메뉴 건너뛰기




Volumn 28, Issue 1, 2013, Pages 36-43

Aldosterone synthase inhibition in humans

Author keywords

aldosterone; enzyme; human; hypertension; inhibitors

Indexed keywords

ALDOSTERONE; ALDOSTERONE SYNTHASE; AMINOGLUTETHIMIDE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CORTICOTROPIN; CORTODOXONE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EPLERENONE; FAD 286; FAD 286A; FADROZOLE; HYDROCORTISONE; LCI 699; METYRAPONE; MINERALOCORTICOID ANTAGONIST; MINERALOCORTICOID RECEPTOR; OXIDOREDUCTASE INHIBITOR; PLACEBO; RENIN; SPIRONOLACTONE; TRILOSTANE; UNCLASSIFIED DRUG;

EID: 84872240598     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfs388     Document Type: Article
Times cited : (78)

References (60)
  • 1
    • 0007810160 scopus 로고
    • Primary aldosteronism
    • Conn JW. Primary aldosteronism. J Lab Clin Med 1955; 45: 661-664
    • (1955) J Lab Clin Med , vol.45 , pp. 661-664
    • Conn, J.W.1
  • 2
    • 1642390149 scopus 로고    scopus 로고
    • Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents
    • Mulatero P, Stowasser M, Loh KC et al. Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents. J Clin Endocrinol Metab 2004; 89: 1045-1050
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 1045-1050
    • Mulatero, P.1    Stowasser, M.2    Loh, K.C.3
  • 3
    • 42049107310 scopus 로고    scopus 로고
    • A lifetime of aldosterone excess: Long-term consequences of altered regulation of aldosterone production for cardiovascular function
    • Connell JM, MacKenzie SM, Freel EM et al. A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function. Endocr Rev 2008; 29: 133-154
    • (2008) Endocr Rev , vol.29 , pp. 133-154
    • Connell, J.M.1    MacKenzie, S.M.2    Freel, E.M.3
  • 4
    • 0000629762 scopus 로고
    • Electrolyte metabolism and aldosterone secretion in benign and malignant hypertension
    • Laragh JH, Ulick S, Januszewicz V et al. Electrolyte metabolism and aldosterone secretion in benign and malignant hypertension. Ann Intern Med 1960; 53: 259-272
    • (1960) Ann Intern Med , vol.53 , pp. 259-272
    • Laragh, J.H.1    Ulick, S.2    Januszewicz, V.3
  • 5
    • 0015338161 scopus 로고
    • Arterial pressure regulation. Overriding dominance of the kidneys in long-term regulation and in hypertension
    • Guyton AC, Coleman TG, Cowley AV, Jr. et al. Arterial pressure regulation. Overriding dominance of the kidneys in long-term regulation and in hypertension. Am J Med 1972; 52: 584-594
    • (1972) Am J Med , vol.52 , pp. 584-594
    • Guyton, A.C.1    Coleman, T.G.2    Cowley Jr., A.V.3
  • 6
    • 0021240867 scopus 로고
    • Body elemental composition, with particular reference to total and exchangeable sodium and potassium and total chlorine, in untreated and treated primary hyperaldosteronism
    • Williams ED, Boddy K, Brown JJ et al. Body elemental composition, with particular reference to total and exchangeable sodium and potassium and total chlorine, in untreated and treated primary hyperaldosteronism. J Hypertens 1984; 2: 171-176
    • (1984) J Hypertens , vol.2 , pp. 171-176
    • Williams, E.D.1    Boddy, K.2    Brown, J.J.3
  • 7
    • 18844387606 scopus 로고    scopus 로고
    • Aldosterone and end-organ damage
    • Brown NJ. Aldosterone and end-organ damage. Curr Opin Nephrol Hypertens 2005; 14: 235-241
    • (2005) Curr Opin Nephrol Hypertens , vol.14 , pp. 235-241
    • Brown, N.J.1
  • 8
    • 60249096205 scopus 로고    scopus 로고
    • Aldosterone and mineralocorticoid receptors: Clinical studies and basic biology
