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Volumn 43, Issue 1, 2013, Pages 184-190

Increased expression of P450scc and CYP17 in development of endogenous hyperandrogenism in a rat model of PCOS

Author keywords

CYP17; P450scc; Polycystic ovary syndrome; Rat

Indexed keywords

ANDROSTENEDIONE; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CHORIONIC GONADOTROPIN; CYTOCHROME P450 17; INSULIN; TESTOSTERONE;

EID: 84872310504     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-012-9739-3     Document Type: Article
Times cited : (34)

References (23)
  • 1
    • 0034457559 scopus 로고    scopus 로고
    • A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain
    • 10902790 10.1210/jc.85.7.2434 1:CAS:528:DC%2BD3cXlt1Wnt78%3D
    • M. Asuncion, R.M. Calvo, J.L. San Millan, J. Sancho et al., A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain. J. Clin. Endocrinol. Metab. 85(7), 2434-2438 (2000)
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , Issue.7 , pp. 2434-2438
    • Asuncion, M.1    Calvo, R.M.2    San Millan, J.L.3    Sancho, J.4
  • 2
    • 2942642477 scopus 로고    scopus 로고
    • The prevalence and feature of the polycystic ovary syndrome in an unselected population
    • 15181052 10.1210/jc.2003-032046 1:CAS:528:DC%2BD2cXmtlGqurs%3D
    • R. Azziz, K.S. Woods, R. Reyna et al., The prevalence and feature of the polycystic ovary syndrome in an unselected population. J. Clin. Endocrinol. Metab. 89(6), 2745-2749 (2004)
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , Issue.6 , pp. 2745-2749
    • Azziz, R.1    Woods, K.S.2    Reyna, R.3
  • 3
    • 77949912770 scopus 로고    scopus 로고
    • Prevalence of Hyperandrogenemia in the polycystic ovary syndrome diagnosed by the NIH 1990 criteria
    • 19249030 10.1016/j.fertnstert.2008.12.138
    • A. Huang, K. Brennan, R. Azziz, Prevalence of Hyperandrogenemia in the polycystic ovary syndrome diagnosed by the NIH 1990 criteria. Fertil. Steril. 93(6), 1938-1941 (2010)
    • (2010) Fertil. Steril. , vol.93 , Issue.6 , pp. 1938-1941
    • Huang, A.1    Brennan, K.2    Azziz, R.3
  • 4
    • 70349459787 scopus 로고    scopus 로고
    • Selective impairment in glycogen synthase kinase-3 and mitogen-activated protein kinase phosphorylation: Comparisons with the hyperandrogenic and the hyperinsulinemic rats
    • 19027112 10.1016/j.fertnstert.2008.08.073 1:CAS:528:DC%2BD1MXhsFaisbnI
    • Y. Chen, J. Qiao, L.Y. Yan et al., Selective impairment in glycogen synthase kinase-3 and mitogen-activated protein kinase phosphorylation: comparisons with the hyperandrogenic and the hyperinsulinemic rats. Fertil. Steril. 92(4), 1447-1455 (2009)
    • (2009) Fertil. Steril. , vol.92 , Issue.4 , pp. 1447-1455
    • Chen, Y.1    Qiao, J.2    Yan, L.Y.3
  • 5
    • 0035032081 scopus 로고    scopus 로고
    • The genetics, pathophysiology, and management of human deficiencies of P450c17
    • 10.1016/S0889-8529(08)70021-5 1:CAS:528:DC%2BD3MXjvVamsb8%3D
    • R.J. Auchus, The genetics, pathophysiology, and management of human deficiencies of P450c17. Endocrinol. Metab. Clin. N. Am. 30(1), 101-119 (2001)
    • (2001) Endocrinol. Metab. Clin. N. Am. , vol.30 , Issue.1 , pp. 101-119
    • Auchus, R.J.1
  • 6
    • 0031907004 scopus 로고    scopus 로고
