Analysis of the MTHFR (methylenetetrahydrofolate reductase) 677 C>T and 1298 A>C polymorphisms in BCR-ABL-negative myeloproliferative neoplasms

International Journal of Laboratory Hematology

Volumn 35, Issue 1, 2013, Pages

  Trifa, A P ^a   Cucuianu, A ^b   Popp, R A ^a   Costache, R M ^a   Coada C A ^a   Sarca, A D ^a   Urian, L G ^b   Dima, D ^b   Petrov, L ^b   Farcas, M F ^a   Militaru, M S ^a   Pop, I V ^a  

^a IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^b Cancer Institute Ion Chiricuta Cluj Napoca   (Romania)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTETRAHYDROFOLATE HOMOCYSTEINE METHYLTRANSFERASE; 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BCR ABL PROTEIN; DNA; GENOMIC DNA; JANUS KINASE 2;

ADULT; AGED; CANCER RISK; CATALYSIS; DNA METHYLATION; ENZYME ACTIVITY; FEMALE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOTE; HUMAN; LETTER; MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; MYELOID METAPLASIA; MYELOPROLIFERATIVE NEOPLASM; PRIORITY JOURNAL; THROMBOCYTHEMIA;

ADULT; AGED; AGED, 80 AND OVER; COHORT STUDIES; FEMALE; GENETIC ASSOCIATION STUDIES; HETEROZYGOTE; HUMANS; JANUS KINASE 2; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; MUTATION; POLYCYTHEMIA VERA; POLYMORPHISM, SINGLE NUCLEOTIDE; PRIMARY MYELOFIBROSIS; ROMANIA; THROMBOCYTHEMIA, ESSENTIAL; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84872262764     PISSN: 17515521     EISSN: 1751553X     Source Type: Journal    
DOI: 10.1111/ijlh.12017     Document Type: Letter

References (10)

1. Jones AV, Kreil S, Zoi K, Waghorn K, Curtis C, Zhang L, Score J, Seear R, Chase AJ, Grand FH, White H, Zoi C, Loukopoulos D, Terpos E, Vervessou EC, Schultheis B, Emig M, Ernst T, Lengfelder E, Hehlmann R, Hochhaus A, Oscier D, Silver RT, Reiter A, Cross NC. Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders. Blood 2005;106:2162-8.
2. Robien K, Ulrich CM. 5, 10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a HuGE minireview. Am J Epidemiol 2003;157:571-82.
3. Krajinovic M, Lamothe S, Labuda D, Lemieux-Blanchard E, Theoret Y, Moghrabi A, Sinnett D. Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood 2004;103:252-7.
4. Yan J, Yin M, Dreyer ZE, Scheurer ME, Kamdar K, Wei Q, Okcu MF. A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in children. Pediatr Blood Cancer 2012;58:513-8.
5. Moon HW, Kim TY, Oh BR, Min HC, Cho HI, Bang SM, Lee JH, Yoon SS, Lee DS. MTHFR 677CC/1298CC genotypes are highly associated with chronic myelogenous leukemia: a case-control study in Korea. Leuk Res 2007;31:1213-7.
6. Vahid P, Farnaz R, Zaker F, Farzaneh A, Parisa R. Methylenetetrahydrofolate Reductase Gene Polymorphisms and Risk of Myeloid Leukemia. Lab Med 2010;41:490-4.
7. Jakovljevic K, Malisic E, Cavic M, Radulovic S, Jankovic R. Association between methylenetetrahydrofolate reductase polymorphism C677T and risk of chronic myeloid leukemia in Serbian population. Leuk Lymphoma 2012;53:1327-30.
8. Tefferi A, Vardiman JW. Classification and diagnosis of myeloproliferative neoplasms: the 2008 World Health Organization criteria and point-of-care diagnostic algorithms. Leukemia 2008;22:14-22.
9. A ZC, Yang Y, Zhang SZ, Li N, Zhang W. Single nucleotide polymorphism C677T in the methylenetetrahydrofolate reductase gene might be a genetic risk factor for infertility for Chinese men with azoospermia or severe oligozoospermia. Asian J Androl 2007;9:57-62.
10. Wu J, Li Y, Ma H, Bai J, Chen F, Fu S. Association between single nucleotide polymorphisms of MTHFR gene and susceptibility of psoriasis. Int J Genet 2007;30:173-7.