메뉴 건너뛰기




Volumn 34, Issue 4, 2013, Pages 1080-1089

Age-related changes in neuroactive steroid levels in 3xTg-AD mice

Author keywords

Alzheimer's disease; GABA A receptors; Limbic region; Metabolic pathways; Progesterone; Testosterone

Indexed keywords

17ALPHA ESTRADIOL; 20ALPHA DIHYDROPROGESTERONE; 3BETA ANDROSTANEDIOL; 4 AMINOBUTYRIC ACID A RECEPTOR; AMYLOID BETA PROTEIN; ANDROSTANEDIOL; ANDROSTANOLONE; ESTRADIOL; PRASTERONE; PREGNENOLONE; PROGESTERONE; SEPRANOLONE; STEROID; TESTOSTERONE; TETRAHYDROPROGESTERONE;

EID: 84872318571     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2012.10.007     Document Type: Article
Times cited : (95)

References (52)
  • 3
    • 70350322693 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators decrease reactive astrogliosis in the injured brain: effects of aging and prolonged depletion of ovarian hormones
    • Barreto G., Santos-Galindo M., Diz-Chaves Y., Pernia O., Carrero P., Azcoitia I., Garcia-Segura L.M. Selective estrogen receptor modulators decrease reactive astrogliosis in the injured brain: effects of aging and prolonged depletion of ovarian hormones. Endocrinology 2009, 150:5010-5015.
    • (2009) Endocrinology , vol.150 , pp. 5010-5015
    • Barreto, G.1    Santos-Galindo, M.2    Diz-Chaves, Y.3    Pernia, O.4    Carrero, P.5    Azcoitia, I.6    Garcia-Segura, L.M.7
  • 4
    • 34249994344 scopus 로고    scopus 로고
    • Testosterone decreases reactive astroglia and reactive microglia after brain injury in male rats: role of its metabolites, oestradiol and dihydrotestosterone
    • Barreto G., Veiga S., Azcoitia I., Garcia-Segura L.M., Garcia-Ovejero D. Testosterone decreases reactive astroglia and reactive microglia after brain injury in male rats: role of its metabolites, oestradiol and dihydrotestosterone. Eur. J. Neurosci. 2007, 25:3039-3046.
    • (2007) Eur. J. Neurosci. , vol.25 , pp. 3039-3046
    • Barreto, G.1    Veiga, S.2    Azcoitia, I.3    Garcia-Segura, L.M.4    Garcia-Ovejero, D.5
  • 6
    • 0025918687 scopus 로고
    • Anxiolytic effects of 3 alpha-hydroxy-5 alpha[beta]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor
    • Bitran D., Hilvers R.J., Kellogg C.K. Anxiolytic effects of 3 alpha-hydroxy-5 alpha[beta]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor. Brain Res. 1991, 561:157-161.
    • (1991) Brain Res. , vol.561 , pp. 157-161
    • Bitran, D.1    Hilvers, R.J.2    Kellogg, C.K.3
  • 9
    • 33745591621 scopus 로고    scopus 로고
    • Therapeutic potential of neurogenesis for prevention and recovery from Alzheimer's disease: allopregnanolone as a proof of concept neurogenic agent
    • Brinton R.D., Wang J.M. Therapeutic potential of neurogenesis for prevention and recovery from Alzheimer's disease: allopregnanolone as a proof of concept neurogenic agent. Curr. Alzheimer Res. 2006, 3:185-190.
    • (2006) Curr. Alzheimer Res. , vol.3 , pp. 185-190
    • Brinton, R.D.1    Wang, J.M.2
  • 10
    • 78149318021 scopus 로고    scopus 로고
    • Age-dependent changes in TDP-43 levels in a mouse model of Alzheimer disease are linked to Abeta oligomers accumulation
    • Caccamo A., Magri A., Oddo S. Age-dependent changes in TDP-43 levels in a mouse model of Alzheimer disease are linked to Abeta oligomers accumulation. Mol. Neurodegener. 2010, 5:51.
    • (2010) Mol. Neurodegener. , vol.5 , pp. 51
    • Caccamo, A.1    Magri, A.2    Oddo, S.3
  • 12
    • 77954460733 scopus 로고    scopus 로고
    • Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice
    • Carroll J.C., Rosario E.R., Villamagna A., Pike C.J. Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice. Endocrinology 2010, 151:2713-2722.
