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Volumn 32, Issue 1, 2013, Pages 50-60

Role of the integrin-linked kinase (ILK)/Rictor complex in TGFβ-1-induced epithelial-mesenchymal transition (EMT)

Author keywords

breast epithelial cells; cancer; EMT; ILK Rictor complex; integrin linked kinase; Rictor

Indexed keywords

INTEGRIN LINKED KINASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84871971370     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.30     Document Type: Article
Times cited : (122)

References (49)
  • 1
    • 54549091060 scopus 로고    scopus 로고
    • Integrin-linked kinase regulates E-cadherin expression through PARP-1
    • McPhee TR, McDonald PC, Oloumi A, Dedhar S. Integrin-linked kinase regulates E-cadherin expression through PARP-1. Dev Dyn 2008; 237: 2737-2747.
    • (2008) Dev Dyn , vol.237 , pp. 2737-2747
    • McPhee, T.R.1    McDonald, P.C.2    Oloumi, A.3    Dedhar, S.4
  • 2
    • 0034798707 scopus 로고    scopus 로고
    • Leaving the neighborhood: Molecular mechanisms involved during epithelial-mesenchymal transition
    • Savagner P. Leaving the neighborhood: Molecular mechanisms involved during epithelial-mesenchymal transition. Bioessays 2001; 23: 912-923.
    • (2001) Bioessays , vol.23 , pp. 912-923
    • Savagner, P.1
  • 3
    • 77951707634 scopus 로고    scopus 로고
    • ILK expression in human basal cell carcinoma correlates with epithelial-mesenchymal transition markers and tumour invasion
    • Papanikolaou S, Bravou V, Gyftopoulos K, Nakas D, Repanti M, Papadaki H. ILK expression in human basal cell carcinoma correlates with epithelial-mesenchymal transition markers and tumour invasion. Histopathology 2010; 56: 799-809.
    • (2010) Histopathology , vol.56 , pp. 799-809
    • Papanikolaou, S.1    Bravou, V.2    Gyftopoulos, K.3    Nakas, D.4    Repanti, M.5    Papadaki, H.6
  • 4
    • 0035185853 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
    • Bhowmick NA, Ghiassi M, Bakin A, Aakre M, Lundquist CA, Engel ME et al. Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell 2001; 12: 27-36.
    • (2001) Mol Biol Cell , vol.12 , pp. 27-36
    • Bhowmick, N.A.1    Ghiassi, M.2    Bakin, A.3    Aakre, M.4    Lundquist, C.A.5    Engel, M.E.6
  • 5
    • 75949103899 scopus 로고    scopus 로고
    • Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing
    • Margadant C, Sonnenberg A. Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing. EMBO Rep 2010; 11: 97-105.
    • (2010) EMBO Rep , vol.11 , pp. 97-105
    • Margadant, C.1    Sonnenberg, A.2
  • 6
    • 69849100333 scopus 로고    scopus 로고
    • Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis
    • Li Y, Tan X, Dai C, Stolz DB, Wang D, Liu Y. Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis. J Am Soc Nephrol 2009; 20: 1907-1918.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1907-1918
    • Li, Y.1    Tan, X.2    Dai, C.3    Stolz, D.B.4    Wang, D.5    Liu, Y.6
  • 7
    • 47749141502 scopus 로고    scopus 로고
    • Beyond focal adhesions: Integrin-linked kinase associates with tubulin and regulates mitotic spindle organization
    • Fielding AB, Dobreva I, Dedhar S. Beyond focal adhesions: Integrin-linked kinase associates with tubulin and regulates mitotic spindle organization. Cell Cycle 2008; 7: 1899-1906.
    • (2008) Cell Cycle , vol.7 , pp. 1899-1906
    • Fielding, A.B.1    Dobreva, I.2    Dedhar, S.3
  • 8
    • 47749087950 scopus 로고    scopus 로고
    • Integrin-linked kinase-essential roles in physiology and cancer biology
    • McDonald PC, Fielding AB, Dedhar S. Integrin-linked kinase-essential roles in physiology and cancer biology. J Cell Sci 2008; 121: 3121-3132.
