Decrease of the atrial fibrillatory rate, increased organization of the atrial rhythm and termination of atrial fibrillation by AZD7009

Journal of Electrocardiology

Volumn 46, Issue 1, 2013, Pages 29-35

  Aunes Jansson, Maria ^a   Edvardsson, Nils ^b   Stridh, Martin ^c   Sörnmo, Leif ^c   Frison, Lars ^a   Berggren, Anders ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^c LUND UNIVERSITY   (Sweden)

Author keywords

Atrial fibrillation; Atrial fibrillatory rate; Pharmacological conversion

Indexed keywords

AMLODIPINE; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIURETIC AGENT; ENALAPRIL; FUROSEMIDE; HYDROCHLOROTHIAZIDE; INAKALANT; LOSARTAN; METOPROLOL; PLACEBO;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ACTIVITY; DRUG DOSE REGIMEN; DRUG EFFECT; ELECTROCARDIOGRAM; ELECTROGRAPHY; HEART ATRIUM FIBRILLATION; HEART ATRIUM FIBRILLATORY RATE; HEART ELECTROPHYSIOLOGY; HEART RHYTHM; HUMAN; HYPERTENSION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE;

AGED; AGED, 80 AND OVER; ANTI-ARRHYTHMIA AGENTS; ATRIAL FIBRILLATION; ELECTROCARDIOGRAPHY; FEMALE; HEART ATRIA; HEART CONDUCTION SYSTEM; HEART RATE; HUMANS; MALE; MIDDLE AGED; ORGANIC CHEMICALS; PLACEBO EFFECT; SINGLE-BLIND METHOD; TREATMENT OUTCOME;

EID: 84872138059     PISSN: 00220736     EISSN: 15328430     Source Type: Journal    
DOI: 10.1016/j.jelectrocard.2012.09.002     Document Type: Article

References (25)

1. F. Nilsson, M. Stridh, A. Bollmann, and L. Sörnmo Predicting spontaneous termination of atrial fibrillation using the surface ECG Med Eng Phys 28 2006 802
2. T. Sasaki, S. Niwano, and S. Sasaki Long-term follow-up of changes in fibrillation waves in patients with persistent atrial fibrillation Circ J 70 2006 169
3. S. Petrutiu, A.V. Sahakian, and S. Swiryn Abrupt changes in fibrillatory wave characteristics at the termination of paroxysmal atrial fibrillation in humans Europace 9 2007 466
4. A. Fujiki, M. Sakabe, K. Nishida, K. Mizumaki, and H. Inoue Role of fibrillation cycle length in spontaneous and drug-induced termination of human atrial fibrillation Circ J 67 2003 391
5. F. Holmqvist, M. Stridh, J.E.P. Waktare, L. Sörnmo, S.B. Olson, and C.J. Meurling Atrial fibrillatory rate and sinus rhythm maintenance in patients undergoing cardioversion of persistent atrial fibrillation Eur Heart J 27 2006 2201
6. F. Holmqvist, M. Stridh, and J.E.P. Waktare Atrial fibrillation signal organization predicts sinus rhythm maintenance in patients undergoing cardioversion of atrial fibrillation Europace 8 2006 559
7. C.J. Meurling, M.P. Ingemansson, and A. Roijer Attenuation of electrical remodelling in chonical atrial fibrillation following oral treatment with verapamil Europace 1 1999 234
8. C.J. Meurling, A. Roijer, and J.E.P. Waktare Prediction of sinus rhythm maintenance following DC-cardioversion of persistent atrial fibrillation - the role of atrial cycle length BMC Cardiovasc Disord 6 2006 11
9. S. Niwano, T. Sasaki, and S. Kurokawa Predicting the efficacy of antiarrhythmic agents for interrupting persistent atrial fibrillation according to spectral analysis of the fibrillation waves of the surface ECG Circ J 73 2009 1210
10. D. Husser, M. Stridh, L. Sörnmo, P. Platonov, S.B. Olsson, and A. Bollmann Analysis of the surface electrocardiogram for monitoring and predicting antiarrhythmic drug effects in atrial fibrillation Cardiovasc Drugs Ther 18 2004 377
11. Y. Aoyama, S. Niwano, and H. Niwano Repetitive evaluation of fibrillation cycle length predicts the efficacy of bepridil for interruption of long-lasting persistent atrial fibrillation Int Heart J 52 2011 353
12. L. Carlsson, D. Cartier, and S. Nattel Characterization of the in vivo and the in vitro electrophysiological effects of the novel antiarrhythmic agent AZD7009 in atrial and ventricular tissue of the dog J Cardiovasc Pharmacol 47 2006 123
13. H.J. Crijns, I.C. Van Gelder, and H. Walfridsson Safe and effective conversion of persistent atrial fibrillation to sinus rhythm by intravenous AZD7009 Heart Rhythm 3 2006 1321
14. J.C. Geller, K. Egstrup, and P. Kułakowski Rapid conversion of persistent atrial fibrillation to sinus rhythm by intravenous AZD7009 J Clin Pharmacol 49 2009 312
15. M. Stridh, L. Sörnmo, C.J. Meurling, and S.B. Olsson Sequential characterization of atrial tachyarrhythmias based on ECG time-frequency analysis IEEE Trans Biomed Eng 51 2004 100
16. M. Stridh, and L. Sörnmo Spatiotemporal QRST cancellation techniques for analysis of atrial fibrillation IEEE Trans Biomed Eng 48 2001 105
17. D. Husser, M. Stridh, and D.S. Cannom Validation and clinical application of time-frequency analysis of atrial fibrillation electrocardiograms J Cardiovasc Electrophysiol 18 2007 41
18. K.T. Konings, C.J. Kirchhof, J.R. Smeets, H.J. Wellens, O.C. Penn, and M.A. Allessie High-density mapping of electrically induced atrial fibrillation in humans Circulation 89 1994 1665
19. M.A. Allessie, K. Konings, C.J.H.J. Kirchhof, and M. Wiffels Electrophysiological mechanisms on perpetuation of atrial fibrillation Am J Cardiol 77 1996 10A
20. D. Husser, M. Stridh, and L. Sörnmo Time-frequency analysis of the surface electrocardiogram for monitoring of antiarrhythmic drug effects in atrial fibrillation Am J Cardiol 95 2005 526
21. L. Löfberg, I. Jacobson, and L. Carlsson Electrophysiological and antiarrhythmic effects of the novel antiarrhythmic agent AZD7009: a comparison with azimilide and AVE0118 in the acutely dilated right atrium of the rabbit in vitro Europace 8 2006 549
22. Y. Yin, D. Dalal, and Z. Liu Prospective randomized study comparing amiodarone vs. amiodarone plus losartan vs. amiodarone plus perindopril for the prevention of atrial fibrillation recurrence in patients with lone paroxysmal atrial fibrillation Eur Heart J 27 2006 1841
23. J.S. Healey, A. Baranchuk, and E. Crystal Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: a meta-Analysis J Am Coll Cardiol 45 2005 1832
24. G. Lee, K. Roberts-Thomson, and A. Madry Relationship among complex signals, short cycle length activity, and dominant frequency in patients with long-lasting persistent AF: a high density epicardial mapping study in humans Heart Rhythm 8 2011 1714
25. N. Edvardsson, H. Walfridsson, and H. Aass Predominant effects on atrial versus ventricular refractoriness in man by the novel antiarrhythmic agent AZD7009 Eur Heart J 26 suppl 1 2005 506