    • (2010) Endocrinology , vol.151 , pp. 2713-2722
    • Carroll, J.C.1    Rosario, E.R.2    Villamagna, A.3    Pike, C.J.4
  • 14
    • 77958568334 scopus 로고    scopus 로고
    • Effects of short- and long-term gonadectomy on neuroactive steroid levels in the central and peripheral nervous system of male and female rats
    • Caruso D., Pesaresi M., Maschi O., Giatti S., Garcia-Segura L.M., Melcangi R.C. Effects of short- and long-term gonadectomy on neuroactive steroid levels in the central and peripheral nervous system of male and female rats. J. Neuroendocrinol. 2010, 22:1137-1147.
    • (2010) J. Neuroendocrinol. , vol.22 , pp. 1137-1147
    • Caruso, D.1    Pesaresi, M.2    Maschi, O.3    Giatti, S.4    Garcia-Segura, L.M.5    Melcangi, R.C.6
  • 15
    • 38349123293 scopus 로고    scopus 로고
    • Evaluation of neuroactive steroid levels by liquid chromatography-tandem mass spectrometry in central and peripheral nervous system: effect of diabetes
    • Caruso D., Scurati S., Maschi O., De Angelis L., Roglio I., Giatti S., Garcia-Segura L.M., Melcangi R.C. Evaluation of neuroactive steroid levels by liquid chromatography-tandem mass spectrometry in central and peripheral nervous system: effect of diabetes. Neurochem. Int. 2008, 52:560-568.
    • (2008) Neurochem. Int. , vol.52 , pp. 560-568
    • Caruso, D.1    Scurati, S.2    Maschi, O.3    De Angelis, L.4    Roglio, I.5    Giatti, S.6    Garcia-Segura, L.M.7    Melcangi, R.C.8
  • 16
    • 80052279560 scopus 로고    scopus 로고
    • Allopregnanolone promotes regeneration and reduces beta-amyloid burden in a preclinical model of Alzheimer's disease
    • Chen S., Wang J.M., Irwin R.W., Yao J., Liu L., Brinton R.D. Allopregnanolone promotes regeneration and reduces beta-amyloid burden in a preclinical model of Alzheimer's disease. PLoS One 2011, 6:e24293.
    • (2011) PLoS One , vol.6
    • Chen, S.1    Wang, J.M.2    Irwin, R.W.3    Yao, J.4    Liu, L.5    Brinton, R.D.6
  • 19
    • 84860170321 scopus 로고    scopus 로고
    • A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neurons
    • Ghosh D., Levault K.R., Barnett A.J., Brewer G.J. A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neurons. J. Neurosci. 2012, 32:5821-5832.
    • (2012) J. Neurosci. , vol.32 , pp. 5821-5832
    • Ghosh, D.1    Levault, K.R.2    Barnett, A.J.3    Brewer, G.J.4
  • 22
    • 26444515048 scopus 로고    scopus 로고
    • The decline of androgen levels in elderly men and its clinical and therapeutic implications
    • Kaufman J.M., Vermeulen A. The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr. Rev. 2005, 26:833-876.
    • (2005) Endocr. Rev. , vol.26 , pp. 833-876
    • Kaufman, J.M.1    Vermeulen, A.2
  • 23
  • 25
    • 80052266362 scopus 로고    scopus 로고
    • Neurosteroid and GABA-A receptor alterations in Alzheimer's disease, Parkinson's disease and multiple sclerosis
    • Luchetti S., Huitinga I., Swaab D.F. Neurosteroid and GABA-A receptor alterations in Alzheimer's disease, Parkinson's disease and multiple sclerosis. Neuroscience 2011, 191:6-21.
    • (2011) Neuroscience , vol.191 , pp. 6-21
    • Luchetti, S.1    Huitinga, I.2    Swaab, D.F.3
  • 27
    • 34249782015 scopus 로고    scopus 로고
    • Steroid profiling in brain and plasma of male and pseudopregnant female rats after traumatic brain injury: analysis by gas chromatography/mass spectrometry
    • Meffre D., Pianos A., Liere P., Eychenne B., Cambourg A., Schumacher M., Stein D.G., Guennoun R. Steroid profiling in brain and plasma of male and pseudopregnant female rats after traumatic brain injury: analysis by gas chromatography/mass spectrometry. Endocrinology 2007, 148:2505-2517.