    • (2008) J Cell Sci , vol.121 , pp. 3121-3132
    • McDonald, P.C.1    Fielding, A.B.2    Dedhar, S.3
  • 9
    • 31544439674 scopus 로고    scopus 로고
    • Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival
    • Troussard AA, McDonald PC, Wederell ED, Mawji NM, Filipenko NR, Gelmon KA et al. Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival. CancerRes 2006; 66: 393-403.
    • (2006) CancerRes , vol.66 , pp. 393-403
    • Troussard, A.A.1    McDonald, P.C.2    Wederell, E.D.3    Mawji, N.M.4    Filipenko, N.R.5    Gelmon, K.A.6
  • 10
    • 40949083412 scopus 로고    scopus 로고
    • Rictor andintegrin-linked kinase interact and regulate Akt phosphorylation and cancer cellsurvival
    • McDonald PC, Oloumi A, Mills J, Dobreva I, Maidan M, Gray V et al. Rictor andintegrin-linked kinase interact and regulate Akt phosphorylation and cancer cellsurvival. Cancer Res 2008; 68: 1618-1624.
    • (2008) Cancer Res , vol.68 , pp. 1618-1624
    • McDonald, P.C.1    Oloumi, A.2    Mills, J.3    Dobreva, I.4    Maidan, M.5    Gray, V.6
  • 11
    • 77952007543 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR): Conducting thecellular signaling symphony
    • Foster KG, Fingar DC. Mammalian target of rapamycin (mTOR): conducting thecellular signaling symphony. J Biol Chem 2010; 285: 14071-14077.
    • (2010) J Biol Chem , vol.285 , pp. 14071-14077
    • Foster, K.G.1    Fingar, D.C.2
  • 13
    • 75749105049 scopus 로고    scopus 로고
    • Roux PP. mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling
    • Julien LA, Carriere A, Moreau J, Roux PP. mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Mol Cell Biol 2010; 30:908-921.
    • (2010) Mol Cell Biol , vol.30 , pp. 908-921
    • Julien, L.A.1    Carriere, A.2    Moreau J3
  • 14
    • 77953763269 scopus 로고    scopus 로고
    • Rictor phosphorylation on the Thr-1135 site does not require mammalian targetof rapamycin complex 2
    • Boulbes D, Chen CH, Shaikenov T, Agarwal NK, Peterson TR, Addona TA et al.Rictor phosphorylation on the Thr-1135 site does not require mammalian targetof rapamycin complex 2. Mol Cancer Res 2010; 8: 896-906.
    • (2010) Mol Cancer Res , vol.8 , pp. 896-906
    • Boulbes, D.1    Chen, C.H.2    Shaikenov, T.3    Agarwal, N.K.4    Peterson, T.R.5    Addona, T.A.6
  • 16
    • 82255175153 scopus 로고    scopus 로고
    • The importanceof integrin-linked kinase in the regulation of bladder cancer invasion
    • Matsui Y, Assi K, Ogawa O, Raven PA, Dedhar S, Gleave ME et al. The importanceof integrin-linked kinase in the regulation of bladder cancer invasion. Int J Cancer 2012; 130: 521-531.
    • (2012) Int J Cancer , vol.130 , pp. 521-531
    • Matsui, Y.1    Assi, K.2    Ogawa, O.3    Raven, P.A.4    Dedhar, S.5    Gleave, M.E.6
  • 17
    • 0035067120 scopus 로고    scopus 로고
    • Overexpression of the integrin-linked kinase mesenchymally transforms mammary epithelial cells
    • Somasiri A, Howarth A, Goswami D, Dedhar S, Roskelley CD. Overexpression of the integrin-linked kinase mesenchymally transforms mammary epithelial cells. J Cell Sci 2001; 114: 1125-1136.
    • (2001) J Cell Sci , vol.114 , pp. 1125-1136
    • Somasiri, A.1    Howarth, A.2    Goswami, D.3    Dedhar, S.4    Roskelley, C.D.5
  • 18
    • 16344378397 scopus 로고    scopus 로고
    • TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelialmesenchymal cell transition
    • Valcourt U, Kowanetz M, Niimi H, Heldin CH, Moustakas A. TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelialmesenchymal cell transition. Mol Biol Cell 2005; 16: 1987-2002.
