Study of stillbirth and major congenital anomaly among newborns in the high-level natural radiation areas of Kerala, India

Journal of Community Genetics

Volumn 4, Issue 1, 2013, Pages 21-31

  Jaikrishan, G ^a   Sudheer, K R ^a   Andrews, V J ^a   Koya, P K M ^a   Madhusoodhanan, M ^b   Jagadeesan, C K ^c   Seshadri, M ^a  

^a BHABHA ATOMIC RESEARCH CENTRE   (India)

^b Peadiatrics Unit   (India)

^c GOVERNMENT OF KERALA   (India)

Author keywords

Cleft lip palate; Clubfoot; Down syndrome; High level natural radiation; Hypospadias; Major congenital anomaly; Stillbirth

Indexed keywords

THORIUM;

ARTICLE; CLEFT LIP PALATE; CLUBFOOT; CONGENITAL HEART DISEASE; CONGENITAL MALFORMATION; CONSANGUINITY; DOSIMETRY; DOWN SYNDROME; ENVIRONMENTAL RADIOACTIVITY; ETHNICITY; FEMALE; HUMAN; HYPOSPADIAS; INDIA; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MATERNAL AGE; MULTIPLE PREGNANCY; NEURAL TUBE DEFECT; NEWBORN; PARITY; PREVALENCE; PRIORITY JOURNAL; RADIATION DOSE; SEX DIFFERENCE; STILLBIRTH; TWINS;

EID: 84872371988     PISSN: 1868310X     EISSN: 18686001     Source Type: Journal    
DOI: 10.1007/s12687-012-0113-1     Document Type: Article

References (46)