    • Funder JW, Mihailidou AS. Aldosterone and mineralocorticoid receptors: clinical studies and basic biology. Mol Cell Endocrinol 2009; 301: 2-6
    • (2009) Mol Cell Endocrinol , vol.301 , pp. 2-6
    • Funder, J.W.1    Mihailidou, A.S.2
  • 9
    • 33748174236 scopus 로고    scopus 로고
    • Renal damage in primary aldosteronism: Results of the PAPY Study
    • Rossi GP, Bernini G, Desideri G et al. Renal damage in primary aldosteronism: results of the PAPY Study. Hypertension 2006; 48: 232-238
    • (2006) Hypertension , vol.48 , pp. 232-238
    • Rossi, G.P.1    Bernini, G.2    Desideri, G.3
  • 10
    • 34047233709 scopus 로고    scopus 로고
    • Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sample
    • Newton-Cheh C, Guo CY, Gona P et al. Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sample. Hypertension 2007; 49: 846-856
    • (2007) Hypertension , vol.49 , pp. 846-856
    • Newton-Cheh, C.1    Guo, C.Y.2    Gona, P.3
  • 11
    • 3042731163 scopus 로고    scopus 로고
    • Serum aldosterone and the incidence of hypertension in nonhypertensive persons
    • Vasan RS, Evans JC, Larson MG et al. Serum aldosterone and the incidence of hypertension in nonhypertensive persons. N Engl J Med 2004; 351: 33-41
    • (2004) N Engl J Med , vol.351 , pp. 33-41
    • Vasan, R.S.1    Evans, J.C.2    Larson, M.G.3
  • 12
    • 48049123234 scopus 로고    scopus 로고
    • High plasma aldosterone and low renin predict blood pressure increase and hypertension in middle-aged caucasian populations
    • Meneton P, Galan P, Bertrais S et al. High plasma aldosterone and low renin predict blood pressure increase and hypertension in middle-aged caucasian populations. J Hum Hypertens 2008; 22: 550-558
    • (2008) J Hum Hypertens , vol.22 , pp. 550-558
    • Meneton, P.1    Galan, P.2    Bertrais, S.3
  • 13
    • 0036898286 scopus 로고    scopus 로고
    • Hyperaldosteronism among black and white subjects with resistant hypertension
    • Calhoun DA, Nishizaka MK, Zaman MA et al. Hyperaldosteronism among black and white subjects with resistant hypertension. Hypertension 2002; 40: 892-896
    • (2002) Hypertension , vol.40 , pp. 892-896
    • Calhoun, D.A.1    Nishizaka, M.K.2    Zaman, M.A.3
  • 14
    • 45149100695 scopus 로고    scopus 로고
    • Characterization of resistant hypertension: Association between resistant hypertension, aldosterone, and persistent intravascular volume expansion
    • Gaddam KK, Nishizaka MK, Pratt-Ubunama MN et al. Characterization of resistant hypertension: association between resistant hypertension, aldosterone, and persistent intravascular volume expansion. Arch Intern Med 2008; 168: 1159-1164
    • (2008) Arch Intern Med , vol.168 , pp. 1159-1164
    • Gaddam, K.K.1    Nishizaka, M.K.2    Pratt-Ubunama, M.N.3
  • 15
    • 35948958973 scopus 로고    scopus 로고
    • Body mass index predicts aldosterone production in normotensive adults on a high-salt diet
    • Bentley-Lewis R, Adler GK, Perlstein T et al. Body mass index predicts aldosterone production in normotensive adults on a high-salt diet. J Clin Endocrinol Metab 2007; 92: 4472-4475
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4472-4475
    • Bentley-Lewis, R.1    Adler, G.K.2    Perlstein, T.3
  • 16
    • 77951649148 scopus 로고    scopus 로고
    • Aldosterone production and insulin resistance in healthy adults
    • Garg R, Hurwitz S, Williams GH et al. Aldosterone production and insulin resistance in healthy adults. J Clin Endocrinol Metab 2010; 95: 1986-1990
