SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 3, 2013, Pages 614-619

  Guerrero, Miguel ^a   Urbano, Mariangela ^a   Schaeffer, Marie Therese ^a   Brown, Steven ^a   Rosen, Hugh ^a   Roberts, Edward ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Analgesia; Anorexia; NPBWR1 (GPR7) antagonists; Stress

Indexed keywords

5 CHLORO 2 ( 3,5 DIMETHYLPHENYL) 4 ( 4 METHOXYPHENOXY)PYRIDAZIN 3 (2H) ONE; 5 CHLORO 2 ( 9H FLUOREN 9 YL) 4 ( 4 METHOXYPHENOXY)PYRIDAZIN 3 (2H) ONE; 5 CHLORO 4 ( 4 ALKOXYPHENOXY) 2 (BENZYL)PYRIDAZINE 3 (2H) ONE; ANALGESIC AGENT; CYM 50719; CYM 50769; CYM 50775; NPBWR1 AGONIST; PYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIA; ARTICLE; CONTROLLED STUDY; DRUG HALF LIFE; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG SYNTHESIS; FEEDING BEHAVIOR; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; MOLECULE; NEUROENDOCRINE SYSTEM; PAIN; STRESS; STRUCTURE ACTIVITY RELATION;

ANALGESICS; FLUORENES; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PEPTIDES; PROTEIN BINDING; PYRIDAZINES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84872306528     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.12.030     Document Type: Article

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