Diabetes mellitus impacts risk of macrovascular invasion in patients undergoing transplantation for hepatocellular carcinoma

BMC Gastroenterology

Volumn 13, Issue 1, 2013, Pages

  Connolly, Gregory C ^a   Safadjou, Saman ^b   Kashyap, Randeep ^b   Chen, Rui ^b   Orloff, Mark S ^b   Hezel, Aram F ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

Author keywords

Diabetes mellitus; Hepatocellular carcinoma; Vascular invasion

Indexed keywords

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER PROGNOSIS; COHORT ANALYSIS; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; FEMALE; HISTOPATHOLOGY; HUMAN; LIVER CELL CARCINOMA; LIVER TRANSPLANTATION; MACROVASCULAR INVASION; MAJOR CLINICAL STUDY; MALE; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; VASCULAR TUMOR;

AGED; CARCINOMA, HEPATOCELLULAR; COHORT STUDIES; DIABETES COMPLICATIONS; FEMALE; HUMANS; INCIDENCE; LIVER NEOPLASMS; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOVASCULARIZATION, PATHOLOGIC; PROGNOSIS; PROSPECTIVE STUDIES; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 84872160660     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-13-9     Document Type: Article

References (33)

1. Gomaa AI, et al. Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis. World J Gastroenterol 2008, 14(27):4300-4308. 10.3748/wjg.14.4300, 2731180, 18666317.
2. Altekruse SF, McGlynn KA, Reichman ME. Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol 2009, 27(9):1485-1491. 10.1200/JCO.2008.20.7753, 2668555, 19224838.
3. El-Serag HB, et al. The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update.[see comment][erratum appears in Ann Intern Med. 2004 Jan 20;140(2):151][summary for patients in Ann Intern Med. 2003 Nov 18;139(10):I28; PMID: 14623640]. Ann Intern Med 2003, 139(10):817-823.
4. Tanaka Y, et al. Inaugural Article: A comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decades. Proc Natl Acad Sci USA 2002, 99(24):15584-15589. 10.1073/pnas.242608099, 137760, 12438687.
5. El-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 1999, 340(10):745-750. 10.1056/NEJM199903113401001, 10072408.
6. Hassan MM, et al. Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women: case-control study. Int J Cancer 2008, 123(8):1883-1891. 10.1002/ijc.23730, 2673571, 18688864.
7. Page JM, Harrison SA. NASH and HCC. Clin Liver Dis 2009, 13(4):631-647. 10.1016/j.cld.2009.07.007, 19818310.
8. Werner M, et al. Hepatic and extrahepatic malignancies in autoimmune hepatitis. A long-term follow-up in 473 Swedish patients. J Hepatol 2009, 50(2):388-393. 10.1016/j.jhep.2008.08.022, 19070390.
9. Ohki T, et al. Visceral fat accumulation is an independent risk factor for hepatocellular carcinoma recurrence after curative treatment in patients with suspected NASH. Gut 2009, 58(6):839-844. 10.1136/gut.2008.164053, 19174415.
10. Wu HC, et al. Aflatoxin B1 exposure, hepatitis B virus infection, and hepatocellular carcinoma in Taiwan. Cancer Epidemiol Biomarkers Prev 2009, 18(3):846-853. 10.1158/1055-9965.EPI-08-0697, 3535829, 19273485.
11. Adami HO, et al. Excess risk of primary liver cancer in patients with diabetes mellitus.[see comment]. J Natl Cancer Inst 1996, 88(20):1472-1477. 10.1093/jnci/88.20.1472, 8841022.
12. Lai MS, et al. Type 2 diabetes and hepatocellular carcinoma: A cohort study in high prevalence area of hepatitis virus infection.[see comment]. Hepatology 2006, 43(6):1295-1302. 10.1002/hep.21208, 16729295.
13. Wideroff L, et al. Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark. J Natl Cancer Inst 1997, 89(18):1360-1365. 10.1093/jnci/89.18.1360, 9308706.
14. Davila JA, et al. Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study. Gut 2005, 54(4):533-539. 10.1136/gut.2004.052167, 1774454, 15753540.
