메뉴 건너뛰기




Volumn 75, Issue 2, 2013, Pages 334-346

Pharmacogenomics of warfarin in populations of African descent

Author keywords

African ancestry; CYP2C9; Global pharmacogenomics; Population diversity; VKORC1; Warfarin algorithms

Indexed keywords

APOLIPOPROTEIN E; BLOOD CLOTTING FACTOR 7; CALUMENIN; CHAPERONE; CYTOCHROME P450 2C9; CYTOCHROME P450 F2; UNCLASSIFIED DRUG; VITAMIN K DEPENDENT CARBOXYLASE; VITAMIN K EPOXIDE REDUCTASE COMPLEX 1; WARFARIN;

EID: 84872236997     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2012.04354.x     Document Type: Article
Times cited : (37)

References (64)
  • 2
    • 0037461782 scopus 로고    scopus 로고
    • The mosaic that is our genome
    • Pääbo S. The mosaic that is our genome. Nature 2003; 421: 409-412.
    • (2003) Nature , vol.421 , pp. 409-412
    • Pääbo, S.1
  • 4
    • 79961161857 scopus 로고    scopus 로고
    • Pharmacogenetics in the Brazilian population
    • Suarez-Kurtz G. Pharmacogenetics in the Brazilian population. Front Pharmacogenet 2010; 1: 1-10.
    • (2010) Front Pharmacogenet , vol.1 , pp. 1-10
    • Suarez-Kurtz, G.1
  • 5
    • 36448936819 scopus 로고    scopus 로고
    • Admixture in North America
    • In:, ed. Suarez-Kurtz G. Austin. TX: Landes Bioscience
    • Parra EJ, Suarez-Kurtz G. Admixture in North America. In: Pharmacogenomics in Admixed Populations, ed. Suarez-Kurtz G. Austin. TX: Landes Bioscience, 2007; 28-46.
    • (2007) Pharmacogenomics in Admixed Populations , pp. 28-46
    • Parra, E.J.1    Suarez-Kurtz, G.2
  • 7
    • 16344384807 scopus 로고    scopus 로고
    • Implications of correlations between skin color and genetic ancestry for biomedical research
    • Parra EJ, Kittles RA, Shriver MD. Implications of correlations between skin color and genetic ancestry for biomedical research. Nat Genet 2004; 36: S54-60.
    • (2004) Nat Genet , vol.36
    • Parra, E.J.1    Kittles, R.A.2    Shriver, M.D.3
  • 20
    • 27444433157 scopus 로고    scopus 로고
    • CYP2C9, CYP2C19, ABCB1 (MDR1) genetic polymorphisms and phenytoin metabolism in a Black Beninese population
    • Allabi AC, Gala JL, Horsmans Y. CYP2C9, CYP2C19, ABCB1 (MDR1) genetic polymorphisms and phenytoin metabolism in a Black Beninese population. Pharmacogenet Genomics 2005; 15: 779-786.
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 779-786
    • Allabi, A.C.1    Gala, J.L.2    Horsmans, Y.3
  • 22
    • 79960777339 scopus 로고    scopus 로고
    • Novel CYP2C9 and VKORC1 gene variants associated with warfarin dosage variability in the South African black population
    • Mitchell C, Gregersen N, Krause A. Novel CYP2C9 and VKORC1 gene variants associated with warfarin dosage variability in the South African black population. Pharmacogenomics 2011; 12: 953-963.
    • (2011) Pharmacogenomics , vol.12 , pp. 953-963
    • Mitchell, C.1    Gregersen, N.2    Krause, A.3
  • 25
    • 84872239315 scopus 로고    scopus 로고
    • CYP2C9 allele nomenclature
    • The Human Cytochrome P450 (CYP) Allele Nomenclature Database. Available at (last accessed 18 May 2012).
    • The Human Cytochrome P450 (CYP) Allele Nomenclature Database. CYP2C9 allele nomenclature. Available at http://www.cypalleles.ki.se/cyp2c9.htm (last accessed 18 May 2012).
  • 29
    • 44949234553 scopus 로고    scopus 로고
    • Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans
    • Limdi NA, Arnett DK, Goldstein JA, Beasley TM, McGwin G, Adler BK, Acton RT. Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans. Pharmacogenomics 2008; 9: 511-526.
    • (2008) Pharmacogenomics , vol.9 , pp. 511-526
    • Limdi, N.A.1    Arnett, D.K.2    Goldstein, J.A.3    Beasley, T.M.4    McGwin, G.5    Adler, B.K.6    Acton, R.T.7
  • 31
    • 51649084617 scopus 로고    scopus 로고
    • Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement
    • Wang D, Chen H, Momary KM, Cavallari LH, Johnson JA, Sadée W. Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement. Blood 2008; 112: 1013-1021.
    • (2008) Blood , vol.112 , pp. 1013-1021
    • Wang, D.1    Chen, H.2    Momary, K.M.3    Cavallari, L.H.4    Johnson, J.A.5    Sadée, W.6
  • 34
    • 12344331747 scopus 로고    scopus 로고
    • Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1
    • Harrington DJ, Underwood S, Morse C, Shearer MJ, Tuddenham EG, Mumford AD. Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1. Thromb Haemost 2005; 93: 23-26.
    • (2005) Thromb Haemost , vol.93 , pp. 23-26
    • Harrington, D.J.1    Underwood, S.2    Morse, C.3    Shearer, M.J.4    Tuddenham, E.G.5    Mumford, A.D.6
  • 36
    • 43549104967 scopus 로고    scopus 로고
    • VKORC1 Asp36Tyr warfarin resistance marker is common in Ethiopian individuals
    • Aklillu E, Leong C, Loebstein R, Halkin H, Gak E. VKORC1 Asp36Tyr warfarin resistance marker is common in Ethiopian individuals. Blood 2008; 111: 3903-3904.
    • (2008) Blood , vol.111 , pp. 3903-3904
    • Aklillu, E.1    Leong, C.2    Loebstein, R.3    Halkin, H.4    Gak, E.5
  • 37
    • 78650792903 scopus 로고    scopus 로고
    • VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey
    • Crawford DC, Brown-Gentry K, Rieder MJ. VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey. PLoS ONE 2010; 5: e15088.
    • (2010) PLoS ONE , vol.5
    • Crawford, D.C.1    Brown-Gentry, K.2    Rieder, M.J.3
  • 39
  • 45
    • 2942627237 scopus 로고    scopus 로고
    • The inhibitory effect of calumenin on the vitamin K-dependent gamma-carboxylation system - characterization of the system in normal and warfarin-resistant rats
    • Wajih N, Sane DC, Hutson SM, Wallin R. The inhibitory effect of calumenin on the vitamin K-dependent gamma-carboxylation system - characterization of the system in normal and warfarin-resistant rats. J Biol Chem 2004; 279: 25276-25283.
    • (2004) J Biol Chem , vol.279 , pp. 25276-25283
    • Wajih, N.1    Sane, D.C.2    Hutson, S.M.3    Wallin, R.4
  • 47
    • 84855252084 scopus 로고    scopus 로고
    • Database of single nucleotide polymorphisms
    • National Center for Biotechnology Information - dbSNP. Available at (last accessed 18 May 2012).
    • National Center for Biotechnology Information - dbSNP. Database of single nucleotide polymorphisms. Available at http://www.ncbi.nlm.nih.gov/projects/SNP/snprefcgi?rs=2108622 (last accessed 18 May 2012).
  • 50
    • 70349595550 scopus 로고    scopus 로고
    • Exploring warfarin pharmacogenomics with the extreme-discordant-phenotype methodology: impact of FVII polymorphisms on stable anticoagulation with warfarin
    • Fuchshuber-Moraes M, Perini JA, Rosskopf D, Suarez-Kurtz G. Exploring warfarin pharmacogenomics with the extreme-discordant-phenotype methodology: impact of FVII polymorphisms on stable anticoagulation with warfarin. Eur J Clin Pharmacol 2009; 65: 789-793.
    • (2009) Eur J Clin Pharmacol , vol.65 , pp. 789-793
    • Fuchshuber-Moraes, M.1    Perini, J.A.2    Rosskopf, D.3    Suarez-Kurtz, G.4
  • 51
    • 0034723040 scopus 로고    scopus 로고
    • Extreme discordant phenotype methodology: an intuitive approach to clinical pharmacogenetics
    • Nebert DW. Extreme discordant phenotype methodology: an intuitive approach to clinical pharmacogenetics. Eur J Pharmacol 2000; 410: 107-120.
    • (2000) Eur J Pharmacol , vol.410 , pp. 107-120
    • Nebert, D.W.1
  • 52
    • 79961135011 scopus 로고    scopus 로고
    • Population diversity and the performance of warfarin dosing algorithms
    • Suarez-Kurtz G. Population diversity and the performance of warfarin dosing algorithms. Br J Clin Pharmacol 2011; 72: 451-453.
    • (2011) Br J Clin Pharmacol , vol.72 , pp. 451-453
    • Suarez-Kurtz, G.1
  • 53
    • 79955766600 scopus 로고    scopus 로고
