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Volumn 28, Issue , 2013, Pages 25-43

Daily exercise improves memory, stimulates hippocampal neurogenesis and modulates immune and neuroimmune cytokines in aging rats

Author keywords

Adult neurogenesis; Bio Plex; Biomarker; Chemokine; Cytokine; Fisher 344; Hippocampus; Learning; Memory; Running; Water maze

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 18; INTERLEUKIN 19; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 9; LEPTIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

EID: 84872200865     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2012.09.013     Document Type: Review
Times cited : (145)

References (147)
  • 1
    • 73349120950 scopus 로고    scopus 로고
    • Age-dependent alteration in hippocampal neurogenesis correlates with learning performance of macaque monkeys
    • Aizawa K., Ageyama N., Yokoyama C., Hisatsune T. Age-dependent alteration in hippocampal neurogenesis correlates with learning performance of macaque monkeys. Exp. Anim. 2009, 58:403-407.
    • (2009) Exp. Anim. , vol.58 , pp. 403-407
    • Aizawa, K.1    Ageyama, N.2    Yokoyama, C.3    Hisatsune, T.4
  • 2
    • 32044464079 scopus 로고    scopus 로고
    • Mild forced treadmill exercise enhances spatial learning in the aged rat
    • Albeck D.S., Sano K., Prewitt G.E., Dalton L. Mild forced treadmill exercise enhances spatial learning in the aged rat. Behav. Brain Res. 2006, 168:345-348.
    • (2006) Behav. Brain Res. , vol.168 , pp. 345-348
    • Albeck, D.S.1    Sano, K.2    Prewitt, G.E.3    Dalton, L.4
  • 3
    • 12144262454 scopus 로고    scopus 로고
    • Production and in vivo effects of chemokines CXCL1-3/KC and CCL2/JE in a model of inflammatory angiogenesis in mice
    • Barcelos L.S., Talvani A., Teixeira A.S., Cassali G.D., Andrade S.P., Teixeira M.M. Production and in vivo effects of chemokines CXCL1-3/KC and CCL2/JE in a model of inflammatory angiogenesis in mice. Inflamm. Res. 2004, 53:576-584.
    • (2004) Inflamm. Res. , vol.53 , pp. 576-584
    • Barcelos, L.S.1    Talvani, A.2    Teixeira, A.S.3    Cassali, G.D.4    Andrade, S.P.5    Teixeira, M.M.6
  • 4
    • 0023020183 scopus 로고
    • The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations
    • Baron R.M., Kenny D.A. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J. Pers. Soc. Psychol. 1986, 51:1173-1182.
    • (1986) J. Pers. Soc. Psychol. , vol.51 , pp. 1173-1182
    • Baron, R.M.1    Kenny, D.A.2
  • 5
    • 56949099327 scopus 로고    scopus 로고
    • Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection
    • Barrientos R.M., Frank M.G., Hein A.M., Higgins E.A., Watkins L.R., Rudy J.W., Maier S.F. Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection. Brain Behav. Immun. 2009, 23:46-54.
    • (2009) Brain Behav. Immun. , vol.23 , pp. 46-54
    • Barrientos, R.M.1    Frank, M.G.2    Hein, A.M.3    Higgins, E.A.4    Watkins, L.R.5    Rudy, J.W.6    Maier, S.F.7
  • 7
    • 0142247472 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist
    • Barrientos R.M., Sprunger D.B., Campeau S., Higgins E.A., Watkins L.R., Rudy J.W., Maier S.F. Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist. Neuroscience 2003, 121:847-853.
    • (2003) Neuroscience , vol.121 , pp. 847-853
    • Barrientos, R.M.1    Sprunger, D.B.2    Campeau, S.3    Higgins, E.A.4    Watkins, L.R.5    Rudy, J.W.6    Maier, S.F.7
  • 8
    • 81355149680 scopus 로고    scopus 로고
    • Chronic neuroinflammation impacts the recruitment of adult-born neurons into behaviorally relevant hippocampal networks
    • Belarbi K., Arellano C., Ferguson R., Jopson T., Rosi S. Chronic neuroinflammation impacts the recruitment of adult-born neurons into behaviorally relevant hippocampal networks. Brain Behav. Immun. 2012, 26:18-23.
    • (2012) Brain Behav. Immun. , vol.26 , pp. 18-23
    • Belarbi, K.1    Arellano, C.2    Ferguson, R.3    Jopson, T.4    Rosi, S.5
  • 9
  • 10
    • 13844257516 scopus 로고    scopus 로고
    • Neurogenesis in a rat model of age-related cognitive decline
    • Bizon J.L., Lee H.J., Gallagher M. Neurogenesis in a rat model of age-related cognitive decline. Aging Cell 2004, 3:227-234.
    • (2004) Aging Cell , vol.3 , pp. 227-234
    • Bizon, J.L.1    Lee, H.J.2    Gallagher, M.3
  • 11
    • 0038206578 scopus 로고    scopus 로고
    • Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment
    • Blalock E.M., Chen K.C., Sharrow K., Herman J.P., Porter N.M., Foster T.C., Landfield P.W. Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment. J. Neurosci. 2003, 23:3807-3819.
    • (2003) J. Neurosci. , vol.23 , pp. 3807-3819
    • Blalock, E.M.1    Chen, K.C.2    Sharrow, K.3    Herman, J.P.4    Porter, N.M.5    Foster, T.C.6    Landfield, P.W.7
  • 12
    • 1242271233 scopus 로고    scopus 로고
    • Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice
    • Bondolfi L., Ermini F., Long J.M., Ingram D.K., Jucker M. Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice. Neurobiol. Aging 2004, 25:33-40.
    • (2004) Neurobiol. Aging , vol.25 , pp. 33-40
    • Bondolfi, L.1    Ermini, F.2    Long, J.M.3    Ingram, D.K.4    Jucker, M.5
  • 13
    • 79955026350 scopus 로고    scopus 로고
    • Design-based stereology: introduction to basic concepts and practical approaches for estimation of cell number
    • Boyce R.W., Dorph-Petersen K.A., Lyck L., Gundersen H.J. Design-based stereology: introduction to basic concepts and practical approaches for estimation of cell number. Toxicol. Pathol. 2010, 38:1011-1025.
    • (2010) Toxicol. Pathol. , vol.38 , pp. 1011-1025
    • Boyce, R.W.1    Dorph-Petersen, K.A.2    Lyck, L.3    Gundersen, H.J.4
  • 15
  • 16
    • 0033306418 scopus 로고    scopus 로고
    • Restoring production of hippocampal neurons in old age
    • Cameron H.A., McKay R.D. Restoring production of hippocampal neurons in old age. Nat. Neurosci. 1999, 2:894-897.
