POU1F1 is a novel fusion partner of NUP98 in acute myeloid leukemia with t(3;11)(p11;p15)

Molecular Cancer

Volumn 12, Issue 1, 2013, Pages

  Lisboa, Susana ^a   Cerveira, Nuno ^a   Bizarro, Susana ^a   Correia, Cecília ^a   Vieira, Joana ^a   Torres, Lurdes ^a   Mariz, José M ^a   Teixeira, Manuel R ^a,b  

^a PORTUGUESE ONCOLOGY INSTITUTE   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

Acute leukemia; Gene fusion; NP98 POU1F1; NUP98 gene

Indexed keywords

CYCLOPHOSPHAMIDE; CYCLOSPORIN; CYTARABINE; DAUNORUBICIN; EPIRUBICIN; FLUOROURACIL; HYBRID PROTEIN; NUCLEOPORIN 98; TAMOXIFEN; TRANSCRIPTION FACTOR PIT 1;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE MYELOBLASTIC LEUKEMIA; ADULT; ARTICLE; ASTHENIA; BREAST ADENOCARCINOMA; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CASE REPORT; CHROMOSOME 3P; CYTOGENETICS; FEMALE; GENE FUSION; GENE IDENTIFICATION; GENE MUTATION; GENE REARRANGEMENT; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; MALIGNANT TRANSFORMATION; MULTIPLE CYCLE TREATMENT; NUCLEOTIDE SEQUENCE; PROTEIN FUNCTION;

ADENOCARCINOMA; BASE SEQUENCE; BREAST NEOPLASMS; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 3; COMBINED MODALITY THERAPY; FEMALE; HUMANS; LEUKEMIA, MYELOID, ACUTE; MIDDLE AGED; NEOPLASMS, SECOND PRIMARY; NUCLEAR PORE COMPLEX PROTEINS; ONCOGENE PROTEINS, FUSION; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION FACTOR PIT-1; TRANSLOCATION, GENETIC;

EID: 84872323686     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-12-5     Document Type: Article

References (16)

1. Gough SM, Slape CI, Aplan PD. NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights. Blood 2011, 118:6247-6257. 10.1182/blood-2011-07-328880, 3236115, 21948299.
2. Nebral K, König M, Schmidt HH, Lutz D, Sperr WR, Kalwak K, Brugger S, Dworzak MN, Haas OA, Strehl S. Screening for NUP98 rearrangements in hematopoietic malignancies by fluorescence in situ hybridization. Haematologica 2005, 90:746-752.
3. Eklund E. The role of Hox proteins in leukemogenesis: insights into key regulatory events in hematopoiesis. Crit Rev Oncog 2011, 16:65-76. 10.1615/CritRevOncog.v16.i1-2.70, 3243967, 22150308.
4. Shaffer LG, Slovak ML, Campbell LJ. An International System for Human Cytogenetic Nomenclature 2009, , BaselKarger Publishers.
5. Chou WC, Chen CY, Hou HA, Lin LI, Tang JL, Yao M, Tsay W, Ko BS, Wu SJ, Huang SY, et al. Acute myeloid leukemia bearing t(7;11)(p15;p15) is a distinct cytogenetic entity with poor outcome and a distinct mutation profile: comparative analysis of 493 adult patients. Leukemia 2009, 23:1303-1310. 10.1038/leu.2009.25, 19225539.
6. Andersen B, Rosenfeld MG. POU domain factors in the neuroendocrine system: lessons from developmental biology provide insights into human disease. Endocr Rev 2011, 22:2-35.
7. Delhase M, Vergani P, Malur A, Hooghe-Peters EL, Hooghe RJ. The transcription factor Pit-1/GHF-1 is expressed in hematopoietic and lymphoid tissues. Eur J Immunol 1993, 23:951-955. 10.1002/eji.1830230428, 8458380.
8. Ben-Batalla I, Seoane S, Garcia-Caballero T, Gallego R, Macia M, Gonzalez LO, Vizoso F, Perez-Fernandez R. Deregulation of the Pit-1 transcription factor in human breast cancer cells promotes tumor growth and metastasis. J Clin Invest 2010, 120:4289-4302. 10.1172/JCI42015, 2993584, 21060149.
9. Ben-Batalla I, Seoane S, Macia M, Garcia-Caballero T, Gonzalez LO, Vizoso F, Perez-Fernandez R. The Pit-1/Pou1f1 transcription factor regulates and correlates with prolactin expression in human breast cell lines and tumors. Endocr Relat Cancer 2010, 17:73-85. 10.1677/ERC-09-0100, 2828808, 19808898.
10. Costoya JA, García-Barros M, Gallego R, Señarís R, Arce VM, Devesa J. Correlation of Pit-1 gene expression and Pit-1 content with proliferation and differentiation in human myeloid leukemic cells. Exp Cell Res 1998, 245:132-136. 10.1006/excr.1998.4232, 9828108.
11. Capelson M, Liang Y, Schulte R, Mair W, Wagner U, Hetzer MW. Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. Cell 2010, 140:372-383. 10.1016/j.cell.2009.12.054, 2821818, 20144761.
12. Kalverda B, Pickersgill H, Shloma VV, Fornerod M. Nucleoporins directly stimulate expression of developmental and cell-cycle genes inside the nucleoplasm. Cell 2010, 140:360-371. 10.1016/j.cell.2010.01.011, 20144760.
13. Xu S, Powers MA. Nup98-homeodomain fusions interact with endogenous Nup98 during interphase and localize to kinetochores and chromosome arms during mitosis. Mol Biol Cell 2010, 21:1585-1596. 10.1091/mbc.E09-07-0561, 2861616, 20237156.
14. Argiropoulos B, Humphries RK. Hox genes in hematopoiesis and leukemogenesis. Oncogene 2007, 26:6766-6776. 10.1038/sj.onc.1210760, 17934484.
15. Kosmider O, Moreau-Gachelin F. From mice to human: the " two-hit model" of leukemogenesis. Cell Cycle 2006, 5:569-570. 10.4161/cc.5.6.2577, 16582609.
16. Taketani T, Taki T, Nakamura T, Kobayashi Y, Ito E, Fukuda S, Yamaguchi S, Hayashi Y. High frequencies of simultaneous FLT3-ITD, WT1 and KIT mutations in hematological malignancies with NUP98-fusion genes. Leukemia 2010, 24:1975-1977. 10.1038/leu.2010.207, 20861915.