Residual beta cell function at diagnosis of type 1 diabetes in children and adolescents varies with gender and season

Diabetes/Metabolism Research and Reviews

Volumn 29, Issue 1, 2013, Pages 85-89

  Samuelsson, U ^a   Lindblad, B ^b   Carlsson, A ^c   Forsander, G ^b   Ivarsson, S ^c   Kockum, I ^d   Lernmark, A ^e   Marcus, C ^f   Ludvigsson, J ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b QUEEN SILVIA CHILDREN'S HOSPITAL   (Sweden)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d KAROLINSKA INSTITUTE   (Sweden)

^e LUND UNIVERSITY   (Sweden)

^f KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

C peptide; Children; Gender; Immune intervention; Seasonal variation; Type 1 diabetes

Indexed keywords

C PEPTIDE; GLUCOSE; HEMOGLOBIN A1C; INSULIN;

ADOLESCENT; ADULT; AGE; ARTICLE; AUTOIMMUNE DISEASE; BODY MASS; CELL FUNCTION; CHILD; DIABETIC PATIENT; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MAJOR CLINICAL STUDY; MALE; PANCREAS ISLET BETA CELL; PH; POLYDIPSIA; POLYURIA; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PUBERTY; SCHOOL CHILD; SEASONAL VARIATION; SEX DIFFERENCE; WEIGHT REDUCTION;

ADOLESCENT; BLOOD GLUCOSE; C-PEPTIDE; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INFANT; INSULIN-SECRETING CELLS; MALE; PROSPECTIVE STUDIES; SEASONS; SEX CHARACTERISTICS;

EID: 84872236732     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.2365     Document Type: Article

References (21)

1. Ludvigsson J, Faresjö M, Hjorth M, et al. GAD treatment and insulin secretion in recent-onset type 1 diabetes. N Engl J Med 2008; 359: 1909-1920.
2. Ludvigsson J, Krisky D, Casas R, et al. GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus. N Engl J Med 2012; 366(5): 433-442.
3. Moltchanova EV, Schreier N, Lammi N, Karvonen M. Seasonal variation of diagnosis of type 1 diabetes mellitus in children worldwide. Diabet Med 2009; 26(7): 673-8.4.
4. Gamble DR. The epidemiology of insulin dependent diabetes with particular reference to the relationship of virus infection to its etiology. Epidemiol Rev 1980; 2: 49-70.
5. Hanberger L, Samuelsson U, Lindblad B, Ludvigsson J. Swedish Childhood Diabetes Registry SWEDIABKIDS A1C in children and adolescents with diabetes in relation to certain clinical parameters: the Swedish Childhood Diabetes Registry SWEDIABKIDS. Diabetes Care 2008; 31(5): 927-929.
6. Bradley CB, McMurray RG, Harrell JS, Deng S. Changes in common activities of 3rd through 10th graders: the CHIC study. Med Sci Sports Exerc 2000; 32(12): 2071-2078.
7. Roemmich JN, Clark PA, Walter K, Patrie J, Weltman A, Rogol AD. Pubertal alterations in growth and body composition. V. Energy expenditure, adiposity, and fat distribution. Am J Physiol Endocrinol Metab 2000; 279(6): E1426-E1436.
8. Quiles-Marcos Y, Balaguer-Solá I, Pamies-Aubalat L, Quiles-Sebastián MJ, Marzo-Campos JC, Rodríguez-Marín J. Eating habits, physical activity, consumption of substances and eating disorders in adolescents. Span J Psychol 2011; 14(2): 712-723.
9. Pundziute-Lyckå A, Dahlquist G, Nyström L, et al. The incidence of type I diabetes has not increased but shifted to a younger age at diagnosis in the 0-34 years group in Sweden 1983-1998. Diabetologia 2002; 45: 783-791.
10. The expert Committee on the diagnosis and classification of diabetes mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 2003; 26(suppl 1): S5-S20.
11. The Swedish pediatric diabetes quality register, (SWEDIABKIDS) (2010). https://www.ndr.nu/ndr2/
12. Ludvigsson J, Carlsson A, Forsander G, et al. C-peptide in the classification of diabetes in children and adolescents. Pediatr Diabetes 2011 Sep 13. DOI: 10.1111/j.1399-5448.2011.00807.
13. Ludvigsson J, Heding LG. C-peptide in children with juvenile diabetes. A preliminary report. Diabetologia 1976; 12: 627-630.
14. Christau B, Åkerblom H, Joner G, Dahlquist G, Ludvigsson J, Nerup J. Incidence of childhood diabetes mellitus in Denmark, Finland, Norway and Sweden. Acta Endocrinol Suppl 1981; 245(Suppl): 68-77.
15. Ludvigsson J, Afoke A. Seasonality of type I (insulin-dependent) diabetes mellitus: values of C-peptide, insulin antibodies and haemoglobin A1c show evidence of a more rapid loss of insulin secretion in epidemic patients. Diabetologia 1989; 32: 8491.
16. Afoke A, Ludvigsson J, Hed J, Lindblom B. Raised IgG and IgM in 'epidemic' IDDM suggest that infections are responsible for the seasonality of type I diabetes. Diab Res 1991; 16: 11-17.
17. Afoke A, Eeg-Olofsson O, Hed J, Kjellman N-IM, Lindblom B, Ludvigsson J. Seasonal variations and sex differences of circulating macrophages, immunoglobulins and lymphocytes in healthy school children. Scand J Immunol 1993; 37: 209-215.
18. Lindholm E, Hallengren B, Agardh CD. Gender differences in GAD antibody-positive diabetes mellitus in relation to age at onset, C-peptide and other endocrine autoimmune diseases. Diabetes Metab Res Rev 2004; 20: 158-164.
19. Okuyama K, Hamanaka Y, Kawano T, et al. T cell subsets related with a sex difference in IL-5 production. Int Arch Allergy Immunol 2011; 155(Suppl) 1: 21-26
20. Dinesh RK, Hahn BH, Singh RP. PD-1, gender, and autoimmunity. Autoimmun Rev 2010; 9(8): 583-587. Epub 2010 Apr 28
21. Cohen-Solal JF, Jeganathan V, Hill L, et al. Hormonal regulation of B-cell function and systemic lupus erythematosus. Lupus 2008; 17(6): 528-532.