    • (1999) Nat. Neurosci. , vol.2 , pp. 894-897
    • Cameron, H.A.1    McKay, R.D.2
  • 17
    • 0035833068 scopus 로고    scopus 로고
    • Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus
    • Cameron H.A., McKay R.D. Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J. Comp. Neurol. 2001, 435:406-417.
    • (2001) J. Comp. Neurol. , vol.435 , pp. 406-417
    • Cameron, H.A.1    McKay, R.D.2
  • 18
    • 67650652033 scopus 로고    scopus 로고
    • Influence of calorie restriction on measures of age-related cognitive decline: role of increased physical activity
    • Carter C.S., Leeuwenburgh C., Daniels M., Foster T.C. Influence of calorie restriction on measures of age-related cognitive decline: role of increased physical activity. J. Gerontol. A Biol. Sci. Med. Sci. 2009, 64:850-859.
    • (2009) J. Gerontol. A Biol. Sci. Med. Sci. , vol.64 , pp. 850-859
    • Carter, C.S.1    Leeuwenburgh, C.2    Daniels, M.3    Foster, T.C.4
  • 19
    • 38649119160 scopus 로고    scopus 로고
    • Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system
    • Chen J., Buchanan J.B., Sparkman N.L., Godbout J.P., Freund G.G., Johnson R.W. Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system. Brain Behav. Immun. 2008, 22:301-311.
    • (2008) Brain Behav. Immun. , vol.22 , pp. 301-311
    • Chen, J.1    Buchanan, J.B.2    Sparkman, N.L.3    Godbout, J.P.4    Freund, G.G.5    Johnson, R.W.6
  • 20
    • 55749105157 scopus 로고    scopus 로고
    • Effects of physical training on IL-1beta, IL-6 and IL-1ra concentrations in various brain areas of the rat
    • Chennaoui M., Drogou C., Gomez-Merino D. Effects of physical training on IL-1beta, IL-6 and IL-1ra concentrations in various brain areas of the rat. Eur. Cytokine Netw. 2008, 19:8-14.
    • (2008) Eur. Cytokine Netw. , vol.19 , pp. 8-14
    • Chennaoui, M.1    Drogou, C.2    Gomez-Merino, D.3
  • 21
    • 0027153277 scopus 로고
    • The association between mental, social and physical activity and cognitive performance in young and old subjects
    • Christensen H., Mackinnon A. The association between mental, social and physical activity and cognitive performance in young and old subjects. Age Ageing 1993, 22:175-182.
    • (1993) Age Ageing , vol.22 , pp. 175-182
    • Christensen, H.1    Mackinnon, A.2
  • 24
    • 0038050784 scopus 로고    scopus 로고
    • Fitness effects on the cognitive function of older adults: a meta-analytic study
    • Colcombe S., Kramer A.F. Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol. Sci. 2003, 14:125-130.
    • (2003) Psychol. Sci. , vol.14 , pp. 125-130
    • Colcombe, S.1    Kramer, A.F.2
  • 27
    • 1342309530 scopus 로고    scopus 로고
    • Cognitive functions in survivors of primary central nervous system lymphoma
    • Correa D.D., DeAngelis L.M., Shi W., Thaler H., Glass A., Abrey L.E. Cognitive functions in survivors of primary central nervous system lymphoma. Neurology 2004, 62:548-555.
    • (2004) Neurology , vol.62 , pp. 548-555
    • Correa, D.D.1    DeAngelis, L.M.2    Shi, W.3    Thaler, H.4    Glass, A.5    Abrey, L.E.6
  • 29
    • 0028356814 scopus 로고
    • Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy
    • Crossen J.R., Garwood D., Glatstein E., Neuwelt E.A. Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy. J. Clin. Oncol. 1994, 12:627-642.
    • (1994) J. Clin. Oncol. , vol.12 , pp. 627-642
    • Crossen, J.R.1    Garwood, D.2    Glatstein, E.3    Neuwelt, E.A.4
  • 30
    • 65249086293 scopus 로고    scopus 로고
    • Comparison of lifelong and late life exercise on oxidative stress in the cerebellum
    • Cui L., Hofer T., Rani A., Leeuwenburgh C., Foster T.C. Comparison of lifelong and late life exercise on oxidative stress in the cerebellum. Neurobiol. Aging 2009, 30:903-909.
    • (2009) Neurobiol. Aging , vol.30 , pp. 903-909
    • Cui, L.1    Hofer, T.2    Rani, A.3    Leeuwenburgh, C.4    Foster, T.C.5
  • 31
  • 32
    • 77951498581 scopus 로고    scopus 로고
    • New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
    • Deng W., Aimone J.B., Gage F.H. New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?. Nat. Rev. Neurosci. 2010, 11:339-350.
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 339-350
    • Deng, W.1    Aimone, J.B.2    Gage, F.H.3
  • 34
    • 55049116337 scopus 로고    scopus 로고
    • Alpha-chemokines regulate proliferation, neurogenesis, and dopaminergic differentiation of ventral midbrain precursors and neurospheres
    • Edman L.C., Mira H., Erices A., Malmersjö S., Andersson E., Uhlén P., Arenas E. Alpha-chemokines regulate proliferation, neurogenesis, and dopaminergic differentiation of ventral midbrain precursors and neurospheres. Stem Cells 2008, 26:1891-1900.
    • (2008) Stem Cells , vol.26 , pp. 1891-1900
    • Edman, L.C.1    Mira, H.2    Erices, A.3    Malmersjö, S.4    Andersson, E.5    Uhlén, P.6    Arenas, E.7
  • 36
    • 77953998455 scopus 로고    scopus 로고
    • Task difficulty in the Morris water task influences the survival of new neurons in the dentate gyrus
    • Epp J.R., Haack A.K., Galea L.A. Task difficulty in the Morris water task influences the survival of new neurons in the dentate gyrus. Hippocampus 2010, 20:866-867.
    • (2010) Hippocampus , vol.20 , pp. 866-867
    • Epp, J.R.1    Haack, A.K.2    Galea, L.A.3
  • 37
    • 78650719644 scopus 로고    scopus 로고
    • Strain differences in neurogenesis and activation of new neurons in the dentate gyrus in response to spatial learning
    • Epp J.R., Scott N.A., Galea L.A. Strain differences in neurogenesis and activation of new neurons in the dentate gyrus in response to spatial learning. Neuroscience 2011, 172:342-354.
    • (2011) Neuroscience , vol.172 , pp. 342-354
    • Epp, J.R.1    Scott, N.A.2    Galea, L.A.3
  • 39
    • 80053900477 scopus 로고    scopus 로고
    • Cytokine and chemokine responses in serum and brain after single and repeated injections of lipopolysaccharide: multiplex quantification with path analysis
    • Erickson M.A., Banks W.A. Cytokine and chemokine responses in serum and brain after single and repeated injections of lipopolysaccharide: multiplex quantification with path analysis. Brain Behav. Immun. 2011, 25:1637-1648.