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 1986-1990
    • Garg, R.1    Hurwitz, S.2    Williams, G.H.3
  • 17
    • 31944432423 scopus 로고    scopus 로고
    • Mechanisms of mineralocorticoid action
    • Fuller PJ, Young MJ. Mechanisms of mineralocorticoid action. Hypertension 2005; 46: 1227-1235
    • (2005) Hypertension , vol.46 , pp. 1227-1235
    • Fuller, P.J.1    Young, M.J.2
  • 19
    • 33644987045 scopus 로고    scopus 로고
    • Effects of aldosterone on the vasculature
    • Schiffrin EL. Effects of aldosterone on the vasculature. Hypertension 2006; 47: 312-318
    • (2006) Hypertension , vol.47 , pp. 312-318
    • Schiffrin, E.L.1
  • 20
    • 79955974994 scopus 로고    scopus 로고
    • The role of aldosterone in the metabolic syndrome
    • Briet M, Schiffrin EL. The role of aldosterone in the metabolic syndrome. Curr Hypertens Rep 2011; 13: 163-172
    • (2011) Curr Hypertens Rep , vol.13 , pp. 163-172
    • Briet, M.1    Schiffrin, E.L.2
  • 21
    • 84864458519 scopus 로고    scopus 로고
    • Human aldosterone synthase: Recombinant expression in E. coli and purification enables a detailed biochemical analysis of the protein on the molecular level
    • doi:10.1016/j. jsbmb.2012.03.002
    • Hobler A, Kagawa N, Hutter MC et al. Human aldosterone synthase: recombinant expression in E. coli and purification enables a detailed biochemical analysis of the protein on the molecular level. J Steroid Biochem Mol Biol 2012, doi:10.1016/j. jsbmb.2012.03.002
    • (2012) J Steroid Biochem Mol Biol
    • Hobler, A.1    Kagawa, N.2    Hutter, M.C.3
  • 22
    • 0036806162 scopus 로고    scopus 로고
    • The human steroid hydroxylases CYP1B1 and CYP11B2
    • Bureik M, Lisurek M, Bernhardt R. The human steroid hydroxylases CYP1B1 and CYP11B2. Biol Chem 2002; 383: 1537-1551
    • (2002) Biol Chem , vol.383 , pp. 1537-1551
    • Bureik, M.1    Lisurek, M.2    Bernhardt, R.3
  • 23
    • 34548822986 scopus 로고    scopus 로고
    • Effects of aldosterone and angiotensin II receptor blockade on cardiac angiotensinogen and angiotensin-converting enzyme 2 expression in Dahl salt-sensitive hypertensive rats
    • Takeda Y, Zhu A, Yoneda T et al. Effects of aldosterone and angiotensin II receptor blockade on cardiac angiotensinogen and angiotensin-converting enzyme 2 expression in Dahl salt-sensitive hypertensive rats. Am J Hypertens 2007; 20: 1119-1124
    • (2007) Am J Hypertens , vol.20 , pp. 1119-1124
    • Takeda, Y.1    Zhu, A.2    Yoneda, T.3
  • 24
    • 84856334802 scopus 로고    scopus 로고
    • Acute and chronic regulation of aldosterone production
    • Hattangady NG, Olala LO, Bollag WB et al. Acute and chronic regulation of aldosterone production. Mol Cell Endocrinol 2012; 350: 151-162
    • (2012) Mol Cell Endocrinol , vol.350 , pp. 151-162
    • Hattangady, N.G.1    Olala, L.O.2    Bollag, W.B.3
  • 25
    • 24344483486 scopus 로고    scopus 로고
    • Expression profiles for steroidogenic enzymes in adrenocortical disease
    • Bassett MH, Mayhew B, Rehman K et al. Expression profiles for steroidogenic enzymes in adrenocortical disease. J Clin Endocrinol Metab 2005; 90: 5446-5455
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5446-5455
    • Bassett, M.H.1    Mayhew, B.2    Rehman, K.3
  • 26
    • 2342511545 scopus 로고    scopus 로고
    • The 45-year story of the development of an anti-aldosterone more specific than spironolactone
    • Menard J. The 45-year story of the development of an anti-aldosterone more specific than spironolactone. Mol Cell Endocrinol 2004; 217: 45-52
