What causes false-negative PET findings for solid-type lung cancer?

Lung Cancer

Volumn 79, Issue 2, 2013, Pages 132-136

  Iwano, Shingo ^a   Ito, Shinji ^a   Tsuchiya, Kenichi ^a   Kato, Katsuhiko ^a   Naganawa, Shinji ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Adenocarcinoma; Computed tomography; FDG PET CT; Fluorodeoxyglucose F18; Lung neoplasms; Non small cell lung cancer; Positron emission tomography; Standard uptake value

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLUCOSE;

ADULT; AGED; ARTICLE; BODY WEIGHT; CANCER CLASSIFICATION; CANCER LOCALIZATION; CANCER SIZE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; FEMALE; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; LARGE CELL CARCINOMA; LUNG ADENOCARCINOMA; LUNG ADENOSQUAMOUS CARCINOMA; LUNG ALVEOLUS CELL CARCINOMA; LUNG CANCER; LUNG LARGE CELL CANCER; LUNG SMALL CELL CANCER; LUNG SQUAMOUS CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; POSITRON EMISSION TOMOGRAPHY; PREDICTOR VARIABLE; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; RETROSPECTIVE STUDY;

ADULT; AGED; AGED, 80 AND OVER; AREA UNDER CURVE; BLOOD GLUCOSE; BODY WEIGHT; FALSE NEGATIVE REACTIONS; FEMALE; FLUORODEOXYGLUCOSE F18; HUMANS; LOGISTIC MODELS; LUNG NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RETROSPECTIVE STUDIES; ROC CURVE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84872143429     PISSN: 01695002     EISSN: 18728332     Source Type: Journal    
DOI: 10.1016/j.lungcan.2012.10.018     Document Type: Article

References (28)

