Low expression of FCGRIIB in macrophages of immune thrombocytopenia- affected individuals

International Journal of Hematology

Volumn 96, Issue 5, 2012, Pages 588-593

  Wu, Zhong ^a   Zhou, Jin ^a   Prsoon, Pankaj ^a   Wei, Xiaoxia ^a   Liu, Xiaojin ^a   Peng, Bing ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

FC gamma receptor IIB; FC gamma receptor IIIA; Immune thrombocytopenia; Immunohistochemistry

Indexed keywords

FC RECEPTOR IIA; FC RECEPTOR IIB; IMMUNOGLOBULIN; PREDNISOLONE;

ADULT; ARTICLE; AUTOIMMUNE THROMBOCYTOPENIA; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HELICOBACTER INFECTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; PROTEIN EXPRESSION; SPLEEN;

ADOLESCENT; ADULT; BIOLOGICAL MARKERS; BLOOD PLATELETS; CHILD; FEMALE; GENE EXPRESSION REGULATION; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MALE; MIDDLE AGED; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; RECEPTORS, IGG; SPLEEN;

EID: 84872171276     PISSN: 09255710     EISSN: 18653774     Source Type: Journal    
DOI: 10.1007/s12185-012-1187-6     Document Type: Article

References (27)

1. Wright JF, Blanchette VS, Wang H, et al. Characterization of platelet reactive antibodies in children with varicella-associated acute immune thrombocytopenic purpura. Br J Haematol. 1996;95:145-52.
2. Crow AR, Lazarus AH. Role of FC gamma receptors in the pathogenesis and treatment of idiopathic thrombocytopenic purpura. J Pediatr Hematol Oncol. 2003;25:14-8.
3. Breunis WB, Mirre EV, Bruin M, Geissler J, Boer MD, Peters M, Roos D, Haas MD, Koene HR, Kuijpers TW. Copy number variation of the activating FCGR2C gene predisposes to idiopathic thrombocytopenic purpura. Blood. 2008;111:1029-38.
4. Wu Z, Zhou J, Prasoon P, Peng B. Laparoscopic splenectomy for immune thrombocytopenia (ITP) patients with platelet counts lower than 1 9 109/L. Int J Hematol. 2011;94(6):533-8.
5. Cines DB, Bussel JB. How I treat idiopathic thrombocytopenic purpura (ITP). Blood. 2005;106:2244-51.
6. Bruin M, Bierings M, Uiterwaal C, et al. Platelet count, previous infection and FCGR2B genotype predict development of chronic disease in newly diagnosed idiopathic thrombocytopenia in childhood: results of a prospective study. Br JHaematol. 2004;127:561-7.
7. George JN, Ei-Harake MA, Raskob GE. Chronic idiopathic thrombocytopenic purpura. N Engl J Med. 1995;331:1207-11.
8. Berchtold P, McMillan R. Therapy of chronic idiopathic thrombocytopenic purpura in adults. Blood. 1989;74:2309-17.
9. Ravetch JV. Fc receptors: rubor redux. Cell. 1994;78:553-60.
10. He XY, Sun XM, Wang JF, Wang XN, Zhang QS, Tzipori S, Feng HP. Antibody-enhanced, Fc gamma receptor-mediated endocytosis of Clostridium difficile toxin A. Infect Immun. 2009;77:2294-303.
11. Cines DB, Blanchette VS. Immune thrombocytopenic purpura. N Engl J Med. 2002;346:995-1008.
12. Daeron M. Fc receptor biology. Annu Rev Immunol. 1997;15: 203-34.
13. Liu XG, Ma SH, Sun JZ, Ren J, Shi Y, Sun L, Dong XY, Qin P, Guo CS, Hou M, Peng J. High-dose dexamethasone shifts the balance of stimulatory and inhibitory FCG receptors on monocytes in patients with primary immune thrombocytopenia. Blood. 2011;117:2061-9.
14. Kong XH, Meng WJ, Zhou ZG, Li Y, Zhou B. Overexpression of activating transcription factor 5 in human rectal cancer. Exp Ther Med. doi:10.3892/etm.2011.295.
15. Beardsley DS. Pathophysiology of immune thrombocytopenic purpura. Blood Rev. 2002;16:13-4.
16. Psaila B, Bussel JB. Fc receptors in immune thrombocytopenias: a target for immunomodulation? J Clin Invest. 2008;118:2677-81.
17. Clarkson SB, Bussel JB, Kimberly RP, et al. Treatment of refractory immune thrombocytopenic purpura with an anti-Fc gamma receptor antibody. N Engl J Med. 1986;314:1236-9.
18. Ericson SG, Coleman KD, Wardwell K, et al. Monoclonal antibody 197 (anti-Fc gamma RI) infusion in a patient with immune thrombocytopenia purpura (ITP) results in down-modulation of Fc gamma on circulating monocytes. Br J Haematol. 1996;92:718-24.
19. Nimmerjahn F, Ravetch JV. Fc gamma receptors: old friends and new family members. Immunity. 2006;24:19-28.
20. Samuelsson A, Towers TL, Ravetch JV. Anti-inflammatory activity of IVIG mediated through the inhibitor Fc receptor. Science. 2001;291:484-6.
21. Song S, Crow AR, Freedman J. Monoclonal IgG can ameliorate immune thrombocytopenia in a murine model of ITP: an alternative to IVIG. Blood. 2003;101:3708-13.
22. Flesch BK, Achtert G, Neppert J. Inhibition of monocyte and polymorphonuclear granulocyte immune phagocytosis by monoclonal antibodies specific for Fc gamma RI II and III. Ann Hematol. 1997;74:15-22.
23. Takai T, Ono M, Hikida M, et al. Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature. 1996;379:346-9.
24. Karpatkin S. Autoimmune (idiopathic) thrombocytopenic purpura. Lancet. 1997;349:1531-6.
25. Matzdorff AC, Arnold G, Salama A, Ostermann H, Eberle S, Hummler S. Advances in ITP-therapy and quality of life-a patient survey. PLoS ONE. 2011;6(11):e27350.
26. Stasi R, Provan D. Helicobacter pylori and chronic ITP. Hematology. 2008:206-11.
27. Asahi A, Nishimoto T, Okazaki Y, Suzuki H, Masaoka T, Kawakami Y, Ikeda Y, Kuwana M. Helicobacter pylori eradication shifts monocyte Fcr receptor balance toward inhibitory FcrRIIB in immune thrombocytopenic purpura patients. J Clin Invest. 2008;118:2939-49.