    • High-dimensional pharmacogenetic prediction of a continuous trait using machine learning techniques with application to warfarin dose prediction in African Americans
    • Cosgun E, Limdi NA, Duarte CW. High-dimensional pharmacogenetic prediction of a continuous trait using machine learning techniques with application to warfarin dose prediction in African Americans. Bioinformatics 2011; 27: 1384-1389.
    • (2011) Bioinformatics , vol.27 , pp. 1384-1389
    • Cosgun, E.1    Limdi, N.A.2    Duarte, C.W.3
  • 56
    • 42449136621 scopus 로고    scopus 로고
    • Dosing algorithm for warfarin using CYP2C9 and VKORC1 genotyping from a multi-ethnic population: comparison with other equations
    • Wu AH, Wang P, Smith A, Haller C, Drake K, Linder M, Valdes R. Dosing algorithm for warfarin using CYP2C9 and VKORC1 genotyping from a multi-ethnic population: comparison with other equations. Pharmacogenomics 2008; 9: 169-178.
    • (2008) Pharmacogenomics , vol.9 , pp. 169-178
    • Wu, A.H.1    Wang, P.2    Smith, A.3    Haller, C.4    Drake, K.5    Linder, M.6    Valdes, R.7
  • 58
    • 79959411039 scopus 로고    scopus 로고
    • Combined CYP2C9, VKORC1 and CYP4F2 frequencies among Amerindians, Mozambicans and Brazilians
    • Vargens DD, Damasceno A, Petzl-Erler ML, Suarez-Kurtz G. Combined CYP2C9, VKORC1 and CYP4F2 frequencies among Amerindians, Mozambicans and Brazilians. Pharmacogenomics 2011; 12: 769-772.
    • (2011) Pharmacogenomics , vol.12 , pp. 769-772
    • Vargens, D.D.1    Damasceno, A.2    Petzl-Erler, M.L.3    Suarez-Kurtz, G.4
  • 59
    • 84872237910 scopus 로고    scopus 로고
    • The Brazilian Pharmacogenomic Network
    • Rede Nacional de Farmacogenética. Available at (last accessed 18 May 2012).
    • Rede Nacional de Farmacogenética. The Brazilian Pharmacogenomic Network. Available at http://www.refargen.org.br (last accessed 18 May 2012).
  • 60
    • 82255193118 scopus 로고    scopus 로고
    • Genetic variants in CYP (-1A2, -2C9, -2C19, -3A4 and -3A5), VKORC1 and ABCB1 genes in a black South African population: a window into diversity
    • Dandara C, Lombard Z, Du Plooy I, McLellan T, Norris SA, Ramsay M. Genetic variants in CYP (-1A2, -2C9, -2C19, -3A4 and -3A5), VKORC1 and ABCB1 genes in a black South African population: a window into diversity. Pharmacogenomics 2011; 12: 1663-1670.
    • (2011) Pharmacogenomics , vol.12 , pp. 1663-1670
    • Dandara, C.1    Lombard, Z.2    Du Plooy, I.3    McLellan, T.4    Norris, S.A.5    Ramsay, M.6
  • 61
    • 84872227603 scopus 로고    scopus 로고
    • The International Project. Available at (last accessed 18 May 2012).
    • The International Project. Available at http://hapmap.ncb.inlm.nih.gov/ (last accessed 18 May 2012).
  • 62
    • 84863716564 scopus 로고    scopus 로고
    • Acenocoumarol sensitivity and pharmacokinetic characterization of CYP2C9 *5/*8,*8/*11,*9/*11 and VKORC1*2 in black African healthy Beninese subjects
    • Allabi AC, Horsmans Y, Alvarez JC, Bigot A, Verbeeck RK, Yasar U, Gala JL. Acenocoumarol sensitivity and pharmacokinetic characterization of CYP2C9 *5/*8, *8/*11, *9/*11 and VKORC1*2 in black African healthy Beninese subjects. Eur J Drug Metab Pharmacokinet 2012; 37: 125-132.
    • (2012) Eur J Drug Metab Pharmacokinet , vol.37 , pp. 125-132
    • Allabi, A.C.1    Horsmans, Y.2    Alvarez, J.C.3    Bigot, A.4    Verbeeck, R.K.5    Yasar, U.6    Gala, J.L.7
  • 64
    • 65449178456 scopus 로고    scopus 로고
    • Relative contribution of VKORC1, CYP2C9, and INR response to warfarin stable dose
    • Suarez-Kurtz G, Perini JA, Silva-Assunção E, Struchiner CJ. Relative contribution of VKORC1, CYP2C9, and INR response to warfarin stable dose. Blood 2009; 113: 4125-4126.
    • (2009) Blood , vol.113 , pp. 4125-4126
    • Suarez-Kurtz, G.1    Perini, J.A.2    Silva-Assunção, E.3    Struchiner, C.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.