Goeckerman therapy: A very effective, yet often forgotten treatment for severe generalized psoriasis

Journal of Dermatological Treatment

Volumn 24, Issue 1, 2013, Pages 34-37

  Moscaliuc, Manuela L ^a   Heller, Misha M ^b   Lee, Eric S ^c   Koo, John ^d  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biologics; Goeckerman; Psoriasis; Treatment; Ultraviolet B

Indexed keywords

CLOBETASOL; COAL TAR; DESONIDE; STEROID; TRIAMCINOLONE;

ADULT; ARTICLE; BEDTIME DOSAGE; BODY SURFACE; CASE REPORT; DISEASE EXACERBATION; DISEASE SEVERITY; GOECKERMAN METHOD; HEALTH CARE FACILITY; HUMAN; MALE; OUTPATIENT CARE; PHOTOTHERAPY; PRIORITY JOURNAL; PSORIASIS VULGARIS; TREATMENT DURATION; TREATMENT RESPONSE; ULTRAVIOLET B RADIATION; UNITED STATES;

COAL TAR; HUMANS; KERATOLYTIC AGENTS; MALE; MIDDLE AGED; PHOTOCHEMOTHERAPY; PSORIASIS; SAN FRANCISCO; TREATMENT OUTCOME; ULTRAVIOLET RAYS;

EID: 84872311780     PISSN: 09546634     EISSN: 14711753     Source Type: Journal    
DOI: 10.3109/09546634.2012.658014     Document Type: Article

References (31)

1. Christophers E. Psoriasis-epidemiology and clinical spectrum. Clin Exp Dermatol. 2001;26:314-320.
2. Marsico AR, Eaglstein WH, Weinstein GD. Ultraviolet light and tar in the Goeckerman treatment of psoriasis. Arch Dermatol. 1976;112:1249-1250.
3. Petrozzi JW, Barton JO, Kaidbey KK, Kligman AM. Updating the Goeckerman regimen for psoriasis. Br J Dermatol. 1978; 98:437-444.
4. WH G. The treatment of psoriasis. Northwest Med. 1925;24: 229-231.
5. Lowe NJ, Breeding JH, Wortzman MS. New coal tar extract and coal tar shampoos. Evaluation by epidermal cell DNA synthesis suppression assay. Arch Dermatol. 1982; 118:487-489.
6. Finch PW, Murphy F, Cardinale I, Krueger JG. Altered expression of keratinocyte growth factor and its receptor in psoriasis. Am J Pathol. 1997;151:1619-1628.
7. Fiala Z, Borska L, Pastorkova A, et al. Genotoxic effect of Goeckerman regimen of psoriasis. Arch Dermatol Res. 2006; 298:243-251.
8. Arbiser JL, Govindarajan B, Battle TE, et al. Carbazole is a naturally occurring inhibitor of angiogenesis and inflammation isolated from antipsoriatic coal tar. J Invest Dermatol. 2006; 126:1396-1402.
9. Krueger JG, Wolfe JT, Nabeya RT, et al. Successful ultraviolet B treatment of psoriasis is accompanied by a reversal of keratinocyte pathology and by selective depletion of intraepidermal T cells. J Exp Med. 1995;182:2057-2068.
10. Ozawa M, Ferenczi K, Kikuchi T, et al. 312-nanometer ultraviolet B light (narrow-band UVB) induces apoptosis of T cells within psoriatic lesions. J Exp Med. 1999;189: 711-718.
11. Comaish JS. Tar and related compounds in the therapy of psoriasis. Clin Exp Dermatol. 1981;6:639-645.
12. Le Vine MJ, White HA, Parrish JA. Components of the Goeckerman regimen. J Invest Dermatol. 1979;73:170-173.
13. Muller SA, Kierland RR. Crude coal tar in dermatologic therapy. Mayo Clin Proc. 1964;39:275-280.
14. Perry HO, Soderstrom CW, Schulze RW. The Goeckerman treatment of psoriasis. Arch Dermatol. 1968;98:178-182.
15. Harber LC, Armstrong RB, Leach EE, Walther RR, Fleiss JL. Preliminary report: modified Goeckerman therapy for hospitalized patients: ambulatory day care center and improved quantitative dosimetry. J Invest Dermatol. 1981; 77:162-166.
16. Armstrong RB, Leach EE, Fleiss JL, Harber LC. Modified Goeckerman therapy for psoriasis. a two-year follow-up of a combined hospital-ambulatory care program. Arch Dermatol. 1984;120:313-318.
17. Cram DL, King RI. Psoriasis day care centers. JAMA. 1976; 235:177-178.
18. Cram DL. Psoriasis day care center. Int J Dermatol. 1975;14: 577-578.
19. Koo J, Lebwohl M. Duration of remission of psoriasis therapies. J Am Acad Dermatol. 1999;41:51-59.
20. Menter A, Cram DL. The Goeckerman regimen in two psoriasis day care centers. J Am Acad Dermatol. 1983;9: 59-65.
21. Feldman SR. Where has Goeckerman treatment gone? J Dermatolog Treat. 2005;16:73-74.
22. de Miguel R, el-Azhary R. Efficacy, safety, and cost of Goeckerman therapy compared with biologics in the treatment of moderate to severe psoriasis. Int J Dermatol. 2009;48:653-658.
23. Lee E, Koo J. Modern modified 'ultra' Goeckerman therapy: a PASI assessment of a very effective therapy for psoriasis resistant to both prebiologic and biologic therapies. J Dermatolog Treat. 2005;16:102-107.
24. Menkes A, Stern RS, Arndt KA. Psoriasis treatment with suberythemogenic ultraviolet B radiation and a coal tar extract. J Am Acad Dermatol. 1985;12:21-25.
25. Frost P, Horwitz SN, Caputo RV, Berger SM. Tar gelphototherapy for psoriasis. combined therapy with suberythemogenic doses of fluorescent sunlamp ultraviolet radiation. Arch Dermatol. 1979;115:840-846.
26. Lowe NJ, Wortzman MS, Breeding J, Koudsi H, Taylor L. Coal tar phototherapy for psoriasis reevaluated: erythemogenic versus suberythemogenic ultraviolet with a tar extract in oil and crude coal tar. J Am Acad Dermatol. 1983;8:781-789.
27. Bagel J. LCD plus NB-UVB reduces time to improvement of psoriasis vs. NB-UVB alone. J Drugs Dermatol. 2009;8: 351-357.
28. Muller SA, Perry HO. The Goeckerman treatment in psoriasis: six decades of experience at the mayo clinic. Cutis. 1984; 34:265-268; 70.
29. Finlay AY, Young DW. Short contact crude coal tar therapy for psoriasis. Clin Exp Dermatol. 1985;10:371-374.
30. Stern RS, Zierler S, Parrish JA. Skin carcinoma in patients with psoriasis treated with topical tar and artificial ultraviolet radiation. Lancet. 1980;1:732-735.
31. Pittelkow MR, Perry HO, Muller SA, Maughan WZ, O'Brien PC. Skin cancer in patients with psoriasis treated with coal tar. A 25-year follow-up study. Arch Dermatol. 1981;117:465-468.