메뉴 건너뛰기




Volumn 33, Issue SUPPL. 1, 2013, Pages 23-29

How to optimize HCV therapy in genotype 1 patients: Predictors of response

Author keywords

Chronic hepatits C; Triple therapy

Indexed keywords

BOCEPREVIR; PEGINTERFERON; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; RIBAVIRIN; TELAPREVIR; VIRUS RNA;

EID: 84872024767     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12053     Document Type: Review
Times cited : (23)

References (27)
  • 1
    • 84860322902 scopus 로고    scopus 로고
    • New direct-acting antiviral agents for the treatment of hepatitis C virus infection and perspectives
    • Welsch C, Jesudian A, Zeuzem S, Jacobson I. New direct-acting antiviral agents for the treatment of hepatitis C virus infection and perspectives. Gut 2012; 61(Suppl. 1): i36-46.
    • (2012) Gut , vol.61 , Issue.SUPPL 1
    • Welsch, C.1    Jesudian, A.2    Zeuzem, S.3    Jacobson, I.4
  • 2
    • 79953173221 scopus 로고    scopus 로고
    • Boceprevir for untreated chronic HCV genotype 1 infection
    • SPRINT-2 Investigators
    • Poordad F, McCone J Jr, Bacon BR, et al., SPRINT-2 Investigators Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med 2011; 364: 1195-206.
    • (2011) N Engl J Med , vol.364 , pp. 1195-1206
    • Poordad, F.1    McCone Jr, J.2    Bacon, B.R.3
  • 3
    • 79959438789 scopus 로고    scopus 로고
    • Telaprevir for previously untreated chronic hepatitis C virus infection
    • ADVANCE Study Team
    • Jacobson IM, McHutchison JG, Dusheiko G, et al., ADVANCE Study Team Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med 2011; 364: 2405-16.
    • (2011) N Engl J Med , vol.364 , pp. 2405-2416
    • Jacobson, I.M.1    McHutchison, J.G.2    Dusheiko, G.3
  • 4
    • 80052826527 scopus 로고    scopus 로고
    • Response-guided telaprevir combination treatment for hepatitis C virus infection
    • ILLUMINATE Study Team
    • Sherman KE, Flamm SL, Afdhal NH, et al., ILLUMINATE Study Team Response-guided telaprevir combination treatment for hepatitis C virus infection. N Engl J Med 2011; 365: 1014-24.
    • (2011) N Engl J Med , vol.365 , pp. 1014-1024
    • Sherman, K.E.1    Flamm, S.L.2    Afdhal, N.H.3
  • 5
    • 79953176289 scopus 로고    scopus 로고
    • Boceprevir for previously treated chronic HCV genotype 1 infection
    • HCV RESPOND-2 Investigators
    • Bacon BR, Gordon SC, Lawitz E, et al., HCV RESPOND-2 Investigators Boceprevir for previously treated chronic HCV genotype 1 infection. N Engl J Med 2011; 364: 1207-17.
    • (2011) N Engl J Med , vol.364 , pp. 1207-1217
    • Bacon, B.R.1    Gordon, S.C.2    Lawitz, E.3
  • 6
    • 84867554717 scopus 로고    scopus 로고
    • Sustained virological response (SVR) in prior peginterferon/ribavirin (PR) treatment failure after retreatment with boceprevir (BOC)-+-PR: the PROVIDE study interim results
    • Bronowicki JP, Davis M, Flamm S, et al. Sustained virological response (SVR) in prior peginterferon/ribavirin (PR) treatment failure after retreatment with boceprevir (BOC)-+-PR: the PROVIDE study interim results. J Hepatol 2012; 56(Suppl. 2): S611.
    • (2012) J Hepatol , vol.56 , Issue.SUPPL 2
    • Bronowicki, J.P.1    Davis, M.2    Flamm, S.3
  • 7
    • 79959381354 scopus 로고    scopus 로고
    • Telaprevir for retreatment of HCV infection
    • REALIZE Study Team
    • Zeuzem S, Andreone P, Pol S, et al., REALIZE Study Team Telaprevir for retreatment of HCV infection. N Engl J Med 2011; 364: 2417-28.
    • (2011) N Engl J Med , vol.364 , pp. 2417-2428
    • Zeuzem, S.1    Andreone, P.2    Pol, S.3
  • 8
    • 84865560854 scopus 로고    scopus 로고
    • Cost-effectiveness of boceprevir or telaprevir for untreated patients with genotype 1 chronic hepatitis C
    • on behalf of the WEF Study Group.
    • Cammà C, Petta S, Enea M, et al., on behalf of the WEF Study Group. Cost-effectiveness of boceprevir or telaprevir for untreated patients with genotype 1 chronic hepatitis C. Hepatology 2012; 56: 850-60.
    • (2012) Hepatology , vol.56 , pp. 850-860