    • (2011) Brain Behav. Immun. , vol.25 , pp. 1637-1648
    • Erickson, M.A.1    Banks, W.A.2
  • 41
    • 0442307920 scopus 로고    scopus 로고
    • Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo
    • Farmer J., Zhao X., van Praag H., Wodtke K., Gage F.H., Christie B.R. Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo. Neuroscience 2004, 124:71-79.
    • (2004) Neuroscience , vol.124 , pp. 71-79
    • Farmer, J.1    Zhao, X.2    van Praag, H.3    Wodtke, K.4    Gage, F.H.5    Christie, B.R.6
  • 43
    • 33947596408 scopus 로고    scopus 로고
    • Susceptibility to induction of long-term depression is associated with impaired memory in aged Fischer 344 rats
    • Foster T.C., Kumar A. Susceptibility to induction of long-term depression is associated with impaired memory in aged Fischer 344 rats. Neurobiol. Learn. Mem. 2007, 87:522-535.
    • (2007) Neurobiol. Learn. Mem. , vol.87 , pp. 522-535
    • Foster, T.C.1    Kumar, A.2
  • 44
    • 0142043947 scopus 로고    scopus 로고
    • Interaction of age and chronic estradiol replacement on memory and markers of brain aging
    • Foster T.C., Sharrow K.M., Kumar A., Masse J. Interaction of age and chronic estradiol replacement on memory and markers of brain aging. Neurobiol. Aging 2003, 24:839-852.
    • (2003) Neurobiol. Aging , vol.24 , pp. 839-852
    • Foster, T.C.1    Sharrow, K.M.2    Kumar, A.3    Masse, J.4
  • 46
    • 49649118850 scopus 로고    scopus 로고
    • Leptin increases adult hippocampal neurogenesis in vivo and in vitro
    • Garza J.C., Guo M., Zhang W., Lu X.Y. Leptin increases adult hippocampal neurogenesis in vivo and in vitro. J. Biol. Chem. 2008, 283:18238-18247.
    • (2008) J. Biol. Chem. , vol.283 , pp. 18238-18247
    • Garza, J.C.1    Guo, M.2    Zhang, W.3    Lu, X.Y.4
  • 47
    • 0035829382 scopus 로고    scopus 로고
    • Behavioral tests of hippocampal function: simple paradigms complex problems
    • Gerlai R. Behavioral tests of hippocampal function: simple paradigms complex problems. Behav. Brain Res. 2001, 125:269-277.
    • (2001) Behav. Brain Res. , vol.125 , pp. 269-277
    • Gerlai, R.1
  • 48
    • 56549083170 scopus 로고    scopus 로고
    • Inflammatory markers and cognitive function in middle-aged adults: the Whitehall II study
    • Gimeno D., Marmot M.G., Singh-Manoux A. Inflammatory markers and cognitive function in middle-aged adults: the Whitehall II study. Psychoneuroendocrinology 2008, 33:1322-1334.
    • (2008) Psychoneuroendocrinology , vol.33 , pp. 1322-1334
    • Gimeno, D.1    Marmot, M.G.2    Singh-Manoux, A.3
  • 49
    • 23444443814 scopus 로고    scopus 로고
    • Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system
    • Godbout J.P., Chen J., Abraham J., Richwine A.F., Berg B.M., Kelley K.W., Johnson R.W. Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J. 2005, 19:1329-1331.
    • (2005) FASEB J. , vol.19 , pp. 1329-1331
    • Godbout, J.P.1    Chen, J.2    Abraham, J.3    Richwine, A.F.4    Berg, B.M.5    Kelley, K.W.6    Johnson, R.W.7
  • 50
    • 0033363319 scopus 로고    scopus 로고
    • Learning enhances adult neurogenesis in the hippocampal formation
    • Gould E., Beylin A., Tanapat P., Reeves A., Shors T.J. Learning enhances adult neurogenesis in the hippocampal formation. Nat. Neurosci. 1999, 2:260-265.
    • (1999) Nat. Neurosci. , vol.2 , pp. 260-265
    • Gould, E.1    Beylin, A.2    Tanapat, P.3    Reeves, A.4    Shors, T.J.5
  • 52
    • 33750480549 scopus 로고    scopus 로고
    • The age-related attenuation in long-term potentiation is associated with microglial activation
    • Griffin R., Nally R., Nolan Y., McCartney Y., Linden J., Lynch M.A. The age-related attenuation in long-term potentiation is associated with microglial activation. J. Neurochem. 2006, 99:1263-1272.
    • (2006) J. Neurochem. , vol.99 , pp. 1263-1272
    • Griffin, R.1    Nally, R.2    Nolan, Y.3    McCartney, Y.4    Linden, J.5    Lynch, M.A.6
  • 54
    • 0024354973 scopus 로고
    • Production of transforming growth factor beta by human peripheral blood monocytes and neutrophils
    • Grotendorst G.R., Smale G., Pencev D. Production of transforming growth factor beta by human peripheral blood monocytes and neutrophils. J. Cell. Physiol. 1989, 140:396-402.
    • (1989) J. Cell. Physiol. , vol.140 , pp. 396-402
    • Grotendorst, G.R.1    Smale, G.2    Pencev, D.3
  • 56
    • 36048947606 scopus 로고    scopus 로고
    • Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus
    • Hattiangady B., Shetty A.K. Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus. Neurobiol. Aging 2008, 29:129-147.
    • (2008) Neurobiol. Aging , vol.29 , pp. 129-147
    • Hattiangady, B.1    Shetty, A.K.2
  • 59
    • 0037072548 scopus 로고    scopus 로고
    • Leptin regulates interleukin-1beta expression in the brain via the STAT3-independent mechanisms
    • Hosoi T., Okuma Y., Nomura Y. Leptin regulates interleukin-1beta expression in the brain via the STAT3-independent mechanisms. Brain Res. 2002, 949:139-146.
    • (2002) Brain Res. , vol.949 , pp. 139-146
    • Hosoi, T.1    Okuma, Y.2    Nomura, Y.3
  • 61
    • 70349471128 scopus 로고    scopus 로고
    • Stress differentially regulates the effects of voluntary exercise on cell proliferation in the dentate gyrus of mice
    • Kannangara T.S., Webber A., Gil-Mohapel J., Christie B.R. Stress differentially regulates the effects of voluntary exercise on cell proliferation in the dentate gyrus of mice. Hippocampus 2009, 19:889-897.
    • (2009) Hippocampus , vol.19 , pp. 889-897
    • Kannangara, T.S.1    Webber, A.2    Gil-Mohapel, J.3    Christie, B.R.4
  • 63
    • 0036325981 scopus 로고    scopus 로고
    • Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment
    • Kempermann G., Gast D., Gage F.H. Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Ann. Neurol. 2002, 52:135-143.
