Up-regulated ATP-sensitive potassium channels play a role in increased inflammation and plaque vulnerability in macrophages

Atherosclerosis

Volumn 226, Issue 2, 2013, Pages 348-355

  Ling, Ming Ying ^a   Ma, Zhi Yong ^a   Wang, Yuan Yuan ^a   Qi, Jia ^a   Liu, Lin ^a   Li, Li ^a   Zhang, Yun ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Apolipoprotein E null mice; Atherosclerosis; ATP sensitive potassium channels; Glibenclamide; Inflammation; Macrophages; Transcription factor NF B

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; BETA GALACTOSIDASE; GLIBENCLAMIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.1; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PINACIDIL; PROTEIN; SUR2A PROTEIN; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME PHOSPHORYLATION; GENE TRANSFER; IN VITRO STUDY; INFLAMMATION; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ATHEROSCLEROSIS; CELL LINE; GLYBURIDE; INFLAMMATION; KATP CHANNELS; MACROPHAGES; MICE; PINACIDIL; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84872368978     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2012.11.016     Document Type: Article

References (30)

1. Tabas I. Macrophage death and defective inflammation resolution in atherosclerosis. Nat Rev Immunol 2010, 10(1):36-46.
2. Libby P. Inflammation in atherosclerosis. Nature 2002, 420(6917):868-874.
3. Al-Shawaf E., Naylor J., Taylor H., et al. Acute stimulation of calcium-permeable TRPC5-containing channels by oxidized phospholipids. Arterioscler Thromb Vasc Biol 2010, 30(7):1453-1459.
4. Hong L., Xie Z.Z., Du Y.H., et al. Alteration of volume-regulated chloride channel during macrophage-derived foam cell formation in atherosclerosis. Atherosclerosis 2011, 216(1):59-66.
5. Schilling T., Eder C. Lysophosphatidylcholine- and MCP-1-induced chemotaxis of monocytes requires potassium channel activity. Pflugers Arch 2009, 459(1):71-77.
6. Aguilar-Bryan L., Clement J.P., Gonzalez G., Kunjilwar K., Babenko A., Bryan J. Toward understanding the assembly and structure of K-ATP channels. Physiol Rev 1998, 78:227-245.
7. Nichols C.G. KATP channels as molecular sensors of cellular metabolism. Nature 2006, 440(7083):470-476.
8. Aziz Q., Thomas A., Khambra T., Tinker A. Phenformin has a direct inhibitory effect on the ATP-sensitive potassium channel. Eur J Pharmacol 2010, 634(1-3):26-32.
9. Kuo J.H., Chen S.J., Shih C.C., Lue W.M., Wu C.C. Abnormal activation of potassium channels in aortic smooth muscle of rats with peritonitis-induced septic shock. Shock 2009, 32(1):74-79.
10. Lindauer U., Vogt J., Schuh-Hofer S., Dreier J.P., Dirnagl U. Cerebrovascular vasodilation to extraluminal acidosis occurs via combined activation of ATP-sensitive and Ca2+-activated potassium channels. J Cereb Blood Flow Metab 2003, 23(10):1227-1238.
11. Ha S.J., Kim W., Woo J.S., et al. Preventive effects of exenatide on endothelial dysfunction induced by ischemia-reperfusion injury via KATP channels. Arterioscler Thromb Vasc Biol 2012, 32(2):474-480.
12. Mustafa A.K., Sikka G., Gazi S.K., et al. Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels. Circ Res 2011, 109(11):1259-1268.
13. Rong S., Cao Q., Liu M., et al. Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis. J Lipid Res 2012, 53(4):686-695.
14. Teramoto N. Physiological roles of ATP-sensitive K+ channels in smooth muscle. J Physiol (Lond.) 2006, 572:617-624.
15. von der Thüsen Jan H., van Vlijmen Bart JM., Hoeben Rob C., et al. Induction of atherosclerotic plaque rupture in apolipoprotein E-/- mice after adenovirus-mediated transfer of p53. Circulation 2002, 105:2064-2070.
16. Shiomi M., Ito T., Hirouchi Y., Enomoto M. Stability of atheromatous plaque affected by lesional composition: study of WHHL rabbits treated with statins. Ann N Y Acad Sci 2001, 947:419-423.
17. Liu J., Yang T., Liu Y., et al. Krüppel-like factor 4 inhibits the expression of interleukin-1 beta in lipopolysaccharide-induced RAW264.7 macrophages. FEBS Lett 2012, 586(6):834-840.
18. Hayakawa M., Miyashita H., Sakamoto I., et al. Evidence that reactive oxygen species do not mediate NF-kappaB activation. EMBO J 2003, 22(13):3356-3366.
19. Loewe R., Holnthoner W., Gröger M., et al. Dimethylfumarate inhibits TNF-induced nuclear entry of NF-kappa B/p65 in human endothelial cells. J Immunol 2002, 168(9):4781-4787.
20. Mercer J., Figg N., Stoneman V., Braganza D., Bennett M.R. Endogenous p53 protects vascular smooth muscle cells from apoptosis and reduces atherosclerosis in ApoE knockout mice. Circ Res 2005, 96(6):667-674.
21. Yuan X.M., Osman E., Miah S., et al. p53 expression in human carotid atheroma is significantly related to plaque instability and clinical manifestations. Atherosclerosis 2010, 210(2):392-399.
22. Mercer J., Bennett M. The role of p53 in atherosclerosis. Cell Cycle 2006, 5(17):1907-1909.
23. Lin H.L., Xu X.S., Lu H.X., et al. Pathological mechanisms and dose dependency of erythrocyte-induced vulnerability of atherosclerotic plaques. J Mol Cell Cardiol 2007, 43(3):272-280.
24. Flagg T.P., Enkvetchakul D., Koster J.C., Nichols C.G. Muscle KATP channels: recent insights to energy sensing and myoprotection. Physiol Rev 2010, 90:799-829.
25. Yoshida H., Feig J.E., Morrissey A., Ghiu I.A., Artman M., Coetzee W.A. KATP channels of primary human coronary artery endothelial cells consist of a heteromultimeric complex of Kir6.1, Kir6.2, and SUR2B subunits. J Mol Cell Cardiol 2004, 37(4):857-869.
26. Schmid D., Staudacher D.L., Bueno R., Spieckermann P.G., Moeslinger T. ATP-sensitive potassium channels expressed by human monocytes play a role in stasis-induced thrombogenesis via tissue factor pathway. Life Sci 2007, 80(11):989-998.
27. Figura M., Chilton L., Liacini A., et al. Blockade of K(ATP) channels reduces endothelial hyperpolarization and leukocyte recruitment upon reperfusion after hypoxia. Am J Transplant 2009, 9(4):687-696.
28. Spiller F., Orrico M.I., Nascimento D.C., et al. Hydrogen sulfide improves neutrophil migration and survival in sepsis via K+ATP channel activation. Am J Respir Crit Care Med 2010, 182(3):360-368.
29. Eleftherianos I., Won S., Chtarbanova S., et al. ATP-sensitive potassium channel (KATP)-dependent regulation of cardiotropic viral infections. Proc Natl Acad Sci U S A 2011, 108(29):12024-12029.
30. Shi W., Cui N., Wu Z., et al. Lipopolysaccharides up-regulate Kir6.1/SUR2B channel expression and enhance vascular KATP channel activity via NF-kappaB-dependent signaling. J Biol Chem 2010, 285(5):3021-3029.