An association between uric acid levels and renal arteriolopathy in chronic kidney disease: A biopsy-based study

Hypertension Research

Volumn 36, Issue 1, 2013, Pages 43-49

  Kohagura, Kentaro ^a   Kochi, Masako ^a   Miyagi, Tsuyoshi ^a   Kinjyo, Takanori ^a   Maehara, Yuichi ^a   Nagahama, Kazufumi ^a   Sakima, Atsushi ^a   Iseki, Kunitoshi ^b   Ohya, Yusuke ^a  

^a UNIVERSITY OF THE RYUKYUS SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

chronic kidney disease; renal arteriolopathy; uric acid

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; DIURETIC AGENT; URIC ACID;

ADULT; ARTICLE; CHRONIC KIDNEY DISEASE; DIABETES MELLITUS; FEMALE; GLOMERULUS FILTRATION RATE; HIGH RISK PATIENT; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYALINE DEGENERATION; HYPERTENSION; HYPERURICEMIA; KIDNEY BIOPSY; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; RENAL ARTERIOLOPATHY; URIC ACID BLOOD LEVEL;

ADULT; ARTERIOLES; BIOPSY; CROSS-SECTIONAL STUDIES; FEMALE; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; HYPERURICEMIA; MALE; MIDDLE AGED; ODDS RATIO; PREVALENCE; RENAL ARTERY OBSTRUCTION; RENAL CIRCULATION; RENAL INSUFFICIENCY, CHRONIC; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SEX DISTRIBUTION; URIC ACID; YOUNG ADULT;

EID: 84872094694     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1038/hr.2012.135     Document Type: Article

References (21)

1. Kang DH, Nakagawa T, Feng L, Watanabe S, Han L, Mazzali M, Truong L, Harris R, Johnson RJ. A role for uric acid in the progression of renal disease. J Am Soc Nephrol 2002; 13: 2888-2897.
2. Iseki K, Ikemiya Y, Inoue T, Iseki C, Kinjo K, Takishita S. Significance of hyperuricemia as a risk factor for developing esrd in a screened cohort. Am J Kidney Dis 2004; 44: 642-650.
3. Iseki K, Oshiro S, Tozawa M, Iseki C, Ikemiya Y, Takishita S. Significance of hyperuricemia on the early detection of renal failure in a cohort of screened subjects. Hypertens Res 2001; 24: 691-697.
4. Bo S, Cavallo-Perin P, Gentile L, Repetti E, Pagano G. Hypouricemia and hyperuricemia in type 2 diabetes: two different phenotypes. Eur J Clin Invest 2001; 31: 318-321.
5. Ohno I, Hosoya T, Gomi H, Ichida K, Okabe H, Hikita M. Serum uric acid and renal prognosis in patients with iga nephropathy. Nephron 2001; 87: 333-339.
6. Mazzali M, Kanellis J, Han L, Feng L, Xia YY, Chen Q, Kang DH, Gordon KL, Watanabe S, Nakagawa T, Lan HY, Johnson RJ. Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. Am J Physiol Renal Physiol 2002; 282: F991-F997.
7. Hill GS, Heudes D, Bariéty J. Morphometric study of arterioles and glomeruli in the aging kidney suggests focal loss of autoregulation. Kidney Int 2003; 63: 1027-1036.
8. Hill GS, Heudes D, Jacquot C, Gauthier E, Bariéty J. Morphometric evidence for impairment of renal autoregulation in advanced essential hypertension. Kidney Int 2006; 69: 823-831.
9. Sánchez-Lozada LG, Tapia E, Avila-Casado C, Soto V, Franco M, Santamaŕa J, Nakagawa T, Rodŕguez-Iturbe B, Johnson RJ, Herrera-Acosta J. Mild hyperuricemia induces glomerular hypertension in normal rats. Am J Physiol Renal Physiol 2002; 283: F1105-F1110.
10. Kubo M, Kiyohara Y, Kato I, Tanizaki Y, Katafuchi R, Hirakata H, Okuda S, Tsuneyoshi M, Sueishi K, Fujishima M, Iida M. Risk factors for renal glomerular and vascular changes in an autopsy-based population survey: The Hisayama study. Kidney Int 2003; 63: 1508-1515.
11. Bader H, Meyer DS. The size of the juxtaglomerular apparatus in diabetic glomerulosclerosis and its correlation with arteriolosclerosis and arterial hypertension: a morphometric light microscopic study on human renal biopsies. Clin Nephrol 1977; 8: 308-311.
12. Lhotta K, Rumpelt HJ, König P, Mayer G, Kronenberg F. Cigarette smoking and vascular pathology in renal biopsies. Kidney Int 2002; 61: 648-654.
13. Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, Yamagata K, Tomino Y, Yokoyama H, Hishida A, GFR CdtJefe. Revised equations for estimated GFR from serum creatinine in japan. Am J Kidney Dis 2009; 53: 982-992.
14. Wu J, Chen X, Xie Y, Yamanaka N, Shi S, Wu D, Liu S, Cai G. Characteristics and risk factors of intrarenal arterial lesions in patients with iga nephropathy. Nephrol Dial Transplant 2005; 20: 719-727.
15. Kang DH, Park SK, Lee IK, Johnson RJ. Uric acid-induced c-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol 2005; 16: 3553-3562.
16. Khosla UM, Zharikov S, Finch JL, Nakagawa T, Roncal C, Mu W, Krotova K, Block ER, Prabhakar S, Johnson RJ. Hyperuricemia induces endothelial dysfunction. Kidney Int 2005; 67: 1739-1742.
17. Mazzali M, Kim YG, Suga S, Gordon KL, Kang DH, Jefferson JA, Hughes J, Kivlighn SD, Lan HY, Johnson RJ. Hyperuricemia exacerbates chronic cyclosporine nephropathy. Transplantation 2001; 71: 900-905.
18. Christensen PK, Hommel EE, Clausen P, Feldt-Rasmussen B, Parving HH. Impaired autoregulation of the glomerular filtration rate in patients with nondiabetic nephropathies. Kidney Int 1999; 56: 1517-1523.
19. Christensen PK, Hansen HP, Parving HH. Impaired autoregulation of GFR in hypertensive non-insulin dependent diabetic patients. Kidney Int 1997; 52: 1369-1374.
20. Miao Y, Ottenbros SA, Laverman GD, Brenner BM, Cooper ME, Parving HH, Grobbee DE, Shahinfar S, de Zeeuw D. Lambers Heerspink HJ. Effect of a reduction in uric acid on renal outcomes during losartan treatment: a post hoc analysis of the reduction of endpoints in non-insulin-dependent diabetes mellitus with the angiotensin II antagonist losartan trial. Hypertension 2011; 58: 2-7.
21. Ficociello LH, Rosolowsky ET, Niewczas MA, Maselli NJ, Weinberg JM, Aschengrau A, Eckfeldt JH, Stanton RC, Galecki AT, Doria A, Warram JH, Krolewski AS. High-normal serum uric acid increases risk of early progressive renal function loss in type 1 diabetes: results of a 6-year follow-up. Diabetes Care 2010; 33: 1337-1343.