    • (2002) Ann. Neurol. , vol.52 , pp. 135-143
    • Kempermann, G.1    Gast, D.2    Gage, F.H.3
  • 64
    • 0034661792 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor modulates rapid eye movement (REM) sleep and non-REM sleep in rats
    • Kimura M., Kodama T., Aguila M.C., Zhang S.Q., Inoue S. Granulocyte-macrophage colony-stimulating factor modulates rapid eye movement (REM) sleep and non-REM sleep in rats. J. Neurosci. 2000, 20:5544-5551.
    • (2000) J. Neurosci. , vol.20 , pp. 5544-5551
    • Kimura, M.1    Kodama, T.2    Aguila, M.C.3    Zhang, S.Q.4    Inoue, S.5
  • 66
    • 84855166859 scopus 로고    scopus 로고
    • Running is the neurogenic and neurotrophic stimulus in environmental enrichment
    • Kobilo T., Liu Q.R., Gandhi K., Mughal M., Shaham Y., van Praag H. Running is the neurogenic and neurotrophic stimulus in environmental enrichment. Learn Mem. 2011, 18:605-609.
    • (2011) Learn Mem. , vol.18 , pp. 605-609
    • Kobilo, T.1    Liu, Q.R.2    Gandhi, K.3    Mughal, M.4    Shaham, Y.5    van Praag, H.6
  • 68
    • 84861986137 scopus 로고    scopus 로고
    • Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice
    • Kohman R.A., Deyoung E.K., Bhattacharya T.K., Peterson L.N., Rhodes J.S. Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice. Brain Behav. Immun. 2011, 26:803-810.
    • (2011) Brain Behav. Immun. , vol.26 , pp. 803-810
    • Kohman, R.A.1    Deyoung, E.K.2    Bhattacharya, T.K.3    Peterson, L.N.4    Rhodes, J.S.5
  • 69
    • 0033559869 scopus 로고    scopus 로고
    • Embryonic and postnatal injections of bromodeoxyuridine produce age-dependent morphological and behavioral abnormalities
    • Kolb B., Pedersen B., Ballermann M., Gibb R., Whishaw I.Q. Embryonic and postnatal injections of bromodeoxyuridine produce age-dependent morphological and behavioral abnormalities. J. Neurosci. 1999, 19:2337-2346.
    • (1999) J. Neurosci. , vol.19 , pp. 2337-2346
    • Kolb, B.1    Pedersen, B.2    Ballermann, M.3    Gibb, R.4    Whishaw, I.Q.5
  • 70
    • 5644277476 scopus 로고    scopus 로고
    • Interleukin-17 family members and inflammation
    • Kolls J.K., Linden A. Interleukin-17 family members and inflammation. Immunity 2004, 21:467-476.
    • (2004) Immunity , vol.21 , pp. 467-476
    • Kolls, J.K.1    Linden, A.2
  • 73
    • 33748188974 scopus 로고    scopus 로고
    • Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus
    • Kronenberg G., Bick-Sander A., Bunk E., Wolf C., Ehninger D., Kempermann G. Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus. Neurobiol. Aging 2006, 27:1505-1513.
    • (2006) Neurobiol. Aging , vol.27 , pp. 1505-1513
    • Kronenberg, G.1    Bick-Sander, A.2    Bunk, E.3    Wolf, C.4    Ehninger, D.5    Kempermann, G.6
  • 74
  • 75
    • 0029863342 scopus 로고    scopus 로고
    • Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
    • Kuhn H.G., Dickinson-Anson H., Gage F.H. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J. Neurosci. 1996, 16:2027-2033.
    • (1996) J. Neurosci. , vol.16 , pp. 2027-2033
    • Kuhn, H.G.1    Dickinson-Anson, H.2    Gage, F.H.3
  • 76
    • 84856957321 scopus 로고    scopus 로고
    • Influence of late-life exposure to environmental enrichment or exercise on hippocampal function and CA1 senescent physiology
    • 828.e821-828.e817
    • Kumar A., Rani A., Tchigranova O., Lee W.H., Foster T.C. Influence of late-life exposure to environmental enrichment or exercise on hippocampal function and CA1 senescent physiology. Neurobiol. Aging 2012, 33. 828.e821-828.e817.
    • (2012) Neurobiol. Aging , vol.33
    • Kumar, A.1    Rani, A.2    Tchigranova, O.3    Lee, W.H.4    Foster, T.C.5
  • 77
    • 16844383069 scopus 로고    scopus 로고
    • Different types of environmental enrichment have discrepant effects on spatial memory and synaptophysin levels in female mice
    • Lambert T.J., Fernandez S.M., Frick K.M. Different types of environmental enrichment have discrepant effects on spatial memory and synaptophysin levels in female mice. Neurobiol. Learn. Mem. 2005, 83:206-216.
    • (2005) Neurobiol. Learn. Mem. , vol.83 , pp. 206-216
    • Lambert, T.J.1    Fernandez, S.M.2    Frick, K.M.3
  • 79
    • 70149121742 scopus 로고    scopus 로고
    • Social isolation prevents exercise-induced proliferation of hippocampal progenitor cells in female rats
    • Leasure J.L., Decker L. Social isolation prevents exercise-induced proliferation of hippocampal progenitor cells in female rats. Hippocampus 2009, 19:907-912.
    • (2009) Hippocampus , vol.19 , pp. 907-912
    • Leasure, J.L.1    Decker, L.2
  • 80
    • 0034489693 scopus 로고    scopus 로고
    • Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats
    • Lee J., Duan W., Long J.M., Ingram D.K., Mattson M.P. Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats. J. Mol. Neurosci. 2000, 15:99-108.
    • (2000) J. Mol. Neurosci. , vol.15 , pp. 99-108
    • Lee, J.1    Duan, W.2    Long, J.M.3    Ingram, D.K.4    Mattson, M.P.5
  • 81
    • 77957371012 scopus 로고    scopus 로고
    • Alpha-synuclein stimulation of astrocytes: potential role for neuroinflammation and neuroprotection
    • Lee H.J., Kim C., Lee S.J. Alpha-synuclein stimulation of astrocytes: potential role for neuroinflammation and neuroprotection. Oxid. Med. Cell. Longev. 2010, 3:283-287.
    • (2010) Oxid. Med. Cell. Longev. , vol.3 , pp. 283-287
    • Lee, H.J.1    Kim, C.2    Lee, S.J.3
  • 82
    • 33645098296 scopus 로고    scopus 로고
    • Is there a link between adult neurogenesis and learning?
    • Leuner B., Gould E., Shors T.J. Is there a link between adult neurogenesis and learning?. Hippocampus 2006, 16:216-224.
    • (2006) Hippocampus , vol.16 , pp. 216-224
    • Leuner, B.1    Gould, E.2    Shors, T.J.3
  • 83
    • 70449530620 scopus 로고    scopus 로고
    • Effects of granulocyte colony-stimulating factor on the proliferation and cell-fate specification of neural stem cells
    • Liu H., Jia D., Fu J., Zhao S., He G., Ling E.A., Gao J., Hao A. Effects of granulocyte colony-stimulating factor on the proliferation and cell-fate specification of neural stem cells. Neuroscience 2009, 164:1521-1530.
