Cost-effectiveness of early intervention in first-episode psychosis: Economic evaluation of a randomised controlled trial (the OPUS study)

British Journal of Psychiatry

Volumn 202, Issue 1, 2013, Pages 35-41

  Hastrup, Lene Halling ^a   Kronborg, Christian ^b   Bertelsen, Mette ^c   Jeppesen, Pia ^c   Jorgensen, Per ^d   Petersen, Lone ^c   Thorup, Anne ^c   Simonsen, Erik ^a   Nordentoft, Merete ^c  

^a Region Zealand   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d Central Region of Denmark ^*  (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; ASSERTIVE COMMUNITY TREATMENT; BOOTSTRAPPING; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; EARLY INTERVENTION; ECONOMIC EVALUATION; FOLLOW UP; GLOBAL ASSESSMENT OF FUNCTIONING SCORE; GROUP THERAPY; HEALTH CARE COST; HEALTH ECONOMICS; HUMAN; INTERMETHOD COMPARISON; ORGANIZATION AND MANAGEMENT; PROBABILITY; PSYCHOEDUCATION; PSYCHOSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); SCORING SYSTEM; SOCIAL ADAPTATION;

ADOLESCENT; ADULT; ANTIPSYCHOTIC AGENTS; COMMUNITY MENTAL HEALTH SERVICES; COST-BENEFIT ANALYSIS; DENMARK; DIAGNOSIS-RELATED GROUPS; EARLY MEDICAL INTERVENTION; FAMILY THERAPY; HEALTH CARE COSTS; HEALTH SERVICES; HUMANS; INTENTION TO TREAT ANALYSIS; MIDDLE AGED; OUTCOME AND PROCESS ASSESSMENT (HEALTH CARE); PATIENT CARE TEAM; PATIENT EDUCATION AS TOPIC; PSYCHOTIC DISORDERS; SCHIZOPHRENIA; SINGLE-BLIND METHOD; SOCIALIZATION; YOUNG ADULT;

EID: 84872146539     PISSN: 00071250     EISSN: 14721465     Source Type: Journal    
DOI: 10.1192/bjp.bp.112.112300     Document Type: Article

References (35)