    • (2004) Mol Cell Endocrinol , vol.217 , pp. 45-52
    • Menard, J.1
  • 27
    • 63849278544 scopus 로고    scopus 로고
    • Aldosterone-receptor antagonism in hypertension
    • Jansen PM, Danser AH, Imholz BP et al. Aldosterone-receptor antagonism in hypertension. J Hypertens 2009; 27: 680-691
    • (2009) J Hypertens , vol.27 , pp. 680-691
    • Jansen, P.M.1    Danser, A.H.2    Imholz, B.P.3
  • 28
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized aldactone evaluation study investigators
    • Pitt B, Zannad F, Remme WJ et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized aldactone evaluation study investigators. N Engl J Med 1999; 341: 709-717
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3
  • 29
    • 0037417252 scopus 로고    scopus 로고
    • Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
    • Pitt B, Remme W, Zannad F et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003; 348: 1309-1321
    • (2003) N Engl J Med , vol.348 , pp. 1309-1321
    • Pitt, B.1    Remme, W.2    Zannad, F.3
  • 30
    • 78650399880 scopus 로고    scopus 로고
    • Eplerenone in patients with systolic heart failure and mild symptoms
    • Zannad F, McMurray JJ, Krum H et al. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med 2011; 364: 11-21
    • (2011) N Engl J Med , vol.364 , pp. 11-21
    • Zannad, F.1    McMurray, J.J.2    Krum, H.3
  • 31
    • 53249090182 scopus 로고    scopus 로고
    • ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The task force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM)
    • Dickstein K, Cohen-Solal A, Filippatos G et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the task force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur Heart J 2008; 29: 2388-2442
    • (2008) Eur Heart J , vol.29 , pp. 2388-2442
    • Dickstein, K.1    Cohen-Solal, A.2    Filippatos, G.3
  • 32
    • 0037222490 scopus 로고    scopus 로고
    • Effectiveness of aldosterone blockade in patients with diabetic nephropathy
    • Sato A, Hayashi K, Naruse M et al. Effectiveness of aldosterone blockade in patients with diabetic nephropathy. Hypertension 2003; 41: 64-68
    • (2003) Hypertension , vol.41 , pp. 64-68
    • Sato, A.1    Hayashi, K.2    Naruse, M.3
  • 33
    • 33750331264 scopus 로고    scopus 로고
    • Selective aldosterone blockade with eplerenone reduces albuminuria in patients with type 2 diabetes
    • Epstein M, Williams GH, Weinberger M et al. Selective aldosterone blockade with eplerenone reduces albuminuria in patients with type 2 diabetes. Clin J Am Soc Nephrol 2006; 1: 940-951
    • (2006) Clin J Am Soc Nephrol , vol.1 , pp. 940-951
    • Epstein, M.1    Williams, G.H.2    Weinberger, M.3
  • 34
    • 72049109463 scopus 로고    scopus 로고
    • Addition of angiotensin receptor blockade or mineralocorticoid antagonism to maximal angiotensin-converting enzyme inhibition in diabetic nephropathy
    • Mehdi UF, Adams-Huet B, Raskin P et al. Addition of angiotensin receptor blockade or mineralocorticoid antagonism to maximal angiotensin-converting enzyme inhibition in diabetic nephropathy. J Am Soc Nephrol 2009; 20: 2641-2650
    • (2009) J Am Soc Nephrol , vol.20 , pp. 2641-2650
    • Mehdi, U.F.1    Adams-Huet, B.2    Raskin, P.3
  • 35
    • 3042845741 scopus 로고    scopus 로고
    • Aldosterone in the development and progression of renal injury
    • Hollenberg NK. Aldosterone in the development and progression of renal injury. Kidney Int 2004; 66: 1-9
    • (2004) Kidney Int , vol.66 , pp. 1-9
    • Hollenberg, N.K.1
  • 36