    • (2005) Mol Biol Cell , vol.16 , pp. 1987-2002
    • Valcourt, U.1    Kowanetz, M.2    Niimi, H.3    Heldin, C.H.4    Moustakas, A.5
  • 19
    • 11144225205 scopus 로고    scopus 로고
    • Integrin-linked kinase: A cancer therapeutic target unique among its ILK
    • Hannigan G, Troussard AA, Dedhar S. Integrin-linked kinase: A cancer therapeutic target unique among its ILK. Nat Rev Cancer 2005; 5: 51-63.
    • (2005) Nat Rev Cancer , vol.5 , pp. 51-63
    • Hannigan, G.1    Troussard, A.A.2    Dedhar, S.3
  • 20
    • 79955712722 scopus 로고    scopus 로고
    • Evidence for partial epithelial-to-mesenchymal transition (pEMT) and recruitment of motile blastoderm edge cells during avian epiboly
    • Futterman MA, Garcia AJ, Zamir EA. Evidence for partial epithelial-to-mesenchymal transition (pEMT) and recruitment of motile blastoderm edge cells during avian epiboly. Dev Dyn 2011; 240: 1502-1511.
    • (2011) Dev Dyn , vol.240 , pp. 1502-1511
    • Futterman, M.A.1    Garcia, A.J.2    Zamir, E.A.3
  • 21
    • 79958201891 scopus 로고    scopus 로고
    • Knockdown of beta-catenin through shRNA cause a reversal of EMT and metastatic phenotypes induced by HIF-1alpha
    • Zhao JH, Luo Y, Jiang YG, He DL, Wu CT. Knockdown of beta-catenin through shRNA cause a reversal of EMT and metastatic phenotypes induced by HIF-1alpha. Cancer Invest 2011; 29: 377-382.
    • (2011) Cancer Invest , vol.29 , pp. 377-382
    • Zhao, J.H.1    Luo, Y.2    Jiang, Y.G.3    He, D.L.4    Wu, C.T.5
  • 22
    • 80053358029 scopus 로고    scopus 로고
    • Expression of Snail and Slug in renal cell carcinoma: E-cadherin repressor Snail is associated with cancer invasion and prognosis
    • Mikami S, Katsube K, Oya M, Ishida M, Kosaka T, Mizuno R et al. Expression of Snail and Slug in renal cell carcinoma: E-cadherin repressor Snail is associated with cancer invasion and prognosis. Lab Invest 2011; 91: 1443-1458.
    • (2011) Lab Invest , vol.91 , pp. 1443-1458
    • Mikami, S.1    Katsube, K.2    Oya, M.3    Ishida, M.4    Kosaka, T.5    Mizuno, R.6
  • 23
    • 0035804215 scopus 로고    scopus 로고
    • Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/ Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells
    • Tan C, Costello P, Sanghera J, Dominguez D, Baulida J, de Herreros AG et al. Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/ Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells. Oncogene 2001; 20: 133-140.
    • (2001) Oncogene , vol.20 , pp. 133-140
    • Tan, C.1    Costello, P.2    Sanghera, J.3    Dominguez, D.4    Baulida, J.5    De Herreros, A.G.6
  • 24
    • 80052403945 scopus 로고    scopus 로고
    • The EMT regulator slug and lung carcinogenesis
    • Shih JY, Yang PC. The EMT regulator slug and lung carcinogenesis. Carcinogenesis2011; 32: 1299-1304.
    • Carcinogenesis2011 , vol.32 , pp. 1299-1304
    • Shih, J.Y.1    Yang, P.C.2
  • 25
    • 24644487312 scopus 로고    scopus 로고
    • TGF-beta and epithelial-to-mesenchymal transitions
    • Zavadil J, Bottinger EP. TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 2005; 24: 5764-5774.
    • (2005) Oncogene , vol.24 , pp. 5764-5774
    • Zavadil, J.1    Bottinger, E.P.2
  • 26
    • 79955486858 scopus 로고    scopus 로고
    • MTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways
    • Gulhati P, Bowen KA, Liu J, Stevens PD, Rychahou PG, Chen M et al. mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res 2011; 71: 3246-3256.