    • (2009) Neuroscience , vol.164 , pp. 1521-1530
    • Liu, H.1    Jia, D.2    Fu, J.3    Zhao, S.4    He, G.5    Ling, E.A.6    Gao, J.7    Hao, A.8
  • 84
    • 24044485264 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha and interleukin-18 modulate neuronal cell fate in embryonic neural progenitor culture
    • Liu Y.P., Lin H.I., Tzeng S.F. Tumor necrosis factor-alpha and interleukin-18 modulate neuronal cell fate in embryonic neural progenitor culture. Brain Res. 2005, 1054:152-158.
    • (2005) Brain Res. , vol.1054 , pp. 152-158
    • Liu, Y.P.1    Lin, H.I.2    Tzeng, S.F.3
  • 85
    • 77955368742 scopus 로고    scopus 로고
    • Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging
    • Lugert S., Basak O., Knuckles P., Haussler U., Fabel K., Gotz M., Haas C.A., Kempermann G., Taylor V., Giachino C. Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging. Cell Stem Cell 2010, 6:445-456.
    • (2010) Cell Stem Cell , vol.6 , pp. 445-456
    • Lugert, S.1    Basak, O.2    Knuckles, P.3    Haussler, U.4    Fabel, K.5    Gotz, M.6    Haas, C.A.7    Kempermann, G.8    Taylor, V.9    Giachino, C.10
  • 86
    • 58149248080 scopus 로고    scopus 로고
    • Inhibition of neurosphere proliferation by IFNgamma but not IFNbeta is coupled to neuronal differentiation
    • Lum M., Croze E., Wagner C., McLenachan S., Mitrovic B., Turnley A.M. Inhibition of neurosphere proliferation by IFNgamma but not IFNbeta is coupled to neuronal differentiation. J. Neuroimmunol. 2009, 206:32-38.
    • (2009) J. Neuroimmunol. , vol.206 , pp. 32-38
    • Lum, M.1    Croze, E.2    Wagner, C.3    McLenachan, S.4    Mitrovic, B.5    Turnley, A.M.6
  • 87
    • 77956194308 scopus 로고    scopus 로고
    • Effects of enriched physical and social environments on motor performance, associative learning, and hippocampal neurogenesis in mice
    • Madronal N., Lopez-Aracil C., Rangel A., del Rio J.A., Delgado-Garcia J.M., Gruart A. Effects of enriched physical and social environments on motor performance, associative learning, and hippocampal neurogenesis in mice. PLoS One 2010, 5:e11130.
    • (2010) PLoS One , vol.5
    • Madronal, N.1    Lopez-Aracil, C.2    Rangel, A.3    del Rio, J.A.4    Delgado-Garcia, J.M.5    Gruart, A.6
  • 88
    • 33846377517 scopus 로고    scopus 로고
    • Increased production of inflammatory cytokines in mild cognitive impairment
    • Magaki S., Mueller C., Dickson C., Kirsch W. Increased production of inflammatory cytokines in mild cognitive impairment. Exp. Gerontol. 2007, 42:233-240.
    • (2007) Exp. Gerontol. , vol.42 , pp. 233-240
    • Magaki, S.1    Mueller, C.2    Dickson, C.3    Kirsch, W.4
  • 89
    • 20944451548 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced leptin synthesis and release are differentially controlled by alpha-melanocyte-stimulating hormone
    • Mastronardi C.A., Srivastava V., Yu W.H., Les Dees W., McCann S.M. Lipopolysaccharide-induced leptin synthesis and release are differentially controlled by alpha-melanocyte-stimulating hormone. Neuroimmunomodulation 2005, 12:182-188.
    • (2005) Neuroimmunomodulation , vol.12 , pp. 182-188
    • Mastronardi, C.A.1    Srivastava, V.2    Yu, W.H.3    Les Dees, W.4    McCann, S.M.5
  • 90
    • 82355160899 scopus 로고    scopus 로고
    • Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats
    • BMC Neurosci. 12
    • Mawhinney, L.J., de Vaccari Rivero, J.P., Dale, G.A., Keane, R.W., Bramlett, H.M., 2011. Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats. BMC Neurosci. 12, 123.
    • (2011) , pp. 123
    • Mawhinney, L.J.1    de Vaccari Rivero, J.P.2    Dale, G.A.3    Keane, R.W.4    Bramlett, H.M.5
  • 91
    • 84859508946 scopus 로고    scopus 로고
    • GABA(B) receptor GTP-binding is decreased in the prefrontal cortex but not the hippocampus of aged rats
    • 1124.e1121-e1112
    • McQuail J.A., Banuelos C., LaSarge C.L., Nicolle M.M., Bizon J.L. GABA(B) receptor GTP-binding is decreased in the prefrontal cortex but not the hippocampus of aged rats. Neurobiol. Aging 2012, 33. 1124.e1121-e1112.
    • (2012) Neurobiol. Aging , vol.33
    • McQuail, J.A.1    Banuelos, C.2    LaSarge, C.L.3    Nicolle, M.M.4    Bizon, J.L.5
  • 92
    • 0345189366 scopus 로고    scopus 로고
    • Inflammatory blockade restores adult hippocampal neurogenesis
    • Monje M.L., Toda H., Palmer T.D. Inflammatory blockade restores adult hippocampal neurogenesis. Science 2003, 302:1760-1765.
    • (2003) Science , vol.302 , pp. 1760-1765
    • Monje, M.L.1    Toda, H.2    Palmer, T.D.3
  • 93
    • 37349127393 scopus 로고    scopus 로고
    • Impaired human hippocampal neurogenesis after treatment for central nervous system malignancies
    • Monje M.L., Vogel H., Masek M., Ligon K.L., Fisher P.G., Palmer T.D. Impaired human hippocampal neurogenesis after treatment for central nervous system malignancies. Ann. Neurol. 2007, 62:515-520.
    • (2007) Ann. Neurol. , vol.62 , pp. 515-520
    • Monje, M.L.1    Vogel, H.2    Masek, M.3    Ligon, K.L.4    Fisher, P.G.5    Palmer, T.D.6
  • 94
    • 64249132485 scopus 로고    scopus 로고
    • Leptin signaling in brain: a link between nutrition and cognition?
    • Morrison C.D. Leptin signaling in brain: a link between nutrition and cognition?. Biochim. Biophys. Acta 2009, 1792:401-408.