    • 0035120424 scopus 로고    scopus 로고
    • A review of the medical treatment of primary aldosteronism
    • Lim PO, Young WF, MacDonald TM. A review of the medical treatment of primary aldosteronism. J Hypertens 2001; 19: 353-361
    • (2001) J Hypertens , vol.19 , pp. 353-361
    • Lim, P.O.1    Young, W.F.2    MacDonald, T.M.3
  • 37
    • 79954692757 scopus 로고    scopus 로고
    • A double-blind, randomized study comparing the antihypertensive effect of eplerenone and spironolactone in patients with hypertension and evidence of primary aldosteronism
    • Parthasarathy HK, Menard J, White WB et al. A double-blind, randomized study comparing the antihypertensive effect of eplerenone and spironolactone in patients with hypertension and evidence of primary aldosteronism. J Hypertens 2011; 29: 980-990
    • (2011) J Hypertens , vol.29 , pp. 980-990
    • Parthasarathy, H.K.1    Menard, J.2    White, W.B.3
  • 38
    • 34547559617 scopus 로고    scopus 로고
    • The spironolactone, amiloride, losartan, and thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio
    • Hood SJ, Taylor KP, Ashby MJ, Brown MJ. The spironolactone, amiloride, losartan, and thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio. Circulation 2007; 116: 268-275
    • (2007) Circulation , vol.116 , pp. 268-275
    • Hood, S.J.1    Taylor, K.P.2    Ashby, M.J.3    Brown, M.J.4
  • 39
    • 34047197931 scopus 로고    scopus 로고
    • Effect of spironolactone on blood pressure in subjects with resistant hypertension
    • Chapman N, Dobson J, Wilson S et al. Effect of spironolactone on blood pressure in subjects with resistant hypertension. Hypertension 2007; 49: 839-845
    • (2007) Hypertension , vol.49 , pp. 839-845
    • Chapman, N.1    Dobson, J.2    Wilson, S.3
  • 40
    • 57149110441 scopus 로고    scopus 로고
    • Effectiveness of the selective aldosterone blocker, eplerenone, in patients with resistant hypertension
    • Calhoun DA, White WB. Effectiveness of the selective aldosterone blocker, eplerenone, in patients with resistant hypertension. J Am Soc Hypertens 2008; 2: 462-468
    • (2008) J Am Soc Hypertens , vol.2 , pp. 462-468
    • Calhoun, D.A.1    White, W.B.2
  • 41
    • 79956349197 scopus 로고    scopus 로고
    • Addition of spironolactone in patients with resistant arterial hypertension (ASPIRANT): A randomized, double-blind, placebo-controlled trial
    • Vaclavik J, Sedlak R, Plachy M et al. Addition of spironolactone in patients with resistant arterial hypertension (ASPIRANT): a randomized, double-blind, placebo-controlled trial. Hypertension 2011; 57: 1069-1075
    • (2011) Hypertension , vol.57 , pp. 1069-1075
    • Vaclavik, J.1    Sedlak, R.2    Plachy, M.3
  • 42
    • 0142085752 scopus 로고    scopus 로고
    • Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: The 4E-left ventricular hypertrophy study
    • Pitt B, Reichek N, Willenbrock R et al. Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study. Circulation 2003; 108: 1831-1838
    • (2003) Circulation , vol.108 , pp. 1831-1838
    • Pitt, B.1    Reichek, N.2    Willenbrock, R.3
  • 43
    • 0023620145 scopus 로고
    • Efficacy and tolerance of spironolactone in essential hypertension
    • Jeunemaitre X, Chatellier G, Kreft-Jais C et al. Efficacy and tolerance of spironolactone in essential hypertension. Am J Cardiol 1987; 60: 820-825
    • (1987) Am J Cardiol , vol.60 , pp. 820-825
    • Jeunemaitre, X.1    Chatellier, G.2    Kreft-Jais, C.3
  • 44
    • 0035997359 scopus 로고    scopus 로고
    • Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension
    • Weinberger MH, Roniker B, Krause SL et al. Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension. Am J Hypertens 2002; 15: 709-716
    • (2002) Am J Hypertens , vol.15 , pp. 709-716
    • Weinberger, M.H.1    Roniker, B.2    Krause, S.L.3
  • 45
    • 33646828753 scopus 로고    scopus 로고
    • Investigation of aldosterone-synthase inhibition in rats
    • Menard J, Gonzalez MF, Guyene TT et al. Investigation of aldosterone-synthase inhibition in rats. J Hypertens 2006; 24: 1147-1155
    • (2006) J Hypertens , vol.24 , pp. 1147-1155
    • Menard, J.1    Gonzalez, M.F.2    Guyene, T.T.3
  • 47
    • 78149282496 scopus 로고    scopus 로고
    • Hormonal and electrolyte responses to the aldosterone synthase inhibitor lci699 in sodium depleted healthy subjects
    • E583
    • Menard J, Watson C, Rebello S et al. Hormonal and electrolyte responses to the aldosterone synthase inhibitor lci699 in sodium depleted healthy subjects. J Am Coll Cardiol 2010; 55: A61.E583
    • (2010) J Am Coll Cardiol , vol.55
    • Menard, J.1    Watson, C.2    Rebello, S.3
  • 48
    • 78149238346 scopus 로고    scopus 로고
    • Aldosterone synthase inhibition with LCI699: A proof-of-concept study in patients with primary aldosteronism
    • Amar L, Azizi M, Menard J et al. Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronism. Hypertension 2010; 56: 831-838
    • (2010) Hypertension , vol.56 , pp. 831-838
    • Amar, L.1    Azizi, M.2    Menard, J.3
  • 49
    • 80255141746 scopus 로고    scopus 로고
    • Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: Results of a randomized, double-blind, placebo-and active-controlled phase 2 trial
    • Calhoun DA, White WB, Krum H et al. Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: results of a randomized, double-blind, placebo-and active-controlled phase 2 trial. Circulation 2011; 124: 1945-1955
    • (2011) Circulation , vol.124 , pp. 1945-1955
    • Calhoun, D.A.1    White, W.B.2    Krum, H.3
  • 50
    • 0024467059 scopus 로고
    • The new aromatase inhibitor CGS-16949A suppresses aldosterone and cortisol production by human adrenal cells in vitro
    • Lamberts SW, Bruining HA, Marzouk H et al. The new aromatase inhibitor CGS-16949A suppresses aldosterone and cortisol production by human adrenal cells in vitro. J Clin Endocrinol Metab 1989; 69: 896-901
    • (1989) J Clin Endocrinol Metab , vol.69 , pp. 896-901
    • Lamberts, S.W.1    Bruining, H.A.2    Marzouk, H.3
  • 51
    • 0025361466 scopus 로고
    • The effects of CGS 16949A, an aromatase inhibitor on adrenal mineralocorticoid biosynthesis
    • Demers LM, Melby JC, Wilson TE et al. The effects of CGS 16949A, an aromatase inhibitor on adrenal mineralocorticoid biosynthesis. J Clin Endocrinol Metab 1990; 70: 1162-1166
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 1162-1166
    • Demers, L.M.1    Melby, J.C.2    Wilson, T.E.3
  • 52
    • 0026503989 scopus 로고
    • The effects of fadrozole hydrochloride on aldosterone secretion in healthy male subjects
    • Trunet PF, Mueller P, Girard F et al. The effects of fadrozole hydrochloride on aldosterone secretion in healthy male subjects. J Clin Endocrinol Metab 1992; 74: 571-576
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 571-576
    • Trunet, P.F.1    Mueller, P.2    Girard, F.3
  • 53
    • 33646824898 scopus 로고    scopus 로고
    • Can the dextroenantiomer of the aromatase inhibitor fadrozole be useful for clinical investigation of aldosteronesynthase inhibition?
