Paraquat research: Do recent advances in limiting its toxicity make its use safer?

British Journal of Pharmacology

Volumn 168, Issue 1, 2013, Pages 44-45

  Baltazar, Teresa ^a   Dinis Oliveira, Ricardo Jorge ^a,b,c   Duarte, José Alberto ^a   De Lourdes Bastos, Maria ^a   Carvalho, Félix ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b CESPU   (Portugal)

^c University of Porto   (Portugal)

Author keywords

human poisoning; paraquat; Parkinson's disease; quinone oxidoreductase 2; survival

Indexed keywords

FLAVOPROTEIN; LYSINE ACETYLSALICYLATE; PARAQUAT; QUINONE OXIDOREDUCTASE 2; SALICYLATE SODIUM; UNCLASSIFIED DRUG;

ACUTE TOXICITY; DISEASE SEVERITY; ENZYME INHIBITION; GENE SILENCING; IN VITRO STUDY; LONG TERM EXPOSURE; LUNG ALVEOLUS CELL; MACROGLIA; MORTALITY; NEUROTOXICITY; NONHUMAN; PARAQUAT POISONING; PRIORITY JOURNAL; REVIEW; SAFETY;

ANIMALS; ANTIDOTES; APOPTOSIS; EPITHELIAL CELLS; HERBICIDES; HUMANS; OXIDATIVE STRESS; PARAQUAT; QUINONE REDUCTASES;

EID: 84872031404     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.02017.x     Document Type: Review

References (6)

1. Bromilow RH, (2004). Paraquat and sustainable agriculture. Pest Manag Sci 60: 340-349.
2. Dinis-Oliveira RJ, Sousa C, Remião F, Duarte JA, Navarro AS, Bastos ML, et al,. (2007). Full survival of paraquat-exposed rats after treatment with sodium salicylate. Free Radic Biol Med 42: 1017-1028.
3. Dinis-Oliveira RJ, Duarte JA, Sánchez-Navarro A, Remião F, Bastos ML, Carvalho F, (2008). Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment. Crit Rev Toxicol 38: 13-71.
4. Dinis-Oliveira RJ, Pontes H, Bastos ML, Remião F, Duarte JA, Carvalho F, (2009). An effective antidote for paraquat poisonings: the treatment with lysine acetylsalicylate. Toxicology 255: 187-193.
5. Hart TB, (1987). Paraquat-a review of safety in agricultural and horticultural use. Hum Toxicol 6: 13-18.
6. Janda E, Parafati M, Aprigliano S, Carresi C, Visalli V, Sacco I, et al,. (2012). The antidote effect of quinone oxidoreductase 2 (QR2) inhibitor on paraquat-induced toxicity in vitro and in vivo. Br J Pharmacol 168: 46-59.