    • (2009) Biochim. Biophys. Acta , vol.1792 , pp. 401-408
    • Morrison, C.D.1
  • 95
    • 84864024224 scopus 로고    scopus 로고
    • Aerobic exercise is the critical variable in an enriched environment that increases hippocampal neurogenesis and water maze learning in male C57BL/6J mice
    • Mustroph M.L., Chen S., Desai S.C., Cay E.B., Deyoung E.K., Rhodes J.S. Aerobic exercise is the critical variable in an enriched environment that increases hippocampal neurogenesis and water maze learning in male C57BL/6J mice. Neuroscience 2012, 219:62-71.
    • (2012) Neuroscience , vol.219 , pp. 62-71
    • Mustroph, M.L.1    Chen, S.2    Desai, S.C.3    Cay, E.B.4    Deyoung, E.K.5    Rhodes, J.S.6
  • 96
    • 42549169556 scopus 로고    scopus 로고
    • Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid
    • Nichol K.E., Poon W.W., Parachikova A.I., Cribbs D.H., Glabe C.G., Cotman C.W. Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid. J. Neuroinflamm. 2008, 5:13.
    • (2008) J. Neuroinflamm. , vol.5 , pp. 13
    • Nichol, K.E.1    Poon, W.W.2    Parachikova, A.I.3    Cribbs, D.H.4    Glabe, C.G.5    Cotman, C.W.6
  • 97
    • 5444269113 scopus 로고    scopus 로고
    • Effects of life-long exercise on circulating free fatty acids and muscle triglyceride content in ageing rats
    • Novelli M., Pocai A., Skalicky M., Viidik A., Bergamini E., Masiello P. Effects of life-long exercise on circulating free fatty acids and muscle triglyceride content in ageing rats. Exp. Gerontol. 2004, 39:1333-1340.
    • (2004) Exp. Gerontol. , vol.39 , pp. 1333-1340
    • Novelli, M.1    Pocai, A.2    Skalicky, M.3    Viidik, A.4    Bergamini, E.5    Masiello, P.6
  • 98
    • 70349451730 scopus 로고    scopus 로고
    • Long-term treadmill exposure protects against age-related neurodegenerative change in the rat hippocampus
    • O'Callaghan R.M., Griffin E.W., Kelly A.M. Long-term treadmill exposure protects against age-related neurodegenerative change in the rat hippocampus. Hippocampus 2009, 19:1019-1029.
    • (2009) Hippocampus , vol.19 , pp. 1019-1029
    • O'Callaghan, R.M.1    Griffin, E.W.2    Kelly, A.M.3
  • 99
    • 0034090602 scopus 로고    scopus 로고
    • Anti-inflammatory cytokines
    • Opal S.M., DePalo V.A. Anti-inflammatory cytokines. Chest 2000, 117:1162-1172.
    • (2000) Chest , vol.117 , pp. 1162-1172
    • Opal, S.M.1    DePalo, V.A.2
  • 100
    • 0037154112 scopus 로고    scopus 로고
    • Water maze versus radial maze: differential performance of rats in a spatial delayed match-to-position task and response to scopolamine
    • Ormerod B.K., Beninger R.J. Water maze versus radial maze: differential performance of rats in a spatial delayed match-to-position task and response to scopolamine. Behav. Brain Res. 2002, 128:139-152.
    • (2002) Behav. Brain Res. , vol.128 , pp. 139-152
    • Ormerod, B.K.1    Beninger, R.J.2
  • 101
    • 0037402860 scopus 로고    scopus 로고
    • Estradiol initially enhances but subsequently suppresses (via adrenal steroids) granule cell proliferation in the dentate gyrus of adult female rats
    • Ormerod B.K., Lee T.T., Galea L.A. Estradiol initially enhances but subsequently suppresses (via adrenal steroids) granule cell proliferation in the dentate gyrus of adult female rats. J. Neurobiol. 2003, 55:247-260.
    • (2003) J. Neurobiol. , vol.55 , pp. 247-260
    • Ormerod, B.K.1    Lee, T.T.2    Galea, L.A.3
  • 102
    • 4644357752 scopus 로고    scopus 로고
    • Estradiol enhances neurogenesis in the dentate gyri of adult male meadow voles by increasing the survival of young granule neurons
    • Ormerod B.K., Lee T.T., Galea L.A. Estradiol enhances neurogenesis in the dentate gyri of adult male meadow voles by increasing the survival of young granule neurons. Neuroscience 2004, 128:645-654.
    • (2004) Neuroscience , vol.128 , pp. 645-654
    • Ormerod, B.K.1    Lee, T.T.2    Galea, L.A.3
  • 103
    • 0035384902 scopus 로고    scopus 로고
    • MIP-1alpha, MCP-1, GM-CSF, and TNF-alpha control the immune cell response that mediates rapid phagocytosis of myelin from the adult mouse spinal cord
    • Ousman S.S., David S. MIP-1alpha, MCP-1, GM-CSF, and TNF-alpha control the immune cell response that mediates rapid phagocytosis of myelin from the adult mouse spinal cord. J. Neurosci. 2001, 21:4649-4656.
    • (2001) J. Neurosci. , vol.21 , pp. 4649-4656
    • Ousman, S.S.1    David, S.2
  • 104
    • 0034597430 scopus 로고    scopus 로고
    • Vascular niche for adult hippocampal neurogenesis
    • Palmer T.D., Willhoite A.R., Gage F.H. Vascular niche for adult hippocampal neurogenesis. J. Comp. Neurol. 2000, 425:479-494.
    • (2000) J. Comp. Neurol. , vol.425 , pp. 479-494
    • Palmer, T.D.1    Willhoite, A.R.2    Gage, F.H.3
  • 105
    • 40849112965 scopus 로고    scopus 로고
    • Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition
    • Parachikova A., Nichol K.E., Cotman C.W. Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition. Neurobiol. Dis. 2008, 30:121-129.
    • (2008) Neurobiol. Dis. , vol.30 , pp. 121-129
    • Parachikova, A.1    Nichol, K.E.2    Cotman, C.W.3
  • 108
    • 79955643508 scopus 로고    scopus 로고
    • Leptin induces proliferation of neuronal progenitors and neuroprotection in a mouse model of Alzheimer's disease
    • Perez-Gonzalez R., Antequera D., Vargas T., Spuch C., Bolos M., Carro E. Leptin induces proliferation of neuronal progenitors and neuroprotection in a mouse model of Alzheimer's disease. J. Alzheimers Dis. 2011, 24(Suppl. 2):17-25.
    • (2011) J. Alzheimers Dis. , vol.24 , Issue.SUPPL 2 , pp. 17-25
    • Perez-Gonzalez, R.1    Antequera, D.2    Vargas, T.3    Spuch, C.4    Bolos, M.5    Carro, E.6
  • 109
    • 35148835215 scopus 로고    scopus 로고
    • CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells
    • Ponomarev E.D., Maresz K., Tan Y., Dittel B.N. CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells. J. Neurosci. 2007, 27:10714-10721.
