Concise asymmetric synthesis of (+)-conocarpan and obtusafuran

Synlett

Volumn 24, Issue 2, 2013, Pages 189-192

  Chen, Cheng Yi ^a   Weisel, Mark ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

(+) and ( ) obtusafuran; (+) conocarpan; 8,5 neolignans; 8 aryl 2,3 dihydro benzofuran; dynamic kinetic resolution; metal catalyzed C O bond formation; Sr reaction; trans dihydrobenzofuran

Indexed keywords

8,5' NEOLIGNAN; ALCOHOL; BROMOPHENOL; CONOCARPAN; CONOCARPAN METHY ETHER; DIHYDROBENZOFURAN DERIVATIVE; KETONE; METHANOL; NATURAL PRODUCT; OBTUSAFURAN; TARANABANT; UNCLASSIFIED DRUG; WEINREB AMIDE;

ARTICLE; ASYMMETRIC SYNTHESIS; CHEMICAL BOND; CHEMICAL REACTION; COMPLEX FORMATION; CRYSTALLIZATION; DEMETHYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; DYNAMIC KINETIC RESOLUTION; ENANTIOSELECTIVITY; FRIEDEL CRAFTS REACTION; HYDROGENATION; REDUCTION; SUZUKI REACTION;

EID: 84872297412     PISSN: 09365214     EISSN: 14372096     Source Type: Journal    
DOI: 10.1055/s-0032-1317704     Document Type: Article

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21. 3) δ = 17.8, 18.4, 45.2, 92.6, 109.3, 115.5, 120.7, 123.0, 126.3, 127.9, 130.8, 131.3, 132.4, 132.9, 155.7, 158.3. The enantiopurity of (+)-conocarpan was determined to be 99.6% using the reported method cited in reference 7a.