Teriparatide, a nonsurgical solution for femoral nonunion? A report of three cases

Osteoporosis International

Volumn 23, Issue 12, 2012, Pages 2897-2900

  Lee, Y K ^a   Ha, Y C ^b   Koo, K H ^a  

^a Seoul National University Bundang Hospital   (South Korea)

^b Chung Ang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

PARATHYROID HORMONE[1-34];

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; CASE REPORT; FEMALE; FEMORAL NONUNION; FEMUR FRACTURE; HUMAN; INTRAMEDULLARY NAILING; MALE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PSEUDARTHROSIS; REOPERATION; TREATMENT DURATION;

ADULT; BONE DENSITY CONSERVATION AGENTS; FEMALE; FEMORAL FRACTURES; FEMORAL NECK FRACTURES; FRACTURES, UNUNITED; HUMANS; MALE; MIDDLE AGED; TERIPARATIDE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84872081929     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-012-2172-x     Document Type: Article

References (24)

1. Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster JY, Hodsman AB, Eriksen EF, Ish-Shalom S, Genant HK, Wang O, Mitlak BH (2001) Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med 344:1434-1441 (Pubitemid 32402100)
2. Jiang Y, Zhao JJ, Mitlak BH, Wang O, Genant HK, Eriksen EF (2003) Recombinant human parathyroid hormone (1-34) [teriparatide] improves both cortical and cancellous bone structure. J Bone Miner Res 18:1932-1941 (Pubitemid 37377441)
3. Zanchetta JR, Bogado CE, Ferretti JL, Wang O, Wilson MG, Sato M, Gaich GA, Dalsky GP, Myers SL (2003) Effects of teriparatide [recombinant human parathyroid hormone (1-34)] on cortical bone in postmenopausal women with osteoporosis. J Bone Miner Res 18:539-543 (Pubitemid 36241071)
4. Rubin MR, Cosman F, Lindsay R, Bilezikian JP (2002) The anabolic effects of parathyroid hormone. Osteoporos Int 13:267-277 (Pubitemid 34506735)
5. Cipriano CA, Issack PS, Shindle L, Werner CM, Helfet DL, Lane JM (2009) Recent advances toward the clinical application of PTH (1-34) in fracture healing. HSS J 5:149-153
6. Daugaard H, Elmengaard B, Andreassen TT, Baas J, Bechtold JE, Soballe K (2011) The combined effect of parathyroid hormone and bone graft on implant fixation. J Bone Joint Surg Br 93:131-139
7. O'Loughlin PF, Cunningham ME, Bukata SV, Tomin E, Poynton AR, Doty SB, Sama AA, Lane JM (2009) Parathyroid hormone (1-34) augments spinal fusion, fusion mass volume, and fusion mass quality in a rabbit spinal fusion model. Spine (Phila Pa 1976) 34:121-130
8. Jacobson JA, Yanoso-Scholl L, Reynolds DG, Dadali T, Bradica G, Bukata S, Puzas EJ, Zuscik MJ, Rosier R, O'Keefe RJ, Schwarz EM, Awad HA (2011) Teriparatide therapy and beta-tricalcium phosphate enhance scaffold reconstruction of mouse femoral defects. Tissue Eng Part A 17:389-398
9. Aspenberg P, Genant HK, Johansson T, Nino AJ, See K, Krohn K, Garcia-Hernandez PA, Recknor CP, Einhorn TA, Dalsky GP, Mitlak BH, Fierlinger A, Lakshmanan MC (2010) Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures. J Bone Miner Res 25:404-414
10. Peichl P, Holzer LA, Maier R, Holzer G (2011) Parathyroid hormone 1-84 accelerates fracture-healing in pubic bones of elderly osteoporotic women. J Bone Joint Surg Am 93:1583-1587
11. Puzas JE, Houck J, Bukata SV (2006) Accelerated fracture healing. J Am Acad Orthop Surg 14:S145-151
12. Knecht TP (2004) Teriparatide and fracture healing in cortical bone. Endocr Pract 10:293
13. Resmini G, Iolascon G (2007) 79-year-old post-menopausal woman with humerus fracture during teriparatide treatment. Aging Clin Exp Res 19:30-31
14. Marsh D (1998) Concepts of fracture union, delayed union, and nonunion. Clin Orthop Relat Res S22-30
15. Pihlajamaki HK, Salminen ST, Bostman OM (2002) The treatment of nonunions following intramedullary nailing of femoral shaft fractures. J Orthop Trauma 16:394-402 (Pubitemid 34785156)
16. Rodriguez-Merchan EC, Gomez-Castresana F (2004) Internal fixation of nonunions. Clin Orthop Relat Res 13-20 (Pubitemid 38269665)
17. Barnes GL, Kakar S, Vora S, Morgan EF, Gerstenfeld LC, Einhorn TA (2008) Stimulation of fracture-healing with systemic intermittent parathyroid hormone treatment. J Bone Joint Surg Am 90(Suppl 1):120-127 (Pubitemid 351329130)
18. Brinker MR, O'Connor DP, Monla YT, Earthman TP (2007) Metabolic and endocrine abnormalities in patients with nonunions. J Orthop Trauma 21:557-570 (Pubitemid 47367964)
19. Mahendra A, Maclean AD (2007) Available biological treatments for complex non-unions. Injury 38(Suppl 4):S7-12 (Pubitemid 351162867)
20. Finkemeier CG (2002) Bone-grafting and bone-graft substitutes. J Bone Joint Surg Am 84-A:454-464 (Pubitemid 37107720)
21. Bishop GB, Einhorn TA (2007) Current and future clinical applications of bone morphogenetic proteins in orthopaedic trauma surgery. Int Orthop 31:721-727 (Pubitemid 350160314)
22. Oteo-Alvaro A, Moreno E (2010) Atrophic humeral shaft nonunion treated with teriparatide (rh PTH 1-34): a case report. J Shoulder Elbow Surg 19:e22-28
23. Rubery PT, Bukata SV (2010) Teriparatide may accelerate healing in delayed unions of type III odontoid fractures: a report of 3 cases. J Spinal Disord Tech 23:151-155
24. Chintamaneni S, Finzel K, Gruber BL (2010) Successful treatment of sternal fracture nonunion with teriparatide. Osteoporos Int 21:1059-1063