15. El-Serag HB, Richardson PA, Everhart JE. The role of diabetes in hepatocellular carcinoma: a case-control study among United States Veterans. Am J Gastroenterol 2001, 96(8):2462-2467. 10.1111/j.1572-0241.2001.04054.x, 11513191.
16. Lagiou P, et al. Role of diabetes mellitus in the etiology of hepatocellular carcinoma. J Natl Cancer Inst 2000, 92(13):1096-1099. 10.1093/jnci/92.13.1096, 10880555.
17. Huo TI, et al. Differential mechanism and prognostic impact of diabetes mellitus on patients with hepatocellular carcinoma undergoing surgical and nonsurgical treatment.[see comment]. Am J Gastroenterol 2004, 99(8):1479-1487. 10.1111/j.1572-0241.2004.30024.x, 15307864.
18. Ikeda Y, et al. Prognosis of hepatocellular carcinoma with diabetes mellitus after hepatic resection. Hepatology 1998, 27(6):1567-1571. 10.1002/hep.510270615, 9620328.
19. Komura T, et al. Impact of diabetes on recurrence of hepatocellular carcinoma after surgical treatment in patients with viral hepatitis. Am J Gastroenterol 2007, 102(9):1939-1946. 10.1111/j.1572-0241.2007.01354.x, 17573788.
20. Toyoda H, et al. Impact of diabetes mellitus on the prognosis of patients with hepatocellular carcinoma. Cancer 2001, 91(5):957-963. 10.1002/1097-0142(20010301)91:5<957::AID-CNCR1085>3.0.CO;2-J, 11251947.
21. Chan EY, et al. Identifying risk for recurrent hepatocellular carcinoma after liver transplantation: implications for surveillance studies and new adjuvant therapies. Liver Transpl 2008, 14(7):956-965. 10.1002/lt.21449, 18581511.
22. Shah SA, et al. Does microvascular invasion affect outcomes after liver transplantation for HCC? A histopathological analysis of 155 consecutive explants. J Gastrointest Surg 2007, 11(4):464-471. 10.1007/s11605-006-0033-7, 1852377, 17436131.
23. Jonas S, et al. Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis. Hepatology 2001, 33(5):1080-1086. 10.1053/jhep.2001.23561, 11343235.
24. Hao K, et al. Predicting prognosis in hepatocellular carcinoma after curative surgery with common clinicopathologic parameters. BMC Cancer 2009, 9:389. 10.1186/1471-2407-9-389, 2785835, 19886989.
25. Imamura H, et al. Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy. J Hepatol 2003, 38(2):200-207. 10.1016/S0168-8278(02)00360-4, 12547409.
26. Siddiqui AA, et al. Elevated HbA1c is an independent predictor of aggressive clinical behavior in patients with colorectal cancer: a case-control study. Dig Dis Sci 2008, 53(9):2486-2494. 10.1007/s10620-008-0264-4, 18409001.
27. Wolf I, et al. Association between diabetes mellitus and adverse characteristics of breast cancer at presentation. Eur J Cancer 2006, 42(8):1077-1082. 10.1016/j.ejca.2006.01.027, 16574404.
28. Gillespie EF, et al. Obesity and angiolymphatic invasion in primary breast cancer. Ann Surg Oncol 2010, 17(3):752-759. 10.1245/s10434-009-0797-6, 19898898.
29. Vaulont S, Vasseur-Cognet M, Kahn A. Glucose regulation of gene transcription. J Biol Chem 2000, 275(41):31555-31558.
30. Donadon V, et al. Association between hepatocellular carcinoma and type 2 diabetes mellitus in Italy: potential role of insulin. World J Gastroenterol 2008, 14(37):5695-5700. 10.3748/wjg.14.5695, 2748204, 18837086.
31. Desbois-Mouthon C, et al. Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma. Clin Cancer Res 2009, 15(17):5445-5456. 10.1158/1078-0432.CCR-08-2980, 19706799.
32. Chen YW, Boyartchuk V, Lewis BC. Differential roles of insulin-like growth factor receptor- and insulin receptor-mediated signaling in the phenotypes of hepatocellular carcinoma cells. Neoplasia (New York) 2009, 11(9):835-845.
33. Garcia-Compean D, et al. Liver cirrhosis and diabetes: risk factors, pathophysiology, clinical implications and management. World J Gastroenterol 2009, 15(3):280-288. 10.3748/wjg.15.280, 2653324, 19140227.