Design and synthesis of tricyclic cores for kinase inhibition

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 3, 2013, Pages 693-698

  Van Epps, Stacy ^a   Fiamengo, Bryan ^a   Edmunds, Jeremy ^a   Ericsson, Anna ^b   Frank, Kristine ^a   Friedman, Michael ^a   George, Dawn ^a   George, Jonathan ^a   Goedken, Eric ^a   Kotecki, Brian ^a   Martinez, Gloria ^a   Merta, Philip ^a   Morytko, Michael ^a   Shekhar, Shashank ^a   Skinner, Barbara ^a   Stewart, Kent ^a   Voss, Jeffrey ^a   Wallace, Grier ^a   Wang, Lu ^a   Wishart, Neil ^a  

^a ABBOTT LABORATORIES   (United States)

^b Forma Therapeutics   (United States)

Author keywords

Kinase inhibitors; Tricyclic pyrrolopyrazines; Tricyclic pyrrolopyridines

Indexed keywords

FOSTAMATINIB; JANUS KINASE 2; PHOSPHOTRANSFERASE INHIBITOR; PYRAZINE DERIVATIVE; PYRIDINE DERIVATIVE; TOFACITINIB; TRICYCLIC AROMATIC COMPOUND; TRICYCLIC PYRROLOPYRAZINE; TRICYCLIC PYRROLOPYRIDINE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; IC 50; IN VITRO STUDY;

CELLS, CULTURED; CYCLIZATION; DRUG DESIGN; ENZYME ACTIVATION; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PYRAZINES; PYRIDINES; PYRROLES;

EID: 84872289474     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.11.108     Document Type: Article

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