Efficacy of a multi micronutrient-fortified drink in improving iron and micronutrient status among schoolchildren with low iron stores in India: A randomised, double-masked placebo-controlled trial

European Journal of Clinical Nutrition

Volumn 67, Issue 1, 2013, Pages 36-41

  Thankachan, P ^a   Selvam, S ^a   Surendran, D ^a   Chellan, S ^a   Pauline, M ^a   Abrams, S A ^b   Kurpad, A V ^a  

^a ST JOHN'S NATIONAL ACADEMY OF HEALTH SCIENCES   (India)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Anemia; Children; Fortification; Iron deficiency; Iron deficiency anemia; Micronutrients

Indexed keywords

ASCORBIC ACID; CYANOCOBALAMIN; FERRITIN; FOLIC ACID; IRON; PLACEBO; ZINC;

ANEMIA; ARTICLE; ASCORBIC ACID DEFICIENCY; CELL LEVEL; CHILD; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; FEMALE; FERRITIN BLOOD LEVEL; FOOD INTAKE; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN CELL; INDIA; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; IRON STORAGE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NUTRITIONAL STATUS; OUTCOME ASSESSMENT; PATIENT COMPLIANCE; PRESCHOOL CHILD; PREVALENCE; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; VITAMIN BLOOD LEVEL; ZINC BLOOD LEVEL;

ANEMIA, IRON-DEFICIENCY; ASCORBIC ACID DEFICIENCY; BEVERAGES; CHILD; CHILD DEVELOPMENT; DOUBLE-BLIND METHOD; FEMALE; FOOD SERVICES; FOOD, FORTIFIED; HUMANS; INDIA; LOST TO FOLLOW-UP; MALE; MICRONUTRIENTS; NUTRITIONAL STATUS; PATIENT COMPLIANCE; PREVALENCE; SCHOOLS; SEVERITY OF ILLNESS INDEX; VITAMIN B 12 DEFICIENCY;

EID: 84872169323     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2012.188     Document Type: Article

References (35)