    • (2011) Cancer Res , vol.71 , pp. 3246-3256
    • Gulhati, P.1    Bowen, K.A.2    Liu, J.3    Stevens, P.D.4    Rychahou, P.G.5    Chen, M.6
  • 27
    • 84859242866 scopus 로고    scopus 로고
    • Osteopontin regulates alpha-smooth muscle actin and calponin in vascular smooth muscle cells
    • Gao H, Steffen MC, Ramos KS. Osteopontin regulates alpha-smooth muscle actin and calponin in vascular smooth muscle cells. Cell Biol Int 2012; 36: 155-161.
    • (2012) Cell Biol Int , vol.36 , pp. 155-161
    • Gao, H.1    Steffen, M.C.2    Ramos, K.S.3
  • 28
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002; 2: 442-454.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 29
    • 84858288644 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in tumor microenvironment
    • Jing Y, Han Z, Zhang S, Liu Y, Wei L. Epithelial-mesenchymal transition in tumor microenvironment. Cell Biosci 2011; 1: 29.
    • (2011) Cell Biosci , vol.1 , pp. 29
    • Jing, Y.1    Han, Z.2    Zhang, S.3    Liu, Y.4    Wei, L.5
  • 30
    • 69249111313 scopus 로고    scopus 로고
    • Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling
    • Jo M, Lester RD, Montel V, Eastman B, Takimoto S, Gonias SL. Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling. J Biol Chem 2009; 284: 22825-22833.
    • (2009) J Biol Chem , vol.284 , pp. 22825-22833
    • Jo, M.1    Lester, R.D.2    Montel, V.3    Eastman, B.4    Takimoto, S.5    Gonias, S.L.6
  • 31
    • 70350545722 scopus 로고    scopus 로고
    • Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1
    • Dibble CC, Asara JM, Manning BD. Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol Cell Biol 2009; 29: 5657-5670.
    • (2009) Mol Cell Biol , vol.29 , pp. 5657-5670
    • Dibble, C.C.1    Asara, J.M.2    Manning, B.D.3
  • 33
    • 0033377867 scopus 로고    scopus 로고
    • TGF-(beta) type I receptor/ ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells
    • Piek E, Moustakas A, Kurisaki A, Heldin CH, ten Dijke P. TGF-(beta) type I receptor/ ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J Cell Sci 1999; 112: 4557-4568.
    • (1999) J Cell Sci , vol.112 , pp. 4557-4568
    • Piek, E.1    Moustakas, A.2    Kurisaki, A.3    Heldin, C.H.4    Ten Dijke, P.5
  • 35
    • 0035861541 scopus 로고    scopus 로고
    • Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity
    • Bhowmick NA, Zent R, Ghiassi M, McDonnell M, Moses HL. Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity. J Biol Chem 2001; 276: 46707-46713.
    • (2001) J Biol Chem , vol.276 , pp. 46707-46713
    • Bhowmick, N.A.1    Zent, R.2    Ghiassi, M.3    McDonnell, M.4    Moses, H.L.5
  • 36
    • 0034711307 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration
    • Bakin AV, Tomlinson AK, Bhowmick NA, Moses HL, Arteaga CL. Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem 2000; 275: 36803-36810.
    • (2000) J Biol Chem , vol.275 , pp. 36803-36810
    • Bakin, A.V.1    Tomlinson, A.K.2    Bhowmick, N.A.3    Moses, H.L.4    Arteaga, C.L.5
  • 37
    • 1642307942 scopus 로고    scopus 로고
    • Integrin-linked kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition
    • Lee YI, Kwon YJ, Joo CK. Integrin-linked kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition. Biochem Biophys Res Commun 2004; 316: 997-1001.
    • (2004) Biochem Biophys Res Commun , vol.316 , pp. 997-1001
    • Lee, Y.I.1    Kwon, Y.J.2    Joo, C.K.3
  • 40
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119: 1420-1428.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 41
    • 0035844886 scopus 로고    scopus 로고
    • Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation
    • Persad S, Troussard AA, McPhee TR, Mulholland DJ, Dedhar S. Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation. J Cell Biol 2001; 153: 1161-1174.
