Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 3, 2013, Pages 750-756

  Burgeson, James R ^a   Moore, Amy L ^a   Gharaibeh, Dima N ^a   Larson, Ryan A ^a   Cerruti, Natasha R ^a   Amberg, Sean M ^a   Hruby, Dennis E ^a   Dai, Dongcheng ^a  

^a SIGA Technologies Incorporated   (United States)

Author keywords

Antiviral; Arenavirus; Broad spectrum inhibitor; Entry inhibitor; Lassa fever; Lassa virus; SAR

Indexed keywords

ANTIVIRUS AGENT; BENZIMIDAZOLE; IMIDAZOPYRIDINE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARENAVIRUS; ARTICLE; DRUG POTENCY; LASSA VIRUS; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION;

ANTIVIRAL AGENTS; ARENAVIRUS; BENZIMIDAZOLES; DRUG DISCOVERY; HETEROCYCLIC COMPOUNDS; LASSA VIRUS; STRUCTURE-ACTIVITY RELATIONSHIP;

ARENAVIRUS; LASSA VIRUS;

EID: 84872354376     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.11.093     Document Type: Article

References (5)

1. D. Dai, J.R. Burgeson, D.N. Gharaibeh, A.L. Moore, R.A. Larson, N.R. Cerruti, S.M. Amberg, T.C. Bolken, and D.E. Hruby Bioorg. Med. Chem. Lett. 2012 10.1016/j.bmcl.2012.11.095
2. R.A. Larson, D. Dai, V.T. Hosack, Y. Tan, T.C. Bolken, D.E. Hruby, and S.M. Amberg J. Virol. 82 2008 10768
3. K.A. Cashman, M.A. Smith, N.A. Twenhafel, R.A. Larson, K.F. Jones, R.D. Allen III, D. Dai, J. Chinsangaram, T.C. Bolken, D.E. Hruby, S.M. Amberg, L.E. Hensley, and M.C. Guttieri Antiviral Res. 90 2011 70
4. Bonfanti, J-F.; Muller, P.; Fortin, J. M. C., Doublet, F. M. M. PCT Application WO2006136563, December 28, 2006.
5. W.L. Mosby Heterocyclic Systems with Bridgehead Nitrogen Atoms A. Weissberger, The Chemistry of Heterocyclic Compounds, A Series of Monographs Part Two 1961 Interscience Publishers New York 749