Carcinoma of the ampulla of vater: Morphological and immunophenotypical classification predicts overall survival

Pancreas

Volumn 42, Issue 1, 2013, Pages 60-66

  Morini, Sergio ^a   Perrone, Giuseppe ^a,b   Borzomati, Domenico ^c   Vincenzi, Bruno ^a   Rabitti, Carla ^b   Righi, Daniela ^b   Castri, Federica ^d   Manazza, Andrea D ^e   Santini, Daniele ^a   Tonini, Giuseppe ^a   Coppola, Roberto ^c   Onetti Muda, Andrea ^b  

^a UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^b Pathology Oncology CIR   (Italy)

^c Surgery Oncology CIR   (Italy)

^d CATHOLIC UNIVERSITY   (Italy)

^e UNIVERSITY OF TURIN   (Italy)

Author keywords

cancer; histology; immunohistochemistry; survival; vater ampulla

Indexed keywords

CYTOKERATIN 20; CYTOKERATIN 7;

ADULT; AGED; ARTICLE; BILE DUCT CARCINOMA; CANCER SURGERY; CANCER SURVIVAL; DISEASE CLASSIFICATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; INTESTINE CARCINOMA; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PANCREAS CARCINOMA; PANCREATOBILIARY CARCINOMA; PRIORITY JOURNAL; VATER PAPILLA CARCINOMA;

ADULT; AGED; AMPULLA OF VATER; CARCINOMA; COMMON BILE DUCT NEOPLASMS; FEMALE; HUMANS; IMMUNOPHENOTYPING; ITALY; KAPLAN-MEIER ESTIMATE; KERATIN-20; KERATIN-7; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREDICTIVE VALUE OF TESTS; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; TIME FACTORS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 84872059322     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0b013e318258fda8     Document Type: Article

References (37)

