Multilevel anterior cervical discectomy and fusion with and without rhBMP-2: A comparison of dysphagia rates and outcomes in 150 patients - Clinical article

Journal of Neurosurgery: Spine

Volumn 18, Issue 1, 2013, Pages 43-49

  Lu, Daniel C ^a   Tumialán, Luis M ^b   Chou, Dean ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BARROW NEUROLOGICAL INSTITUTE   (United States)

Author keywords

Anterior cervical discectomy and fusion; Bone morphogenetic protein; Polyetheretherketone

Indexed keywords

POLYETHERETHERKETONE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ALLOGRAFT; ANTERIOR SPINE FUSION; ARTICLE; CERVICAL PLATE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DISEASE SEVERITY; DYSPHAGIA; FOLLOW UP; HUMAN; INTERVERTEBRAL DISKECTOMY; MAJOR CLINICAL STUDY; PLATE FIXATION; PSEUDARTHROSIS; QUALITY OF LIFE; TREATMENT OUTCOME;

ADULT; BONE MORPHOGENETIC PROTEIN 2; BONE PLATES; BONE TRANSPLANTATION; CERVICAL VERTEBRAE; DEGLUTITION DISORDERS; DISKECTOMY; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; RECOMBINANT PROTEINS; RETROSPECTIVE STUDIES; SPINAL FUSION; TRANSFORMING GROWTH FACTOR BETA; TREATMENT OUTCOME;

EID: 84872185593     PISSN: 15475654     EISSN: 15475646     Source Type: Journal    
DOI: 10.3171/2012.10.SPINE10231     Document Type: Article

References (21)

1. Bazaz R, Lee MJ, Yoo JU: Incidence of dysphagia after anterior cervical spine surgery: a prospective study. Spine (Phila Pa 1976) 27:2453-2458, 2002
2. Bennett M, Reynolds AS, Dickerman RD: Recent article by Shields et al titled "adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion." Spine (Phila Pa 1976) 31: 2029-2030, 2006 (Letter)
3. Boakye M, Mummaneni PV, Garrett M, Rodts G, Haid R: Anterior cervical discectomy and fusion involving a polyetheretherketone spacer and bone morphogenetic protein. J Neurosurg Spine 2:521-525, 2005
4. Boden SD, Zdeblick TA, Sandhu HS, Heim SE: The use of rhBMP-2 in interbody fusion cages. Definitive evidence of osteoinduction in humans: a preliminary report. Spine (Phila Pa 1976) 25:376-381, 2000
5. Burkus JK: Bone morphogenetic proteins in anterior lumbar interbody fusion: old techniques and new technologies. J Neu rosurg Spine 1:254-260, 2004
6. Burkus JK, Gornet MF, Dickman CA, Zdeblick TA: Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages. J Spinal Disord Tech 15:337-349, 2002
7. Burkus JK, Heim SE, Gornet MF, Zdeblick TA: The effectiveness of rhBMP-2 in replacing autograft: an integrated analysis of three human spine studies. Orthopedics 27:723-728, 2004
8. Burkus JK, Sandhu HS, Gornet MF: Influence of rhBMP-2 on the healing patterns associated with allograft interbody constructs in comparison with autograft. Spine (Phila Pa 1976) 31:775-781, 2006
9. Carlisle E, Fischgrund JS: Bone morphogenetic proteins for spinal fusion. Spine J 5 (6 Suppl):240S-249S, 2005
10. Giannoudis PV, Dinopoulos H, Tsiridis E: Bone substitutes: an update. Injury 36 (Suppl 3):S20-S27, 2005
11. Heary RF, Schlenk RP, Sacchieri TA, Barone D, Brotea C: Persistent iliac crest donor site pain: independent outcome assessment. Neurosurgery 50:510-517, 2002
12. Kaiser MG, Mummaneni PV, Matz PG, Anderson PA, Groff MW, Heary RF, et al: Radiographic assessment of cervical subaxial fusion. J Neurosurg Spine 11:221-227, 2009
13. Lanman TH, Hopkins TJ: Early findings in a pilot study of anterior cervical interbody fusion in which recombinant human bone morphogenetic protein-2 was used with poly(L-lactideco-D,L-lactide) bioabsorbable implants. Neurosurg Focus 16(3):E6, 2004
14. McHorney CA, Robbins J, Lomax K, Rosenbek JC, Chignell K, Kramer AE, et al: The SWAL-QOL and SWAL-CARE outcomes tool for oropharyngeal dysphagia in adults: III. Documentation of reliability and validity. Dysphagia 17:97-114, 2002
15. Patel VV, Zhao L, Wong P, Kanim L, Bae HW, Pradhan BB, et al: Controlling bone morphogenetic protein diffusion and bone morphogenetic protein-stimulated bone growth using fibrin glue. Spine (Phila Pa 1976) 31:1201-1206, 2006
16. Perri B, Cooper M, Lauryssen C, Anand N: Adverse swelling associated with use of rh-BMP-2 in anterior cervical dis cectomy and fusion: a case study. Spine J 7:235-239, 2007
17. Samartzis D, Shen FH, Goldberg EJ, An HS: Is autograft the gold standard in achieving radiographic fusion in one-level anterior cervical discectomy and fusion with rigid anterior plate fixation? Spine (Phila Pa 1976) 30:1756-1761, 2005
18. Shields LB, Raque GH, Glassman SD, Campbell M, Vitaz T, Harpring J, et al: Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion. Spine (Phila Pa 1976) 31:542-547, 2006
19. Smucker JD, Rhee JM, Singh K, Yoon ST, Heller JG: Increased swelling complications associated with off-label usage of rhBMP-2 in the anterior cervical spine. Spine (Phila Pa 1976) 31:2813-2819, 2006
20. Tomford WW: Bone allografts: past, present and future. Cell Tissue Bank 1:105-109, 2000
21. Tumialán LM, Pan J, Rodts GE, Mummaneni PV: The safety and efficacy of anterior cervical discectomy and fusion with polyetheretherketone spacer and recombinant human bone morphogenetic protein-2: a review of 200 patients. J Neu rosurg Spine 8:529-535, 2008