    • (2007) J. Neurosci. , vol.27 , pp. 10714-10721
    • Ponomarev, E.D.1    Maresz, K.2    Tan, Y.3    Dittel, B.N.4
  • 110
    • 0030595982 scopus 로고    scopus 로고
    • Increased interleukin-6 production by cerebral cortical tissue of adult versus young mice
    • Prechel M.M., Halbur L., Devata S., Vaidya A.M., Young M.R. Increased interleukin-6 production by cerebral cortical tissue of adult versus young mice. Mech. Ageing Dev. 1996, 92:185-194.
    • (1996) Mech. Ageing Dev. , vol.92 , pp. 185-194
    • Prechel, M.M.1    Halbur, L.2    Devata, S.3    Vaidya, A.M.4    Young, M.R.5
  • 111
    • 43149085744 scopus 로고    scopus 로고
    • Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment
    • Qin L., He J., Hanes R.N., Pluzarev O., Hong J.S., Crews F.T. Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment. J. Neuroinflammation 2008, 5:10.
    • (2008) J. Neuroinflammation , vol.5 , pp. 10
    • Qin, L.1    He, J.2    Hanes, R.N.3    Pluzarev, O.4    Hong, J.S.5    Crews, F.T.6
  • 115
    • 0032535771 scopus 로고    scopus 로고
    • The chemokine growth-regulated oncogene-alpha promotes spinal cord oligodendrocyte precursor proliferation
    • Robinson S., Tani M., Strieter R.M., Ransohoff R.M., Miller R.H. The chemokine growth-regulated oncogene-alpha promotes spinal cord oligodendrocyte precursor proliferation. J. Neurosci. 1998, 18:10457-10463.
    • (1998) J. Neurosci. , vol.18 , pp. 10457-10463
    • Robinson, S.1    Tani, M.2    Strieter, R.M.3    Ransohoff, R.M.4    Miller, R.H.5
  • 118
    • 77958512427 scopus 로고    scopus 로고
    • The protective effects of interleukin-18 and interferon-gamma on neuronal damages in the rat hippocampus following status epilepticus
    • Ryu H.J., Kim J.E., Kim M.J., Kwon H.J., Suh S.W., Song H.K., Kang T.C. The protective effects of interleukin-18 and interferon-gamma on neuronal damages in the rat hippocampus following status epilepticus. Neuroscience 2010, 170:711-721.
    • (2010) Neuroscience , vol.170 , pp. 711-721
    • Ryu, H.J.1    Kim, J.E.2    Kim, M.J.3    Kwon, H.J.4    Suh, S.W.5    Song, H.K.6    Kang, T.C.7
  • 120
    • 24144460032 scopus 로고    scopus 로고
    • Stem/progenitor cell proliferation factors FGF-2, IGF-1, and VEGF exhibit early decline during the course of aging in the hippocampus: role of astrocytes
    • Shetty A.K., Hattiangady B., Shetty G.A. Stem/progenitor cell proliferation factors FGF-2, IGF-1, and VEGF exhibit early decline during the course of aging in the hippocampus: role of astrocytes. Glia 2005, 51:173-186.
    • (2005) Glia , vol.51 , pp. 173-186
    • Shetty, A.K.1    Hattiangady, B.2    Shetty, G.A.3
  • 121
    • 2342656874 scopus 로고    scopus 로고
    • Microglia expressing interleukin-13 undergo cell death and contribute to neuronal survival in vivo
    • Shin W.H., Lee D.Y., Park K.W., Kim S.U., Yang M.S., Joe E.H., Jin B.K. Microglia expressing interleukin-13 undergo cell death and contribute to neuronal survival in vivo. Glia 2004, 46:142-152.
    • (2004) Glia , vol.46 , pp. 142-152
    • Shin, W.H.1    Lee, D.Y.2    Park, K.W.3    Kim, S.U.4    Yang, M.S.5    Joe, E.H.6    Jin, B.K.7
  • 122
    • 34547662888 scopus 로고    scopus 로고
    • Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function
    • Siwak-Tapp C.T., Head E., Muggenburg B.A., Milgram N.W., Cotman C.W. Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function. Neurobiol. Learn. Mem. 2007, 88:249-259.
    • (2007) Neurobiol. Learn. Mem. , vol.88 , pp. 249-259
    • Siwak-Tapp, C.T.1    Head, E.2    Muggenburg, B.A.3    Milgram, N.W.4    Cotman, C.W.5
  • 123
    • 67949089966 scopus 로고    scopus 로고
    • The effects of exercise and stress on the survival and maturation of adult-generated granule cells
    • Snyder J.S., Glover L.R., Sanzone K.M., Kamhi J.F., Cameron H.A. The effects of exercise and stress on the survival and maturation of adult-generated granule cells. Hippocampus 2009, 19:898-906.
    • (2009) Hippocampus , vol.19 , pp. 898-906
    • Snyder, J.S.1    Glover, L.R.2    Sanzone, K.M.3    Kamhi, J.F.4    Cameron, H.A.5
  • 125
    • 46549085907 scopus 로고    scopus 로고
    • Differential 24h responsiveness of Prox1-expressing precursor cells in adult hippocampal neurogenesis to physical activity, environmental enrichment, and kainic acid-induced seizures
    • Steiner B., Zurborg S., Horster H., Fabel K., Kempermann G. Differential 24h responsiveness of Prox1-expressing precursor cells in adult hippocampal neurogenesis to physical activity, environmental enrichment, and kainic acid-induced seizures. Neuroscience 2008, 154:521-529.
    • (2008) Neuroscience , vol.154 , pp. 521-529
    • Steiner, B.1    Zurborg, S.2    Horster, H.3    Fabel, K.4    Kempermann, G.5
  • 126
    • 84857502547 scopus 로고    scopus 로고
    • Adult neural progenitor cells reactivate superbursting in mature neural networks
    • Stephens C.L., Toda H., Palmer T.D., DeMarse T.B., Ormerod B.K. Adult neural progenitor cells reactivate superbursting in mature neural networks. Exp. Neurol. 2012, 234:20-30.
    • (2012) Exp. Neurol. , vol.234 , pp. 20-30
    • Stephens, C.L.1    Toda, H.2    Palmer, T.D.3    DeMarse, T.B.4    Ormerod, B.K.5
  • 127
    • 33645357517 scopus 로고    scopus 로고
    • Social isolation delays the positive effects of running on adult neurogenesis
    • Stranahan A.M., Khalil D., Gould E. Social isolation delays the positive effects of running on adult neurogenesis. Nat. Neurosci. 2006, 9:526-533.
    • (2006) Nat. Neurosci. , vol.9 , pp. 526-533
    • Stranahan, A.M.1    Khalil, D.2    Gould, E.3
  • 129
    • 61449224570 scopus 로고    scopus 로고
    • Microglia: gatekeepers of central nervous system immunology
    • Tambuyzer B.R., Ponsaerts P., Nouwen E.J. Microglia: gatekeepers of central nervous system immunology. J. Leukoc. Biol. 2009, 85:352-370.