    • Cammà, C.1    Petta, S.2    Enea, M.3
  • 9
    • 77953881002 scopus 로고    scopus 로고
    • Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus
    • Thompson AJ, Muir AJ, Sulkowski MS, et al. Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus. Gastroenterology 2010; 139: 120-9. e18.
    • (2010) Gastroenterology , vol.139
    • Thompson, A.J.1    Muir, A.J.2    Sulkowski, M.S.3
  • 10
    • 71349085573 scopus 로고    scopus 로고
    • Shortened treatment duration in treatment-naive genotype 1 HCV patients with rapid virological response: a meta-analysis
    • Moreno C, Deltenre P, Pawlotsky JM, et al. Shortened treatment duration in treatment-naive genotype 1 HCV patients with rapid virological response: a meta-analysis. J Hepatol 2010; 52: 25-31.
    • (2010) J Hepatol , vol.52 , pp. 25-31
    • Moreno, C.1    Deltenre, P.2    Pawlotsky, J.M.3
  • 11
    • 79960453276 scopus 로고    scopus 로고
    • EASL Clinical Practice Guidelines: management of hepatitis C virus infection
    • European Association for the Study of the Liver.
    • European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of hepatitis C virus infection. J Hepatol 2011; 55: 245-64.
    • (2011) J Hepatol , vol.55 , pp. 245-264
  • 12
    • 80053339008 scopus 로고    scopus 로고
    • An update on treatment of genotype 1 chronic hepatitis c virus infection: 2011 practice guidelines by the American Association for the Study of Liver Diseases
    • Ghany M, Nelson D, Strader D, Thomas DL, Seeff LB. An update on treatment of genotype 1 chronic hepatitis c virus infection: 2011 practice guidelines by the American Association for the Study of Liver Diseases. Hepatology 2011; 54: 1433-44.
    • (2011) Hepatology , vol.54 , pp. 1433-1444
    • Ghany, M.1    Nelson, D.2    Strader, D.3    Thomas, D.L.4    Seeff, L.B.5
  • 13
    • 84868252003 scopus 로고    scopus 로고
    • Informed deferral: a moral requirement for entry into the HCV treatment warehouse
    • Aronsohn A, Jensen D. Informed deferral: a moral requirement for entry into the HCV treatment warehouse. Hepatology 2012; 56: 1591-2.
    • (2012) Hepatology , vol.56 , pp. 1591-1592
    • Aronsohn, A.1    Jensen, D.2
  • 14
    • 77956268467 scopus 로고    scopus 로고
    • Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial
    • Kwo PY, Lawitz EJ, McCone J, et al. Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial. Lancet 2010; 376: 705-16.
    • (2010) Lancet , vol.376 , pp. 705-716
    • Kwo, P.Y.1    Lawitz, E.J.2    McCone, J.3
  • 15
    • 84872034161 scopus 로고    scopus 로고
    • Victrelis [boceprevir]. European Medicines Agency. Available at Accessed: 17 August 2011.
    • Victrelis [boceprevir]. European Medicines Agency. Available at http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/002332/human_med_001464.jsp. Accessed: 17 August 2011.
  • 16
    • 84872019510 scopus 로고    scopus 로고
    • Incivo [telaprevir]. European Medicines Agency. Available at
    • Incivo [telaprevir]. European Medicines Agency. Available at http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_product_Information/human/002313/WC500115529.pdf
  • 17
    • 0013297123 scopus 로고    scopus 로고
    • Incivek. Cambridge, MA: Vertex Pharmaceuticals Inc
    • Incivek. Package insert. Cambridge, MA: Vertex Pharmaceuticals Inc, 2011.
    • (2011) Package insert
  • 18
    • 0013297123 scopus 로고    scopus 로고
    • Victrelis. Whitehouse Station, NJ: Merck and Co, Inc
    • Victrelis. Package insert. Whitehouse Station, NJ: Merck and Co, Inc, 2011.
    • (2011) Package insert
  • 19
    • 84859162561 scopus 로고    scopus 로고
    • Clinical relevance of detectable but not quantifiable hepatitis C virus RNA during boceprevir or telaprevir treatment
    • Harrington PR, Zeng W, Naeger LK. Clinical relevance of detectable but not quantifiable hepatitis C virus RNA during boceprevir or telaprevir treatment. Hepatology 2012; 55: 1048-57.
    • (2012) Hepatology , vol.55 , pp. 1048-1057
    • Harrington, P.R.1    Zeng, W.2    Naeger, L.K.3