    • Genetic linkage mapping of the CYP11A1 gene encoding the cholesterol side-chain cleavage P450scc close to the CYP1A1 gene and D15S204 in the chromosome 15q22.33-q23 region
    • 9511181 10.1097/00008571-199802000-00007 1:CAS:528:DyaK1cXhs1ylu78%3D
    • F. Durocher, J. Morissette, J. Simard, Genetic linkage mapping of the CYP11A1 gene encoding the cholesterol side-chain cleavage P450scc close to the CYP1A1 gene and D15S204 in the chromosome 15q22.33-q23 region. Pharmacogenetics 8(1), 49-53 (1998)
    • (1998) Pharmacogenetics , vol.8 , Issue.1 , pp. 49-53
    • Durocher, F.1    Morissette, J.2    Simard, J.3
  • 7
    • 0037203495 scopus 로고    scopus 로고
    • Androgen biosynthesis from cholesterol to DHEA
    • 12573809 10.1016/S0303-7207(02)00363-5 1:CAS:528:DC%2BD3sXovFCguw%3D%3D
    • W.L. Miller, Androgen biosynthesis from cholesterol to DHEA. Mol. Cell. Endocrinol. 198(1-2), 7-14 (2002)
    • (2002) Mol. Cell. Endocrinol. , vol.198 , Issue.1-2 , pp. 7-14
    • Miller, W.L.1
  • 8
    • 0030832255 scopus 로고    scopus 로고
    • Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome
    • 10.1046/j.1365-2265.1997.2321049.x 1:STN:280:DyaK2svksl2gtQ%3D%3D
    • C. Gilling-Smith, H. Story, V. Rogers et al., Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome. Clin. Endocrinol. (Oxf.) 47(1), 93-99 (1997)
    • (1997) Clin. Endocrinol. (Oxf.) , vol.47 , Issue.1 , pp. 93-99
    • Gilling-Smith, C.1    Story, H.2    Rogers, V.3
  • 9
    • 0034789352 scopus 로고    scopus 로고
    • Clinical, endocrine and metabolic effects of acarbose, an α-glucosidase inhibitor, in PCOS patients with increased insulin response and normal glucose tolerance
    • 11574493 10.1093/humrep/16.10.2066 1:CAS:528:DC%2BD3MXnvVGhtb8%3D
    • L. Ciotta, A.E. Calogero, M. Farina et al., Clinical, endocrine and metabolic effects of acarbose, an α-glucosidase inhibitor, in PCOS patients with increased insulin response and normal glucose tolerance. Hum. Reprod. 16(10), 2066-2072 (2001)
    • (2001) Hum. Reprod. , vol.16 , Issue.10 , pp. 2066-2072
    • Ciotta, L.1    Calogero, A.E.2    Farina, M.3
  • 10
    • 0038508940 scopus 로고    scopus 로고
    • Selective effects of pioglitazone on insulin and androgen abnormalities in normo- and hyperinsulinaemic obese patients with polycystic ovary syndrome
    • 12773448 10.1093/humrep/deg264 1:CAS:528:DC%2BD3sXltFygt74%3D
    • D. Romualdi, M. Guido, M. Ciampelli et al., Selective effects of pioglitazone on insulin and androgen abnormalities in normo- and hyperinsulinaemic obese patients with polycystic ovary syndrome. Hum. Reprod. 18(6), 1210-1218 (2003)
    • (2003) Hum. Reprod. , vol.18 , Issue.6 , pp. 1210-1218
    • Romualdi, D.1    Guido, M.2    Ciampelli, M.3
  • 11
    • 0030783316 scopus 로고    scopus 로고
    • Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450c17 alpha activity and serum androgens
    • 9398716 10.1210/jc.82.12.4075 1:CAS:528:DyaK2sXnvFyktLw%3D
    • J.E. Nestler, D.J. Jakubowicz, Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450c17 alpha activity and serum androgens. J. Clin. Endocrinol. Metab. 82(12), 4075-4079 (1997)
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , Issue.12 , pp. 4075-4079
    • Nestler, J.E.1    Jakubowicz, D.J.2
  • 12
    • 33747878619 scopus 로고    scopus 로고
