Role of decreased plasma tryptophan in memory deficits observed in Type-I diabetes

Journal of the Pakistan Medical Association

Volumn 63, Issue 1, 2013, Pages 65-68

  Ahmad, Saara ^a   Tabassum, Saiqa ^a   Haider, Saida ^a  

^a UNIVERSITY OF KARACHI   (Pakistan)

Author keywords

5 HT; Diabetes; Memory impairment; Tryptophan

Indexed keywords

SEROTONIN; TRYPTOPHAN;

ADULT; AMNESIA; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DIABETIC PATIENT; FEMALE; GLUCOSE BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; QUESTIONNAIRE;

ADULT; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 1; FEMALE; HUMANS; MALE; MEMORY DISORDERS; MIDDLE AGED; TRYPTOPHAN;

EID: 84872031290     PISSN: 00309982     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Tuzcu M, Baydas G. Effect of melatonin and vitamin E on diabetesinduced learning and memory impairment in rats. Eur J Pharmacol 2006; 573: 106-10.
2. Reaven GM, Thompson L, Nahum D, Haskins E. Relationship between hyperglycemia and cognitive function in older NIDDM patients. Diabetes Care 1990; 13: 16-21.
3. Heng LJ, Yang RH, Dong J. Diabetes impairs learning performance through affecting membrane excitability of hippocampal pyramidal neurons. Behav Brain Res 2011; 224: 250-8.
4. Fernstorm JD, Wurtman RJ. Brain serotonin content: physiological dependence on plasma tryptophan levels. Science 1971; 173: 149-52.
5. Herrera R, Manjarrez G, Nishimura E, Hernandez J. Serotoninrelated tryptophan in children with insulin-dependent diabetes. Pediatr Neurol 2003; 28: 20-3.
6. Meneses A. 5-HT system and cognition: Review. Neurosci Biobehav Rev 1999; 23: 1111-25.
7. Haider S, Khaliq S, Haleem DJ. Enhanced serotonergic neurotransmission in the hippocampus following tryptophan administration improves learning acquisition and memory consolidation in rats. Pharmacol Rep 2007; 59: 53-7.
8. Haider S, Khaliq S, Ahmed SP, Perveen T, Haleem DJ. Relationship of brain tryptophan and serotonin in improving cognitive performance in rats. Pak J Pharm Sci 2006; 19: 11-5.
9. Donkelaar EL, Rutten K, Blokland A, Akkerman S, Steinbusch HWM, Pricaerts. Phosphodiesterase 2 and 5 inhibition attenuates the object memory deficit induced by acute tryptophan depletion. Euro J Pharmacol 2008; 600; 98-104.
10. Jans LA, Kote-Bouws GA, Korte SM. Blokland A. The effects of acute tryptophan depletion on affective behavior and cognition in Brown Norway and Sprague Dawley rats. J Psychopharmacol 2010; 24: 605-14.
11. Haleem DJ, Haider S. Food restriction decreases serotonin and its synthesis rate in the hypothalamus. Neuro Report 1996; 7: 1153-6.
12. Fernstorm JD, Wurtman RJ. Brain serotonin content: increase following ingestion of carbohydrate diet. Science 1971; 174: 1023-5.
13. Ryan CM. Neurobehavioral complications of type I diabetes: Examination of possible risk factors. Diabetes Care 1988; 11: 86-93.
14. Madras BK, Cohen EL, Fernstrom JD, Larin F, Monro HN, Wurtman RJ. Letter: Dietary carbohydrate increases brain tryptophan and decreases free plasma tryptophan. Nature 1973; 244: 34-5.
15. Madras BK, Cohen EL, Messing R, Monro HN, Wurtman RJ. Relevance of free tryptophan in serum to tissue tryptophan concentrations. Metabolism 1974; 23: 1107-16.
16. Curzon G, Marsden CA. Metabolism of a tryptophan load in the hypothalamus and other brain regions. J Neurochem 1975; 25: 251-6.
17. Cangiano C, Laviano A, Del Ben M, Preziosa I, Angelico F, Cascino A, et al. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients. Int J Obes Relat Metab Disord 1988; 22: 648-54.
18. Atienza G, Andres MD, Rebolledo E, Aldegunde M. Brain tryptophan uptake and sodium-potassium ATPase activity in long-term Streptozotocin diabetic rats. Neurochem Res 1992; 17: 289-92.
19. Fierabracci V, Novelli M, Ciccarone AM, Masiello P, Benzi L, Navalesi R, et al. Effects of tryptophan load on amino acid metabolism in type I diabetic patients. Diabetes Metab 1996; 22: 51-6.
20. Russo S, Kema IP, Fokkema MR, Boon CJ, Willemse HBP, Elisabeth GE de Vries, et al. Tryptophan as a link between psychopathology and somatic states. Psychosomatic Medicine 2003; 65: 665-71.
21. Leathwood PD, Fernstorm JD. Effect of an oral tryptophan/ carbohydrate load on tryptophan, large neutral amino acid, and serotonin and 5-hydroxyindoleacetic acid levels in monkey brain. J Neural Transm Gen Sect 1990; 79: 25-34.
22. Trulson ME, Jacoby JH, MacKenzie RG. Streptozotocin-induced diabetes reduces brain serotonin synthesis in rats. J Neurochem 1986; 46: 1068-72.
23. Mackenzie RG, Trulson ME. Effects of insulin and streptozotocininduced diabetes on brain tryptophan and serotonin metabolism in rats. J Neurochem 1978; 30: 205-11.
24. Caron MG, Zhang X, Beaulieu JM, Sotnikova TD, Gainetdinov RR. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science 2004; 305: 217.
25. Haider S, Khaliq S. Ahmed SP and Haleem DJ. Long-term tryptophan administration enhances cognitive performance and increases 5-HT metabolism in the hippocampus of female rats. Amino Acids 2006; 31: 421-5.