Variations of subunit ε of the Mycobacterium tuberculosis F 1FO ATP synthase and a novel model for mechanism of action of the tuberculosis drug TMC207

Antimicrobial Agents and Chemotherapy

Volumn 57, Issue 1, 2013, Pages 168-176

  Biuković, Goran ^a   Basak, Sandip ^a   Manimekalai, Malathy Sony Subramanian ^a   Rishikesan, Sankaranarayanan ^a   Roessle, Manfred ^b   Dick, Thomas ^c   Rao, Srinivasa P S ^d   Hunke, Cornelia ^a   Grüber, Gerhard ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; BEDAQUILINE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; BACTERIAL PROTEIN; F1F0 ATP SYNTHASE; F1F0-ATP SYNTHASE; PROTON; QUINOLINE DERIVATIVE; RECOMBINANT PROTEIN; TUBERCULOSTATIC AGENT;

ALPHA HELIX; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CIRCULAR DICHROISM; DRUG PROTEIN BINDING; ENZYME STRUCTURE; FLUORESCENCE SPECTROSCOPY; HETERONUCLEAR SINGLE QUANTUM COHERENCE; ISOTHERMAL TITRATION CALORIMETRY; MUTAGENESIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; AMINO ACID SEQUENCE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; MOLECULAR DOCKING; MOLECULAR GENETICS; PROTEIN SUBUNIT; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; SPECTROFLUOROMETRY;

AMINO ACID SEQUENCE; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; ESCHERICHIA COLI; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MYCOBACTERIUM TUBERCULOSIS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN SUBUNITS; PROTONS; QUINOLINES; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SPECTROMETRY, FLUORESCENCE;

EID: 84872038902     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01039-12     Document Type: Article

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