The intracellular metabolism of legionella by isotopologue profiling

Methods in Molecular Biology

Volumn 954, Issue , 2013, Pages 163-181

  Heuner, Klaus ^a   Eisenreich, Wolfgang ^b  

^a ROBERT KOCH INSTITUTE   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Isotopologue profiling; Legionella; Mass spectroscopy; Metabolism; NMR spectroscopy

Indexed keywords

LEGIONELLA; LEGIONELLA PNEUMOPHILA;

EID: 84872076379     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-161-5_8     Document Type: Article

References (23)

1. Faulkner G, Garduno RA (2002) Ultrastructural analysis of differentiation in Legionella pneumophila . J Bacteriol 184:7025-7041
2. Garduno RA, Garduno E, Hiltz M, Hoffman PS (2002) Intracellular growth of Legionella pneumophila gives rise to a differentiated form dissimilar to stationary-phase forms. Infect Immun 70:6273-6283
3. Greub G, Raoult D (2003) Morphology of Legionella pneumophila according to their location within Hartmanella vermiformis . Res Microbiol 154:619-621
4. Molofsky AB, Swanson MS (2004) Differentiate to thrive: lessons from the Legionella pneumophila life cycle. Mol Microbiol 53:29-40
5. Eisenreich W, Knispel N, Beck A (2011) Advanced methods for the study of the chemistry and the metabolism of lichens. Phytochemical Rev 10:445-456
6. Eylert E, Schar J, Mertins S, Stoll R, Bacher A, Goebel W, Eisenreich W (2008) Carbon metabolism of Listeria monocytogenes growing inside macrophages. Mol Microbiol 69:1008-1017
7. Eisenreich W, Dandekar T, Heesemann J, Goebel W (2010) Carbon metabolism of intracellular bacterial pathogens and possible links to virulence. Nat Rev Microbiol 8:401-412
8. Götz A, Eylert E, Eisenreich W, Goebel W (2010) Carbon metabolism of enterobacterial human pathogens growing in epithelial colorectal adenocarcinoma (Caco-2) cells. PLoS One 5:e10586
9. Reeves MW, Pine L, Hutner SH, George JR, Harrell WK (1981) Metal requirements of Legionella pneumophila . J Clin Microbiol 13:688-695
10. Ristroph JD, Hedlund KW, Gowda S (1981) Chemically de fi ned medium for Legionella pneumophila growth. J Clin Microbiol 13:115-119
11. Pine L, George JR, Reeves MW, Harrell WK (1979) Development of a chemically de fi ned liquid medium for growth of Legionella pneumophila . J Clin Microbiol 9:615-626
12. Tesh MJ, Morse SA, Miller RD (1983) Intermediary metabolism in Legionella pneumophila: utilization of amino acids and other compounds as energy sources. J Bacteriol 154:1104-1109
13. Hoffman PS (1984) Bacterial physiology. In: Thronsberry C, Balows A, Feeley JC, Jakubowsky W (eds) Proceedings of the 2nd international symposium on legionella, American Society for Microbiology, Washington, DC, pp 61-67
14. Hoffman PS (2008) Microbial physiology. In: Hoffman PS, Klein T, Friedman H (eds) Legionella pneumophila: pathogenesis and immunity. Springer, pp 113-131 2008 Springer Science+Business Media, LLC, New York
15. Sauer JD, Bachman MA, Swanson MS (2005) The phagosomal transporter A couples threonine acquisition to differentiation and replication of Legionella pneumophila in macrophages. Proc Natl Acad Sci USA 102:9924-9929
16. Wieland H, Ullrich S, Lang F, Neumeister B (2005) Intracellular multiplication of Legionella pneumophila depends on host cell amino acid transporter SLC1A5. Mol Microbiol 55: 1528-1537
17. Fonseca MV, Sauer J-D, Swanson MS (2008) Nutrient acquisition and assimilation strategies of Legionella pneumophila . In: Heuner K, Swanson MS (eds) Legionella Y molecular microbiology. Horizon Scienti fi c Press, Norwich, UK, pp 213-226
18. Keen MG, Hoffman MS (1984) Metabolic pathways and nitrogen metabolism in Legionella pneumophila . Curr Microbiol 11:81-88
19. Sexton JA, Vogel JP (2002) Type IVB secretion by intracellular pathogens. Traffic 3:178-185
20. Eylert E, Herrmann V, Jules M, Gillmaier N, Lautner M, Buchrieser C, Eisenreich W, Heuner K (2010) Isotopologue pro fi ling of Legionella pneumophila: role of serine and glucose as carbon substrates. J Biol Chem 285:22232-22243
21. Herrmann V, Eidner A, Rydzewski K, Bladel I, Jules M, Buchrieser C, Eisenreich W, Heuner K (2011) GamA is a eukaryotic-like glucoamylase responsible for glycogen- and starch-degrading activity of Legionella pneumophila . Int J Med Microbiol 301:133-139
22. Harada E, Iida K, Shiota S, Nakayama H, Yoshida S (2010) Glucose metabolism in Legionella pneumophila: dependence on the Entner-Doudoroff pathway and connection with intracellular bacterial growth. J Bacteriol 192:2892-2899
23. Lee WN, Byerley LO, Bergner EA, Edmond J (1991) Mass isotopomer analysis: theoretical and practical considerations. Biol Mass Spectrom 20:451-458