and Alternative Medicine, 7(1), 121-127.
74. Simmonds, D.J., Pekar, J.J., Mostofsky, S.H. (2008). Meta-analysis of Go/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependent. Neuropsychologia, 46(1), 224-32.
75. Singer, T., Critchley, H.D., Preuschoff, K. (2009). A common role of insula in feelings, empathy and uncertainty. Trends in Cognitive Science, 13(8), 334-40.
76. Slagter, H.A., Davidson, R.J., Lutz, A. (2011). Mental training as a tool in the neuroscientific study of brain and cognitive plasticity. Frontiers in Human Neuroscience, 5, 17.
77. Soufer, R., Bremner, J.D., Arrighi, J.A., et al. (1998). Cerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease. Proceeings of the National Academy of Sciences of the United States of America, 95(11), 6454-9.
78. Speca, M., Carlson, L.E., Goodey, E., Angen, M. (2000). A randomized, wait-list controlled clinical trial: the effect of a mindfulness meditation-based stress reduction program on mood and symptoms of stress in cancer outpatients. Psychosomatic Medicine, 62(5), 613-22.
79. Spielberger, C.D., Gorsuch, R.L., Lushene, R., Vagg, P.R., Jacobs, G.A. (1983). Manual for the Statie-Trait Anxiety Inventory (Form Y). Palo Alto, CA: Consulting Psychologists Press, Inc.
80. Stanton, S.J., Beehner, J.C., Saini, E.K., Kuhn, C.M., Labar, K.S. (2009). Dominance, politics, and physiology: voters' testosterone changes on the night of the 2008 United States presidential election. PLoS One, 4(10), e7543.
81. Teasdale, J.D., Segal, Z.V., Williams, J.M., Ridgeway, V.A., Soulsby, J.M., Lau, M.A. (2000). Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Journal of Consulting and Clinical Psychology, 68(4), 615-23.
82. van Aalderen, J.R., Donders, A.R., Giommi, F., Spinhoven, P., Barendregt, H.P., Speckens, A.E. (2012). The efficacy of mindfulness-based cognitive therapy in recurrent depressed patients with and without a current depressive episode: a randomized controlled trial. Psychological Medicine, 42(5), 989-1001.
83. Walach, H., Buchheld, N., Buttenmüller, V., et al. (2006). Measuring mindfulness_the Freiburg Mindfulness Inventory (FMI). Personality and Individual Differences, 40(8), 1543-55.
84. Wang, J., Rao, H., Wetmore, G.S., et al. (2005). Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress. Proceedings of the National Academy of Sciences of the United States of America, 102(49), 17804-9.
85. Watson, D., Clark, L.A., Tellegen, A. (1988). Development and validation of brief measures of positive and negative affect: the PANAS scales. Journal of Personality and Social Psychology, 54(6), 1063-70.
86. Wichers, M., Myin-Germeys, I., Jacobs, N., et al. (2007). Genetic risk of depression and stress-induced negative affect in daily life. The British Journal of Psychiatry, 191, 218-23.
87. Zeidan, F., Martucci, K.T., Kraft, R.A., Gordon, N.S., McHaffie, J.G., Coghill, R.C. (2011). Brain mechanisms supporting the modulation of pain by mindfulness meditation. Journal of Neuroscience, 31(14), 5540-8.