    • (2009) J. Leukoc. Biol. , vol.85 , pp. 352-370
    • Tambuyzer, B.R.1    Ponsaerts, P.2    Nouwen, E.J.3
  • 131
    • 74449090471 scopus 로고    scopus 로고
    • Exercise-induced VEGF transcriptional activation in brain, lung and skeletal muscle
    • Tang K., Xia F.C., Wagner P.D., Breen E.C. Exercise-induced VEGF transcriptional activation in brain, lung and skeletal muscle. Respir. Physiol. Neurobiol. 2010, 170:16-22.
    • (2010) Respir. Physiol. Neurobiol. , vol.170 , pp. 16-22
    • Tang, K.1    Xia, F.C.2    Wagner, P.D.3    Breen, E.C.4
  • 132
    • 0035279012 scopus 로고    scopus 로고
    • Pro-inflammatory and anti-inflammatory cytokine mRNA induction in the periphery and brain following intraperitoneal administration of bacterial lipopolysaccharide
    • Turrin N.P., Gayle D., Ilyin S.E., Flynn M.C., Langhans W., Schwartz G.J., Plata-Salaman C.R. Pro-inflammatory and anti-inflammatory cytokine mRNA induction in the periphery and brain following intraperitoneal administration of bacterial lipopolysaccharide. Brain Res. Bull. 2001, 54:443-453.
    • (2001) Brain Res. Bull. , vol.54 , pp. 443-453
    • Turrin, N.P.1    Gayle, D.2    Ilyin, S.E.3    Flynn, M.C.4    Langhans, W.5    Schwartz, G.J.6    Plata-Salaman, C.R.7
  • 133
    • 0022981487 scopus 로고
    • Morphometry of size/volume variables and comparison of their bivariate relations in the nervous system under different conditions
    • Uylings H.B., van Eden C.G., Hofman M.A. Morphometry of size/volume variables and comparison of their bivariate relations in the nervous system under different conditions. J. Neurosci. Methods 1986, 18:19-37.
    • (1986) J. Neurosci. Methods , vol.18 , pp. 19-37
    • Uylings, H.B.1    van Eden, C.G.2    Hofman, M.A.3
  • 134
    • 0037079993 scopus 로고    scopus 로고
    • Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6
    • Vallieres L., Campbell I.L., Gage F.H., Sawchenko P.E. Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6. J. Neurosci. 2002, 22:486-492.
    • (2002) J. Neurosci. , vol.22 , pp. 486-492
    • Vallieres, L.1    Campbell, I.L.2    Gage, F.H.3    Sawchenko, P.E.4
  • 135
    • 34249689618 scopus 로고    scopus 로고
    • Exercise improves memory acquisition and retrieval in the Y-maze task: relationship with hippocampal neurogenesis
    • Van der Borght K., Havekes R., Bos T., Eggen B.J., Van der Zee E.A. Exercise improves memory acquisition and retrieval in the Y-maze task: relationship with hippocampal neurogenesis. Behav. Neurosci. 2007, 121:324-334.
    • (2007) Behav. Neurosci. , vol.121 , pp. 324-334
    • Van der Borght, K.1    Havekes, R.2    Bos, T.3    Eggen, B.J.4    Van der Zee, E.A.5
  • 138
    • 25444533023 scopus 로고    scopus 로고
    • Exercise enhances learning and hippocampal neurogenesis in aged mice
    • van Praag H., Shubert T., Zhao C., Gage F.H. Exercise enhances learning and hippocampal neurogenesis in aged mice. J. Neurosci. 2005, 25:8680-8685.
    • (2005) J. Neurosci. , vol.25 , pp. 8680-8685
    • van Praag, H.1    Shubert, T.2    Zhao, C.3    Gage, F.H.4
  • 140
    • 33846461062 scopus 로고    scopus 로고
    • Morris water maze: procedures for assessing spatial and related forms of learning and memory
    • Vorhees C.V., Williams M.T. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat. Protoc. 2006, 1:848-858.
    • (2006) Nat. Protoc. , vol.1 , pp. 848-858
    • Vorhees, C.V.1    Williams, M.T.2
  • 141
    • 0037072285 scopus 로고    scopus 로고
    • Interleukin-6 and risk of cognitive decline: MacArthur studies of successful aging
    • Weaver J.D., Huang M.H., Albert M., Harris T., Rowe J.W., Seeman T.E. Interleukin-6 and risk of cognitive decline: MacArthur studies of successful aging. Neurology 2002, 59:371-378.
    • (2002) Neurology , vol.59 , pp. 371-378
    • Weaver, J.D.1    Huang, M.H.2    Albert, M.3    Harris, T.4    Rowe, J.W.5    Seeman, T.E.6
  • 142
    • 0026339976 scopus 로고
    • Unbiased stereological estimation of the total number of neurons in thesubdivisions of the rat hippocampus using the optical fractionator
    • West M.J., Slomianka L., Gundersen H.J. Unbiased stereological estimation of the total number of neurons in thesubdivisions of the rat hippocampus using the optical fractionator. Anat. Rec. 1991, 231:482-497.
    • (1991) Anat. Rec. , vol.231 , pp. 482-497
    • West, M.J.1    Slomianka, L.2    Gundersen, H.J.3
  • 143
    • 71749095117 scopus 로고    scopus 로고
    • Regulation of cytokine signaling and T-cell recruitment in the aging mouse brain in response to central inflammatory challenge
    • Xu Y.Z., Nygard M., Kristensson K., Bentivoglio M. Regulation of cytokine signaling and T-cell recruitment in the aging mouse brain in response to central inflammatory challenge. Brain Behav. Immun. 2010, 24:138-152.
    • (2010) Brain Behav. Immun. , vol.24 , pp. 138-152
    • Xu, Y.Z.1    Nygard, M.2    Kristensson, K.3    Bentivoglio, M.4
  • 144
    • 70350185424 scopus 로고    scopus 로고
    • Interleukin-18 regulates motor activity, anxiety and spatial learning without affecting synaptic plasticity
    • Yaguchi T., Nagata T., Yang D., Nishizaki T. Interleukin-18 regulates motor activity, anxiety and spatial learning without affecting synaptic plasticity. Behav. Brain Res. 2010, 206:47-51.
    • (2010) Behav. Brain Res. , vol.206 , pp. 47-51
    • Yaguchi, T.1    Nagata, T.2    Yang, D.3    Nishizaki, T.4
  • 145
    • 0032916578 scopus 로고    scopus 로고
    • Increased interleukin-6 expression by microglia from brain of aged mice
    • Ye S.M., Johnson R.W. Increased interleukin-6 expression by microglia from brain of aged mice. J. Neuroimmunol. 1999, 93:139-148.
    • (1999) J. Neuroimmunol. , vol.93 , pp. 139-148
    • Ye, S.M.1    Johnson, R.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.