    • (2007) Endocrinology , vol.148 , pp. 2505-2517
    • Meffre, D.1    Pianos, A.2    Liere, P.3    Eychenne, B.4    Cambourg, A.5    Schumacher, M.6    Stein, D.G.7    Guennoun, R.8
  • 28
    • 84858826382 scopus 로고    scopus 로고
    • Modifications of neuroactive steroid levels in an experimental model of nigrostriatal degeneration: potential relevance to the pathophysiology of Parkinson's disease
    • Melcangi R.C., Caruso D., Levandis G., Abbiati F., Armentero M.T., Blandini F. Modifications of neuroactive steroid levels in an experimental model of nigrostriatal degeneration: potential relevance to the pathophysiology of Parkinson's disease. J. Mol. Neurosci. 2012, 46:177-183.
    • (2012) J. Mol. Neurosci. , vol.46 , pp. 177-183
    • Melcangi, R.C.1    Caruso, D.2    Levandis, G.3    Abbiati, F.4    Armentero, M.T.5    Blandini, F.6
  • 29
    • 73049114855 scopus 로고    scopus 로고
    • Sex-specific therapeutic strategies based on neuroactive steroids: in search for innovative tools for neuroprotection
    • Melcangi R.C., Garcia-Segura L.M. Sex-specific therapeutic strategies based on neuroactive steroids: in search for innovative tools for neuroprotection. Horm. Behav. 2010, 57:2-11.
    • (2010) Horm. Behav. , vol.57 , pp. 2-11
    • Melcangi, R.C.1    Garcia-Segura, L.M.2
  • 31
  • 33
    • 79960887452 scopus 로고    scopus 로고
    • Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission?
    • Olabarria M., Noristani H.N., Verkhratsky A., Rodriguez J.J. Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission?. Mol. Neurodegener. 2011, 6:55.
    • (2011) Mol. Neurodegener. , vol.6 , pp. 55
    • Olabarria, M.1    Noristani, H.N.2    Verkhratsky, A.3    Rodriguez, J.J.4
  • 34
    • 68149169022 scopus 로고    scopus 로고
    • Brainstem Alzheimer's-like pathology in the triple transgenic mouse model of Alzheimer's disease
    • Overk C.R., Kelley C.M., Mufson E.J. Brainstem Alzheimer's-like pathology in the triple transgenic mouse model of Alzheimer's disease. Neurobiol. Dis. 2009, 35:415-425.
    • (2009) Neurobiol. Dis. , vol.35 , pp. 415-425
    • Overk, C.R.1    Kelley, C.M.2    Mufson, E.J.3
  • 36
    • 73049086234 scopus 로고    scopus 로고
    • Sex differences in neuroactive steroid levels in the nervous system of diabetic and non-diabetic rats
    • Pesaresi M., Maschi O., Giatti S., Garcia-Segura L.M., Caruso D., Melcangi R.C. Sex differences in neuroactive steroid levels in the nervous system of diabetic and non-diabetic rats. Horm. Behav. 2010, 57:46-55.
    • (2010) Horm. Behav. , vol.57 , pp. 46-55
    • Pesaresi, M.1    Maschi, O.2    Giatti, S.3    Garcia-Segura, L.M.4    Caruso, D.5    Melcangi, R.C.6
  • 37
    • 77957982982 scopus 로고    scopus 로고
    • Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways
    • Rosario E.R., Carroll J., Pike C.J. Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways. Brain Res. 2010, 1359:281-290.
    • (2010) Brain Res. , vol.1359 , pp. 281-290
    • Rosario, E.R.1    Carroll, J.2    Pike, C.J.3
  • 38
    • 33845789124 scopus 로고    scopus 로고
    • Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease
    • Rosario E.R., Carroll J.C., Oddo S., LaFerla F.M., Pike C.J. Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease. J. Neurosci. 2006, 26:13384-13389.
    • (2006) J. Neurosci. , vol.26 , pp. 13384-13389
    • Rosario, E.R.1    Carroll, J.C.2    Oddo, S.3    LaFerla, F.M.4    Pike, C.J.5
  • 40
