Expression of hMLH1, hMSH2 and hMSH6 in small intestinal carcinomas

Hepato-Gastroenterology

Volumn 59, Issue 119, 2012, Pages 2228-2232

  Gu, Mi Jin ^a   Bae, Young Kyung ^a   Kim, Aeri ^a   Hong, Seung Mo ^b   Yu, Eunsil ^b   Kim, Jihun ^b   Jang, Kee Taek ^c   Chang, Hee Kyung ^d   Jung, Eun Sun ^e   Bae, Han Ik ^f   Yoon, Ghil Suk ^f   Kim, Joon Mee ^g   Kim, Jung Yeon ^h   Kim, Gwang Il ⁱ   Oh, Young Ha ^j   Jang, Kyu Yun ^k   Jun, Sun Young ^l   Eom, Dae Woon ^b   Kwon, Kye Won ^m   Kang, Gyeong Hoon ⁿ   Park, Jae Bok ^o   Hong, Soon Won ^p   Jung, Soo Jin ^q   Lee, Ji Shin ^r   more..

^a Yeungnam University College of Medicine   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c Sungkyunkwan University School of Medicine   (South Korea)

^d Kosin University   (South Korea)

^e The Catholic University of Korea   (South Korea)

^f Kyungpook National University School of Medicine   (South Korea)

^g Inha University School of Medicine   (South Korea)

^h Inje University College of Medicine   (South Korea)

ⁱ CHA University   (South Korea)

^j Hanyang University   (South Korea)

^k Chonbuk National University   (South Korea)

^l Hallym University   (South Korea)

^m Bundang Jesaeng Hospital   (South Korea)

ⁿ Seoul National University   (South Korea)

^o Catholic University of Daegu   (South Korea)

^p Yonsei University   (South Korea)

^q Inje University   (South Korea)

^r Chonnam National University   (South Korea)

more..

Author keywords

Carcinoma; hMLH1; hMSH2; hMSH6; Mismatch repair; Small intestine

Indexed keywords

PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6;

ADULT; AGED; ARTICLE; CANCER INVASION; CARCINOGENESIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MISMATCH REPAIR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMALL INTESTINE CARCINOMA; TISSUE MICROARRAY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA; CHI-SQUARE DISTRIBUTION; DNA MISMATCH REPAIR; DNA-BINDING PROTEINS; DOWN-REGULATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL NEOPLASMS; INTESTINE, SMALL; KAPLAN-MEIER ESTIMATE; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; MUTS HOMOLOG 2 PROTEIN; NEOPLASM INVASIVENESS; NUCLEAR PROTEINS; PANCREAS; PROGNOSIS; REPUBLIC OF KOREA; RETROPERITONEAL NEOPLASMS; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84872057417     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: 10.5754/hge11601     Document Type: Article

References (25)

