Extremely elevated CA-125 in benign ovarian disease due to stretch of the peritoneum

BMJ Case Reports

Volumn , Issue , 2012, Pages

  Tolman, Christine J ^a   Vaid, Tejasvini ^b   Schreuder, Henk W R ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b KASTURBA HOSPITAL   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CA 125 ANTIGEN; CA 19-9 ANTIGEN;

ADENOFIBROMA; AGED; ANAMNESIS; ARTICLE; BORDERLINE OVARIAN TUMOR; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; CYSTADENOMA; DIFFERENTIAL DIAGNOSIS; FEMALE; HISTOPATHOLOGY; HUMAN; HYPERTENSION; HYSTERECTOMY; IMAGE ANALYSIS; IMAGING; LAPAROTOMY; LIVER FUNCTION TEST; MENORRHAGIA; OMENTECTOMY; OVARIECTOMY; OVARY CANCER; OVARY DISEASE; OVARY FIBROMA; OVARY TERATOMA; PERITONEUM; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; SEROUS CYSTIC ADENOFIBROMA; THORAX RADIOGRAPHY;

EID: 84872193569     PISSN: None     EISSN: 1757790X     Source Type: Journal    
DOI: 10.1136/bcr-2012-006664     Document Type: Article

References (24)

1. Bast RC Jr, Klug TL, St John E, et al. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N Engl J Med. 1983;309:883-7.
2. Ghaemmaghami F, Zarchi MK, Hamedi B. High levels of CA125 (over 1,000 U/mL) in patients with gynecologic disease and no malignant conditions: three cases and literature review. Arch Gynecol Obstet 2007;276:559-61.
3. Moss EL, Hollingworth J, Reynolds TM, et al. The role of CA125 in clinical practice. J Clin Pathol 2005;58:308-12.
4. Myers ER, Bastian A, Havrilesky LJ. Management of adnexal mass. Evid Rep Technol Assess 2006;130:1-145.
5. Jacobs I, Oram D, Fairbanks J, et al. A risk of malignancy index incorporating Ca125, ultrasound and menopausal status for the acurate preoperative diagnosis of ovarian cancer. Br J Obstet Gynaecol 1990;97:922-9.
6. American College of Obstetricians and Gynecologists. ACOG Practice Bulletin. Management of adnexal masses. Obstet Gynecol. 2007;110:201-14.
7. Jacobs I, Bast RC Jr. The CA 125 tumour-associated antigen: a review of the literature. Hum Reprod 1989;4:1-12.
8. Bast RC Jr, Badgwell D, LuZ, Marquez R, et al. New tumor markers: CA125 and beyond. Int J Gynecol Cancer 2005;15:274-81.
9. Johansson J, Santala M, Kauppila A. Explosive rise of serum CA 125 following the rupture of ovarian endometrioma. Hum Reprod 1998;12:3503-4.
10. Kashyap RJ. Extremely elevated serum CA125 due to endometriosis. Austd N Z J Obstet Gynaecol 1999;39:269-70.
11. Kahraman K, Ozguven I, Gungor M, et al. Extremely elevated serum CA-125 level as a result of unruptured unilateral endometrioma: the highest value reported. Fertil Steril. 2007;4:968-7.
12. Sato H, Borsari R, Yajima EK, et al. Adenomyoma associated with high level of CA 125 and CA 19-9: case report. Eur J Gynaecol Oncol 2011;32:455-6.
13. Zheng H, Gao Y. Serum HE4 as a Useful Biomarker in Discriminating Ovarian Cancer From Benign Pelvic Disease. Int J Gynecol Cancer 2012;22:1000-5.
14. Moore RG, Miller MC, Steinhoff MM, et al. Serum HE4 levels are less frequently elevated than CA 125 in women with benign gynaecologic disorders. Am J Obstet Gynecol 2012;206:3511-18.
15. Meigs JV, Cass JW. Fibroma of the ovary with ascites and hydrothorax, with a report of seven cases. Am J Obstet Gynecol 1937;33:249-66.
16. Liou J, Su TC, Hsu JC. Meigs' syndrome with elevated serum cancer antigen 125 levels in a case of ovarian sclerosing stromal tumor. Taiwanese J Obstet Gynecol 2011;50:196-200.
17. Kabawat SE, Bast RC Jr, Welch WR, et al. Tissue distribution of a coelomic-epithelium-related antigen recognized by the monoclonal antibody OC125. Int J Gynecol Pathol 1983;2:275-85.
18. Zuckerman E, Lanir A, Sabo F, et al. Ca 125 as a marker for detection and quantitation of ascites in liver disease Hepatology 1995;22:163-6.
19. Pasqual E, Bacchetti S, Morabito G, et al . The length of peritoneal surgical manipulation correlates with serum CA 125 levels. In Viv 2011;25:105-9.
20. Fujiwara K, Moriya T, Mikami Y, et al. Significant increases in serum CA125 and CA19-9 following torsion from an adenofibroma of the ovary: a case report. Jpn J Clin Oncol 1994;24:116-19.
21. Wehner Buchholz BM, Schuchtrup S, Rocke A, et al. Mechanical strain and TLR4 synergistically induce cell-specific inflammatory gene expression in intestinal smooth muscle cells and peritoneal macrophages, Am J Physiol Gastrointest Liver Physiol 2010;299:1187-97.
22. Georgios K, Kostoula A, Economou M, et al.Tumor necrosis factor-a-related intraperitoneal release of Ca-125 in cirrhotic patients with sterile ascites. Clin Chem 2005;11:2207-8.
23. Higgins RV, Matkins JF, Marroum MC. Comparison of fine-needle aspiration cytologic findings of ovarian cysts with ovarian histologic findings. Am J Obstet Gynecol 1999;180:550-3.
24. Layfield LJ, Berek JS. Fine-needle aspiration cytology in the management of gynecologic oncology patients. Cancer Treat Res. 1994;70:1-13.