Genetic polymorphisms of FCGR2A encoding Fcγ receptor IIa in a Japanese population and functional analysis of the L273P variant

Immunogenetics

Volumn 64, Issue 12, 2012, Pages 869-877

  Tada, Minoru ^a   Ishii Watabe, Akiko ^a   Maekawa, Keiko ^a   Fukushima Uesaka, Hiromi ^a   Kurose, Kouichi ^a   Suzuki, Takuo ^a   Kaniwa, Nahoko ^a   Sawada, Jun Ichi ^a,f   Kawasaki, Nana ^a   Nakajima, Takako Eguchi ^b,g   Kato, Ken ^b   Yamada, Yasuhide ^b   Shimada, Yasuhiro ^b   Yoshida, Teruhiko ^c   Ura, Takashi ^d   Saito, Miyuki ^d   Muro, Kei ^d   Doi, Toshihiko ^e   Fuse, Nozomu ^e   Yoshino, Takayuki ^e   Ohtsu, Atsushi ^e   Saijo, Nagahiro ^e,h   Okuda, Haruhiro ^a   Hamaguchi, Tetsuya ^b   Saito, Yoshiro ^a   Matsumura, Yasuhiro ^e   more..

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b NATIONAL CANCER CENTER HOSPITAL   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^d AICHI CANCER CENTER HOSPITAL   (Japan)

^e NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

^f PHARMACEUTICALS AND MEDICAL DEVICES AGENCY   (Japan)

^g ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^h KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Fc receptor IIa; FCGR2A gene; Functional evaluation; Genetic polymorphism; Nonsynonymous variation

Indexed keywords

BEVACIZUMAB; FC RECEPTOR IIA; IMMUNOGLOBULIN G;

ARTICLE; COLON CANCER; GENE EXPRESSION; GENE FUNCTION; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; HUMAN CELL; JAPANESE; LEUKEMIA CELL LINE; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; POPULATION RESEARCH; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ASIAN CONTINENTAL ANCESTRY GROUP; CELL LINE; EXONS; HUMANS; JURKAT CELLS; LEUCINE; PHOSPHORYLATION; POLYMORPHISM, GENETIC; PROLINE; RECEPTORS, IGG; SIGNAL TRANSDUCTION; TYROSINE;

EID: 84872072629     PISSN: 00937711     EISSN: 14321211     Source Type: Journal    
DOI: 10.1007/s00251-012-0646-9     Document Type: Article

References (18)

1. Bruhns P, Iannascoli B, England P, Mancardi DA, Fernandez N, Jorieux S, Daeron M (2009) Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses. Blood 113:3716-25
2. Duits AJ, Bootsma H, Derksen RH, Spronk PE, Kater L, Kallenberg CG, Capel PJ, Westerdaal NA, Spierenburg GT, Gmelig-Meyling FH et al (1995) Skewed distribution of IgG Fc receptor IIa (CD32) polymorphism is associated with renal disease in systemic lupus erythematosus patients. Arthritis Rheum 38:1832-6 (Pubitemid 26010285)
3. Haseley LA, Wisnieski JJ, Denburg MR, Michael-Grossman AR, Ginzler EM, Gourley MF, Hoffman JH, Kimberly RP, Salmon JE (1997) Antibodies to C1q in systemic lupus erythematosus: characteristics and relation to Fc gamma RIIA alleles. Kidney Int 52:1375-80 (Pubitemid 27496068)
4. Hogarth PM, Pietersz GA (2012) Fc receptor-targeted therapies for the treatment of inflammation, cancer and beyond. Nat Rev Drug Discov 11:311-31
5. Khor CC, Davila S, Breunis WB, Lee YC, Shimizu C, Wright VJ, Yeung RS, Tan DE, Sim KS, Wang JJ, Wong TY, Pang J, Mitchell P, Cimaz R, Dahdah N, Cheung YF, Huang GY, Yang W, Park IS, Lee JK, Wu JY, Levin M, Burns JC, Burgner D, Kuijpers TW, Hibberd ML (2011) Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nat Genet 43:1241-6
6. Kwiatkowska K, Frey J, Sobota A (2003) Phosphorylation of FcgammaRIIA is required for the receptor-induced actin rearrangement and capping: the role of membrane rafts. J Cell Sci 116:537-50 (Pubitemid 36236121)
7. Lehrnbecher T, Foster CB, Zhu S, Leitman SF, Goldin LR, Huppi K, Chanock SJ (1999) Variant genotypes of the low-affinity Fcgamma receptors in two control populations and a review of low-affinity Fcgamma receptor polymorphisms in control and disease populations. Blood 94:4220-32
8. Nimmerjahn F, Ravetch JV (2008) Fcgamma receptors as regulators of immune responses. Nat Rev Immunol 8:34-47
9. Omar AH, Shibata H, Yasunami M, Yamazaki A, Ofori MF, Akanmori BD, Shuaibu MN, Kikuchi M, Hirayama K (2012) The rs150311303 polymorphism in FcgammaRIIa enhances IgG binding capacity. Scand J Immunol
10. Renedo MA, Fernandez N, Crespo MS (2001) FcgammaRIIA exogenously expressed in HeLa cells activates the mitogen-activated protein kinase cascade by a mechanism dependent on the endogenous expression of the protein tyrosine kinase Syk. Eur J Immunol 31:1361-9 (Pubitemid 32457785)
11. Rollet-Labelle E, Marois S, Barbeau K, Malawista SE, Naccache PH (2004) Recruitment of the cross-linked opsonic receptor CD32A (FcgammaRIIA) to high-density detergent-resistant membrane domains in human neutrophils. Biochem J 381:919-28 (Pubitemid 39120504)
12. Saci A, Pain S, Rendu F, Bachelot-Loza C (1999) Fc receptor-mediated platelet activation is dependent on phosphatidylinositol 3-kinase activation and involves p120 (Cbl). J Biol Chem 274:1898-904
13. Salmon JE, Millard S, Schachter LA, Arnett FC, Ginzler EM, Gourley MF, Ramsey-Goldman R, Peterson MG, Kimberly RP (1996) Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans. J Clin Invest 97:1348-54 (Pubitemid 26085492)
14. Sanders LA, van de Winkel JG, Rijkers GT, Voorhorst-Ogink MM, de Haas M, Capel PJ, Zegers BJ (1994) Fc gamma receptor IIa (CD32) heterogeneity in patients with recurrent bacterial respiratory tract infections. J Infect Dis 170:854-61
15. Schneider-Merck T, Lammerts van Bueren JJ, Berger S, Rossen K, van Berkel PH, Derer S, Beyer T, Lohse S, Bleeker WK, Peipp M, Parren PW, van de Winkel JG, Valerius T, Dechant M (2010) Human IgG2 antibodies against epidermal growth factor receptor effectively trigger antibody-dependent cellular cytotoxicity but, in contrast to IgG1, only by cells of myeloid lineage. J Immunol 184:512-20
16. Tan Sardjono C, Mottram PL, Hogarth PM (2003) The role of FcgammaRIIa as an inflammatory mediator in rheumatoid arthritis and systemic lupus erythematosus. Immunol Cell Biol 81:374-81 (Pubitemid 37255411)
17. Weng WK, Levy R (2003) Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma. J Clin Oncol 21:3940-7 (Pubitemid 46606207)
18. Zhang W, Gordon M, Schultheis AM, Yang DY, Nagashima F, Azuma M, Chang HM, Borucka E, Lurje G, Sherrod AE, Iqbal S, Groshen S, Lenz HJ (2007) FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab. J Clin Oncol 25:3712-8 (Pubitemid 47372612)