    • Up-regulation of the phosphatidylinositol 3-kinase/protein kinase B pathway in the ovary of rats by chronic treatment with hCG and insulin
    • 16899578 10.1677/joe.1.06226 1:CAS:528:DC%2BD28Xpt1Wjtbs%3D
    • M.H. Lima, L.C. Souza, L.C. Caperuto et al., Up-regulation of the phosphatidylinositol 3-kinase/protein kinase B pathway in the ovary of rats by chronic treatment with hCG and insulin. J. Endocrinol. 190(2), 451-459 (2006)
    • (2006) J. Endocrinol. , vol.190 , Issue.2 , pp. 451-459
    • Lima, M.H.1    Souza, L.C.2    Caperuto, L.C.3
  • 13
    • 84455188274 scopus 로고    scopus 로고
    • Enhanced thecal androgen production is prenatally programmed in an ovine model of polycystic ovary syndrome
    • 10.1210/en.2011-1607 1:CAS:528:DC%2BC38XovFWrsg%3D%3D
    • K. Hogg, J.M. Young, E.M. Oliver et al., Enhanced thecal androgen production is prenatally programmed in an ovine model of polycystic ovary syndrome. J. Endocrinol. 153(1), 450-461 (2012)
    • (2012) J. Endocrinol. , vol.153 , Issue.1 , pp. 450-461
    • Hogg, K.1    Young, J.M.2    Oliver, E.M.3
  • 14
    • 0023949583 scopus 로고
    • Somatomedin-C/insulin-like growth factor-I as an enhancer of androgen biosynthesis by cultured rat ovarian cells
    • 10.1210/endo-122-4-1603 1:CAS:528:DyaL1cXhvVSqs70%3D
    • E.R. Hernandez, C.E. Resnick, M.E. Svoboda, Somatomedin-C/insulin-like growth factor-I as an enhancer of androgen biosynthesis by cultured rat ovarian cells. J. Endocrinol. 122(4), 1603-1612 (1988)
    • (1988) J. Endocrinol. , vol.122 , Issue.4 , pp. 1603-1612
    • Hernandez, E.R.1    Resnick, C.E.2    Svoboda, M.E.3
  • 15
    • 0033304623 scopus 로고    scopus 로고
    • Augmented androgen production is a stable steroidogenic phenotype of propagated thecal cells from polycystic ovaries
    • 10379893 10.1210/me.13.6.946 1:CAS:528:DyaK1MXjs1yns7w%3D
    • V.L. Nelson, R.S. Legro, J.F. Strauss et al., Augmented androgen production is a stable steroidogenic phenotype of propagated thecal cells from polycystic ovaries. Mol. Endocrinol. 13(6), 946-957 (1999)
    • (1999) Mol. Endocrinol. , vol.13 , Issue.6 , pp. 946-957
    • Nelson, V.L.1    Legro, R.S.2    Strauss, J.F.3
  • 16
    • 0026638365 scopus 로고
    • Hyperinsulinemia and human chorionic gonadotropin synergistically promote the growth of ovarian follicular cyst in rats
    • 1640871 10.1016/0026-0495(92)90175-A 1:CAS:528:DyaK38Xks1Ort70%3D
    • L. Poretsky, J. Clemons, K. Bogovich, Hyperinsulinemia and human chorionic gonadotropin synergistically promote the growth of ovarian follicular cyst in rats. Metabolism 41(8), 903-910 (1992)
    • (1992) Metabolism , vol.41 , Issue.8 , pp. 903-910
    • Poretsky, L.1    Clemons, J.2    Bogovich, K.3
  • 17
    • 0032841019 scopus 로고    scopus 로고
    • Insulin has a biphasic effect on the ability of human chorionic gonadotropin to induce ovarian cysts in the rat
    • 10459564 10.1016/S0026-0495(99)90196-8 1:CAS:528:DyaK1MXlt1aqs7k%3D
    • K. Bogovich, J. Clemons, L. Poretsky, Insulin has a biphasic effect on the ability of human chorionic gonadotropin to induce ovarian cysts in the rat. Metabolism 48(8), 995-1002 (1999)
    • (1999) Metabolism , vol.48 , Issue.8 , pp. 995-1002
    • Bogovich, K.1    Clemons, J.2    Poretsky, L.3