1. World Health Organization. Impact of Disorders. World Health Organization, 2001.
2. Melau M, Jeppesen P, Thorup A, Bertelsen M, Petersen L, Gluud C, et al. The effect of five years versus two years of specialised assertive intervention for first episode psychosis - OPUS II: study protocol for a randomized controlled trial. Trials 2011; 12: 72.
3. Birchwood M, Todd P, Jackson C. Early intervention in psychosis. The critical period hypothesis. Br J Psychiatry 1998; 172 (suppl 33): 53-9.
4. Jeppesen P, Petersen L, Thorup A, Abel MB, Ohlenschlaeger J, Christensen TO, et al. The association between pre-morbid adjustment, duration of untreated psychosis and outcome in first-episode psychosis. Psychol Med 2008; 38: 1157-66.
5. Marshall M, Lewis S, Lockwood A, Drake R, Jones P, Croudace T. Association between duration of untreated psychosis and outcome in cohorts of firstepisode patients: a systematic review. Arch Gen Psychiatry 2005; 62: 975-83.
6. McGorry P, Johanessen JO, Lewis S, Birchwood M, Malla A, Nordentoft M, et al. Early intervention in psychosis: keeping faith with evidence-based health care. Psychol Med 2010; 40: 399-404.
7. Bertelsen M, Jeppesen P, Petersen L, Thorup A, Øhlenschlaeger J, le Quach P, et al. Five-year follow-up of a randomized multicenter trial of intensive early intervention vs standard treatment for patients with a first episode of psychotic illness: the OPUS trial. Arch Gen Psychiatry 2008; 65: 762-71.
8. Craig TK, Garety P, Power P, Rahaman N, Colbert S, Fornells-Ambrojo M, et al. The Lambeth Early Onset (LEO) team: randomised controlled trial of the effectiveness of specialised care for early psychosis. BMJ 2004; 329: 1067.
9. Petersen L, Jeppesen P, Thorup A, Abel MB, Ohlenschlaeger J, Christensen TO, et al. A randomised multicentre trial of integrated versus standard treatment for patients with a first episode of psychotic illness. BMJ 2005; 331: 602.
10. Cullberg J, Mattsson M, Levander S, Holmqvist R, Tomsmark L, Elingfors C, et al. Treatment costs and clinical outcome for first episode schizophrenia patients: a 3-year follow-up of the Swedish ''Parachute Project'' and two comparison groups. Acta Psychiatr Scand 2006; 114: 274-81.
11. Goldberg K, Norman R, Hoch JS, Schmitz N, Windell D, Brown N, et al. Impact of a specialized early intervention service for psychotic disorders on patient characteristics, service use, and hospital costs in a defined catchment area. Can J Psychiatry 2006; 51: 895-903.
12. McCrone P, Craig TKJ, Power P, Garety PA. Cost-effectiveness of an early intervention service for people with psychosis. Br J Psychiatry 2010; 196: 377-82.
13. Mihalopoulos C, McGorry PD, Carter RC. Is phase-specific, communityoriented treatment of early psychosis an economically viable method of improving outcome? Acta Psychiatr Scand 1999; 100: 47-55.
14. Mihalopoulos C, Harris M, Henry L, Harrigan S, McGorry P. Is early intervention in psychosis cost-effective over the long term? Schizophr Bull 2009; 35: 909-18.
15. Malla A, Pelosi AJ. Is treating patients with first-episode psychosis cost-effective? Can J Psychiatry 2010; 55: 3-7.
16. World Health Organization. The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. WHO, 1992.
17. Jorgensen P, Nordentoft M, Abel MB, Gouliaev G, Jeppesen P, Kassow P. Early detection and assertive community treatment of young psychotics: the Opus Study Rationale and design of the trial. Soc Psychiatry Psychiatr Epidemiol 2000; 35 : 283-7.
18. Petersen L, Nordentoft M, Jeppesen P, Øhlenschaeger J, Thorup A, Christensen TO, et al. Improving 1-year outcome in first-episode psychosis: OPUS trial. Br J Psychiatry 2005; 187 (suppl 48): s98-103.
19. Stein LI, Test MA. Alternative to mental hospital treatment. I. Conceptual model, treatment program, and clinical evaluation. Arch Gen Psychiatry 1980; 37 : 392-7.
20. McFarlane WR, Lukens E, Link B, Dushay R, Deakins SA, Newmark M, et al. Multiple-family groups and psychoeducation in the treatment of schizophrenia. Arch Gen Psychiatry 1995; 52: 679-87.
21. McFarlane WR. Multifamily Groups in the Treatment of Severe Psychiatric Disorders. Guilford Press, 2002.
22. Liberman RP, Wallace CJ, Blackwell G, Kopelowicz A, Vaccaro JV, Mintz J. Skills training versus psychosocial occupational therapy for persons with persistent schizophrenia. Am J Psychiatry 1998; 155: 1087-91.
23. Glick H, Doshi JA, Sonnad SS, Polsky D. Economic Evaluation in Clinical Trials. New York: Oxford University Press, 2007.
24. Fenwick E, Byford S. A guide to cost-effectiveness acceptability curves. Br J Psychiatry 2005; 187: 106-8.
25. Mors O, Perto GP, Mortensen PB. The Danish Psychiatric Central Research Register. Scand J Public Health 2011; 39 (suppl 7): 54-7.
26. National Board of Health. Takstsystem 2009 (Hospital charges 2009). Sundhedsstyrelsen, 2011.
27. The National Health Insurance Service. Sygesikringens Administrative Vejledning - Takster (The National Health Insurance Service - Charges). Den Offentlige Sygesikring. Danske Regioner (Danish Regions), 2009.
28. Kildemoes HW, Sørensen HT, Hallas J. The Danish National Prescription Register. Scand J Public Health 2011; 39: 38-41.
29. Drummond MF, Sculpher MJ, Torrance GW, O'Brien BJ, Stoddart GL. Methods for the Economic Evaluation of Health Care Programmes (3rd edn). Oxford University Press, 2005.
30. Gafoor R, Nitsch D, McCrone P, Craig TKJ, Garety PA, Power P, et al. Effect of early intervention on 5-year outcome in non-affective psychosis. Br J Psychiatry 2010; 196: 372-6.
31. Andersen TF, Madsen M, Jorgensen J, Mellemkjoer L, Olsen JH. The Danish National Hospital Register. A valuable source of data for modern health sciences. Dan Med Bull 1999; 46: 263-8.
32. Munk-Jorgensen P, Mortensen PB. The Danish Psychiatric Central Register. Dan Med Bull 1997; 44: 82-4.
33. Olivarius NF, Hollnagel H, Krasnik A, Pedersen PA, Thorsen H. The Danish National Health Service Register. A tool for primary health care research. Dan Med Bull 1997; 44: 449-53.
34. McCrone P. Health economic measures in schizophrenia research. Br J Psychiatry 2007; 191 (suppl 50): s42-5.
35. Awad AG, Voruganti LN. The burden of schizophrenia on caregivers: a review. Pharmacoeconomics 2008; 26: 149-62.