1. Ahman E, Zupan J (2007) Neonatal and perinatal mortality - country, regional and global estimates 2004. World Health Organisation, Geneva
2. Ayengar ARG, Sundaram K, Mistry KB, Suntha CM, Nambi CSV, Kaithuria SP et al (1972) Evaluation of the long term effects of high background radiation on selected population groups of Kerala coasts. In: Proceedings of 4th UN International Conference on Peaceful Uses of Atomic Energy. United Nations, New York, pp 31-51
3. Bharatwal DS, Vaze GH (1959) Radiation dose measurements in the monazite areas of Kerala State in India. In: Proceedings of the 2nd UN International Conference on Peaceful Uses of Atomic Energy. United Nations, New York, p 156
4. Bharucha BA (1998) Study of malformation and Down syndrome in India (SOMDI): Bombay region. Indian J Hum Genet 4:88-92
5. Breslow NE, Day NE (1987) Statistical methods in cancer research, vol II: The design and analysis of cohort studies. Oxford University Press, Oxford
6. Carothers AD, Boyd E, Lowther G, Ellis PM, Couzin DA, Faed MJ et al (1999) Trends in prenatal diagnosis of Down syndrome and other autosomal trisomies in Scotland 1990 to 1994, with associated cytogenetic and epidemiological findings. Genet Epidemiol 16(2):179-190
7. Chaturvedi P, Banerjee KS (1989) Spectrum of congenital malformations in newborns from rural Maharashtra. Indian J Pediatr 56(4):501-507
8. Cherian A, Seena S, Bullock RK, Antony AC (2005) Incidence of neural tube defects in the least-developed area of India: a population-based study. Lancet 366:930-931
9. Cheriyan VD, Kurien CJ, Das B, Ramachandran EN, Karuppasamy CV, Thampi MV et al (1999) Genetic monitoring of the human population from high level natural radiation areas of Kerala on the southwest coast of India. II. Incidence of numerical and structural chromosomal aberrations in the lymphocytes of newborns. Radiat Res 152((Suppl)):S154-S158
10. Choudhury AR, Mukherjee M, Sharma A, Talukder G, Goash PK (1989) Study of 1,26,266 consecutive births for major congenital defects. Ind J Pediatr 56(4):493-499
11. Coggle JE (1983) Biological effects of radiation, 2nd edn. Taylor and Francis Inc, New York
12. Das B, Karuppasamy CV (2009) Spontaneous frequency of micronuclei among the newborns from high level natural radiation areas of Kerala in the southwest coast of India. Int J Radiat Biol 85(3):272-280. doi: 10.1080/09553000902751462
13. Das B, Saini D, Seshadri M (2009) Telomere length in human adults and high level natural background radiation. PLoS One 4(12):e8440
14. Forster L, Forster P, Lutz-Bonengel S, Willkomm H, Brinkmann B (2002) Natural radioactivity and human mitochondrial DNA mutations. Proc Natl Acad Sci USA 99:13950-13954
15. Gaulden ME (1992) Maternal age effect: the enigma of Down syndrome and other trisomic conditions. Mutat Res 296(1-2):69-88
16. Ghirri P, Scaramuzzo RT, Bertelloni S, Pardi D, Celandroni A, Cocchi G et al (2009) Prevalence of hypospadias in Italy according to severity, gestational age and birthweight: an epidemiological study. Ital J Pediatr 35:18. doi: 10.1186/1824-7288-35-18
17. Gruneberg H (1964) Genetic research in an area of high natural radioactivity in South India. Nature 204:222-224
18. Gruneberg H, Bains GS, Berry RJ, Riles LL, Smith CAB, Weiss RA (1966) A search for genetic effects of high natural radioactivity in South India. Report No. SRS 307. London: Medical Research Council, Her Majesty's Stationary Office
19. Gupta RK, Gupta CR, Singh D (2003) Incidence of congenital malformations of the musculoskeletal system in new live borns in Jammu. JK Sci 5(4):157-160
20. Hecht CA, Hook EB (1996) Rates of Down syndrome at live birth by one-year maternal age intervals in studies with apparent close to complete ascertainment in populations of European origin: a proposed revised rate schedule for use in genetic and prenatal screening. Am J Med Genet 62(4):376-385
21. Jaikrishan G, Andrews VJ, Thampi MV, Koya PKM, Chauhan PS (1999) Genetic monitoring of the human population from high level natural radiation areas of Kerala on the Southwest Coast of India. I. Prevalence of congenital malformations in newborns. Radiat Res 152(Sppl):S149-S153
22. Khalil A, Aggarwal R, Thirupuram S, Arora R (1994) Incidence of congenital heart disease among hospital live births in India. Indian Pediatr 31(5):519-527
23. Khan HA, Sempos CT (1989) Statiscal methods in epidemiology. Oxford University Press, Oxford
24. Kochupillai N, Verma IC, Grewal MS, Ramalingaswamy V (1976) Down syndrome and related abnormalities in an area of high background radiation in coastal Kerala. Nature 262:60-61
25. Koya PKM, Chougaonkar MP, Predeep P, Jojo PJ, Cheriyan VD, Mayya YS et al (2012) Effect of low and chronic radiation exposure: a case-control study of mental retardation and cleft lip/palate in the monazite bearing coastal areas of Southern Kerala. Radiat Res 177:109-116
26. Modi UJ, Nayak U, Aiyer S, Bharani S (1998) Study of malformation and Down syndrome in India (SOMDI): Baroda region. Indian J Hum Genet 4:93-98
27. Nair MK, Nambi KSV, Amma SN, Gangadharan P, Jayalekshmi P, Jayadevan S et al (1999) Population study in the high natural background radiation area in Kerala, India. Radiat Res 152(Suppl):S145-S148
28. Nair RRK, Rajan B, Akiba S, Jayalekshmi P, Nair MK, Gangadharan P et al (2009) Background radiation and cancer incidence in Kerala, India-Karunagapally cohort study. Health Phys 96(1):55-66
29. Neel JV, Schull WJ, Awa AA, Satoh C, Kato H, Otake M et al (1990) The children of parents exposed to atomic bombs: estimates of the genetic doubling dose of radiation for humans. Am J Hum Genet 46:1053-1072
30. Radhakrishna U, Ratnamala U, Gaines M, Beiraghi S, Hutchings D, Golla J et al (2006) Genomewide scan for nonsyndromic cleft lip and palate in multigenerational Indian families reveals significant evidence of Linkage at 13q33.1-34. Am J Hum Genet 79:580-585
31. Reddy SG, Reddy RR, Bronkhorst EM, Prasad R, Ettema AM, Sailer HF et al (2010) Incidence of cleft lip and palate in the state of Andhra Pradesh, South India. Indian J Plast Surg 43(2):184-189
32. Ronya R, Gupta D, Ghosh SK, Narang R, Jain KB (2002) Spectrum of congenital surgical malformations in newborns. J Indian Med Assoc 100(9):565-566
33. Seller MJ, Opitz JM (1987) Neural tube defects and sex ratios. Am J Med Genet 26(3):699-707
34. Singh M (1985) Early diagnosis of congenital malformations. In: Care of newborn. 3rd edn. Sagar Publications, New Delhi
35. StatSoft, Inc. (2010). STATISTICA (data analysis software system), version 9.1. www.statsoft.com.
36. Stoltenberg C, Magnus P, Lie RT, Daltveit AK, Irgens LM (1998) Influence of consanguinity and maternal education on risk of stillbirth and infant death in Norway, 1967-1993. Am J Epidemiol 148:452-459
37. Sundaram K (1977) Down's syndrome in Kerala [letter]. Nature 267:728
38. Sunta CM (1993) A review of the studies of high background areas of the S-W coast of India. In: Sohrabi M, Ahmed JU, Durani SA (eds) Proceedings of the international conference on high levels of natural radiation. Atomic Energy Organization of Iran, Tehran, p 71
39. Talukder G, Sharma A (2006) Genetic causes of congenital malformation in India. Int J Hum Genet 6(1):15-25
40. Thampi MV, Cheriyan VD, Kurien CJ, Ramachandran EN, Karuppasamy CV, Koya PKM et al (2002) Cytogenetic studies in the high level natural radiation areas of Kerala. Int Congress Ser 1225:207-211
41. Thampi MV, Cheriyan VD, Jaikrishan G, Das B, Kurien CJ, Ramachandran EN et al (2005) Investigations on the health effects of human population residing in the high-level natural radiation areas in Kerala in the southwest coast of India. Int Congr Ser 1276:8-12
42. United Nations Scientific Committee on the Effects of Atomic Radiation (1993) Report to the general assembly. I. Sources, effects and risks of ionizing radiation. United Nations, New York
43. United Nations Scientific Committee on the Effects of Atomic Radiation (2000) Report to the general assembly with scientific annexes. Vol I. Annex B: exposures from natural radiation sources. United Nations, New York
44. Verma IC, Anand NK, Kabra M, Menon PSN, Sharma N (1998) Study of malformation and Down syndrome in India (SOMDI): Delhi region. Indian J Hum Genet 4:84-87
45. Vogel F, Motulsky AG (1997) Human genetics - problems and approaches, 3rd edn. Springer, New York
46. World Health Organization (1959) Effects of radiation on human heredity: investigations of areas of high natural radiation. WHO Technical Report Series No. 166, Geneva