12-Deoxyphorbol 13-palmitate mediated cell growth inhibition, G2-M cell cycle arrest and apoptosis in BGC823 cells

European Journal of Pharmacology

Volumn 700, Issue 1-3, 2013, Pages 13-22

  Xu, Hui Yu ^a,c   Chen, Zhi Wei ^a,c   Li, He ^b   Zhou, Li ^a   Liu, Feng ^a   Lv, You Yong ^b   Liu, Ji Cheng ^a  

^a QIQIHAR MEDICAL UNIVERSITY   (China)

^b PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

^c HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

12 deoxyphorbol 13 palmitate; Cell cycle; Cyclin B1

Indexed keywords

12 DEOXYPHORBOL 13 PALMITATE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CHECKPOINT KINASE 1; CYCLIN A; CYCLIN B; CYCLIN B1; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN 5; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

AGAR MEDIUM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; EUPHORBIA; EUPHORBIA FISCHERIANA; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; M PHASE CELL CYCLE CHECKPOINT; MOUSE; NONHUMAN; PLANT ROOT; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOLVENT EXTRACTION; STOMACH CANCER; TUMOR CELL; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN B1; ENZYME ACTIVATION; FEMALE; G2 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; MICE; MICE, INBRED BALB C; PALMITATES; PHORBOL ESTERS; REACTIVE OXYGEN SPECIES; STOMACH NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84872127191     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.11.015     Document Type: Article

References (27)