    • Menard J, Pascoe L. Can the dextroenantiomer of the aromatase inhibitor fadrozole be useful for clinical investigation of aldosteronesynthase inhibition? J Hypertens 2006; 24: 993-997
    • (2006) J Hypertens , vol.24 , pp. 993-997
    • Menard, J.1    Pascoe, L.2
  • 54
    • 69249206536 scopus 로고    scopus 로고
    • Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors
    • LaSala D, Shibanaka Y, Jeng AY. Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors. Anal Biochem 2009; 394: 56-61
    • (2009) Anal Biochem , vol.394 , pp. 56-61
    • Lasala, D.1    Shibanaka, Y.2    Jeng, A.Y.3
  • 55
    • 20544453256 scopus 로고    scopus 로고
    • Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage
    • Fiebeler A, Nussberger J, Shagdarsuren E et al. Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage. Circulation 2005; 111: 3087-3094
    • (2005) Circulation , vol.111 , pp. 3087-3094
    • Fiebeler, A.1    Nussberger, J.2    Shagdarsuren, E.3
  • 56
    • 50849123772 scopus 로고    scopus 로고
    • Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: A comparison with spironolactone
    • Mulder P, Mellin V, Favre J et al. Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone. Eur Heart J 2008; 29: 2171-2179
    • (2008) Eur Heart J , vol.29 , pp. 2171-2179
    • Mulder, P.1    Mellin, V.2    Favre, J.3
  • 57
    • 64949189157 scopus 로고    scopus 로고
    • Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt
    • Lea WB, Kwak ES, Luther JM et al. Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt. Kidney Int 2009; 75: 936-944
    • (2009) Kidney Int , vol.75 , pp. 936-944
    • Lea, W.B.1    Kwak, E.S.2    Luther, J.M.3
  • 58
    • 78149264302 scopus 로고    scopus 로고
    • Adrenal cortex remodeling and functional zona glomerulosa hyperplasia in primary aldosteronism
    • Boulkroun S, Samson-Couterie B, Dzib JF et al. Adrenal cortex remodeling and functional zona glomerulosa hyperplasia in primary aldosteronism. Hypertension 2010; 56: 885-892
    • (2010) Hypertension , vol.56 , pp. 885-892
    • Boulkroun, S.1    Samson-Couterie, B.2    Dzib, J.F.3
  • 59
    • 78650514131 scopus 로고    scopus 로고
    • N-(Pyridin-3-yl) benzamides as selective inhibitors of human aldosterone synthase (CYP11B2)
    • Zimmer C, Hafner M, Zender M et al. N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2). Bioorg Med Chem Lett 2011; 21: 186-190
    • (2011) Bioorg Med Chem Lett , vol.21 , pp. 186-190
    • Zimmer, C.1    Hafner, M.2    Zender, M.3
  • 60
    • 77956909015 scopus 로고    scopus 로고
    • A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule
    • Fagart J, Hillisch A, Huyet J et al. A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule. J Biol Chem 2010; 285: 29932-29940
    • (2010) J Biol Chem , vol.285 , pp. 29932-29940
    • Fagart, J.1    Hillisch, A.2    Huyet, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.