  • 18
    • 0036901676 scopus 로고    scopus 로고
    • Involvement of nitric oxide and the ovarian blood follicle barrier in murine follicular cyst development
    • 12477528 10.1016/S0015-0282(02)04340-6
    • R.V. Nemade, O. Carrette, W.J. Larsen et al., Involvement of nitric oxide and the ovarian blood follicle barrier in murine follicular cyst development. Fertil. Steril. 78(6), 1301-1308 (2002)
    • (2002) Fertil. Steril. , vol.78 , Issue.6 , pp. 1301-1308
    • Nemade, R.V.1    Carrette, O.2    Larsen, W.J.3
  • 19
    • 0022800222 scopus 로고
    • Hormonal changes during the early development of ovarian cysts in the rat
    • 3790657 10.1095/biolreprod35.3.542 1:CAS:528:DyaL2sXnsVE%3D
    • M.-T. Lee, B.C. Bruot, W.C. Adams, Hormonal changes during the early development of ovarian cysts in the rat. Biol. Reprod. 35(3), 542-548 (1986)
    • (1986) Biol. Reprod. , vol.35 , Issue.3 , pp. 542-548
    • Lee, M.-T.1    Bruot, B.C.2    Adams, W.C.3
  • 20
    • 0023925874 scopus 로고
    • The effects of experimental hyperinsulinemia on steroid secretion, ovarian [125I] insulin binding, and ovarian [125I] insulin-like growth-factor i binding in the rat
    • 2962853 10.1210/endo-122-2-581 1:CAS:528:DyaL1cXhtVKrtL0%3D
    • L. Poretsky, B. Glover, V. Laumas et al., The effects of experimental hyperinsulinemia on steroid secretion, ovarian [125I] insulin binding, and ovarian [125I] insulin-like growth-factor I binding in the rat. Endocrinology 122(2), 581-585 (1988)
    • (1988) Endocrinology , vol.122 , Issue.2 , pp. 581-585
    • Poretsky, L.1    Glover, B.2    Laumas, V.3
  • 21
    • 0034463967 scopus 로고    scopus 로고
    • Interactive stimulation by luteinizing hormone and insulin of the steroidogenic acute regulatory (StAR) protein and 17alpha-hydroxylase/17,20- lyase (CYP17) genes in porcine theca cells
    • 10919257 10.1210/en.141.8.2735 1:CAS:528:DC%2BD3cXnt1Cmsrg%3D
    • G. Zhang, J.C. Garmey, J.D. Veldhuis, Interactive stimulation by luteinizing hormone and insulin of the steroidogenic acute regulatory (StAR) protein and 17alpha-hydroxylase/17,20-lyase (CYP17) genes in porcine theca cells. Endocrinology 141(8), 2735-2742 (2000)
    • (2000) Endocrinology , vol.141 , Issue.8 , pp. 2735-2742
    • Zhang, G.1    Garmey, J.C.2    Veldhuis, J.D.3
  • 22
    • 68349109438 scopus 로고    scopus 로고
    • Study of RNA interference inhibiting rat ovarian androgen biosynthesis by depressing 17alpha-hydroxylase/17,20-lyase activity in vivo
    • 10.1186/1477-7827-7-73
    • Y. Li, X.Y. Liang, L.N. Wei et al., Study of RNA interference inhibiting rat ovarian androgen biosynthesis by depressing 17alpha-hydroxylase/17,20-lyase activity in vivo. Reprod. Biol. Endocrinol. 17(7), 73 (2009)
    • (2009) Reprod. Biol. Endocrinol. , vol.17 , Issue.7 , pp. 73
    • Li, Y.1    Liang, X.Y.2    Wei, L.N.3
  • 23
    • 77957989339 scopus 로고    scopus 로고
    • Theca: The forgotten cell of the ovarian follicle
    • 20628033 10.1530/REP-10-0094 1:CAS:528:DC%2BC3cXhtlCqurrM
    • M.J. Young, A.S. Mcneilly, Theca: the forgotten cell of the ovarian follicle. Reproduction 140(4), 489-504 (2010)
    • (2010) Reproduction , vol.140 , Issue.4 , pp. 489-504
    • Young, M.J.1    McNeilly, A.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.