Mega-trials for blockbusters

JAMA

Volumn 309, Issue 3, 2013, Pages 239-240

  Ioannidis, John P A ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD LAW SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; ARIPIPRAZOLE; CLOPIDOGREL; DULOXETINE; ERYTHROPOIETIN; ESCITALOPRAM; ETANERCEPT; FLUTICASONE PROPIONATE PLUS SALMETEROL; INFLIXIMAB; MODAFINIL; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; OLANZAPINE; PLACEBO; QUETIAPINE; RECOMBINANT ERYTHROPOIETIN; ROSUVASTATIN; TESTOSTERONE;

CLINICAL DECISION MAKING; CLINICAL EFFECTIVENESS; COST BENEFIT ANALYSIS; COST CONTROL; DISEASE SEVERITY; DRUG EFFICACY; DRUG FATALITY; DRUG MARKETING; DRUG SAFETY; EVIDENCE BASED MEDICINE; FOLLOW UP; HUMAN; LICENCE; PRIORITY JOURNAL; PROFIT; RISK ASSESSMENT; RISK REDUCTION; SHORT SURVEY; ARTICLE; BIOASSAY; COST; DRUG INDUSTRY; DRUG THERAPY; ECONOMICS; FINANCIAL MANAGEMENT; METHODOLOGY; MORTALITY; MULTICENTER STUDY (TOPIC); PATIENT SELECTION; RANDOMIZED CONTROLLED TRIAL (TOPIC); SAMPLE SIZE; STATISTICS; TREATMENT OUTCOME;

COSTS AND COST ANALYSIS; DRUG INDUSTRY; DRUG THERAPY; ENDPOINT DETERMINATION; HUMANS; MORTALITY; MULTICENTER STUDIES AS TOPIC; PATIENT SELECTION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESEARCH DESIGN; RESEARCH SUPPORT AS TOPIC; SAMPLE SIZE; TREATMENT OUTCOME;

MLCS; MLOWN;

EID: 84872379911     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2012.168095     Document Type: Short Survey

References (9)

1. Eisenstein EL, Collins R, Cracknell BS, et al. Sensible approaches for reducing clinical trial costs. Clin Trials. 2008;5(1):75-84.
2. U.S. Pharmaceutical Sales - 2011. Drugs.com website. http://www.drugs. com/stats/top100/2011/sales. Accessed December 6, 2012.
3. Chen ZM, Jiang LX, Chen YP, et al; COMMIT (ClOpidogrel and Metoprolol in Myocardial Infarction Trial) Collaborative Group. Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised placebocontrolled trial. Lancet. 2005;366(9497):1607-1621.
4. Ridker PM, Danielson E, Fonseca FA, et al; JUPITER Study Group. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med. 2008;359(21):2195-2207.
5. Calverley PM, Anderson JA, Celli B, et al; TORCH Investigators. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med. 2007;356(8):775-789.
6. Tashkin DP, Celli B, Senn S, et al; UPLIFT Study Investigators. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med. 2008;359 (15):1543-1554.
7. Bohlius J, Schmidlin K, Brillant C, et al. Erythropoietin or darbepoetin for patients with cancer - meta-analysis based on individual patient data. Cochrane Database Syst Rev. 2009;(3):CD007303.
8. Lathyris DN, Patsopoulos NA, Salanti G, Ioannidis JP. Industry sponsorship and selection of comparators in randomized clinical trials. Eur J Clin Invest. 2010; 40(2):172-182.
9. Rizos EC, Salanti G, Kontoyiannis DP, Ioannidis JP. Homophily and cooccurrence patterns shape randomized trials agendas: illustration in antifungal agents. J Clin Epidemiol. 2011;64(8):830-842.