Do inhaled steroids reduce bone mineral density and increase fracture risk?

Journal of Family Practice

Volumn 61, Issue 8, 2012, Pages

  Wheelock, Chris ^a   Glass, Justin ^b   St Anna, Leilani ^c  

^a Southwest Washington Family Practice   (United States)

^b Family Medicine Residency of Idaho ^*  (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BECLOMETASONE; BUDESONIDE; FLUTICASONE; PLACEBO; STEROID; TRIAMCINOLONE; CORTICOSTEROID;

ARTICLE; ASTHMA; BONE DENSITY; CASE CONTROL STUDY; CHRONIC OBSTRUCTIVE LUNG DISEASE; COHORT ANALYSIS; COMPARATIVE STUDY; FOLLOW UP; HUMAN; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK FACTOR; SPINE FRACTURE; STEROID THERAPY; ADULT; AGED; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG EFFECT; EVIDENCE BASED MEDICINE; FEMALE; INCIDENCE; INHALATIONAL DRUG ADMINISTRATION; MALE; MIDDLE AGED; PATHOLOGIC FRACTURE; PATIENT SAFETY; REVIEW; RISK ASSESSMENT;

ADMINISTRATION, INHALATION; ADRENAL CORTEX HORMONES; ADULT; AGED; AGED, 80 AND OVER; ASTHMA; BONE DENSITY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; EVIDENCE-BASED MEDICINE; FEMALE; FRACTURES, SPONTANEOUS; HUMANS; INCIDENCE; MALE; MIDDLE AGED; PATIENT SAFETY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK ASSESSMENT;

EID: 84872114672     PISSN: 00943509     EISSN: 15337294     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Jones A, Fay JK, Burr M, et al. Inhaled corticosteroid effects on bone metabolism in asthma and mild chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2008;(4):CD003537.
2. Gonelli S, Caffarelli C, Maggi S, et al. Effect of inhaled glucocorticoids and beta(2) agonists on vertebral fracture risk in COPD patients: the EOLO study. Calcif Tissue Int. 2010;87:137-143.
3. Drummond MB, Dasenbrook EC, Pitz MW, et al. Inhaled corticosteroids in patients with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis. JAMA. 2008;300:2407-2416.
4. Etminan M, Sadatsafavi M, Ganjizadeh Zavareh S, et al. Inhaled corticosteroids and the risk of fractures in older adults: a systematic review and meta-analysis. Drug Saf. 2008;31:409-414. (Pubitemid 351563733)
5. Weatherall M, James K, Clay J, et al. Dose-response relationship for risk of nonvertebral fracture with inhaled corticosteroids. Clin Exp Allergy. 2008;38:1451-1458.
6. National Heart Lung and Blood Institute. Expert Panel Report 3 (EPR3): guidelines for the diagnosis and management of asthma. Available at: www.nhlbi.nih.gov/guidelines/asthma/asthgdln.htm. Accessed February 25, 2012.