  • 20
    • 84872035401 scopus 로고    scopus 로고
    • Parere dell'Associazione Italiana per lo Studio del Fegato (AISF) sull'uso della triplice-terapia (Peg-IFN + Ribavirina + inibitore delle proteasi di prima generazione) per il trattamento dei pazienti con epatite cronica da HCV genotipo 1. Available at
    • Parere dell'Associazione Italiana per lo Studio del Fegato (AISF) sull'uso della triplice-terapia (Peg-IFN + Ribavirina + inibitore delle proteasi di prima generazione) per il trattamento dei pazienti con epatite cronica da HCV genotipo 1. Available at http://www.webaisf.org/media/16360/position_paper_definitivo_26_01_12.pdf
  • 21
    • 84864354805 scopus 로고    scopus 로고
    • Refinement of stopping rules during treatment of hepatitis c-genotype 1 infection with boceprevir combined with peginterferon/ribavirin
    • Jacobson IM, Marcellin P, Zeuzem S, et al. Refinement of stopping rules during treatment of hepatitis c-genotype 1 infection with boceprevir combined with peginterferon/ribavirin. Hepatology 2012; 56: 567-75.
    • (2012) Hepatology , vol.56 , pp. 567-575
    • Jacobson, I.M.1    Marcellin, P.2    Zeuzem, S.3
  • 22
    • 84865494240 scopus 로고    scopus 로고
    • Factors that predict response of patients with HCV infection to boceprevir
    • SPRINT-2 and RESPOND-2 Investigators. e1-5.
    • Poordad F, Bronowicki JP, Gordon SC, et al., SPRINT-2 and RESPOND-2 Investigators. Factors that predict response of patients with HCV infection to boceprevir. Gastroenterology 2012; 143: 608-18.e1-5.
    • (2012) Gastroenterology , vol.143 , pp. 608-618
    • Poordad, F.1    Bronowicki, J.P.2    Gordon, S.C.3
  • 23
    • 84866060640 scopus 로고    scopus 로고
    • Insulin resistance and response to telaprevir plus peginterferon α and ribavirin in treatment-naive patients infected with HCV genotype 1
    • Serfaty L, Forns X, Goeser T, et al. Insulin resistance and response to telaprevir plus peginterferon α and ribavirin in treatment-naive patients infected with HCV genotype 1. Gut 2012; 61: 1473-80.
    • (2012) Gut , vol.61 , pp. 1473-1480
    • Serfaty, L.1    Forns, X.2    Goeser, T.3
  • 24
    • 79251554986 scopus 로고    scopus 로고
    • Telaprevir is effective given every 8 or 12 hours with ribavirin and peginterferon alfa-2a or -2b to patients with chronic hepatitis C
    • Marcellin P, Forns X, Goeser T, et al. Telaprevir is effective given every 8 or 12 hours with ribavirin and peginterferon alfa-2a or -2b to patients with chronic hepatitis C. Gastroenterology 2011; 140: 459-68.
    • (2011) Gastroenterology , vol.140 , pp. 459-468
    • Marcellin, P.1    Forns, X.2    Goeser, T.3
  • 25
    • 80055062466 scopus 로고    scopus 로고
    • Retreatment with telaprevir combination therapy in hepatitis C patients with well-characterized prior treatment response
    • Muir AJ, Poordad FF, McHutchison JG, et al. Retreatment with telaprevir combination therapy in hepatitis C patients with well-characterized prior treatment response. Hepatology 2011; 54: 1538-46.
    • (2011) Hepatology , vol.54 , pp. 1538-1546
    • Muir, A.J.1    Poordad, F.F.2    McHutchison, J.G.3
  • 26
    • 84867571865 scopus 로고    scopus 로고
    • Genomics and HCV infection: progression of fibrosis and treatment response
    • Estrabaud E, Vidaud M, Marcellin P, Asselah T. Genomics and HCV infection: progression of fibrosis and treatment response. J Hepatol 2012; 57: 1110-25.
    • (2012) J Hepatol , vol.57 , pp. 1110-1125
    • Estrabaud, E.1    Vidaud, M.2    Marcellin, P.3    Asselah, T.4
  • 27
    • 84855209804 scopus 로고    scopus 로고
    • Direct acting antivirals for the treatment of chronic hepatitis C: one pill a day for tomorrow
    • Asselah T, Marcellin P. Direct acting antivirals for the treatment of chronic hepatitis C: one pill a day for tomorrow. Liver Int 2012; 32(S1): 88-102.
    • (2012) Liver Int , vol.32 , Issue.S1 , pp. 88-102
    • Asselah, T.1    Marcellin, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.