Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 3, 2013, Pages 767-772

  Casimiro Garcia, Agustin ^a   Heemstra, Ronald J ^a   Bigge, Christopher F ^a   Chen, Jing ^a   Ciske, Fred A ^a   Davis, Jo Ann ^a   Ellis, Teresa ^a   Esmaeil, Nadia ^a   Flynn, Declan ^a   Han, Seungil ^a   Jalaie, Mehran ^a   Ohren, Jeffrey F ^a   Powell, Noel A ^a  

^a PFIZER INC   (United States)

Author keywords

Angiotensin; Hypertension; Metabolic syndrome; Peroxisome proliferator activated receptor; PPAR

Indexed keywords

ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; IMIDAZO(4,5 C)PYRIDIN 4 ONE DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; PYRIDINE DERIVATIVE; TELMISARTAN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONFORMATION; CRYSTAL STRUCTURE; DRUG ABSORPTION; DRUG DESIGN; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG METABOLISM; DRUG SYNTHESIS; ENANTIOSELECTIVITY; IC 50; LIGAND BINDING; MITSUNOBU REACTION; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TRANSACTIVATION; X RAY ANALYSIS;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; BENZIMIDAZOLES; BENZOATES; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PPAR GAMMA; PROTEIN BINDING; PYRIDINES; PYRIDONES; RECEPTOR, ANGIOTENSIN, TYPE 1;

EID: 84872362201     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.11.088     Document Type: Article

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