1. M.L. Agarwal, A. Agarwal, W.R. Taylor, and G.R. Stark p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts Cell Biology 92 1995 8493 8497
2. J.Holland Andrew, and S.Taylor Stephen Cyclin-B1-mediated inhibition of excess separase is required for timely chromosome disjunction Journal of Cell Science 119 16 2006 3325 3337
3. S.B. Bratton, and G.S. Salvesen Regulation of the Apaf-1-caspase-9 apoptosome J Cell Sci. 123 2010 3209 3214
4. A.S. Clarke, M.M. Lotz, C. Chao, and A.M. Mercurio Activation of the p21 pathway of growth arrest and apoptosis by the integrin cytoplasmic domain J. Biol. Chem. 270 1995 22673 22676
5. A. Claudia, Benavente, L. Elaine, and Jacobson Niacin restriction upregulates NADPH oxidase and ROS in human Keratinocytes Free Radic Biol Med. 44 4 2008 527 537 (Pubitemid 351172713)
6. M. Glotzer, A.W. Murray, and M.W. Kirschner Cyclin is degraded by the ubiquitin pathway Nature (Lond) 349 1991 132 138 (Pubitemid 21912025)
7. Tang. Jiabin, L. Raymond, Erikson, and Liu. Xiaoqi Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1) PNAS 103 2006 11964 11969 (Pubitemid 44215794)
8. Yuan. Juping, Ruilan Yan, and Kramer. Andrea CyclinB1 depletion inhibits proliferation and induces apoptosis in human tumor cells Oncogene 23 2004 5843 5852 (Pubitemid 39093030)
9. Y. Kajiwara, S. Panchabhai, and V.A. Levin A new preclinical 3-dimensional agarose colony formation assay Technol Cancer Res Treat. 7 2008 329 334
10. Y. Lin, H. Cui, H. Xu, L. Yue, H. Xu, L. Jiang, and J. Liu Jolkinolide B induces apoptosis in MDA-MB-231 cells through inhibition of the PI3K/Akt signaling pathway Oncology Reports. 27 2012 1976 1980
11. A. Lourdes, Alicia de las Pozas Gomez, and Reiner Teresita Increased expression of cyclinB1 sensitizes prostate cancer cells to apoptosis induced by chemotherapy Mol Cancer Ther. 6 5 2007 1534 1542
12. S.C. Luk, S.W. Siu, C.K. Lai, Y.J. Wu, and S.F. Pang Cell Cycle Arrest by a Natural Product via G2/M Checkpoit Int. J. Sci 2 2 2005 64 69 (Pubitemid 40944955)
13. H. Luo, and A. Wang Induction of apoptosis in K562 cells by jolkinolide B Can J Physiol Pharmacol 84 2006 959 965
14. Y. Luo, S.K. Rockow-Magnone, P.E. Kroeger, L. Frost, Z. Chen, E.K. Han, S.C. Ng, R.L. Simmer, and V.L. Giranda Blocking Chk1 expression induces apoptosis and abrogates the G2 checkpoint mechanism Neoplasia 3 2001 411 419 (Pubitemid 32988811)
15. Ganzinelli. Monica, Carrassa. Laura, and Crippa. Francesca Check point Kinase 1 Down-Regulation by an Inducible Small Interfering RNA Expression System Sensitized In vivo Tumors to Treatment with 5-Fluorouracilv Clin Cancer Res 14 16 2008 5131 5141
16. R. Ofir, R. Seidman, T. Rabinski, M. Krup, V. Yavelsky, Y. Weinstein, and M. Wolfson Taxol-induced apoptosis in human SKOV3 ovarian and MCF7 breast carcinoma cells is caspase-3 and caspase-9 Independent Cell Death and Differentiation 9 2002 636 642 (Pubitemid 34618869)
17. M. Ogura, K. Koike, G.A. Cordell, and N.R. Farnsworth Potential anticancer agents VIII. Constituents of Baliospermum montanum (Euphorbiaceae) Planta Medica. 33 1978 128 143 (Pubitemid 8294547)
18. M. Pagano, S.W. Tam, A.M. Theodoras, P. Beer-Romero, G. Del Sal, V. Chau, P.R. Yew, G.F. Draeta, and M. Rolfe Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclindependent kinase inhibitor p27 Science (Washington DC) 269 682-685 1995
19. Huang. Qian, Li. Fang, and Liu. Xinjian Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy Nature Medicine 17 2011 860 866
20. J.C. Spronck, J.L. Nickerson, and J.B. Kirkland Niacin Deficiency Alters p53 Expression and Impairs Etoposide-Induced Cell Cycle Arrest and Apoptosis in Rat Bone Marrow Cells Nutr Cancer 57 2007 88 99 (Pubitemid 46871573)
21. A. Suzuki, Y. Tsutomi, K. Akahane, and T. Araki Resistance to Fas mediated apoptosis: activation of caspase 3 is regulated by cell cycle regulator p21 WAF1 and IAP gene family ILP Oncogene 17 1998 931 939 (Pubitemid 28425403)
22. W.C. Tsai, Y.K. Rao, S.S. Lin, M.Y. Chou, Y.T. Shen, C.H. Wu, M. Geethangili, C.C. Yang, and Y.M. Tzeng Methylantcinate A induces tumor specific growth inhibition in oral cancer cells via Bax-mediated mitochondrial apoptotic pathway Bioorg Med Chem Lett. 20 2010 6145 6148
23. W.R. Taylor, and G.R. Stark Regulation of the G2/M transition by p53 Oncogene 20 2001 1803 1815 (Pubitemid 32458690)
24. N. Walworth, S. Davey, and D. Beach Fission yeast Chk1 protein kinase links the rad checkpoint pathway to cdc2 Nature 363 1993 368 371 (Pubitemid 23161536)
25. H.B. Wang, W.J. Chu, Y. Wang, P. Ji, Y.B. Wang, Q. Yu, and G.W. Qin Diterpenoids from the roots of Euphorbia fischeriana J Asian Nat Prod Res. 12 2010 1038 1043
26. Y. Wang, X. Ma, S. Yan, S. Shen, H. Zhu, Y. Gu, H. Wang, G. Qin, and Q. Yu 17-Hydroxy-jolkinolide B Inhibits Signal Transducers and Activators of Transcription 3Signaling by Covalently Cross-Linking Janus Kinases and Induces Apoptosis of Human Cancer Cells Cancer Res. 69 18 2009 7302 7310
27. S.S. Yan, Y. Li, Y. Wang, S.S. Shen, Y. Gu, H.B. Wang, G.W. Qin, and Q. Yu 17-Acetoxyjolkinolide B irreversibly inhibits IKB kinase and induces apoptosis of tumor cells Mol Cancer Ther. 7 6 2008 1523 1533