1. Diaz JR, de las Cagigas A, Rodriguez R. Micronutrient deficiencies in developing and affluent countries. Eur J Clin Nutr 2003; 57 (Suppl 1): S70-S72. (Pubitemid 37121034)
2. Sivakumar B, Nair KM, Sreeramulu D, Suryanarayana P, Ravinder P, Shatrugna V et al. Effect of micronutrient supplement on health and nutritional status of schoolchildren: biochemical status. Nutrition 2006; 22 (Suppl 1): S15-S25. (Pubitemid 43106679)
3. Ranum P. Solving micronutrient deficiency problems. Cereal Foods World 2001; 46: 441-443.
4. Beaton GH. Iron needs during pregnancy: do we need to rethink our targets? Am J Clin Nutr 2000; 72 (Suppl 1): 265S-271S. (Pubitemid 30439798)
5. Allen LH, Peerson JM, Olney. DK. Provision of multiple rather than two or fewer micronutrients more effectively improves growth and other outcomes in micronutrient-deficient children and adults. J Nutr 2009; 139: 1022-1030.
6. Ash Deborah M, Tatala SR, Frangillo Jr EA, Ndossi GD, Latham MC. Randomized efficacy trial of a micronutrient-fortified beverage in primary school children in Tanzania. Am J Clin Nutr 2003; 77: 891-898.
7. Abrams SA, Mushi A, Hilmers DC, Griffin IJ, Davila P, Allen L. A multinutrientfortified beverage enhances the nutritional status of children in Botswana. J Nutr 2003; 133: 1834-1840. (Pubitemid 36666522)
8. Solon FS, Sarol Jr JN, Bernardo AB, Solon JA, Mehansho H, Sanchez-Fermin LE et al. Effect of a multiple-micronutrient-fortified fruit powder beverage on the nutrition status, physical fitness, and cognitive performance of schoolchildren in the Philippines. Food Nutr Bull 2003; 24 (Suppl 4): S129-S140. (Pubitemid 38187936)
9. Cook JD, Flowers CH, Skikne. BS. The quantitative assessment of body iron. Blood 2003; 101: 3359-3364. (Pubitemid 36857914)
10. Harrison GG, Buskirk ER, Lindsay Carter JE, Johnston FE, Lohman TG, Pollock ML et al. Skinfold thicknesses and measurement technique. In: Lohman TG, Roche AF, Martorell R, (eds). Anthropometric Standardization Reference Manual. Champaign, IL: Human Kinetics, 1988: 55-70.
11. de Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ 2007; 85: 660-667. (Pubitemid 47416716)
12. Nga TT, Winichagoon P, Dijkhuizen MA, Khan NC, Wasantwisut E, Furr H et al. Multi-micronutrient-fortified biscuits decreased prevalence of anemia and improved micronutrient status and effectiveness of deworming in rural Vietnamese school children. J Nutr 2009; 139: 1013-1021.
13. van Stuijvenberg ME, Kvalsvig JD, Faber M, Kruger M, Kenoyer DG, Benade AJ. Effect of iron-, iodine-, and beta-carotene-fortified biscuits on the micronutrient status of primary school children: a randomized controlled trial. Am J Clin Nutr 1999; 69: 497-503. (Pubitemid 29104572)
14. Winichagoon P, McKenzie JE, Chavasit V, Pongcharoen T, Gowachirapant S, Boonpraderm A et al. A multimicronutrient-fortified seasoning powder enhances the hemoglobin, zinc, and iodine status of primary school children in North East Thailand: a randomized controlled trial of efficacy. J Nutr 2006; 136: 1617-1623. (Pubitemid 43765371)
15. Hallberg L, Brune M, Erlandsson M, Sandberg AS, Rossander-Hulten L. Calcium: effect of different amounts on nonheme- and heme-iron absorption in humans. Am J Clin Nutr 1991; 53: 112-119. (Pubitemid 21917618)
16. Thankachan P, Walczyk T, Muthayya S, Kurpad AV, Hurrell RF. Iron absorption in young Indian women: the interaction of iron status with the influence of tea and ascorbic acid. Am J Clin Nutr 2008; 87: 881-886. (Pubitemid 351549232)
17. Walczyk T, Davidsson L, Zavaleta N, Hurrell RF. Stable isotope labels as a tool to determine the iron absorption by Peruvian school children from a breakfast meal. Fresenius J Anal Chem 1997; 359: 445-449. (Pubitemid 127713937)
18. Hurrell RF. Iron Fortification of Foods. Academic Press: Orlando, FL, 1985.
19. Villalpando S, Shamah T, Rivera JA, Lara Y, Monterrubio E. Fortifying milk with ferrous gluconate and zinc oxide in a public nutrition program reduced the prevalence of anemia in toddlers. J Nutr 2006; 136: 2633-2637. (Pubitemid 44521625)
20. Zimmermann MB, Biebinger R, Rohner F, Dib A, Zeder C, Hurrell RF et al. Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron. Am J Clin Nutr 2006; 84: 580-586. (Pubitemid 44713408)
21. Semba RD, Bloem. MW. The anemia of vitamin A deficiency: epidemiology and pathogenesis. Eur J Clin Nutr 2002; 56: 271-281. (Pubitemid 34413819)
22. Combs GF. The Vitamins: Fundamental Aspects in Nutrition and Health. Elsevier: San Diego, 2008.
23. Antony AC. Megoblastic anemias. In: Hoffman R, Benz EJ, Shattil SS et al. (eds). Hematology: Basic Principles and Practice. 5th edn. Elsevier Churchill Livingstone; Philadelphia, PA, 2008, Chapter 39.
24. ICMR. Nutrient Requirements and Recommended Dietary Allowances for Indians. A Report of the Expert Group of the Indian Council of Medical Research. National Institute of Nutrition: Hyderabad, 2009.
25. Zimmermann MB, Biebinger R, Rohner F, Dib A, Zeder C, Hurrell RF et al. Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron. Am J Clin Nutr 2006; 84: 580-586. (Pubitemid 44713408)
26. Evans T. Regulation of hematopoiesis by retinoid signaling. Exp Hematol 2005; 33: 1055-1061. (Pubitemid 41225428)
27. Sirivech S, Frieden E, Osaki S. The release of iron from horse spleen ferritin by reduced flavins. Biochem J 1974; 143: 311-315.
28. Powers HJ, Bates CJ, Prentice AM, Lamb WH, Jepson M, Bowman H. The relative effectiveness of iron and iron with riboflavin in correcting a microcytic anaemia in men and children in rural Gambia. Hum Nutr Clin Nutr 1983; 37: 413-425. (Pubitemid 14183953)
29. Decker K, Dotis B, Glatzle D, Hinselmann M. Riboflavin status and anaemia in pregnant women. Nutr Metab 1977; 21 (Suppl 1): 17-19. (Pubitemid 8126665)
30. Samson D, Halliday D, Chanarin I. Reversal of ineffective erythropoiesis in pernicious anaemia following vitamin B12 therapy. Br J Haematol 1977; 35: 217-224. (Pubitemid 8048246)
31. Smith CLM, Marks DB, Marks AD. Marks' essential medical biochemistry. Lippincott Williams & Wilkins: Hagerstwon, MD, 2007.
32. Kumar MV, Rajagopalan S. Multiple micronutrient fortification of salt and its effect on cognition in Chennai school children. Asia Pac J Clin Nutr 2007; 16: 505-511. (Pubitemid 47463629)
33. Manger MS, Mckenzie JE, Winichagoon P, Gray A, Chavasit V, Pongcharoen T et al. A micronutrient-fortified seasoning powder reduces morbidity and improves short-term cognitive function, but has no effect on anthropometric measures in primary school children in northeast Thailand: a randomized controlled trial. Am J Clin Nutr 2008; 87: 1715-1722. (Pubitemid 351872634)
34. Osendarp SJ, Baghurst KI, Bryan J, Calvaresi E, Hughes D, Hussaini M et al. Effect of a 12-mo micronutrient intervention on learning and memory in well-nourished and marginally nourished school-aged children: 2 parallel, randomized, placebo-controlled studies in Australia and Indonesia. Am J Clin Nutr 2007; 86: 1082-1093. (Pubitemid 47538312)
35. Sumithra Muthayya A, Eilander C, Transler T, Thomas HCM, van der Knaap KS et al. Effect of fortification with multiple micronutrients and n-3 fatty acids on growth and cognitive performance in Indian schoolchildren: the CHAMPION (Children's Health and Mental Performance Influenced by Optimal Nutrition) Study. Am J Clin Nutr 2009; 89: 1766-1775.