1. Bryant A.S., Cerfolio R.J. The maximum standardized uptake values on integrated FDG-PET/CT is useful in differentiating benign from malignant pulmonary nodules. Ann Thorac Surg 2006, 82:1016-1020.
2. Huang Y.E., Pu Y.L., Huang Y.J., Chen C.F., Pu Q.H., Konda S.D., et al. The utility of the nonattenuation corrected 18F-FDG PET images in the characterization of solitary pulmonary lesions. Nucl Med Commun 2010, 31:945-951.
3. Khalaf M., Abdel-Nabi H., Baker J., Shao Y., Lamonica D., Gona J. Relation between nodule size and 18F-FDG-PET SUV for malignant and benign pulmonary nodules. J Hematol Oncol 2008, 1:13.
4. Higashi K., Ueda Y., Sakuma T., Seki H., Oguchi M., Taniguchi M., et al. Comparison of [(18)F]FDG PET and (201)Tl SPECT in evaluation of pulmonary nodules. J Nucl Med 2001, 42:1489-1496.
5. Grgic A., Yuksel Y., Groschel A., Schafers H.J., Sybrecht G.W., Kirsch C.M., et al. Risk stratification of solitary pulmonary nodules by means of PET using (18)F-fluorodeoxyglucose and SUV quantification. Eur J Nucl Med Mol Imaging 2010, 37:1087-1094.
6. Cheran S.K., Nielsen N.D., Patz E.F. False-negative findings for primary lung tumors on FDG positron emission tomography: staging and prognostic implications. AJR Am J Roentgenol 2004, 182:1129-1132.
7. Awab A., Hamadani M., Peyton M., Brown B., False-negative PET scan with bronchioloalveolar carcinoma: an important diagnostic caveat. Am J Med Sci 2007, 334:311-313.
8. Higashi K., Ueda Y., Seki H., Yuasa K., Oguchi M., Noguchi T., et al. Fluorine-18-FDG. PET imaging is negative in bronchioloalveolar lung carcinoma. J Nucl Med 1998, 39:1016-1020.
9. Nomori H., Watanabe K., Ohtsuka T., Naruke T., Suemasu K., Uno K. Evaluation of F-18 fluorodeoxyglucose (FDG) PET scanning for pulmonary nodules less than 3cm in diameter, with special reference to the CT images. Lung Cancer 2004, 45:19-27.
10. Shim S.S., Lee K.S., Kim B.T., Choi J.Y., Chung M.J., Lee E.J. Focal parenchymal lung lesions showing a potential of false-positive and false-negative interpretations on integrated PET/CT. AJR Am J Roentgenol 2006, 186:639-648.
11. Nomori H., Ohba Y., Yoshimoto K., Shibata H., Shiraishi K., Mori T. Positron emission tomography in lung cancer. Gen Thorac Cardiovasc Surg 2009, 57:184-191.
12. Hallett W.A., Marsden P.K., Cronin B.F., O'Doherty M.J. Effect of corrections for blood glucose and body size on [18F]FDG PET standardised uptake values in lung cancer. Eur J Nucl Med 2001, 28:919-922.
13. Ding H.J., Shiau Y.C., Wang J.J., Ho S.T., Kao A. The influences of blood glucose and duration of fasting on myocardial glucose uptake of [18F]fluoro-2-deoxy-D-glucose. Nucl Med Commun 2002, 23:961-965.
14. Suzawa N., Ito M., Qiao S., Uchida K., Takao M., Yamada T., et al. Assessment of factors influencing FDG uptake in non-small cell lung cancer on PET/CT by investigating histological differences in expression of glucose transporters 1 and 3 and tumour size. Lung Cancer 2011, 72:191-198.
15. Hatt M., Cheze-le Rest C., van Baardwijk A., Lambin P., Pradier O., Visvikis D. Impact of tumor size and tracer uptake heterogeneity in (18)F-FDG PET and CT non-small cell lung cancer tumor delineation. J Nucl Med 2011, 52:1690-1697.
16. Keyes J.W. SUV: standard uptake or silly useless value?. J Nucl Med 1995, 36:1836-1839.
17. Kawano T., Ohtake E., Inoue T. Deep-inspiration breath-hold PET/CT of lung cancer: maximum standardized uptake value analysis of 108 patients. J Nucl Med 2008, 49:1223-1231.
18. Jang H.J., Lee K.S., Kwon O.J., Rhee C.H., Shim Y.M., Han J. Bronchioloalveolar carcinoma: focal area of ground-glass attenuation at thin-section CT as an early sign. Radiology 1996, 199:485-488.
19. Marom E.M., Sarvis S., Herndon J.E., Patz E.F. T1 lung cancers: sensitivity of diagnosis with fluorodeoxyglucose PET. Radiology 2002, 223:453-459.
20. Alkhawaldeh K., Bural G., Kumar R., Alavi A. Impact of dual-time-point (18)F-FDG PET imaging and partial volume correction in the assessment of solitary pulmonary nodules. Eur J Nucl Med Mol Imaging 2008, 35:246-252.
21. Iwano S., Koike W., Matsuo K., Kitano M., Kawakami K., Okada T., et al. Correlation between dynamic CT findings and pathological prognostic factors of small lung adenocarcinoma. Cancer Imaging 2012, 12:187-193.
22. Murakami S., Saito H., Sakuma Y., Kondo T., Oshita F., Ito H., et al. Prognostic value of preoperative FDG-PET in stage IA lung adenocarcinoma. Eur J Radiol 2012, 81:1891-1895.
23. Sawada E., Nambu A., Motosugi U., Araki T., Kato S., Sato Y., et al. Localized mucinous bronchioloalveolar carcinoma of the lung: thin-section computed tomography and fluorodeoxyglucose positron emission tomography findings. Jpn J Radiol 2010, 28:251-258.
24. Vesselle H., Salskov A., Turcotte E., Wiens L., Schmidt R., Jordan C.D., et al. Relationship between non-small cell lung cancer FDG uptake at PET, tumor histology, and Ki-67 proliferation index. J Thorac Oncol 2008, 3:971-978.
25. Meirelles G.S., Erdi Y.E., Nehmeh S.A., Squire O.D., Larson S.M., Humm J.L., et al. Deep-inspiration breath-hold PET/CT: clinical findings with a new technique for detection and characterization of thoracic lesions. J Nucl Med 2007, 48:712-719.
26. Daouk J., Leloire M., Fin L., Bailly P., Morvan J., El Esper I., et al. Respiratory-gated 18F-FDG PET imaging in lung cancer: effects on sensitivity and specificity. Acta Radiol 2011, 52:651-657.
27. Nehmeh S.A., Erdi Y.E., Ling C.C., Rosenzweig K.E., Schoder H., Larson S.M., et al. Effect of respiratory gating on quantifying PET images of lung cancer. J Nucl Med 2002, 43:876-881.
28. Kawano T., Ohtake E., Inoue T. Deep-inspiration breath-hold PET/CT versus free breathing PET/CT and respiratory gating PET for reference: evaluation in 95 patients with lung cancer. Ann Nucl Med 2011, 25:109-116.