The development of a novel molecular assay examining the role of aminopeptidase p polymorphisms in acute hypotensive transfusion reactions

Archives of Pathology and Laboratory Medicine

Volumn 137, Issue 1, 2013, Pages 96-99

  Hui, Yiang ^a   Wu, Yan Yun ^b   Tormey, Christopher A ^b,c  

^a UNIVERSITY AT BUFFALO   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE; BRADYKININ; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; PRIMER DNA; X PRO AMINOPEPTIDASE; X-PRO AMINOPEPTIDASE;

ACUTE DISEASE; ADOLESCENT; AGED; ARTICLE; BLOOD TRANSFUSION; CASE CONTROL STUDY; ENZYMOLOGY; FEMALE; GENETIC PREDISPOSITION; GENETICS; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HYPOTENSION; MALE; METABOLISM; MIDDLE AGED; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ACUTE DISEASE; ADOLESCENT; AGED; AMINOPEPTIDASES; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; BASE SEQUENCE; BLOOD TRANSFUSION; BRADYKININ; CASE-CONTROL STUDIES; DNA PRIMERS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; HYPOTENSION; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84872007348     PISSN: 00039985     EISSN: 15432165     Source Type: Journal    
DOI: 10.5858/arpa.2011-0466-OA     Document Type: Article

References (17)

1. Hume HA, Popovsky MA, Benson K, et al. Hypotensive reactions: A previously uncharacterized complication of platelet transfusion? Transfusion. 1996;36(10):904-909.
2. US Food and Drug Administration. Fatalities reported to FDA following blood collection and transfusion. http://www.fda.gov/BiologicsBloodVaccines/ SafetyAvailablility/ReportaProblem/TransfusionDonationFatalities/ucm204763.htm. Accessed August 11, 2011.
3. Cyr M, Eastlund T, Blais C Jr, Rouleau JL, Adam A. Bradykinin metabolism and hypotensive transfusion reactions. Transfusion. 2001;41(1):136-150.
4. Fried MR, Eastlund T, Christie B, Mullin GT, Key NS. Hypotensive reactions to white cell-reduced plasma in a patient undergoing angiotensin-converting enzyme inhibitor therapy. Transfusion. 1996;36(10):900-903.
5. Cyr M, Hume HA, Champagne M, et al. Anomaly of the des-Arg9-bradykinin metabolism associated with severe hypotensive reactions during blood transfusions: A preliminary study. Transfusion. 1999;39(10):1084-1088.
6. Sano H, Koga Y, Hamasaki K, Furuyama H, Itami N. Anaphylaxis associated with white-cell reduction filter. Lancet. 1996;347(9007):1053.
7. Quillen K. Hypotensive transfusion reactions in patients taking angiotensinconverting-enzyme inhibitors. N Engl J Med. 2000;343(19):1422-1423.
8. Kalra A, Palaniswamy C, Patel R, Kalra A, Selvaraj DR. Acute hypotensive transfusion reaction with concomitant use of angiotensinconverting enzyme inhibitors: A case report and review of the literature. Am J Ther. 2012:19(2):e90-e94.
9. Arnold DM, Molinaro G, Warkentin TE, et al. Hypotensive transfusion reactions can occur with blood products that are leukoreduced before storage. Transfusion. 2004;44(9):1361-1366.
10. Mair B, Leparc GF. Hypotensive reactions associated with platelet transfusions and angiotensin-converting enzyme inhibitors. Vox Sang. 1998; 74(1):27-30.
11. Doria C, Elia ES, Kang Y, et al. Acute hypotensive transfusion reaction during liver transplantation in a patient on angiotensin converting enzyme inhibitors from low aminopeptidase P activity. Liver Transpl. 2008;14(5): 684-687.
12. Belloni M, Alghisi A, Bettini C, Soli M, Zampieri L. Hypotensive reactions associated with white cell-reduced apheresis platelet concentrates in patients not receiving ACE Inhibitors. Transfusion. 1998;38(4):412-415.
13. Simmons WH, Orawski AT. Membrane-bound aminopeptidase P from bovine lung: Its purification, properties, and degradation of bradykinin. J Biol Chem. 1992;267(7):4897-4903.
14. Woodard-Grice AV, Lucisano AC, Byrd JB, Stone ER, Simmons WH, Brown NJ. Sex-dependent and race-dependent association of XPNPEP2 C-2399A polymorphism with angiotensin-converting enzyme inhibitor-associated angioedema. Pharmacogenet Genomics. 2010;20(9):532-536.
15. Duan QL, Nikpoor B, Dube MP, et al. A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors. Am J Hum Genet. 2005;77(4):617-626.
16. Adam A, Cugno M, Molinaro G, Perez M, Lepage Y, Agostoni A. Aminopeptidase P in individuals with a history of angio-oedema on ACE inhibitors. Lancet. 2002;359(9323):2088-2089.
17. Shiba M, Tadokoro K, Sawanobori M, Nakajima K, Suzuki K, Juji T. Activation of the contact system by filtration of platelet concentrates with a negatively charged white cell-removal filter and measurement of venous blood bradykinin level in patients who received filtered platelets. Transfusion. 1997; 37(5):457-462.