1. Zhang MQ, Chen ZM, Wang HL: Immunohistochemical investigation of tumorigenic pathways in small intestinal adenocarcinoma: a comparison with colorectal adenocarcinoma. Mod Pathol 2006; 19:573-580.
2. Overman MJ, Pozadzides J, Kopetz S, et al.: Immunophenotype and molecular characterization of adenocarcinoma of small intestine. Br J Cancer 2010; 102:144-150.
3. Svrcek M, Jourdan F, Sebbagh N, et al.: Immunohistochemical analysis of adenocarcinoma of the small intestine: a tissue microarray study. J Clin Pathol 2003; 56:898-903.
4. Wheeler JM, Warren BF, Mortensen NJ, et al.: An insight into the genetic pathway of adenocarcinoma of the small intestine. Gut 2002; 50:218-223.
5. Plank M, Ericson K, Piotrowska Z, Halvarsson B, Rambech E, Nilbert M: Microsatellite instability and expression of MLH1 and MSH2 in carcinomas of the small intestine. Cancer 2003; 97:1551-1557.
6. Berkhout M, Nagtegaal ID, Cornelissen SJ, et al.: Chromosomal and methylation alterations in sporadic and familial adenomatous polyposis-related duodenal carcinomas. Mod Pathol 2007; 20:1253-1262.
7. Lawes DA, SenGupta S, Boulos PB: The clinical importance and prognostic implications of microsatellite instability in sporadic cancer. Eur J Surg Oncol 2003; 29:201-212.
8. Gu M, Kim D, Bae Y, CHoi J, Kim S, Song S: Analysis of microsatellite instability, protein expression and methylation status of hMLH1 and hMSH2 genes in gastric carcinomas. Hepato-gastroenterol 2009; 56:899-904.
9. Yamashita K, Arimura Y, Kurokawa S, et al.: Microsatellite instability in patients with multiple primary cancer of the gastrointestinal tract. Gut 2000; 46:790-794.
10. Liu B, Parsons R, Papadopoulos N, et al.: Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nat Med 1996; 2:169-174.
11. Potter DD, Murray JA, Donohue JH, et al.: The role of defective mismatch repair in small bowel adenocarcinoma in celiac disease. Cancer Res 2004; 64:7073-7077.
12. Muneyuki T, Watanabe M, Yamanaka M, Isaji S, Kawarada T, Yatani T: Combination analysis of genetic alterations and cell proliferation in small intestinal carcinomas. Dig Dis Sci 2000; 45:2022-2028.
13. Schulmann K, Brasch FE, Kunstmann E, et al.: HNPCC-associated small bowel cancer: clinical and molecular characteristics. Gastroenterology 2005; 128:590-599.
14. Hibi K, Kondo K, Akiyama S, Ito K, Takagi H: Frequent genetic instability in small adenocarcinomas. Jpn J Cancer Res 1995; 86:357-360.
15. Rashid M, Hamilton SR: Genetic alterations in sporadic and Crohn's-associated adenocarcinomas of the small intestine. Gastroenterology 1997; 113:127-135.
16. Blaker H, von Herbay A, Penzel R, Gross S, Otto HF: Genetics of adenocarcinomas of the small intestine: frequent deletions at chromosome 18q and mutations of the SMAD4 gene. Oncogene 2002; 21:158-164.
17. Brueckl WM, Heinze E, Milsmann C, et al.: Prognostic significance of microsatellite instability in curative resected adenocarcinoma of the small intestine. Cancer Lett 2004; 203:181-190.
18. Sessa F, Furlan D, Zampatti C, Carnevali I, Franzi F, Capella C: Prognostic factors for ampullary adenocarcinomas: tumor stage, tumor histology, tumor location, immunohistochemistry and microsatellite instability. Virchows Arch 2007; 451:649-657.
19. Kane MF, Loda M, Gaida GM, et al.: Methylation of the hMLH1 promoter correlation with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cells. Cancer Res 1997; 57:808-811.
20. Cunningham JM, Christensen ER, Tester DJ, et al.: Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability. Cancer Res 1998; 58:3455-3460.
21. Lanza G, Gafa R, Maestri I, Santini A, Matteuzzi M, Cavazzini L: Immunohistochemical pattern of hMLH1/MSH2 expression is related to clinical and pathological features in colorectal adenocarcinomas with microsatellite instability. Mod Pathol 2002; 15:741-749.
22. Kim HC, Roh SA, Yook JH, et al.: Microsatellite instability and promoter methylation of hMLH1 in sporadic gastric carcinoma. J Korean Gastric Cancer Assoc 2003; 3:50-55.
23. Kim SG, Chan AO, Wu TT, Issa JP, Hamilton SR, Rashid A: Epigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas. Gastroenterology 2003; 124:1300-1310.
24. INK4A and APC in primary adenocarcinomas of the small bowel. Int J Cancer 2006; 119:1298-1302.
25. Kuismanen SA, Holmberg MT, Salovaara R, de la Chapella A, Peltomaki P: Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers. Am J Pathol 2000; 156:1773-1779.