1. Fischer HP, Zhou H. Pathogenesis of carcinoma of the papilla of Vater. J Hepatobiliary Pancreat Surg. 2004;11:301-309.
2. Howe JR, Klimstra DS, Moccia RD, et al. Factors predictive of survival in ampullary carcinoma. Ann Surg. 1998;228:87-94.
3. Klempnauer J, Ridder GJ, Pichlmayr R. Prognostic factors after resection of ampullary carcinoma: multivariate survival analysis in comparison with ductal cancer of the pancreatic head. Br J Surg. 1995;82:1686-1691.
4. Neoptolemos JP, Talbot IC, Shaw DC, et al. Long-term survival after resection of ampullary carcinoma is associated independently with tumor grade and a new staging classification that assesses local invasiveness. Cancer. 1988;61:1403-1407.
5. Roder JD, Schneider PM, Stein HJ, et al. Number of lymph node metastases is significantly associated with survival in patients with radically resected carcinoma of the ampulla of Vater. Br J Surg. 1995;82:1693-1696.
6. Todoroki T, Koike N, Morishita Y, et al. Patterns and predictors of failure after curative resections of carcinoma of the ampulla of Vater. Ann Surg Oncol. 2003;10:1176-1183.
7. Bouvet M, Gamagami RA, Gilpin EA, et al. Factors influencing survival after resection for periampullary neoplasms. Am J Surg. 2000;180:13-17.
8. Chang MC, Chang YT, Tien YW, et al. Distinct chromosomal aberrations of ampulla of Vater and pancreatic head cancers detected by laser capture microdissection and comparative genomic hybridization. Oncol Rep. 2005;14:867-872.
9. Yeo CJ, Cameron JL, Sohn TA, et al. Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: pathology, complications, and outcomes. Ann Surg. 1997;226:248-257.
10. Kimura W, Futakawa N, Yamagata S, et al. Different clinicopathologic findings in two histologic types of carcinoma of papilla of Vater. Jpn J Cancer Res. 1994;85:161-166.
11. Schirmacher P, Bu?chlerMW.Ampullary adenocarcinomaVdifferentiation matters. BMC Cancer. 2008;8
12. Carter JT, Grenert JP, Rubenstein L, et al. Tumors of the ampulla of Vater: histopathologic classification and predictors of survival. J Am Coll Surg. 2008;207:210-218.
13. Albores-Saavedra J, Henson DE, Klimstra DS. Tumor of the gallbladder, extrahepatic bile duct, and ampulla of Vater. In: Rosai J, Sobin L, eds. Atlas of Tumor Pathology Third series, Fascicle 27. Washington DC: Armed Forces Institute of Pathology; 2000:259-316.
14. Roh YH, Kim YH, Lee HW, et al. The clinicopathologic and immunohistochemical characteristics of ampulla of Vater carcinoma: the intestinal type is associated with a better prognosis. Hepatogastroenterology. 2007;54:1641-1644.
15. Sessa F, Furlan D, Zampatti C, et al. Prognostic factors for ampullary adenocarcinomas: tumor stage, tumor histology, tumor location, immunohistochemistry and microsatellite instability. Virchows Arch. 2007;451:649-657.
16. Zhou H, Schaefer N, Wolff M, et al. Carcinoma of the ampulla of Vater: comparative histologic/immunohistochemical classification and follow-up. Am J Surg Pathol. 2004;28:875-882.
17. Matsubayashi H,Watanabe H, Yamaguchi T, et al. Differences in mucus and K-ras mutation in relation to phenotypes of tumors of the papilla of Vater. Cancer. 1999;86:596-607.
18. Ruemmele P, DietmaierW, Terracciano L, et al. Histopathologic features and microsatellite instability of cancers of the papilla of vater and their precursor lesions. Am J Surg Pathol. 2009;33:691-704.
19. Rosai J. Appendix E. In: Rosai and Ackerman's Surgical Pathology, 9th ed. Edinburgh, UK: Mosby; 2004:2953-2954.
20. Sobin LH, Gospodarowicz M, Wittekind Ch. TNM Classification of Malignant Tumours. UICC International Union Against Cancer. 7th ed. New York, Chichester, Weinheim, Brisbane, Singapore, Toronto: Wiley-Blackwell; 2009.
21. Chu PG, Schwarz RE, Lau SK, et al. Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2. Am J Surg Pathol. 2005;29:359-367.
22. Kaplan EL. Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457-481.
23. Peto R, Pike MC, Armitage P, et al. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. Br J Cancer. 1977;35:1-39.
24. Cox DR. Regression models and life tables. J R Stat Soc. 1972;34:187-220.
25. Chen ZM, Wang HL. Alteration of cytokeratin 7 and cytokeratin 20 expression profile is uniquely associated with tumorigenesis of primary adenocarcinoma of the small intestine. Am J Surg Pathol. 2004;28:1352-1359.
26. Santini D, Vincenzi B, Tonini G, et al. Cyclooxygenase-2 overexpression is associated with a poor outcome in resected ampullary cancer patients. Clin Cancer Res. 2005;11:3784-3789.
27. Santini D, Perrone G, Vincenzi B, et al. Human equilibrative nucleoside transporter 1 (hENT1) protein is associated with short survival in resected ampullary cancer. Ann Oncol. 2008;19:724-728.
28. Vincenzi B, Santini D, Perrone G, et al. Promyelocytic leukemia (PML) gene expression is a prognostic factor in ampullary cancer patients. Ann Oncol. 2009;20:78-83.
29. Kim RD, Kundhal PS, McGilvray ID, et al. Predictors of failure after pancreaticoduodenectomy for ampullary carcinoma. J Am Coll Surg. 2006;202:112-119.
30. Sakata J, Shirai Y, Wakai T, et al. Number of positive lymph nodes independently affects long-term survival after resection in patients with ampullary carcinoma. Eur J Surg Oncol. 2007;33:346-351.
31. Woo SM, Ryu JK, Lee SH, et al. Recurrence and prognostic factors of ampullary carcinoma after radical resection: comparison with distal extrahepatic cholangiocarcinoma. Ann Surg Oncol. 2007;14:3195-3201.
32. Beghelli S, Orlandini S, Moore PS, et al. Ampulla of vater cancers: T-stage and histological subtype but not Dpc4 expression predict prognosis. Virchows Arch. 2002;441:19-24.
33. Westgaard A, Tafjord S, Farstad IN, et al. Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma. BMC Cancer. 2008;8
34. Perrone G, Morini S, Santini D, et al. Human equilibrative nucleoside transporter 1 and carcinoma of the ampulla of Vater: expression differences in tumour histotypes. Eur J Histochem. 2010; 54:e38.
35. Perrone G, Santini D, Zagami M, et al. COX-2 expression of ampullary carcinoma: correlation with different histotypes and clinicopathological parameters. Virchows Arch. 2006;449: 334-340.
36. Kawabata Y, Tanaka T, Nishisaka T, et al. Cytokeratin 20 (CK20) and apomucin 1 (MUC1) expression in ampullary carcinoma: correlation with tumor progression and prognosis. Diagn Pathol. 2010;5:75.
37. Kohler I, Jacob D, Budzies J, et al. Phenotypic and genotypic characterization of carcinomas of the papilla of Vater has prognostic and putative therapeutic implications. Am J Clin Pathol. 2011;135:202-211.