Platelet-activating factor (PAF) induces wheal and flare skin reactions independent of mast cell degranulation

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 68, Issue 2, 2013, Pages 256-258

  Krause, K ^a   Gimenez Arnau A ^b   Martinez Escala, E ^b   Farre Albadalejo M ^b   Abajian, M ^a   Church, M K ^a   Maurer, M ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

histamine; microdialysis; platelet activating factor; prostaglandin D 2; wheal and flare

Indexed keywords

CODEINE; HISTAMINE; PROSTAGLANDIN D2; THROMBOCYTE ACTIVATING FACTOR;

ADULT; ALLERGY TEST; ARTICLE; DISEASE EXACERBATION; FEMALE; HISTAMINE RELEASE; HUMAN; HUMAN EXPERIMENT; MALE; MAST CELL DEGRANULATION; MICRODIALYSIS; NORMAL HUMAN; PRIORITY JOURNAL; SKIN TEST; URTICARIA;

ADULT; CELL DEGRANULATION; CODEINE; FEMALE; GERMANY; HISTAMINE; HISTAMINE RELEASE; HUMANS; INJECTIONS, INTRADERMAL; MALE; MAST CELLS; MICRODIALYSIS; PLATELET ACTIVATING FACTOR; REFERENCE VALUES; SAMPLING STUDIES; SKIN; SKIN TESTS; URTICARIA; YOUNG ADULT;

EID: 84872388682     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/all.12083     Document Type: Article

References (15)

1. Archer CB, Page CP, Paul W, Morley J, MacDonald DM,. Inflammatory characteristics of platelet activating factor (Paf-acether) in human skin. Br J Dermatol 1984; 110: 45-50.
2. Grandel KE, Farr RS, Wanderer AA, Eisenstadt TE, Wasserman SI,. Association of platelet activating factor with primary acquired cold urticaria. N Engl J Med 1985; 313: 405-409.
3. Lai CK, Ollier S, Lau CK, Holgate ST,. Effect of azelastine and ketotifen on the bronchial and skin responses to platelet-activating factor in humans. Clin Exp Allergy 1991; 21: 489-496.
4. Juhlin L, Pihl-Lundin I,. Effects of antihistamines on cutaneous reactions and influx of eosinophils after local injection of PAF, kallikrein, compound 48/80 and histamine in patients with chronic urticaria and healthy subjects. Acta Derm Venereol (Stockh) 1992; 72: 197-200.
5. 1 effects of second- generation antihistamines. Ann Allergy 1992; 68: 190-196.
6. Church MK,. Efficacy and tolerability of rupatadine at four times the recommended dose against histamine- and PAF-induced flare responses and ex vivo platelet aggregation in healthy males. Br J Dermatol 2010; 163: 1330-1332.
7. Kajiwara N, Sasaki T, Bradding P, Cruse G, Sagara H, Ohmori K, et al. Activation of human mast cells through the platelet-activating factor receptor. J Allergy Clin Immunol 2010; 125: 1137-1145.
8. Thomas G, Church MK,. Platelet activating factor does not release histamine from human dispersed cutaneous mast cells. Clin Exp Allergy 1990; 20: 377-382.
9. Petersen LJ, Church MK, Skov PS,. Platelet-activating factor Induces histamine release from human skin mast cells in vivo, which is reduced by local nerve blockade. J Allergy Clin Immunol 1997; 99: 640-647.
10. Clough GF, Jackson CL, Lee JJ, Jamal SC, Church MK,. What can microdialysis tell us about the temporal and spatial generation of cytokines in allergen-induced responses in human skin in vivo? J Invest Dermatol 2007; 127: 2799-2806.
11. Blunk JA, Schmelz M, Zeck S, Skov P, Likar R, Koppert W,. Opioid-induced mast cell activation and vascular responses is not mediated by mu-opioid receptors: an in vivo microdialysis study in human skin. Anesth Analg 2004; 98: 364-370, table.
12. Benyon RC, Robinson C, Church MK,. Differential release of histamine and eicosanoids from human skin mast cells activated by IgE-dependent and non-immunological stimuli. Br J Pharmacol 1989; 97: 898-904.
13. 1antagonists on the cutaneous vascular response to histamine and bradykinin: a study using scanning laser Doppler imaging. Br J Dermatol 1998; 138: 806-814.
14. Christophe B, Maleux MR, Gillard M, Chatelain P, Peck MJ, Massingham R,. The histamine H(1)-receptor antagonist cetirizine does not interact with bradykinin B(1) or B(2)-receptors in vitro. Inflamm Res 2004; 53 (Suppl 1): S81-S82.
15. Birdsall NJ,. Class A GPCR heterodimers: evidence from binding studies. Trends Pharmacol Sci 2010; 31: 499-508.