Ex vivo relaxation effect of Cuscuta chinensis extract on rabbit corpus cavernosum

Asian Journal of Andrology

Volumn 15, Issue 1, 2013, Pages 134-137

  Sun, Kai ^a   Zhao, Chen ^a   Chen, Xiang Feng ^a   Kim, Hye Kyung ^b   Choi, Bo Ram ^b   Huang, Yi Ran ^a   Park, Jong Kwan ^b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Chonbuk National University Medical School   (South Korea)

Author keywords

Cuscuta chinensis; erectile dysfunction (ED); NO cGMP pathway; penile corpus cavernosum (PCC); sildenafil

Indexed keywords

CUSCUTA CHINENSIS EXTRACT; CYCLIC AMP; CYCLIC GMP; KT 5720; N(G) NITROARGININE METHYL ESTER; PHENYLEPHRINE; SILDENAFIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DRUG ISOLATION; DRUG POTENTIATION; MALE; MUSCLE RELAXATION; NONHUMAN;

ANIMALS; CUSCUTA; CYCLIC GMP; ENZYME INHIBITORS; ERECTILE DYSFUNCTION; HERB-DRUG INTERACTIONS; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH; NG-NITROARGININE METHYL ESTER; PENILE ERECTION; PENIS; PHYTOTHERAPY; PIPERAZINES; PLANT EXTRACTS; PURINES; RABBITS; SULFONES;

EID: 84872193318     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.1038/aja.2012.124     Document Type: Article

References (23)

1. Andersson KE. Mechanisms of penile erection and basis for pharmacological treatment of erectile dysfunction. Pharmacol Rev 2011; 63: 811-59.
2. Fode M, Krogh-Jespersen S, Brackett NL, Ohl DA, Lynne CM et al. Male sexual dysfunction and infertility associated with neurological disorders. Asian J Androl 2012; 14: 61-8.
3. Francis SH, Busch JL, Corbin JD, Sibley D. cGMP-Dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action. Pharmacol Rev 2010; 62: 525-63.
4. Bender AT, Beavo JA. Cyclic nucleotide phosphodiesterases: Molecular regulation to clinical use. Pharmacol Rev 2006; 58: 488-520. (Pubitemid 44394910)
5. Montague DK, Jarow JP, Broderick GA, Dmochowski RR, Heaton JP et al. Chapter 1: The management of erectile dysfunction: An AUA update. J Urol 2005; 174: 230-9.
6. Wespes E, Amar E, Hatzichristou D, Hatzimouratidis K, Montorsi F et al. EAU guidelines on erectile dysfunction: An update. Eur Urol 2006; 49: 806-15.
7. Madduri SD. After two years, did Viagra live up to its expectations? Mo Med 2001; 98: 243-5.
8. Wong RW, Rabie AB. Traditional Chinese medicines and bone formation - A review. J Oral Maxillofac Surg 2006; 64: 828-37.
9. Qin L, Han T, Zhang Q, Cao D, Nian H et al. Antiosteoporotic chemical constituents from Er-Xian Decoction, a traditional Chinese herbal formula. J Ethnopharmacol 2008; 118: 271-9.
10. Zheng HZ, Dong ZH, She J. Modern Study of Traditional Chinese Medicine. Beijing: Xue Yuan Press of the People's Republic of China; 1998. p4110.
11. Du XM, Kohinata K, Kawasaki T, Guo YT, Miyahara K. Components of the ether-insoluble resin glycoside-Like fraction from Cuscuta chinensis. Phytochemistry 1998; 48: 843-50. (Pubitemid 28299564)
12. Wang Z, Fang JN, Ge DL, Li XY. Chemical characterization and immunological activities of an acidic polysaccharide isolated from the seeds of Cuscuta chinensis Lam. Acta Pharmacol Sin 2000; 21: 1136-40. (Pubitemid 32012723)
13. Ye M, Yan YN, Qiao L, Ni XM. Studies on chemical constituents of Cuscuta chinensis. Zhongguo Zhong Yao Za Zhi 2002; 27: 115-7.
14. He XH, Yang WZ, Meng AH, He WN, Guo DA et al. Two new lignin glycosides from the seeds of Cuscuta chinensis. J Asian Nat Prod Res 2010; 12: 934-9.
15. Ososki AL, Kennelly EJ. Phytoestrogens: A review of the present state of research. Phytother Res 2003; 17: 845-69. (Pubitemid 37157993)
16. Zhao C, Chae HJ, Kim SH, Cui WS, Lee SW et al. A new perfusion model for studying erectile function. J Sex Med 2010; 7: 1419-28.
17. Zhao C, Kim SH, Lee SW, Jeon JH, Kang KK et al. Activity of phosphodiesterase type 5 inhibitors in patients with lower urinary tract symptoms due to benign prostatic hyperplasia. BJU Int 2011; 107: 1943-7.
18. Escrig A, Gonzalez-Mora JL, Mas M. Nitric oxide release in penile corpora cavernosa in a rat model of erection. J Physiol 1999; 516: 261-9. (Pubitemid 29164008)
19. Kim NN, Huang Y, Moreland RB, Kwak SS, Goldstein I et al. Cross-regulation of intracellular cGMP and cAMP in cultured human corpus cavernosum smooth muscle cells. Mol Cell Biol Res Commun 2000; 4: 10-4.
20. Recio P, Lopez PG, Hernandez M, Prieto D, Contreras J et al. Nitrergic relaxation of the horse corpus cavernosum. Role of cGMP. Eur J Pharmacol 1998; 351: 85-94. (Pubitemid 28300307)
21. Beavo JA. Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms. Physio Rev 1995; 75: 725-48.
22. Ye M, Li Y, Yan Y, Liu H, Ji X. Determination of flavonoids in Semen Cuscutae by RPHPLC. J Pharm Biomed Anal 2002; 28: 621-8. (Pubitemid 34465629)
23. Yang L, Chen Q, Wang F, Zhang G. Antiosteoporotic compounds from seeds of Cuscuta chinensis. J Ethnopharmacol 2011; 135: 553-60.