    • (2001) J Cell Biol , vol.153 , pp. 1161-1174
    • Persad, S.1    Troussard, A.A.2    McPhee, T.R.3    Mulholland, D.J.4    Dedhar, S.5
  • 42
    • 12144266241 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: Implications for the epithelial-mesenchymal transition
    • Bachelder RE, Yoon SO, Franci C, de Herreros AG, Mercurio AM. Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: Implications for the epithelial-mesenchymal transition. J Cell Biol 2005; 168: 29-33.
    • (2005) J Cell Biol , vol.168 , pp. 29-33
    • Bachelder, R.E.1    Yoon, S.O.2    Franci, C.3    De Herreros, A.G.4    Mercurio, A.M.5
  • 43
    • 34250744600 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in cell fate and epithelial- mesenchymal transitions
    • Doble BW, Woodgett Jr. Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions. Cells Tissues Organs 2007; 185: 73-84.
    • (2007) Cells Tissues Organs , vol.185 , pp. 73-84
    • Doble, B.W.1    Woodgett, J.R.2
  • 44
    • 5444269904 scopus 로고    scopus 로고
    • Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
    • Zhou BP, Deng J, Xia W, Xu J, Li YM, Gunduz M et al. Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol 2004; 6: 931-940.
    • (2004) Nat Cell Biol , vol.6 , pp. 931-940
    • Zhou, B.P.1    Deng, J.2    Xia, W.3    Xu, J.4    Li, Y.M.5    Gunduz, M.6
  • 45
    • 69449088675 scopus 로고    scopus 로고
    • Smad3 is a key nonredundant mediator of transforming growth factor beta signaling in Nme mouse mammary epithelial cells
    • Dzwonek J, Preobrazhenska O, Cazzola S, Conidi A, Schellens A, van Dinther M et al. Smad3 is a key nonredundant mediator of transforming growth factor beta signaling in Nme mouse mammary epithelial cells. Mol Cancer Res 2009; 7: 1342-1353.
    • (2009) Mol Cancer Res , vol.7 , pp. 1342-1353
    • Dzwonek, J.1    Preobrazhenska, O.2    Cazzola, S.3    Conidi, A.4    Schellens, A.5    Van Dinther, M.6
  • 46
    • 79952537281 scopus 로고    scopus 로고
    • Expression pattern of the pro-apoptotic gene PAR-4 during the morphogenesis of MCF-10A human mammary epithelial cells
    • de Bessa Garcia SA, Pereira MC, Nagai MA. Expression pattern of the pro-apoptotic gene PAR-4 during the morphogenesis of MCF-10A human mammary epithelial cells. Cancer Microenviron 2010; 4: 33-38.
    • (2010) Cancer Microenviron , vol.4 , pp. 33-38
    • De Bessa Garcia, S.A.1    Pereira, M.C.2    Nagai, M.A.3
  • 47
    • 0036097379 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 inscribes a gene expression profile for angiogenic factors and cancer progression in breast epithelial cells
    • Oh JS, Kucab JE, Bushel PR, Martin K, Bennett L, Collins J et al. Insulin-like growth factor-1 inscribes a gene expression profile for angiogenic factors and cancer progression in breast epithelial cells. Neoplasia 2002; 4: 204-217.
    • (2002) Neoplasia , vol.4 , pp. 204-217
    • Oh, J.S.1    Kucab, J.E.2    Bushel, P.R.3    Martin, K.4    Bennett, L.5    Collins, J.6
  • 49
    • 70949107280 scopus 로고    scopus 로고
    • Losartan-antioxidant hybrids: Novel molecules for the prevention of hypertension-induced cardiovascular damage
    • Garcia G, Rodriguez-Puyol M, Alajarin R, Serrano I, Sanchez-Alonso P, Griera M et al. Losartan-antioxidant hybrids: novel molecules for the prevention of hypertension-induced cardiovascular damage. J Med Chem 2009; 52: 7220-7227.
    • (2009) J Med Chem , vol.52 , pp. 7220-7227
    • Garcia, G.1    Rodriguez-Puyol, M.2    Alajarin, R.3    Serrano, I.4    Sanchez-Alonso, P.5    Griera, M.6


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