    • 79953116520 scopus 로고    scopus 로고
    • Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease
    • Rosario E.R., Chang L., Head E.H., Stanczyk F.Z., Pike C.J. Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease. Neurobiol. Aging 2011, 32:604-613.
    • (2011) Neurobiol. Aging , vol.32 , pp. 604-613
    • Rosario, E.R.1    Chang, L.2    Head, E.H.3    Stanczyk, F.Z.4    Pike, C.J.5
  • 41
    • 4544370855 scopus 로고    scopus 로고
    • Age-related testosterone depletion and the development of Alzheimer disease
    • Rosario E.R., Chang L., Stanczyk F.Z., Pike C.J. Age-related testosterone depletion and the development of Alzheimer disease. JAMA 2004, 292:1431-1432.
    • (2004) JAMA , vol.292 , pp. 1431-1432
    • Rosario, E.R.1    Chang, L.2    Stanczyk, F.Z.3    Pike, C.J.4
  • 42
    • 40949142713 scopus 로고    scopus 로고
    • Dose-dependent and sequence-sensitive effects of amyloid-beta peptide on neurosteroidogenesis in human neuroblastoma cells
    • Schaeffer V., Meyer L., Patte-Mensah C., Eckert A., Mensah-Nyagan A.G. Dose-dependent and sequence-sensitive effects of amyloid-beta peptide on neurosteroidogenesis in human neuroblastoma cells. Neurochem. Int. 2008, 52:948-955.
    • (2008) Neurochem. Int. , vol.52 , pp. 948-955
    • Schaeffer, V.1    Meyer, L.2    Patte-Mensah, C.3    Eckert, A.4    Mensah-Nyagan, A.G.5
  • 43
    • 33745791723 scopus 로고    scopus 로고
    • Modulation of neurosteroid production in human neuroblastoma cells by Alzheimer's disease key proteins
    • Schaeffer V., Patte-Mensah C., Eckert A., Mensah-Nyagan A.G. Modulation of neurosteroid production in human neuroblastoma cells by Alzheimer's disease key proteins. J. Neurobiol. 2006, 66:868-881.
    • (2006) J. Neurobiol. , vol.66 , pp. 868-881
    • Schaeffer, V.1    Patte-Mensah, C.2    Eckert, A.3    Mensah-Nyagan, A.G.4
  • 44
    • 38749117141 scopus 로고    scopus 로고
    • Selective regulation of neurosteroid biosynthesis in human neuroblastoma cells under hydrogen peroxide-induced oxidative stress condition
    • Schaeffer V., Patte-Mensah C., Eckert A., Mensah-Nyagan A.G. Selective regulation of neurosteroid biosynthesis in human neuroblastoma cells under hydrogen peroxide-induced oxidative stress condition. Neuroscience 2008, 151:758-770.
    • (2008) Neuroscience , vol.151 , pp. 758-770
    • Schaeffer, V.1    Patte-Mensah, C.2    Eckert, A.3    Mensah-Nyagan, A.G.4
  • 47
    • 84861882571 scopus 로고    scopus 로고
    • Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice
    • Singh C., Liu L., Wang J.M., Irwin R.W., Yao J., Chen S., Henry S., Thompson R.F., Brinton R.D. Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice. Neurobiol. Aging 2011, 33:1493-1506.
    • (2011) Neurobiol. Aging , vol.33 , pp. 1493-1506
    • Singh, C.1    Liu, L.2    Wang, J.M.3    Irwin, R.W.4    Yao, J.5    Chen, S.6    Henry, S.7    Thompson, R.F.8    Brinton, R.D.9
  • 48
    • 84860519060 scopus 로고    scopus 로고
    • Allopregnanolone increases the number of dopaminergic neurons in substantia nigra of a triple transgenic mouse model of Alzheimer's disease
    • Sun C., Ou X., Farley J.M., Stockmeier C., Bigler S., Brinton R.D., Wang J.M. Allopregnanolone increases the number of dopaminergic neurons in substantia nigra of a triple transgenic mouse model of Alzheimer's disease. Curr. Alzheimer Res. 2012, 9:473-480.
    • (2012) Curr. Alzheimer Res. , vol.9 , pp. 473-480
    • Sun, C.1    Ou, X.2    Farley, J.M.3    Stockmeier, C.4    Bigler, S.5    Brinton, R.D.6    Wang, J.M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.